8a54bd3c84b94f32ddd40c7f37e386b5 pmc_33138175.pdf 135362952b631da642b1f11346721f1b2e8ce92c pmc_33138175.pdf 623e617e9e3b64c4d72534d1219c671a389cd9533c8f64059fa78bc60d568858 pmc_33138175.pdf Title: Clinicopathological Features as Prognostic Predictors of Poor Outcome in Papillary Thyroid Carcinoma Subject: Papillary thyroid cancer (PTC) has an indolent nature and usually excellent prognosis. Some PTC clinicopathological features may contribute to the development of aggressive metastatic disease. In this work, we want to evaluate PTC clinicopathological features that are presurgical prognostic predictors of patients’ outcomes and find which indicators are more adequate for tailoring surgical procedures and follow-up. We studied a series of 241 PTC patients submitted to surgery. All patients’ files and histological tumor samples were reviewed. The 8th edition AJCC/UICC (American Joint Committee on Cancer/Union for International Cancer) Controlstaging system and the 2015 American Thyroid Association risk stratification system were used. Total thyroidectomy was performed in 228 patients, lymphadenectomy in 28 patients. Gross extrathyroidal extension (ETE) was present in 10 patients and 31 tumor resection margins were incomplete. Cervical lymph node metastases (LNMs) were present in 34 patients and distant metastases at diagnosis in four patients. In multivariate analysis, male gender (OR = 15.4, p = 0.015), venous invasion (OR = 16.7, p = 0.022), and lateral compartment LNM (OR = 26.7, p = 0.004) were predictors of mortality; psammoma bodies (PBs) (OR = 4.5, p = 0.008), lymph vessel invasion (OR = 6.9, p < 0.001), and gross ETE (OR = 16.1, p = 0.001) were predictors of structural disease status; male gender (OR = 2.9, p = 0.011), lymph vessel invasion (OR = 2.8, p = 0.006), and incomplete resection margins (OR = 4.6, p < 0.001) were predictors of recurrent/persistent disease. Our study supports that the factors helping to tailor patient’s surgery are male gender, presence of PBs, gross ETE, and lateral compartment LNM. Together with pathological factors, lymph vessel invasion, venous invasion, necrosis, and incomplete surgical resection, should be taken into consideration regarding treatment and follow-up of patients. Keywords: thyroid cancer; prognosis; clinicopatholigical; outcomes Author: Antónia Afonso Póvoa, Elisabete Teixeira, Maria Rosa Bella-Cueto, Miguel Melo, Maria João Oliveira, Manuel Sobrinho-Simões, Jorge Maciel and Paula Soares Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Mon Nov 9 11:30:21 2020 CET ModDate: Mon Nov 9 11:44:08 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1668871 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GXPUKB+VnURWPalladioL Type 1 Custom yes yes no 10 0 VWMJCP+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 RBNCSL+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 GJIEPW+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 OFLXAT+Rpxr Type 1 Builtin yes yes no 28 0 WGKINO+VnURWPalladioL-Bold Type 1 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BLDCKJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 161 0 BLDCLL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 164 0 BLDDHI+TimesNewRoman CID TrueType Identity-H yes yes yes 167 0 BLDCGJ+PalatinoLinotype TrueType WinAnsi yes yes no 187 0 BLDCKJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 190 0 BLDCLL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 193 0 BLDDHI+TimesNewRoman CID TrueType Identity-H yes yes yes 196 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 225 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-29 02:32:02 CEST RepresentationInformation: pmc_33138175.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-11-30 03:48:01 CET Size: 1668871 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 396 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Demography and Histopathology Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Post-Operative Staging and Radioiodine (RAI) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Follow-Up Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Association Between Clinicopathological Features and Recurrent/Persistent Disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Association Between Clinicopathological Features and Recurrent/Persistent Disease, in Stage I Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Association Between Clinicopathological Features and Structural Disease Status Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Association Between Clinicopathological Features and Structural Disease Status, in Stage I Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Association Between Clinicopathological Features and Disease-Specific Mortality Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Patient Cohort and Tissue Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Patient Follow-Up Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Clinical Endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Info: Title: Clinicopathological Features as Prognostic Predictors of Poor Outcome in Papillary Thyroid Carcinoma Author: Antónia Afonso Póvoa, Elisabete Teixeira, Maria Rosa Bella-Cueto, Miguel Melo, Maria João Oliveira, Manuel Sobrinho-Simões, Jorge Maciel and Paula Soares Subject: Papillary thyroid cancer (PTC) has an indolent nature and usually excellent prognosis. Some PTC clinicopathological features may contribute to the development of aggressive metastatic disease. In this work, we want to evaluate PTC clinicopathological features that are presurgical prognostic predictors of patients’ outcomes and find which indicators are more adequate for tailoring surgical procedures and follow-up. We studied a series of 241 PTC patients submitted to surgery. All patients’ files and histological tumor samples were reviewed. The 8th edition AJCC/UICC (American Joint Committee on Cancer/Union for International Cancer) Controlstaging system and the 2015 American Thyroid Association risk stratification system were used. Total thyroidectomy was performed in 228 patients, lymphadenectomy in 28 patients. Gross extrathyroidal extension (ETE) was present in 10 patients and 31 tumor resection margins were incomplete. Cervical lymph node metastases (LNMs) were present in 34 patients and distant metastases at diagnosis in four patients. In multivariate analysis, male gender (OR = 15.4, p = 0.015), venous invasion (OR = 16.7, p = 0.022), and lateral compartment LNM (OR = 26.7, p = 0.004) were predictors of mortality; psammoma bodies (PBs) (OR = 4.5, p = 0.008), lymph vessel invasion (OR = 6.9, p < 0.001), and gross ETE (OR = 16.1, p = 0.001) were predictors of structural disease status; male gender (OR = 2.9, p = 0.011), lymph vessel invasion (OR = 2.8, p = 0.006), and incomplete resection margins (OR = 4.6, p < 0.001) were predictors of recurrent/persistent disease. Our study supports that the factors helping to tailor patient’s surgery are male gender, presence of PBs, gross ETE, and lateral compartment LNM. Together with pathological factors, lymph vessel invasion, venous invasion, necrosis, and incomplete surgical resection, should be taken into consideration regarding treatment and follow-up of patients. 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