57008fffa7f21ed6ab9c5aece908dc3d pmc_33138310.pdf 7cde884bcf4ebe8351334388366f4696ef96f6f1 pmc_33138310.pdf 09385fe19466feba4ab5f43f2b366463dee3988a2f97b6f945502fd6c87693bc pmc_33138310.pdf Title: Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study Subject: Ventilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause of acute respiratory distress syndrome (ARDS) is pneumonia. ARDS can occur in patients with community-acquired or nosocomial pneumonia. Data regarding ARDS incidence, related pathogens, and specific outcomes in patients with VAP is limited. This is a cohort study in which patients with VAP were evaluated in an 800-bed tertiary teaching hospital between 2004 and 2016. Clinical outcomes, microbiological and epidemiological data were assessed among those who developed ARDS and those who did not. Forty-one (13.6%) out of 301 VAP patients developed ARDS. Patients who developed ARDS were younger and presented with higher prevalence of chronic liver disease. Pseudomonas aeruginosa was the most frequently isolated pathogen, but without any difference between groups. Appropriate empirical antibiotic treatment was prescribed to ARDS patients as frequently as to those without ARDS. Ninety-day mortality did not significantly vary among patients with or without ARDS. Additionally, patients with ARDS did not have significantly higher intensive care unit (ICU) and 28-day mortality, ICU, and hospital length of stay, ventilation-free days, and duration of mechanical ventilation. In summary, ARDS deriving from VAP occurs in 13.6% of patients. Although significant differences in clinical outcomes were not observed between both groups, further studies with a higher number of patients are needed due to the possibility of the study being underpowered. Keywords: ventilator-associated pneumonia; acute respiratory distress syndrome; epidemiology Author: Enric Barbeta, Adrian Ceccato, Antoni Artigas, Miquel Ferrer, Laia Fernández, Rubén López, Leticia Bueno, Anna Motos, Gianluigi Li Bassi, Ricard Mellado, Carlos Ferrando, Andrea Catalina Palomeque, Mauro Panigada, Albert Gabarrús, Diego de Mendoza and Antoni Torres Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Sun Nov 1 10:53:45 2020 CET ModDate: Mon Nov 2 09:48:07 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 649961 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YUQXUW+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 JIHRXL+VnURWPalladioL Type 1 Custom yes yes no 15 0 ZJJASS+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 LVWDFI+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 TAGGCV+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 WDLIVJ+Rpxr Type 1 Builtin yes yes no 32 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 40 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 43 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 65 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 69 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 73 0 UEMQDD+Pxsy Type 1 Builtin yes yes no 80 0 ANHOIJ+PalatinoLinotype CID TrueType Identity-H yes yes yes 96 0 ANHOJK+PalatinoLinotype TrueType WinAnsi yes yes no 102 0 ANHOMK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 105 0 ANHONM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 108 0 ANHPDL+TimesNewRoman CID TrueType Identity-H yes yes yes 111 0 JLZORU+EURM10 Type 1 Builtin yes yes no 121 0 VUPETJ+Rpxb Type 1 Builtin yes yes no 128 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes no 132 0 ANHOJK+PalatinoLinotype TrueType WinAnsi yes yes no 153 0 ANHOMK+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 156 0 ANHONM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 159 0 ANHPDL+TimesNewRoman CID TrueType Identity-H yes yes yes 162 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 182 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-29 02:32:00 CEST RepresentationInformation: pmc_33138310.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-11-30 03:47:56 CET Size: 649961 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 300 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Design and Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Definition of Pneumonia and ARDS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Microbiological Evaluation and Diagnosis Criteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Data Collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Antimicrobial Treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Outcome Measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Children: Item: Title: Patient Characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Microbiological Diagnosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Mortality, Length of Stay, and Ventilator-Free Days Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Info: Title: Characteristics and Outcomes in Patients with Ventilator-Associated Pneumonia Who Do or Do Not Develop Acute Respiratory Distress Syndrome. An Observational Study Author: Enric Barbeta, Adrian Ceccato, Antoni Artigas, Miquel Ferrer, Laia Fernández, Rubén López, Leticia Bueno, Anna Motos, Gianluigi Li Bassi, Ricard Mellado, Carlos Ferrando, Andrea Catalina Palomeque, Mauro Panigada, Albert Gabarrús, Diego de Mendoza and Antoni Torres Subject: Ventilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause of acute respiratory distress syndrome (ARDS) is pneumonia. ARDS can occur in patients with community-acquired or nosocomial pneumonia. Data regarding ARDS incidence, related pathogens, and specific outcomes in patients with VAP is limited. This is a cohort study in which patients with VAP were evaluated in an 800-bed tertiary teaching hospital between 2004 and 2016. Clinical outcomes, microbiological and epidemiological data were assessed among those who developed ARDS and those who did not. Forty-one (13.6%) out of 301 VAP patients developed ARDS. Patients who developed ARDS were younger and presented with higher prevalence of chronic liver disease. Pseudomonas aeruginosa was the most frequently isolated pathogen, but without any difference between groups. Appropriate empirical antibiotic treatment was prescribed to ARDS patients as frequently as to those without ARDS. Ninety-day mortality did not significantly vary among patients with or without ARDS. Additionally, patients with ARDS did not have significantly higher intensive care unit (ICU) and 28-day mortality, ICU, and hospital length of stay, ventilation-free days, and duration of mechanical ventilation. In summary, ARDS deriving from VAP occurs in 13.6% of patients. Although significant differences in clinical outcomes were not observed between both groups, further studies with a higher number of patients are needed due to the possibility of the study being underpowered. 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