7751417fa437c86f035ec0c05dc2cd39 pmc_33176887.pdf b9a4245155ccbcb4e7fb247fb4e13d96db3b4a40 pmc_33176887.pdf db5964b70d34277337226b688d4c2d9adfb8e218d2d825fe14d9b308373f1395 pmc_33176887.pdf Title: Immuno-priming durvalumab with bevacizumab in HER2-negative advanced breast cancer: a pilot clinical trial Subject: Breast Cancer Research, 2020, doi:10.1186/s13058-020-01362-y Keywords: Durvalumab,Bevacizumab,HER2-negative breast cancer,Vascular normalization,Immuno-priming Author: Miguel Quintela-Fandino Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sun Nov 8 06:47:09 2020 CET ModDate: Wed Nov 11 13:00:32 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1419639 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 18 0 ODMPIP+BtnqbmAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 21 0 ODNBJD+DmlyvlAdvTTe45e47d2 Type 1C WinAnsi yes yes no 22 0 ODNBKE+TqghjqAdvTTb5929f4c Type 1C WinAnsi yes yes no 23 0 ODNBNE+NcmcpdAdvTT99c4c969 Type 1C WinAnsi yes yes no 24 0 ODNBOE+GfmkysAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 25 0 ODNCMA+VkqprwAdvTT7329fd89.I Type 1C WinAnsi yes yes no 26 0 ODNDAD+GssbvrAdvTT86d47313+20 Type 1C Custom yes yes yes 17 0 ODNDAB+CrrtkxAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 19 0 ODNDAC+VmjgpfAdvTT86d47313 Type 1C WinAnsi yes yes no 20 0 ODNDDC+HlbkjgAdvTT86d47313+22 Type 1C Custom yes yes yes 297 0 ODNDED+JylsvlAdvTT86d47313+03 Type 1C Custom yes yes yes 298 0 ODNDHE+TvxwlkAdvTT8861b38f.I Type 1C WinAnsi yes yes no 10 0 ODNDGD+LbxvqgAdvTT86d47313+21 Type 1C WinAnsi yes yes no 361 0 ODNOBE+VttmdsAdvTTb5929f4c+03 Type 1C Custom yes yes yes 384 0 ODNOHC+RwrhrxAdvTTb5929f4c+22 Type 1C Custom yes yes no 308 0 ODNOKC+PntwpkAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 393 0 ODNOPB+FrmclgAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 405 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-07-07 02:27:00 CEST RepresentationInformation: pmc_33176887.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-11-30 03:47:21 CET Size: 1419639 Format: PDF Version: 1.3 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR6' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR7' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR8' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR9' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR10' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR11' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR13' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR14' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR20' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig1' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR27' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR28' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_Fig2' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR29' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR28' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR15' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR19' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR30' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR25' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR26' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR31' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR32' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR4' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR3' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR33' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR21' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR24' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR34' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR35' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR36' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR5' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR37' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR39' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR40' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR42' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR16' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR17' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR18' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR30' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR43' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR44' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR45' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR46' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR48' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR1' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR2' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR31' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR12' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR36' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR49' cannot be found Offset: 853297 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'link_CR50' cannot be found Offset: 853297 MIMEtype: application/pdf PDFMetadata: Objects: 527 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Children: Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Trial registration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Study population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Trial design and correlative studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Aims and statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: Patients and treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Efficacy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Differences in peripheral blood mononuclear cells (PBMCs) immunophenotyping between progressors and non-progressors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Gene-expression patterns and vascular normalization in tumors from progressors and non-progressors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Safety Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Supplementary information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Abbreviations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Authors’ contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Availability of data and materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Ethics approval and consent to participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Author details Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Publisher’s Note Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Info: Title: Immuno-priming durvalumab with bevacizumab in HER2-negative advanced breast cancer: a pilot clinical trial Author: Miguel Quintela-Fandino Subject: Breast Cancer Research, 2020, doi:10.1186/s13058-020-01362-y Keywords: Durvalumab,Bevacizumab,HER2-negative breast cancer,Vascular normalization,Immuno-priming Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sun Nov 08 06:47:09 CET 2020 ModDate: Wed Nov 11 13:00:32 CET 2020 ID: 0x41da136932b28603ce3f937eec43111c, 0xb260b3d4eddcd346dbd35fa046c7703c Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 176 ImageHeight: 182 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 54 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1420 ImageHeight: 2066 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: ODNOBE+VttmdsAdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: ODNOBE+VttmdsAdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ODNDDC+HlbkjgAdvTT86d47313+22 FontSubset: true FirstChar: 1 LastChar: 139 FontDescriptor: FontName: ODNDDC+HlbkjgAdvTT86d47313+22 Flags: Symbolic FontBBox: -166, -250, 1031, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ODNDGD+LbxvqgAdvTT86d47313+21 FontSubset: true FirstChar: 32 LastChar: 153 FontDescriptor: FontName: ODNDGD+LbxvqgAdvTT86d47313+21 Flags: Nonsymbolic FontBBox: -20, -208, 1208, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ODNOKC+PntwpkAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: ODNOKC+PntwpkAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ODNDED+JylsvlAdvTT86d47313+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: ODNDED+JylsvlAdvTT86d47313+03 Flags: Symbolic FontBBox: -364, -250, 906, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ODNDHE+TvxwlkAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: ODNDHE+TvxwlkAdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ODNDAD+GssbvrAdvTT86d47313+20 FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: ODNDAD+GssbvrAdvTT86d47313+20 Flags: Symbolic FontBBox: -354, -218, 1291, 812 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ODNDAB+CrrtkxAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: ODNDAB+CrrtkxAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ODNDAC+VmjgpfAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 239 FontDescriptor: FontName: ODNDAC+VmjgpfAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ODNOHC+RwrhrxAdvTTb5929f4c+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: ODNOHC+RwrhrxAdvTTb5929f4c+22 Flags: Nonsymbolic FontBBox: -10, -218, 1083, 812 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ODMPIP+BtnqbmAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: ODMPIP+BtnqbmAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ODNOPB+FrmclgAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: ODNOPB+FrmclgAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ODNBJD+DmlyvlAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: ODNBJD+DmlyvlAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ODNBKE+TqghjqAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: ODNBKE+TqghjqAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ODNBNE+NcmcpdAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: ODNBNE+NcmcpdAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ODNBOE+GfmkysAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 151 FontDescriptor: FontName: ODNBOE+GfmkysAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ODNCMA+VkqprwAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: ODNCMA+VkqprwAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: Durvalumab,Bevacizumab,HER2-negative breast cancer,Vascular normalization,Immuno-priming Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) application/pdf 10.1186/s13058-020-01362-y Breast Cancer Research Breast Cancer Research, 2020, doi:10.1186/s13058-020-01362-y Durvalumab Bevacizumab HER2-negative breast cancer Vascular normalization Immuno-priming Immuno-priming durvalumab with bevacizumab in HER2-negative advanced breast cancer: a pilot clinical trial Miguel Quintela-Fandino Esther Holgado Luis Manso Serafin Morales Begoña Bermejo Ramon Colomer Juan V. Apala Raquel Blanco Manuel Muñoz Eduardo Caleiras Vega Iranzo Mario Martinez Orlando Dominguez Javier Hornedo Lucia Gonzalez-Cortijo Javier Cortes Ariadna Gasol Cudos Diego Malon Antonio Lopez-Alonso María C. Moreno-Ortíz Silvana Mouron Santos Mañes 2020-11-11T13:00:32+01:00 2020-11-11T13:00:32+01:00 2020-11-08T13:47:09+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode uuid:e15f2eb5-0b23-42d5-aed4-8ea3a20847ed uuid:f01a790c-a1ba-474e-a8ac-acc89ed35c89 default 1 converted uuid:e15f2eb5-0b23-42d5-aed4-8ea3a20847ed converted to PDF/A-2b pdfToolbox 2020-11-08T14:28:30+08:00 2 B Miguel Quintela-Fandino http://orcid.org/0000-0003-1648-1964 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 496, 635, 538, 677 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 177, 573, 186, 582 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 400, 73, 518, 80 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 65, 477, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 192, 170, 199 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 174, 192, 233, 199 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 232, 514, 290, 524 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 245, 442, 250, 452 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 256, 442, 261, 452 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 226, 406, 230, 416 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 81, 358, 85, 368 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 92, 358, 97, 368 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 215, 358, 219, 368 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 226, 358, 236, 368 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 88, 298, 98, 308 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 244, 274, 254, 284 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 99, 190, 109, 200 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 115, 190, 125, 200 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 225, 166, 234, 176 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 98, 130, 107, 140 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 197, 118, 207, 128 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 213, 118, 222, 128 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 163, 106, 172, 116 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 189, 70, 199, 80 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 204, 70, 213, 80 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 474, 418, 483, 428 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 491, 382, 500, 392 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 506, 382, 516, 392 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 497, 310, 506, 320 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 512, 310, 521, 320 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 388, 250, 397, 260 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 307, 238, 317, 248 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 392, 681, 397, 690 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 530, 525, 535, 534 Flags: Print AppearanceDictionary: true Destination: 5 Annotation: Subtype: Link Rect: 375, 477, 385, 486 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 478, 441, 483, 450 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 494, 441, 499, 450 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 510, 441, 515, 450 Flags: Print AppearanceDictionary: true Destination: 277 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 83, 69, 156, 78 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 260, 57, 290, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 429, 438, 438 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 461, 345, 471, 354 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 531, 645, 536, 654 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 514, 537, 519, 546 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 395, 501, 400, 510 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 163, 261, 168, 270 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 211, 237, 215, 246 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 110, 189, 115, 198 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 139, 153, 144, 162 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 74, 105, 78, 114 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 171, 81, 176, 90 Flags: Print AppearanceDictionary: true Destination: 265 Annotation: Subtype: Link Rect: 398, 333, 403, 342 Flags: Print AppearanceDictionary: true Destination: 265 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 176, 69, 181, 78 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 427, 105, 432, 114 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 456, 69, 461, 78 Flags: Print AppearanceDictionary: true Destination: 269 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 257, 189, 262, 198 Flags: Print AppearanceDictionary: true Destination: 269 Annotation: Subtype: Link Rect: 129, 141, 134, 150 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 214, 117, 219, 126 Flags: Print AppearanceDictionary: true Destination: 277 Annotation: Subtype: Link Rect: 137, 69, 142, 78 Flags: Print AppearanceDictionary: true Destination: 269 Annotation: Subtype: Link Rect: 356, 201, 361, 210 Flags: Print AppearanceDictionary: true Destination: 269 Annotation: Subtype: Link Rect: 455, 177, 460, 186 Flags: Print AppearanceDictionary: true Destination: 5 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 252, 693, 257, 702 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 112, 669, 117, 678 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 233, 633, 238, 642 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 174, 609, 183, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 98, 537, 108, 546 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 157, 465, 162, 474 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 247, 429, 252, 438 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 169, 393, 174, 402 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 148, 369, 153, 378 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 82, 321, 87, 330 Flags: Print AppearanceDictionary: true Destination: 78 Annotation: Subtype: Link Rect: 445, 669, 454, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 460, 669, 470, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 475, 669, 484, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 490, 669, 499, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 504, 669, 514, 678 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 425, 633, 435, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 441, 633, 450, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 420, 525, 430, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 438, 525, 447, 534 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 463, 321, 468, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 369, 285, 374, 294 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 442, 285, 446, 294 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 401, 249, 406, 258 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 469, 237, 474, 246 Flags: Print AppearanceDictionary: true Destination: null Thumb: true Page: Sequence: 10 Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 144, 333, 154, 342 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 222, 153, 226, 162 Flags: Print AppearanceDictionary: true Destination: 286 Annotation: Subtype: Link Rect: 81, 129, 90, 138 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 95, 129, 105, 138 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 211, 81, 220, 90 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 88, 69, 97, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 227, 69, 236, 78 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 456, 609, 461, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 467, 609, 472, 618 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 486, 585, 496, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 501, 585, 511, 594 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 528, 525, 533, 534 Flags: Print AppearanceDictionary: true Destination: 269 Annotation: Subtype: Link Rect: 445, 477, 450, 486 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 386, 441, 395, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 401, 441, 411, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 347, 321, 357, 330 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 457, 273, 461, 282 Flags: Print AppearanceDictionary: true Destination: 274 Annotation: Subtype: Link Rect: 380, 213, 390, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 395, 213, 405, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 410, 213, 420, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 481, 189, 490, 198 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 445, 177, 455, 186 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 508, 69, 513, 78 Flags: Print AppearanceDictionary: true Destination: 274 Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 59, 633, 69, 642 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 117, 465, 127, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 133, 465, 142, 474 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 209, 441, 213, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 219, 441, 224, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 230, 441, 240, 450 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 165, 381, 170, 390 Flags: Print AppearanceDictionary: true Destination: 78 Annotation: Subtype: Link Rect: 94, 309, 104, 318 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 138, 213, 147, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 153, 213, 162, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 168, 213, 177, 222 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 76, 141, 81, 150 Flags: Print AppearanceDictionary: true Destination: 269 Annotation: Subtype: Link Rect: 478, 427, 532, 434 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 418, 381, 425 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 13 Thumb: true Page: Sequence: 14 Thumb: true Checksum: cf1cdbb8 Type: CRC32 Checksum: 7751417fa437c86f035ec0c05dc2cd39 Type: MD5 Checksum: b9a4245155ccbcb4e7fb247fb4e13d96db3b4a40 Type: SHA-1