ba89c1024a9c9f77405e7545a27fe897 pmc_33184423.pdf c59989abdd49bff213ae6e250970e1c6868d92ab pmc_33184423.pdf ae56747da48b5c7d5d01ab8fbe8c2850f292991d4010c250b06faec9b5b26985 pmc_33184423.pdf Title: Unraveling response to temozolomide in preclinical GL261 glioblastoma with MRI/MRSI using radiomics and signal source extraction Subject: Scientific Reports, https://doi.org/10.1038/s41598-020-76686-y Author: Luis Miguel Núñez Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Nov 6 17:27:27 2020 CET ModDate: Sat Nov 7 06:22:45 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2135912 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NOSGIP+Wingdings-Regular Type 1C WinAnsi yes yes yes 650 0 MinionPro-Regular Type 1C Custom yes no yes 33 0 Corbel-BoldItalic TrueType WinAnsi yes no yes 651 0 QOYRAS+Corbel-Bold CID TrueType Identity-H yes yes yes 36 0 Corbel2 TrueType WinAnsi yes no yes 40 0 VLNVSI+Corbel CID TrueType Identity-H yes yes yes 43 0 Corbel2 TrueType WinAnsi yes no yes 605 0 KSFTUE+MinionPro-It2 Type 1C Custom yes yes no 34 0 MinionPro-It Type 1C Custom yes no yes 35 0 KSFTUE+MTSYN Type 1C Custom yes yes yes 37 0 KSFTUE+MinionPro-Regular5 Type 1C Custom yes yes no 38 0 KSFTUE+MinionPro-Regular2 Type 1C Custom yes yes no 39 0 KSFTUE+MinionPro-Regular4 Type 1C Custom yes yes no 41 0 KSFTUE+MinionPro-Regular7 Type 1C Custom yes yes no 42 0 KSFTUE+MinionPro-Regular6 Type 1C Custom yes yes no 44 0 KSFTUE+MTSYN2 Type 1C Custom yes yes yes 45 0 KSFTUE+MinionPro-Regular3 Type 1C Custom yes yes no 46 0 MinionPro-Bold Type 1C Custom yes no yes 83 0 KTYEUE+MinionPro-Regular10 Type 1C Custom yes yes no 84 0 KTYEUE+MinionPro-Regular8 Type 1C Custom yes yes no 85 0 KTYEUE+MinionPro-Regular9 Type 1C Custom yes yes no 86 0 KSFTUE+MinionPro-It7 Type 1C Custom yes yes no 137 0 KSFTUE+MTSYN3 Type 1C Custom yes yes yes 138 0 KSFTUE+MinionPro-It6 Type 1C Custom yes yes no 139 0 KTYEUE+CMEX10 Type 1C Custom yes yes no 140 0 KSFTUE+MinionPro-It5 Type 1C Custom yes yes no 141 0 KSFTUE+MinionPro-Regular11 Type 1C Custom yes yes no 142 0 KSFTUE+MinionPro-It3 Type 1C Custom yes yes no 143 0 KTYEUE+MTMI Type 1C Custom yes yes no 144 0 KSFTUE+MinionPro-It4 Type 1C Custom yes yes no 145 0 KSFTUE+MTSYN5 Type 1C Custom yes yes yes 146 0 KTYEUE+MTMI2 Type 1C Custom yes yes no 147 0 KTYEUE+CMEX103 Type 1C Custom yes yes no 148 0 KSFTUE+MTSYN4 Type 1C Custom yes yes yes 149 0 KTYEUE+MTMI3 Type 1C Custom yes yes no 150 0 KTYEUE+CMEX102 Type 1C Custom yes yes no 151 0 KSFTUE+MinionPro-It9 Type 1C Custom yes yes no 215 0 KSFTUE+MinionPro-It8 Type 1C Custom yes yes no 216 0 KSFTUE+MTSYN9 Type 1C Custom yes yes yes 217 0 KTYEUE+MTMI4 Type 1C Custom yes yes no 218 0 KSFTUE+MinionPro-Regular14 Type 1C Custom yes yes no 219 0 KSFTUE+MinionPro-Regular12 Type 1C Custom yes yes no 220 0 KSFTUE+MinionPro-Regular13 Type 1C Custom yes yes no 221 0 KTYEUE+CMEX104 Type 1C Custom yes yes yes 222 0 KSFTUE+MTSYN7 Type 1C Custom yes yes yes 223 0 KSFTUE+MTSYN6 Type 1C Custom yes yes yes 224 0 KSFTUE+MTSYN8 Type 1C Custom yes yes yes 225 0 KTYEUE+MTMI5 Type 1C Custom yes yes no 226 0 KSFTUE+MinionPro-It10 Type 1C Custom yes yes no 227 0 KTYEUE+MinionPro-It11 Type 1C Custom yes yes no 299 0 KTYEUE+MTMI6 Type 1C Custom yes yes no 300 0 KTYEUE+MinionPro-Regular15 Type 1C Custom yes yes no 301 0 KTYEUE+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 453 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-22 02:36:32 CEST RepresentationInformation: pmc_33184423.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-11-23 03:36:46 CET Size: 2135912 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 717 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Unraveling response to temozolomide in preclinical GL261 glioblastoma with MRIMRSI using radiomics and signal source extraction Children: Item: Title: Methods Children: Item: Title: Data. Item: Title: Radiomics. Item: Title: Convex-NMF. Item: Title: Feature selection. Item: Title: Nosological visualization of the Convex-NMF sources-based classifier. Item: Title: The analytical pipeline in a nutshell. Item: Title: Results Item: Title: Discussion Children: Item: Title: Radiomics study. Item: Title: MRSI study. Item: Title: Conclusions. Item: Title: References Item: Title: Acknowledgements Info: Title: Unraveling response to temozolomide in preclinical GL261 glioblastoma with MRI/MRSI using radiomics and signal source extraction Author: Luis Miguel Núñez Subject: Scientific Reports, https://doi.org/10.1038/s41598-020-76686-y Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Nov 06 17:57:27 CET 2020 ModDate: Sat Nov 07 06:22:45 CET 2020 ID: 0x4d08e96a8137ed38d446fa41c5419f98, 0x3a54456f38b6e19d420f6e84e9adb3f6 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2002 ImageHeight: 618 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2002 ImageHeight: 722 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2003 ImageHeight: 647 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 898 ImageHeight: 919 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1423 ImageHeight: 1251 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2002 ImageHeight: 1616 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1996 ImageHeight: 974 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1069 ImageHeight: 897 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: QOYRAS+Corbel-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: VLNVSI+Corbel Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: KSFTUE+MinionPro-It7 FontSubset: true FirstChar: 26 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-It7 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: NOSGIP+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: NOSGIP+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: KSFTUE+MTSYN3 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KSFTUE+MTSYN3 Flags: Symbolic FontBBox: 0, -181, 724, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KSFTUE+MinionPro-It6 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-It6 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTYEUE+CMEX10 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: KTYEUE+CMEX10 Flags: Symbolic FontBBox: 0, -1810, 999, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-It5 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-It5 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-Regular11 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-Regular11 Flags: Symbolic, SmallCap FontBBox: 0, -117, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-It3 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-It3 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTYEUE+MTMI FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: KTYEUE+MTMI Flags: Symbolic FontBBox: 0, -177, 683, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-It4 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-It4 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MTSYN5 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KSFTUE+MTSYN5 Flags: Symbolic FontBBox: 0, -181, 724, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Bold Flags: Serif, Nonsymbolic FontBBox: -319, -360, 1684, 1024 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KTYEUE+MTMI2 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: KTYEUE+MTMI2 Flags: Symbolic FontBBox: 0, -177, 683, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTYEUE+MinionPro-Regular10 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KTYEUE+MinionPro-Regular10 Flags: Symbolic, AllCap FontBBox: 0, -117, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTYEUE+CMEX103 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KTYEUE+CMEX103 Flags: Symbolic FontBBox: 0, -1810, 999, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTYEUE+MinionPro-Regular8 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KTYEUE+MinionPro-Regular8 Flags: Symbolic, AllCap FontBBox: 0, -117, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MTSYN4 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: KSFTUE+MTSYN4 Flags: Symbolic FontBBox: 0, -181, 724, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KTYEUE+MinionPro-Regular9 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KTYEUE+MinionPro-Regular9 Flags: Symbolic, AllCap FontBBox: 0, -117, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTYEUE+MTMI3 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: KTYEUE+MTMI3 Flags: Symbolic FontBBox: 0, -177, 683, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTYEUE+CMEX102 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: KTYEUE+CMEX102 Flags: Symbolic FontBBox: 0, -1810, 999, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-It9 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-It9 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-It8 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-It8 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MTSYN9 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: KSFTUE+MTSYN9 Flags: Symbolic FontBBox: 0, -181, 724, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KTYEUE+MTMI4 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: KTYEUE+MTMI4 Flags: Symbolic FontBBox: 0, -177, 683, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-Regular14 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-Regular14 Flags: Symbolic, SmallCap FontBBox: 0, -117, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-Regular12 FontSubset: true FirstChar: 25 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-Regular12 Flags: Symbolic, SmallCap FontBBox: 0, -117, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-Regular13 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-Regular13 Flags: Symbolic, SmallCap FontBBox: 0, -117, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTYEUE+CMEX104 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: KTYEUE+CMEX104 Flags: Symbolic FontBBox: 0, -1810, 999, 40 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KSFTUE+MTSYN7 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: KSFTUE+MTSYN7 Flags: Symbolic FontBBox: 0, -181, 724, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KSFTUE+MTSYN6 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: KSFTUE+MTSYN6 Flags: Symbolic FontBBox: 0, -181, 724, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KSFTUE+MTSYN8 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: KSFTUE+MTSYN8 Flags: Symbolic FontBBox: 0, -181, 724, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KSFTUE+MinionPro-It2 FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KSFTUE+MinionPro-It2 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTYEUE+MTMI5 FontSubset: true FirstChar: 27 LastChar: 32 FontDescriptor: FontName: KTYEUE+MTMI5 Flags: Symbolic FontBBox: 0, -177, 683, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MinionPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KSFTUE+MinionPro-It10 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-It10 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MTSYN FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KSFTUE+MTSYN Flags: Symbolic FontBBox: 0, -181, 724, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KSFTUE+MinionPro-Regular5 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-Regular5 Flags: Symbolic, SmallCap FontBBox: 0, -117, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-Regular2 FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: KSFTUE+MinionPro-Regular2 Flags: Symbolic, SmallCap FontBBox: 0, -117, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-Regular4 FontSubset: true FirstChar: 29 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-Regular4 Flags: Symbolic, SmallCap FontBBox: 0, -117, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-Regular7 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-Regular7 Flags: Symbolic, SmallCap FontBBox: 0, -117, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTYEUE+MinionPro-It11 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: KTYEUE+MinionPro-It11 Flags: Symbolic, SmallCap FontBBox: 0, -12, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-Regular6 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-Regular6 Flags: Symbolic, SmallCap FontBBox: 0, -117, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KTYEUE+MTMI6 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: KTYEUE+MTMI6 Flags: Symbolic, AllCap FontBBox: 0, -11, 193, 100 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MTSYN2 FontSubset: true FirstChar: 31 LastChar: 32 FontDescriptor: FontName: KSFTUE+MTSYN2 Flags: Symbolic FontBBox: 0, -181, 724, 680 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KTYEUE+MinionPro-Regular15 FontSubset: true FirstChar: 28 LastChar: 32 FontDescriptor: FontName: KTYEUE+MinionPro-Regular15 Flags: Symbolic, AllCap FontBBox: 0, -117, 500, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: KSFTUE+MinionPro-Regular3 FontSubset: true FirstChar: 30 LastChar: 32 FontDescriptor: FontName: KSFTUE+MinionPro-Regular3 Flags: Symbolic, SmallCap FontBBox: 0, -117, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true TrueType: Font: BaseFont: KTYEUE+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: KTYEUE+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel2 Flags: Nonsymbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: Corbel-BoldItalic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Corbel-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -494, -239, 1194, 952 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: VLNVSI+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: VLNVSI+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: QOYRAS+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QOYRAS+Corbel-Bold Flags: Symbolic FontBBox: -556, -239, 1155, 952 FontFile2: true XMP: 2020-11-06T21:57:27+05:30 Springer 2020-11-07T06:22:45+01:00 2020-11-07T06:22:45+01:00 application/pdf https://doi.org/10.1038/s41598-020-76686-y Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-020-76686-y Unraveling response to temozolomide in preclinical GL261 glioblastoma with MRI/MRSI using radiomics and signal source extraction Luis Miguel Núñez Enrique Romero Margarida Julià-Sapé María Jesús Ledesma-Carbayo Andrés Santos Carles Arús Ana Paula Candiota Alfredo Vellido 10.1038/s41598-020-76686-y 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-020-76686-y 10.1038/s41598-020-76686-y 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-020-76686-y noindex springer.com springerlink.com VoR uuid:3c758ec6-1f9e-4761-aa2c-0d5431291bb6 uuid:b744350a-3593-483c-857f-4233bbc65092 default 1 converted uuid:77411eec-739d-4a08-9c91-27e3f65f0a12 converted to PDF/A-2b pdfToolbox 2020-11-06T21:58:52+05:30 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 374, 271, 377, 259 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 309, 231, 312, 219 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 441, 201, 444, 189 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 285, 191, 288, 179 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 224, 181, 227, 169 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 489, 141, 492, 129 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 481, 675, 556, 658 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 432, 674, 435, 662 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 343, 644, 345, 632 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 473, 634, 475, 622 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 477, 634, 480, 622 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 481, 634, 484, 622 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 193, 504, 198, 492 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 319, 424, 325, 412 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 458, 392, 461, 380 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 462, 392, 465, 380 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 466, 392, 469, 380 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 186, 342, 189, 330 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 447, 192, 451, 180 Flags: Print AppearanceDictionary: true Destination: 72 Annotation: Subtype: Link Rect: 241, 122, 246, 110 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 526, 70, 532, 58 Flags: Print AppearanceDictionary: true Destination: 385 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 442, 176, 448, 164 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 460, 97, 466, 84 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 468, 97, 473, 84 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 342, 77, 346, 64 Flags: Print AppearanceDictionary: true Destination: 72 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 332, 534, 337, 522 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 311, 494, 314, 482 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 361, 434, 365, 422 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 435, 312, 440, 300 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 230, 262, 235, 250 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 364, 252, 369, 240 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 475, 252, 481, 240 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 209, 242, 214, 230 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 285, 212, 289, 200 Flags: Print AppearanceDictionary: true Destination: 128 Annotation: Subtype: Link Rect: 171, 102, 176, 90 Flags: Print AppearanceDictionary: true Destination: 102 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 183, 408, 189, 396 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 170, 338, 175, 326 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 183, 238, 188, 226 Flags: Print AppearanceDictionary: true Destination: 460 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 523, 603, 529, 591 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 518, 329, 550, 317 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 383, 219, 388, 207 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 254, 149, 259, 137 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 298, 79, 302, 67 Flags: Print AppearanceDictionary: true Destination: 312 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 404, 292, 410, 280 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 365, 262, 368, 250 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 369, 262, 375, 250 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 376, 262, 382, 250 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 383, 262, 389, 250 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 290, 242, 296, 230 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 284, 222, 290, 210 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 268, 212, 272, 200 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 464, 132, 470, 120 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 471, 132, 477, 120 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 474, 112, 477, 100 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 544, 102, 548, 90 Flags: Print AppearanceDictionary: true Destination: 329 Annotation: Subtype: Link Rect: 528, 62, 534, 50 Flags: Print AppearanceDictionary: true Destination: 460 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 256, 179, 262, 167 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 270, 169, 276, 157 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 337, 169, 342, 157 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 217, 139, 223, 127 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 280, 129, 286, 117 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 217, 109, 220, 97 Flags: Print AppearanceDictionary: true Destination: 385 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 347, 434, 350, 422 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 423, 404, 426, 392 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 427, 404, 430, 392 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 240, 324, 246, 312 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 403, 314, 408, 302 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 316, 272, 321, 260 Flags: Print AppearanceDictionary: true Destination: 273 Annotation: Subtype: Link Rect: 207, 222, 211, 210 Flags: Print AppearanceDictionary: true Destination: 371 Annotation: Subtype: Link Rect: 349, 192, 353, 180 Flags: Print AppearanceDictionary: true Destination: 371 Annotation: Subtype: Link Rect: 200, 182, 203, 170 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 173, 152, 179, 140 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 180, 152, 186, 140 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 531, 152, 537, 140 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 362, 122, 365, 110 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 386, 122, 389, 110 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 546, 122, 552, 110 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 224, 82, 229, 70 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 429, 82, 434, 70 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 391, 72, 397, 60 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 260, 62, 266, 50 Flags: Print AppearanceDictionary: true Destination: 460 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 330, 289, 334, 277 Flags: Print AppearanceDictionary: true Destination: 312 Annotation: Subtype: Link Rect: 546, 239, 552, 227 Flags: Print AppearanceDictionary: true Destination: 460 Annotation: Subtype: Link Rect: 388, 89, 392, 77 Flags: Print AppearanceDictionary: true Destination: 312 Annotation: Subtype: Link Rect: 283, 79, 286, 67 Flags: Print AppearanceDictionary: true Destination: 385 Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 192, 654, 195, 642 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 197, 654, 199, 642 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 549, 644, 552, 632 Flags: Print AppearanceDictionary: true Destination: 385 Annotation: Subtype: Link Rect: 234, 382, 302, 370 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 311, 554, 300 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 302, 280, 292 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 285, 292, 275 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 415, 268, 554, 258 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 259, 173, 249 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 209, 243, 334, 232 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 468, 226, 554, 215 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 217, 189, 207 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 422, 200, 524, 190 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 263, 183, 381, 173 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 280, 166, 383, 156 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 395, 149, 515, 139 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 519, 141, 554, 130 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 132, 240, 122 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 115, 271, 105 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 220, 106, 306, 96 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 476, 98, 554, 88 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 89, 218, 79 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 229, 81, 351, 71 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 247, 64, 354, 54 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 335, 725, 451, 715 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 233, 716, 537, 706 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 191, 691, 309, 681 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 205, 674, 308, 664 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 194, 657, 332, 647 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 391, 640, 523, 630 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 384, 623, 486, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 235, 606, 337, 596 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 365, 589, 496, 579 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 464, 572, 554, 562 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 563, 210, 553 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 293, 555, 554, 545 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 546, 234, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 256, 538, 501, 528 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 243, 512, 381, 502 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 349, 496, 483, 485 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 444, 479, 554, 468 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 470, 187, 460 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 362, 453, 524, 443 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 305, 428, 407, 417 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 411, 482, 400 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 479, 394, 554, 383 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 385, 233, 375 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 416, 368, 554, 358 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 255, 343, 361, 332 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 389, 326, 527, 315 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 519, 317, 554, 307 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 308, 260, 298 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 532, 275, 554, 264 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 266, 237, 256 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 249, 554, 239 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 240, 276, 230 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 224, 554, 213 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 169, 215, 238, 205 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 227, 190, 338, 179 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 389, 173, 510, 162 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 366, 156, 513, 145 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 230, 139, 343, 128 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 234, 121, 369, 111 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 349, 734, 414, 722 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 363, 593, 521, 581 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 351, 563, 443, 551 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 358, 453, 517, 441 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 7ec66751 Type: CRC32 Checksum: ba89c1024a9c9f77405e7545a27fe897 Type: MD5 Checksum: c59989abdd49bff213ae6e250970e1c6868d92ab Type: SHA-1