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Keywords: non-B DNA, genome fragility, foxo (forkhead box subgroup O), Akt1 (serine/threonine–protein kinase B), Attacin antibacterial genes, immunometabolism, thermal adaptation, seasonal selection Author: Charikleia Karageorgiou, Rosa Tarrío and Francisco Rodríguez-Trelles Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Fri Oct 9 08:21:49 2020 CEST ModDate: Fri Oct 9 09:27:22 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 3239812 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CAGGCP+MTSYN Type 1 Builtin yes yes no 34 0 OWAQUO+MinionPro-Regular Type 1 Custom yes yes no 24 0 MQEJEI+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 25 0 DZRUTU+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 26 0 YWVOOY+HelveticaNeueLTStd-BdIt Type 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Sites and Relocated Immunity and Metabolic Genes Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Species Karyotype and Inversion Nomenclature Item: Title: Drosophila Lines Item: Title: High Molecular Weight Genomic DNA Isolation and PacBio Whole-Genome Sequencing Item: Title: Chromosome-Scale Assembly and Scaffolding Item: Title: Genome Annotation Item: Title: Isolation and Characterization of the O7 Breakpoints Item: Title: Phylogenetic Inferences Item: Title: Non-B DNA Sequence and Transcription Factor Binding Site Scans Item: Title: Results Children: Item: Title: Chromosome-Scale Assembly and Annotation of Chromosome Arrangement Opush0 0 0 1 k 0 0 0 1 Kpop3+4+7 Item: Title: Identification of Inversion O7 Using Chromosome Conserved Synteny Analysis Item: Title: Nature and Properties of the DNA Sequences Surrounding O7 Breakpoint Junctions Children: Item: Title: Proximal Breakpoint of O7 Item: Title: Distal Breakpoint of Inversion O7 Item: Title: Pre-inversion Record of Rearrangement of O7 Breakpoints Item: Title: Potentially Functional Effects of the O7 Mutation Item: Title: Discussion Children: Item: Title: Molecular Mechanism of O7 Formation Children: Item: Title: O7 Is a Complex Multibreak Inversion Formed via Rejoining in trans With the Two Homologous Chromosomes Item: Title: The Breaks of the O7 Inversion Were Likely Induced by Non-B DNA Secondary Structures Item: Title: The Inverted Duplications at the O7 Breakpoints Could Be Footprints of Repair Instead of Staggered Breakage Item: Title: The O7 Breakpoints Carry a Pre-inversion Record of Fragility Item: Title: O7 Breakpoints Potentially Functional Effects Children: Item: Title: O7 Relocated foxo in Tight Linkage Association With Its Antagonistic Regulatory Partner of the IIS Metabolic Pathway Akt1 Item: Title: O7 Disrupted the Concerted Evolution of Two AttA2 Immunity Genes and Reattached Them to Putative dFOXO Metabolic Enhancers Item: Title: Conclusion and 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Charikleia Karageorgiou, Rosa Tarrío and Francisco Rodríguez-Trelles 2020-10-09T11:51:49+05:30 non-B DNA genome fragility foxo (forkhead box subgroup O) Akt1 (serine/threonine–protein kinase B) Attacin antibacterial genes immunometabolism thermal adaptation seasonal selection 2020-10-09T11:51:49+05:30 2020-10-09T12:57:22+05:30 2020-10-09T12:57:22+05:30 LaTeX with hyperref package uuid:7f7f7546-c9bb-4b67-b75f-d1d7aea88dc4 uuid:50622864-d1a8-46d1-9bdc-4cc5fae571f0 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 43, 718, 133, 754 Annotation: Subtype: Link Rect: 474, 736, 551, 745 Annotation: Subtype: Link Rect: 464, 727, 551, 737 Annotation: Subtype: Link Rect: 449, 718, 551, 729 Annotation: Subtype: Link Rect: 86, 462, 160, 472 Annotation: Subtype: Link Rect: 71, 65, 160, 74 Annotation: Subtype: Link Rect: 521, 677, 551, 707 Annotation: Subtype: Link Rect: 176, 533, 551, 647 Annotation: Subtype: Link Rect: 43, 29, 107, 38 Annotation: Subtype: Link Rect: 111, 29, 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