c433ae91f7e5e7a3465751240723ec4d pmc_33194719.pdf 91b6a7ab6ffb3f364bcf7ef283987d7afd00d9c7 pmc_33194719.pdf d910d369e09797339a29d1c9a18977eb65541b5872ee2e24649e962ee2fd91fd pmc_33194719.pdf Title: Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies Subject: Advances in immunotherapy have achieved remarkable clinical outcomes in tumors with low curability, but their effects are limited, and increasing evidence has implicated tumoral and non-tumoral components of the tumor microenvironment as critical mediators of cancer progression. Keywords: radiotherapy, immunotherapy, tumor microenvironment, surgery, cancer Author: Sergi Benavente Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Mon Oct 19 15:33:46 2020 CEST ModDate: Mon Oct 19 16:18:11 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 2420576 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FLCHMM+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 36 0 CMZILC+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 41 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 54 0 HQMBZT+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 56 0 SFBWOS+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 61 0 CFXZIO+MinionPro-Regular Type 1C Custom yes yes no 63 0 ZTULOU+MinionPro-Bold Type 1C 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New Opportunities for Cancer Therapies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Characterizing the Immune Function in the Response to Checkpoint Inhibitor Immunotherapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Combinatorial Approaches to Treat Differences in the Immune Contexture of the TME Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Interactions Within the TME Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Radioimmunotherapy Combinations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: DNA Damage Response Following Radiation and Exposure of Neoantigens Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Central Role of Dendritic Cell Maturation in Radiation-Induced Immunological Response Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Addressing the Evasive Objective of Durable Responses of Radiation-Immunotherapy Combinations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Clinical Implications of Technological Developments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Clinical Implications of the Immunosuppressive Environment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Regulatory T Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Macrophages Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Pre-metastatic Niche and Exosomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Cancer-Associated Fibroblasts Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Clinical Implications of Metabolic Remodeling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Clinical Implications of Angiogenic Responses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Future Perspectives Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: Metabolic Rewiring of the TME Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Nanoparticle-Mediated Immunogenic Cell Death Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Info: Title: Therapy-Induced Modulation of the Tumor Microenvironment: New Opportunities for Cancer Therapies Author: Sergi Benavente Subject: Advances in immunotherapy have achieved remarkable clinical outcomes in tumors with low curability, but their effects are limited, and increasing evidence has implicated tumoral and non-tumoral components of the tumor microenvironment as critical mediators of cancer progression. 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Rect: 97, 651, 181, 659 Annotation: Subtype: Link Rect: 97, 621, 166, 631 Annotation: Subtype: Link Rect: 85, 594, 170, 602 Annotation: Subtype: Link Rect: 188, 574, 281, 583 Annotation: Subtype: Link Rect: 198, 547, 282, 555 Annotation: Subtype: Link Rect: 100, 517, 193, 526 Annotation: Subtype: Link Rect: 101, 490, 177, 498 Annotation: Subtype: Link Rect: 101, 452, 189, 460 Annotation: Subtype: Link Rect: 85, 396, 170, 403 Annotation: Subtype: Link Rect: 88, 366, 173, 375 Annotation: Subtype: Link Rect: 85, 338, 144, 346 Annotation: Subtype: Link Rect: 115, 299, 185, 308 Annotation: Subtype: Link Rect: 85, 262, 164, 271 Annotation: Subtype: Link Rect: 85, 225, 170, 233 Annotation: Subtype: Link Rect: 97, 186, 188, 195 Annotation: Subtype: Link Rect: 104, 140, 203, 148 Annotation: Subtype: Link Rect: 292, 101, 60, 120 Annotation: Subtype: Link Rect: 129, 74, 214, 81 Annotation: Subtype: Link Rect: 445, 697, 504, 706 Annotation: Subtype: Link Rect: 474, 680, 550, 687 Annotation: Subtype: Link Rect: 368, 640, 456, 649 Annotation: Subtype: Link Rect: 354, 604, 439, 611 Annotation: Subtype: Link Rect: 372, 566, 457, 573 Annotation: Subtype: Link Rect: 422, 538, 508, 545 Annotation: Subtype: Link Rect: 375, 498, 460, 508 Annotation: Subtype: Link Rect: 390, 460, 476, 470 Annotation: Subtype: Link Rect: 399, 432, 486, 441 Annotation: Subtype: Link Rect: 345, 404, 424, 413 Annotation: Subtype: Link Rect: 357, 367, 441, 375 Annotation: Subtype: Link Rect: 345, 291, 424, 299 Annotation: Subtype: Link Rect: 432, 262, 511, 271 Annotation: Subtype: Link Rect: 345, 224, 428, 233 Annotation: Subtype: Link Rect: 429, 197, 528, 204 Annotation: Subtype: Link Rect: 368, 150, 459, 157 Annotation: Subtype: Link Rect: 372, 101, 441, 110 Annotation: Subtype: Link Rect: 368, 74, 453, 81 Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 16 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 172, 678, 263, 687 Annotation: Subtype: Link Rect: 153, 651, 242, 659 Annotation: Subtype: Link Rect: 108, 612, 195, 621 Annotation: Subtype: Link Rect: 164, 593, 251, 602 Annotation: Subtype: Link Rect: 118, 555, 209, 564 Annotation: Subtype: Link Rect: 108, 519, 210, 526 Annotation: Subtype: Link Rect: 161, 479, 248, 489 Annotation: Subtype: Link Rect: 292, 440, 60, 461 Annotation: Subtype: Link Rect: 115, 405, 200, 413 Annotation: Subtype: Link Rect: 85, 367, 188, 375 Annotation: Subtype: Link Rect: 133, 339, 218, 346 Annotation: Subtype: Link Rect: 179, 320, 256, 328 Annotation: Subtype: Link Rect: 118, 292, 207, 299 Annotation: Subtype: Link Rect: 163, 263, 240, 271 Annotation: Subtype: Link Rect: 85, 225, 146, 233 Annotation: Subtype: Link Rect: 136, 187, 231, 195 Annotation: Subtype: Link Rect: 85, 150, 155, 157 Annotation: Subtype: Link Rect: 85, 112, 186, 119 Annotation: Subtype: Link Rect: 104, 83, 164, 91 Annotation: Subtype: Link Rect: 376, 678, 455, 687 Annotation: Subtype: Link Rect: 361, 642, 450, 649 Annotation: Subtype: Link Rect: 345, 604, 430, 611 Annotation: Subtype: Link Rect: 368, 565, 432, 573 Annotation: Subtype: Link Rect: 368, 528, 470, 536 Annotation: Subtype: Link Rect: 368, 489, 459, 498 Annotation: Subtype: Link Rect: 345, 452, 444, 460 Annotation: Subtype: Link Rect: 388, 413, 466, 422 Annotation: Subtype: Link Rect: 356, 375, 435, 384 Annotation: Subtype: Link Rect: 470, 358, 532, 365 Annotation: Subtype: Link Rect: 372, 320, 475, 327 Annotation: Subtype: Link Rect: 398, 281, 491, 289 Annotation: Subtype: Link Rect: 372, 243, 459, 252 Annotation: Subtype: Link Rect: 345, 206, 448, 214 Annotation: Subtype: Link Rect: 372, 159, 457, 166 Annotation: Subtype: Link Rect: 345, 121, 397, 129 Annotation: Subtype: Link Rect: 345, 83, 397, 91 Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 17 Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 108, 680, 211, 687 Annotation: Subtype: Link Rect: 154, 642, 228, 649 Annotation: Subtype: Link Rect: 185, 613, 270, 621 Annotation: Subtype: Link Rect: 85, 583, 171, 593 Annotation: Subtype: Link Rect: 101, 546, 159, 554 Annotation: Subtype: Link Rect: 133, 509, 235, 517 Annotation: Subtype: Link Rect: 184, 470, 263, 479 Annotation: Subtype: Link Rect: 85, 434, 186, 441 Annotation: Subtype: Link Rect: 167, 394, 246, 403 Annotation: Subtype: Link Rect: 212, 366, 269, 375 Annotation: Subtype: Link Rect: 129, 339, 188, 346 Annotation: Subtype: Link Rect: 208, 319, 266, 327 Annotation: Subtype: Link Rect: 85, 282, 188, 289 Annotation: Subtype: Link Rect: 157, 254, 222, 261 Annotation: Subtype: Link Rect: 150, 235, 227, 243 Annotation: Subtype: Link Rect: 169, 205, 252, 214 Annotation: Subtype: Link Rect: 114, 167, 207, 176 Annotation: Subtype: Link Rect: 292, 130, 60, 149 Annotation: Subtype: Link Rect: 129, 91, 188, 101 Annotation: Subtype: Link Rect: 435, 699, 520, 706 Annotation: Subtype: Link Rect: 437, 669, 535, 678 Annotation: Subtype: Link Rect: 552, 620, 320, 641 Annotation: Subtype: Link Rect: 348, 583, 431, 592 Annotation: Subtype: Link Rect: 449, 547, 550, 554 Annotation: Subtype: Link Rect: 408, 509, 481, 517 Annotation: Subtype: Link Rect: 375, 481, 461, 488 Annotation: Subtype: Link Rect: 368, 452, 444, 460 Annotation: Subtype: Link Rect: 345, 415, 430, 422 Annotation: Subtype: Link Rect: 459, 377, 548, 384 Annotation: Subtype: Link Rect: 379, 337, 458, 346 Annotation: Subtype: Link Rect: 390, 320, 452, 327 Annotation: Subtype: Link Rect: 348, 292, 434, 299 Annotation: Subtype: Link Rect: 375, 254, 460, 261 Annotation: Subtype: Link Rect: 345, 224, 432, 233 Annotation: Subtype: Link Rect: 352, 186, 452, 195 Annotation: Subtype: Link Rect: 368, 157, 473, 167 Annotation: Subtype: Link Rect: 345, 101, 399, 110 Annotation: Subtype: Link Rect: 470, 72, 549, 81 Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Page: Label: 18 Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 85, 688, 140, 696 Annotation: Subtype: Link Rect: 104, 651, 190, 659 Annotation: Subtype: Link Rect: 85, 613, 173, 621 Annotation: Subtype: Link Rect: 187, 585, 262, 592 Annotation: Subtype: Link Rect: 97, 546, 180, 554 Annotation: Subtype: Link Rect: 89, 508, 172, 517 Annotation: Subtype: Link Rect: 85, 479, 167, 489 Annotation: Subtype: Link Rect: 214, 452, 279, 460 Annotation: Subtype: Link Rect: 177, 424, 259, 432 Annotation: Subtype: Link Rect: 111, 396, 203, 403 Annotation: Subtype: Link Rect: 85, 356, 164, 365 Annotation: Subtype: Link Rect: 209, 328, 288, 337 Annotation: Subtype: Link Rect: 212, 300, 291, 308 Annotation: Subtype: Link Rect: 179, 272, 258, 280 Annotation: Subtype: Link Rect: 189, 234, 288, 243 Annotation: Subtype: Link Rect: 375, 688, 455, 696 Annotation: Subtype: Link Rect: 345, 659, 470, 668 Annotation: Subtype: Link Rect: 354, 632, 437, 640 Annotation: Subtype: Link Rect: 444, 604, 529, 611 Annotation: Subtype: Link Rect: 433, 564, 518, 573 Annotation: Subtype: Link Rect: 390, 536, 474, 545 Annotation: Subtype: Link Rect: 357, 508, 444, 517 Annotation: Subtype: Link Rect: 345, 452, 444, 460 Annotation: Subtype: Link Rect: 372, 414, 437, 422 Annotation: Subtype: Link Rect: 357, 377, 448, 384 Annotation: Subtype: Link Rect: 368, 347, 453, 356 Annotation: Subtype: Link Rect: 491, 282, 518, 289 Annotation: Subtype: Link Rect: 519, 282, 551, 289 Annotation: Subtype: Link Rect: 304, 272, 339, 280 Annotation: Subtype: Link Rect: 339, 272, 362, 279 Annotation: Subtype: Link Rect: 362, 271, 390, 280 Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 421, 29, 551, 38 Checksum: 66ad291d Type: CRC32 Checksum: c433ae91f7e5e7a3465751240723ec4d Type: MD5 Checksum: 91b6a7ab6ffb3f364bcf7ef283987d7afd00d9c7 Type: SHA-1