c9d4b8d0123c78a3878babd0872fda47 pmc_33202919.pdf c614fdfd41b7bd0023618bf226c06a98c392400a pmc_33202919.pdf 187311ccf0345afe360d372f00f3bc3d0d60a1f7f63417e66714baebb406b4ea pmc_33202919.pdf Title: Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study Subject: Breast cancer is the most frequent cause of tumors and net survival is increasing. Achieving a higher survival probability reinforces the importance of studying health-related quality of life (HR-QoL). The main aim of this work is to test the relationship between different sociodemographic, clinical and tumor-intrinsic characteristics, and treatment received with HR-QoL measured using SF-12 and the FACT/NCCN (National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy) Breast Symptom Index (FBSI). Women with breast cancer recruited between 2008 and 2013 and followed-up until 2017–2018 in a prospective cohort answered two HR-QoL surveys: the SF-12 and FBSI. The scores obtained were related to woman and tumor characteristics using linear regression models. The telephone survey was answered by 1078 women out of 1685 with medical record follow-up (64%). Increases in all three HR-QoL scores were associated with higher educational level. The score differences between women with university qualifications and women with no schooling were 5.43 for PCS-12, 6.13 for MCS-12 and 4.29 for FBSI. Histological grade at diagnosis and recurrence in the follow-up displayed a significant association with mental and physical HR-QoL, respectively. First-line treatment received was not associated with HR-QoL scores. On the other hand, most tumor characteristics were not associated with HR-QoL. As breast cancer survival is improving, further studies are needed to ascertain if these differences still hold in the long run. Keywords: quality of life; breast cancer; SF-12; FBSI; educational level Author: Jéssica Alonso-Molero, Trinidad Dierssen-Sotos, Ines Gomez-Acebo, Nerea Fernandez de Larrea Baz, Marcela Guevara, Pilar Amiano, Gemma Castaño-Vinyals, Tania Fernandez-Villa, Victor Moreno, Juan Bayo, Ana Molina-Barceloa, María Fernández-Ortíz, Claudia Suarez-Calleja, Rafael Marcos-Gragera, Xavier Castells, Leire Gil-Majuelo, Eva Ardanaz, Beatriz Pérez-Gómez, Manolis Kogevinas, Marina Pollán and Javier Llorca Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Nov 18 02:47:12 2020 CET ModDate: Wed Nov 18 02:50:56 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1269585 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VJKCUE+VnURWPalladioL Type 1 Custom yes yes no 10 0 MAXTMN+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 UNOCQH+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 QQOCHZ+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 HAKARX+Rpxr Type 1 Builtin yes yes no 28 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 LWQXII+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 40 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 43 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 65 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 69 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 73 0 RVNMSJ+Pxsy Type 1 Builtin yes yes no 83 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 97 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 101 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 105 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 109 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 120 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 135 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 139 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 143 0 ABCDEE+Calibri TrueType WinAnsi yes yes no 147 0 KGSZMU+VnURWPalladioL-Italic Type 1 Custom yes yes no 171 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 181 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-10 02:36:09 CET RepresentationInformation: pmc_33202919.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2020-11-30 03:46:52 CET Size: 1269585 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 344 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design and Participants Destination: subsection.2.1 Item: Title: Health-Related QoL Assessment Destination: subsection.2.2 Item: Title: Study Variables Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Ethics Destination: subsection.2.5 Item: Title: Results Destination: section.3 Children: Item: Title: Recruitment and Response Destination: subsection.3.1 Item: Title: General Description about HR-QoL Scores Destination: subsection.3.2 Item: Title: Socio-Demographic Variables Destination: subsection.3.3 Item: Title: Tumor Characteristics Destination: subsection.3.4 Item: Title: Treatment Received Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Quality of Life in a Cohort of 1078 Women Diagnosed with Breast Cancer in Spain: 7-Year Follow-Up Results in the MCC-Spain Study Author: Jéssica Alonso-Molero, Trinidad Dierssen-Sotos, Ines Gomez-Acebo, Nerea Fernandez de Larrea Baz, Marcela Guevara, Pilar Amiano, Gemma Castaño-Vinyals, Tania Fernandez-Villa, Victor Moreno, Juan Bayo, Ana Molina-Barceloa, María Fernández-Ortíz, Claudia Suarez-Calleja, Rafael Marcos-Gragera, Xavier Castells, Leire Gil-Majuelo, Eva Ardanaz, Beatriz Pérez-Gómez, Manolis Kogevinas, Marina Pollán and Javier Llorca Subject: Breast cancer is the most frequent cause of tumors and net survival is increasing. Achieving a higher survival probability reinforces the importance of studying health-related quality of life (HR-QoL). The main aim of this work is to test the relationship between different sociodemographic, clinical and tumor-intrinsic characteristics, and treatment received with HR-QoL measured using SF-12 and the FACT/NCCN (National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy) Breast Symptom Index (FBSI). Women with breast cancer recruited between 2008 and 2013 and followed-up until 2017 2018 in a prospective cohort answered two HR-QoL surveys: the SF-12 and FBSI. The scores obtained were related to woman and tumor characteristics using linear regression models. The telephone survey was answered by 1078 women out of 1685 with medical record follow-up (64%). Increases in all three HR-QoL scores were associated with higher educational level. The score differences between women with university qualifications and women with no schooling were 5.43 for PCS-12, 6.13 for MCS-12 and 4.29 for FBSI. Histological grade at diagnosis and recurrence in the follow-up displayed a significant association with mental and physical HR-QoL, respectively. First-line treatment received was not associated with HR-QoL scores. On the other hand, most tumor characteristics were not associated with HR-QoL. As breast cancer survival is improving, further studies are needed to ascertain if these differences still hold in the long run. 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