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Keywords: cell plasticity, EMT—epithelial-mesenchymal transition, neuroendocrine, castration-resistant prostate cancer, docetaxel, cabazitaxel, taxanes resistance Author: Natalia Jime´ nez Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed Oct 28 06:57:49 2020 CET ModDate: Wed Oct 28 07:33:28 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 3902794 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IGDCKI+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 1078 0 IGDCGP+AdvOT34fe1490.B Type 1C WinAnsi yes yes no 1056 0 IGDCHA+AdvOT01861455.I Type 1C WinAnsi yes yes no 1057 0 IGDCHB+AdvPSA18C Type 1C WinAnsi yes yes no 1058 0 IGDCIB+AdvOT01861455.I+01 Type 1C MacRoman yes yes no 1059 0 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B53' cannot be found Offset: 3875133 MIMEtype: application/pdf PDFMetadata: Objects: 1152 FreeObjects: 2 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Cell Plasticity-Related Phenotypes and Taxanes Resistance in Castration-Resistant Prostate Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Establishment of Taxane-Resistant Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Cell Viability Assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Cell Adhesion and Proliferation Measurement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Cell Migration Assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Western Blot Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: RNA Extraction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Gene Expression Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Microarrays Hybridization and Differential Expression Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Circulating Tumor Cells Enrichment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: In Silico Analysis in Prostate Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Patients and Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: Phenotypic Characterization of Docetaxel and Cabazitaxel-Resistant Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Differentially Expressed Genes in Taxane-Resistant Versus Parental Cell Lines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Differential Expression Analysis in CZ Versus D-Resistant Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Taxanes Dose-Response Experiments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: In Silico Analysis of Cell Plasticity-Related Genes in Prostate Cancer Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Cell Plasticity in CTCs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Cell Plasticity-Related Gene Expression in Non-Castrate Tumor Biopsies and Clinical Outcome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Info: Title: Cell Plasticity-Related Phenotypes and Taxanes Resistance in Castration-Resistant Prostate Cancer Author: Natalia Jime´ nez Subject: The prostatic tumor cells plasticity is involved in resistance to hormone-therapy, allowing these cells to survive despite androgen receptor inhibition. Keywords: cell plasticity, EMT—epithelial-mesenchymal transition, neuroendocrine, castration-resistant prostate cancer, docetaxel, cabazitaxel, taxanes resistance Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed Oct 28 06:57:49 CET 2020 ModDate: Wed Oct 28 07:33:28 CET 2020 ID: 0xaa6f3986028b309737e3abe9bb775a98, 0x9814817e9b66fa4782c1860316b937d4 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 863 ImageHeight: 149 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 576 ImageHeight: 592 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 863 ImageHeight: 886 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: 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Resistance in Castration-Resistant Prostate Cancer Natalia Jime´ nez Òscar Reig Ruth Montalbo Maria Milà-Guasch Lluis Nadal-Dieste Giancarlo Castellano Juan Jose´ Lozano Iva´ n Victoria Albert Font Alejo Rodriguez-Vida Joan Carles Cristina Sua´ rez Montserrat Domènech Nu´ ria Sala-Gonza´ lez Pedro Luis Ferna´ ndez Leonardo Rodrı´guez-Carunchio Sherley Dı´az Aleix Prat Mercedes Marı´n-Aguilera Begoña Mellado The prostatic tumor cells plasticity is involved in resistance to hormone-therapy, allowing these cells to survive despite androgen receptor inhibition. cell plasticity EMT&mdash epithelial-mesenchymal transition neuroendocrine castration-resistant prostate cancer docetaxel cabazitaxel taxanes resistance uuid:84687dbb-6ce5-4888-9f8f-7e9a35997cef uuid:acdfcee4-8425-49b7-8277-60790ea93087 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 612, 515, 633 Annotation: Subtype: Link Rect: 175, 589, 440, 610 Annotation: Subtype: Link Rect: 175, 566, 546, 587 Annotation: 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