7beca9e4c67fdd7eab0d35fcf0d06cad  pmc_33244004.pdf
d3882fc502aa47aff5decc5db617fc0deecf5b8a  pmc_33244004.pdf
088241cf6eef6901d3cd6b131d643a0604f5c8498b34a892aa5bbb692e83e031  pmc_33244004.pdf

Title:          Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome
Subject:        Scientific Reports, https://doi.org/10.1038/s41598-020-77176-x
Author:         Eloísa Salvo-Romero 
Creator:        Springer
Producer:       Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:   Sat Nov 21 07:02:04 2020 CET
ModDate:        Sat Nov 21 10:14:31 2020 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          13
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      1939784 bytes
Optimized:      no
PDF version:    1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
XOHDGH+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    356  0
DEAWVN+Corbel-Bold                   CID TrueType      Identity-H       yes yes yes     64  0
Corbel2                              TrueType          WinAnsi          yes no  yes     65  0
YERXDX+Corbel                        CID TrueType      Identity-H       yes yes yes     66  0
MinionPro-Bold                       Type 1C           Custom           yes no  yes     61  0
MinionPro-It                         Type 1C           Custom           yes no  yes     62  0
MinionPro-Regular                    Type 1C           Custom           yes no  yes     63  0
Corbel2                              TrueType          WinAnsi          yes no  yes    309  0
LXATWP+MinionPro-BoldIt              Type 1C           WinAnsi          yes yes yes    109  0
SKFVSJ+Corbel-BoldItalic             CID TrueType      Identity-H       yes yes yes    146  0
CHDDCP+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes    275  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-05-27 03:48:44 CEST
 RepresentationInformation: pmc_33244004.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-03-31 11:43:34 CEST
  Size: 1939784
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 430
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome
      Children: 
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Participants and clinical assessment. 
         Item: 
          Title: Experimental design and procedures. 
         Item: 
          Title: Analytical procedures. 
          Children: 
           Item: 
            Title: RNA isolation and microarray analysis. 
           Item: 
            Title: c-DNA synthesis and quantitative real time PCR. 
           Item: 
            Title: Immunohistochemistry. 
           Item: 
            Title: Transmission electron microscopy. 
            Children: 
             Item: 
              Title: Ultrastructure of mucosal eosinophils. 
           Item: 
            Title: Evaluation of CRF in the intestinal mucosa by immuno-gold. 
           Item: 
            Title: Eosinophil response to neuropeptides. 
         Item: 
          Title: Statistical analysis. 
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Study population. 
         Item: 
          Title: Distinctive transcriptional profile linked to eosinophil signaling and activation in IBS-D. 
         Item: 
          Title: Decreased pro-inflammatory activation profile of mucosal eosinophils in IBS-D. 
         Item: 
          Title: Increased secretory profile of mucosal eosinophils in IBS-D. 
         Item: 
          Title: Differential granular CRF content in mucosal eosinophils and mucosal CRHR1 expression in IBS-D. 
         Item: 
          Title: Association between mucosal eosinophil CRF content and CRHR1 expression with IBS-D clinical manifestations. 
         Item: 
          Title: Neuropeptides mediate CRF production and release without induction of a proinflammatory profile in eosinophils. 
       Item: 
        Title: Discussion
       Item: 
        Title: References
       Item: 
        Title: Acknowledgements
   Info: 
    Title: Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome
    Author: Eloísa Salvo-Romero 
    Subject: Scientific Reports, https://doi.org/10.1038/s41598-020-77176-x
    Creator: Springer
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Sat Nov 21 07:32:04 CET 2020
    ModDate: Sat Nov 21 10:14:31 CET 2020
   ID: 0xcac72569e68c870e69f117be8eeaf316, 0xc610d8216b7577c43411579019285ed4
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: CCITTFaxDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/tiff
      CompressionScheme: CCITT 1D
      ImageWidth: 4016
      ImageHeight: 3226
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     ImageMask: true
     Decode: 0, 1
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2008
      ImageHeight: 1014
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1772
      ImageHeight: 1566
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 792
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: DEAWVN+Corbel-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: YERXDX+Corbel
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: SKFVSJ+Corbel-BoldItalic
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: XOHDGH+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: XOHDGH+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LXATWP+MinionPro-BoldIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: LXATWP+MinionPro-BoldIt
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -230, -360, 1684, 1032
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: Corbel2
      FirstChar: 32
      LastChar: 243
      FontDescriptor: 
       FontName: Corbel2
       Flags: Nonsymbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: CHDDCP+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: CHDDCP+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: DEAWVN+Corbel-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: DEAWVN+Corbel-Bold
       Flags: Symbolic
       FontBBox: -556, -239, 1155, 952
       FontFile2: true
     Font: 
      BaseFont: SKFVSJ+Corbel-BoldItalic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: SKFVSJ+Corbel-BoldItalic
       Flags: Symbolic, Italic
       FontBBox: -494, -239, 1194, 952
       FontFile2: true
     Font: 
      BaseFont: YERXDX+Corbel
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: YERXDX+Corbel
       Flags: Symbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2020-11-21T11:32:04+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2020-11-21T10:14:31+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2020-11-21T10:14:31+01:00</xmp:MetadataDate>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1038/s41598-020-77176-x</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Nature Publishing Group UK</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Scientific Reports, https://doi.org/10.1038/s41598-020-77176-x</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Eloísa Salvo-Romero </rdf:li>
               <rdf:li>Cristina Martínez </rdf:li>
               <rdf:li>Beatriz Lobo </rdf:li>
               <rdf:li>Bruno K. Rodiño-Janeiro </rdf:li>
               <rdf:li>Marc Pigrau </rdf:li>
               <rdf:li>Alejandro D. Sánchez-Chardi </rdf:li>
               <rdf:li>Ana M. González-Castro </rdf:li>
               <rdf:li>Marina Fortea </rdf:li>
               <rdf:li>Cristina Pardo-Camacho </rdf:li>
               <rdf:li>Adoración Nieto </rdf:li>
               <rdf:li>Elba Expósito </rdf:li>
               <rdf:li>Danila Guagnozzi </rdf:li>
               <rdf:li>Amanda Rodríguez-Urrutia </rdf:li>
               <rdf:li>Inés de Torres</rdf:li>
               <rdf:li>Ricard Farré </rdf:li>
               <rdf:li>Fernando Azpiroz </rdf:li>
               <rdf:li>Carmen Alonso-Cotoner </rdf:li>
               <rdf:li>Javier Santos </rdf:li>
               <rdf:li>María Vicario </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1038/s41598-020-77176-x</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1038/s41598-020-77176-x</prism:url>
         <prism:doi>10.1038/s41598-020-77176-x</prism:doi>
         <prism:issn>2045-2322</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Scientific Reports</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1038/s41598-020-77176-x</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:91940be6-0df5-4d58-b6d2-a980b6e816cd</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:f4d24f4d-572b-4cdc-9fb7-2537f65bf8cf</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:fcd393f2-a13c-439b-88f3-03d13dc2866c</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2020-11-21T11:32:46+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 481, 675, 556, 658
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 219, 542, 222, 530
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 191, 532, 194, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 549, 532, 552, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 279, 522, 282, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 401, 522, 404, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 228, 502, 231, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 286, 472, 289, 460
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 290, 472, 293, 460
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 294, 472, 297, 460
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 362, 462, 365, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 380, 452, 383, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 376, 432, 382, 420
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 264, 392, 270, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 271, 392, 277, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 546, 372, 552, 360
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 341, 362, 347, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 280, 322, 286, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 287, 322, 293, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 279, 292, 285, 280
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 288, 292, 293, 280
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 548, 220, 554, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 528, 180, 534, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 184, 130, 190, 118
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 213, 100, 219, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 392, 100, 398, 88
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 400, 90, 406, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 226, 80, 231, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 384, 70, 390, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 518, 70, 523, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 257, 60, 263, 48
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 210, 734, 216, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 356, 682, 361, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 437, 550, 443, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 318, 540, 441, 528
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 213, 510, 219, 498
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 544, 358, 549, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 301, 244, 307, 232
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 529, 184, 535, 172
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 201, 447, 204, 435
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 205, 447, 208, 435
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 210, 447, 215, 435
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 464, 325, 470, 313
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 265, 243, 271, 231
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 272, 243, 278, 231
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 292, 223, 296, 211
       Flags: Print
       AppearanceDictionary: true
       Destination: 91
      Annotation: 
       Subtype: Link
       Rect: 269, 171, 274, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 276, 171, 281, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 546, 161, 552, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 175, 201, 179, 189
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
      Annotation: 
       Subtype: Link
       Rect: 240, 171, 245, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
      Annotation: 
       Subtype: Link
       Rect: 256, 161, 260, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 112
      Annotation: 
       Subtype: Link
       Rect: 295, 109, 299, 97
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 174, 334, 179, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 495, 334, 499, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 445, 324, 450, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 451, 314, 456, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 288, 254, 292, 242
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 482, 234, 486, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 538, 224, 542, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 174, 162, 178, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 337, 142, 342, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 297, 132, 301, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 155
     Thumb: true
    Page: 
     Sequence: 7
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 180, 203, 184, 191
       Flags: Print
       AppearanceDictionary: true
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 425, 153, 429, 141
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 444, 91, 448, 79
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 295, 71, 299, 59
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 470, 61, 475, 49
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 362, 724, 366, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 283, 674, 287, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 161
      Annotation: 
       Subtype: Link
       Rect: 462, 582, 464, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 466, 582, 471, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 281, 542, 287, 530
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 483, 532, 489, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 474, 512, 479, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 481, 512, 486, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 488, 512, 493, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 495, 512, 500, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 368, 492, 374, 480
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 360, 482, 366, 470
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 402, 392, 408, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 412, 332, 418, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 286, 322, 292, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 345, 312, 351, 300
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 484, 302, 489, 290
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 305, 292, 311, 280
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 412, 282, 415, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 416, 282, 422, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 425, 282, 430, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 192, 252, 198, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 472, 242, 478, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 546, 242, 552, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 504, 232, 510, 220
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 511, 232, 517, 220
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 442, 182, 445, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 446, 182, 449, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 450, 182, 456, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 237, 152, 243, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 207, 142, 213, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 426, 132, 432, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 433, 132, 439, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 257, 122, 263, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 260, 102, 265, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 171, 72, 177, 60
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 223, 72, 229, 60
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 349, 72, 352, 60
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 372, 694, 374, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 267, 684, 273, 672
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 241, 664, 247, 652
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 248, 664, 254, 652
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 545, 654, 547, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 549, 654, 552, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 240
      Annotation: 
       Subtype: Link
       Rect: 187, 614, 193, 602
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 194, 614, 200, 602
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 468, 554, 474, 542
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 274, 544, 279, 532
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 499, 534, 505, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 296, 504, 302, 492
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 207, 494, 212, 482
       Flags: Print
       AppearanceDictionary: true
       Destination: 282
      Annotation: 
       Subtype: Link
       Rect: 470, 484, 475, 472
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 476, 444, 481, 432
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 483, 444, 488, 432
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 458, 424, 464, 412
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
      Annotation: 
       Subtype: Link
       Rect: 437, 314, 443, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 286
     Thumb: true
    Page: 
     Sequence: 11
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 363, 129, 521, 117
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 351, 99, 443, 87
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 358, 664, 517, 652
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 5ca6217f
   Type: CRC32
  Checksum: 7beca9e4c67fdd7eab0d35fcf0d06cad
   Type: MD5
  Checksum: d3882fc502aa47aff5decc5db617fc0deecf5b8a
   Type: SHA-1