d0697cf42159a19334e5a95715780894 pmc_33291746.pdf a083a69002e1f4e164f035dea5d192fc2dc04dd8 pmc_33291746.pdf b82ba01fd023a6cdf2f0d3aa7743f815b89ab65b3f32fe0f9387f2497e59fb1d pmc_33291746.pdf Title: Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases Subject: Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the natural biosynthesis and degradation of lipids. There is an important number of lipid-failed associated metabolic diseases and an increasing number of studies suggesting that certain types of lipids might be beneficial to the treatment of many metabolic diseases. The aim of the present work is to expose an overview of de novo biosynthesis, storage, and degradation of lipids in mammalian cells, as well as, to review the published data describing the beneficial effects of these processes and the potential of some dietary lipids to improve metabolic diseases. Keywords: dietary lipids; phospholipids synthesis; metabolism; mitofusin-2 Author: Sabina Cisa-Wieczorek and María Isabel Hernández-Alvarez Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Mon Dec 7 03:58:26 2020 CET ModDate: Mon Dec 7 04:52:49 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1480903 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SSNIUI+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 MWHIBA+VnURWPalladioL Type 1 Custom yes yes no 15 0 ZMASTF+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 ZLBIWY+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 FUTYSX+URWPalladioL-Roma Type 1 Custom yes yes no 28 0 LZYNPF+Rpxr Type 1 Builtin yes yes no 32 0 PFKOHU+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 40 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 62 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 66 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 70 0 MNTAPZ+EURM10 Type 1 Builtin yes yes no 89 0 MHORSP+Pxsy Type 1 Builtin yes yes no 114 0 LGZKLX+Rpxi Type 1 Builtin yes yes no 128 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 147 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-05-10 02:29:42 CEST RepresentationInformation: pmc_33291746.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2021-01-04 03:37:03 CET Size: 1480903 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 500 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Lipids: Diet Incorporation, Biosynthesis and Storage Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Children: Item: Title: Triglycerides Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Phospholipids Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Sterols Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Eicosanoids Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Lipid Droplets Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Dietary Lipid Metabolism in Metabolic Diseases Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: TAG Associated with Lipid Disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Cholesterol Associated with Lipid Disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Eicosanoids Associated with Lipid Disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Phospholipids Associated with Lipid Disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Potential Role of Autophagy in the Modulation of Lipid Metabolism Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Children: Item: Title: Phospholipid Dependence of Autophagosome Formation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Metabolic Diseases Related to Defective Autophagy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Regulation of Lipid Stores and Metabolism by Lipophagy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Info: Title: Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases Author: Sabina Cisa-Wieczorek and María Isabel Hernández-Alvarez Subject: Lipids are important molecules for human health. The quantity and quality of fats consumed in the diet have important effects on the modulation of both the natural biosynthesis and degradation of lipids. There is an important number of lipid-failed associated metabolic diseases and an increasing number of studies suggesting that certain types of lipids might be beneficial to the treatment of many metabolic diseases. The aim of the present work is to expose an overview of de novo biosynthesis, storage, and degradation of lipids in mammalian cells, as well as, to review the published data describing the beneficial effects of these processes and the potential of some dietary lipids to improve metabolic diseases. 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