5c2e12120634fc90580bb454e62160d6 pmc_33321931.pdf 75fe951de119bbb5058371e5ec67cecc50fd3ea0 pmc_33321931.pdf 8c593751d521f0011d2317458857c011d31387a87d27ad47b15dfd79ff804b53 pmc_33321931.pdf Title: MicroRNAs in Several Cutaneous Autoimmune Diseases: Psoriasis, Cutaneous Lupus Erythematosus and Atopic Dermatitis Subject: MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that regulate the gene expression at a post-transcriptional level and participate in maintaining the correct cell homeostasis and functioning. Different specific profiles have been identified in lesional skin from autoimmune cutaneous diseases, and their deregulation cause aberrant control of biological pathways, contributing to pathogenic conditions. Detailed knowledge of microRNA-affected pathways is of crucial importance for understating their role in skin autoimmune diseases. They may be promising therapeutic targets with novel clinical implications. They are not only present in skin tissue, but they have also been found in other biological fluids, such as serum, plasma and urine from patients, and therefore, they are potential biomarkers for the diagnosis, prognosis and response to treatment. In this review, we discuss the current understanding of the role of described miRNAs in several cutaneous autoimmune diseases: psoriasis (Ps, 33 miRNAs), cutaneous lupus erythematosus (CLE, 2 miRNAs) and atopic dermatitis (AD, 8 miRNAs). We highlight their role as crucial elements implicated in disease pathogenesis and their applicability as biomarkers and as a novel therapeutic approach in the management of skin inflammatory diseases. Keywords: microRNAs; skin autoimmunity; nanoparticles; biomarkers; pathogenesis; psoriasis; atopic dermatitis; cutaneous lupus erythematosus Author: Sandra Domingo, Cristina Solé, Teresa Moliné, Berta Ferrer and Josefina Cortés-Hernández Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Dec 10 12:55:48 2020 CET ModDate: Thu Dec 10 12:55:48 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 25 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 7497045 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XIRBKE+URWPalladioL-Ital Type 1 Custom yes yes no 93 0 IVEUDQ+URWPalladioL-Bold Type 1 Custom yes yes no 94 0 GIFXFT+VnURWPalladioL-Bold Type 1 Custom yes yes no 95 0 UXBNGN+URWPalladioL-Roma Type 1 Custom yes yes no 96 0 NBMIUS+VnURWPalladioL Type 1 Custom yes yes no 97 0 QJKKBB+Rpxr 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Type 1 Builtin yes yes no 339 0 EIKOKP+PalatinoLinotype TrueType WinAnsi yes yes no 458 0 EIKPBP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 459 0 EIKPJO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 460 0 EILACL+TimesNewRoman CID TrueType Identity-H yes yes yes 461 0 EIKOKP+PalatinoLinotype TrueType WinAnsi yes yes no 644 0 EIKPBP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 645 0 EIKPJO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 646 0 EILACL+TimesNewRoman CID TrueType Identity-H yes yes yes 647 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 880 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:47:56 CEST RepresentationInformation: pmc_33321931.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 11:43:38 CEST Size: 7497045 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げはぬづぜ〴ぜ〰はてぜ〴ぜ〰ねどげぎぁびぜ〴ぜ〰どのぜ〴ぜ〰ぴとづぜ〴ぜ〰こにどのぜ〴ぜ〰ぐちぴとはでづのづびどびぜ〴ぜ〰はてぜ〴ぜ〰ぃふぴちのづはふびぜ〴ぜ〰ぉねねふのづぜ〴ぜ〰いどびはひつづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐびはひどちびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぃふぴちのづはふびぜ〴ぜ〰がふばふびぜ〴ぜ〰ぅひべぴとづねちぴはびふびぜ〴ぜ〰ぜ〵ぜ〰ぃがぅぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁぴはばどっぜ〴ぜ〰いづひねちぴどぴどびぜ〴ぜ〰ぜ〵ぜ〰ぁいぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぐびはひどちびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぃふぴちのづはふびぜ〴ぜ〰がふばふびぜ〴ぜ〰ぅひべぴとづねちぴはびふびぜ〴ぜ〰ぜ〵ぜ〰ぃがぅぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁぴはばどっぜ〴ぜ〰いづひねちぴどぴどびぜ〴ぜ〰ぜ〵ぜ〰ぁいぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃふぴちのづはふびぜ〴ぜ〰がふばふびぜ〴ぜ〰ぅひべぴとづねちぴはびふびぜ〴ぜ〰ぜ〵ぜ〰ぃがぅぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぁぴはばどっぜ〴ぜ〰いづひねちぴどぴどびぜ〴ぜ〰ぜ〵ぜ〰ぁいぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぁぴはばどっぜ〴ぜ〰いづひねちぴどぴどびぜ〴ぜ〰ぜ〵ぜ〰ぁいぜ〵ㅜ〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃはねねはのぜ〴ぜ〰いづひづでふぬちぴづつぜ〴ぜ〰ねどげぎぁびぜ〴ぜ〰どのぜ〴ぜ〰こにどのぜ〴ぜ〰ぁふぴはどねねふのづぜ〴ぜ〰ぃはのつどぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ねどげぎぁびぜ〴ぜ〰ちびぜ〴ぜ〰ぐはぴづのぴどちぬぜ〴ぜ〰あどはねちひにづひびぜ〴ぜ〰どのぜ〴ぜ〰こにどのぜ〴ぜ〰ぉのてぬちねねちぴはひべぜ〴ぜ〰いどびづちびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰ねどげぎぁびぜ〴ぜ〰ちびぜ〴ぜ〰いどちでのはびぴどっぜ〴ぜ〰あどはねちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ねどげぎぁぜ〴ぜ〰ちびぜ〴ぜ〰いどびづちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰こづぶづひどぴべぜ〴ぜ〰あどはねちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ねどげぎぁぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぴはぜ〴ぜ〰きはのどぴはひぜ〴ぜ〰ごとづひちばづふぴどっぜ〴ぜ〰ぅててづっぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびはっどちぴづつぜ〴ぜ〰ぃはねはひぢどつどぴべぜ〴ぜ〰あどはねちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Children: Item: Title: ねどげぎぁびぜ〴ぜ〰ちびぜ〴ぜ〰いどちでのはびぴどっぜ〴ぜ〰あどはねちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ねどげぎぁぜ〴ぜ〰ちびぜ〴ぜ〰いどびづちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰こづぶづひどぴべぜ〴ぜ〰あどはねちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ねどげぎぁぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぴはぜ〴ぜ〰きはのどぴはひぜ〴ぜ〰ごとづひちばづふぴどっぜ〴ぜ〰ぅててづっぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびはっどちぴづつぜ〴ぜ〰ぃはねはひぢどつどぴべぜ〴ぜ〰あどはねちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ねどげぎぁぜ〴ぜ〰ちびぜ〴ぜ〰いどびづちびづぜ〴ぜ〰ぁっぴどぶどぴべぜ〴ぜ〰ちのつぜ〴ぜ〰こづぶづひどぴべぜ〴ぜ〰あどはねちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ねどげぎぁぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぴはぜ〴ぜ〰きはのどぴはひぜ〴ぜ〰ごとづひちばづふぴどっぜ〴ぜ〰ぅててづっぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびはっどちぴづつぜ〴ぜ〰ぃはねはひぢどつどぴべぜ〴ぜ〰あどはねちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ねどげぎぁぜ〴ぜ〰がづぶづぬびぜ〴ぜ〰ぴはぜ〴ぜ〰きはのどぴはひぜ〴ぜ〰ごとづひちばづふぴどっぜ〴ぜ〰ぅててづっぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㐩‾㸊⡜㌷㙜㌷㝜〰ぁびびはっどちぴづつぜ〴ぜ〰ぃはねはひぢどつどぴべぜ〴ぜ〰あどはねちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぁびびはっどちぴづつぜ〴ぜ〰ぃはねはひぢどつどぴべぜ〴ぜ〰あどはねちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ごちひでづぴどのでぜ〴ぜ〰ねどげぎぁびぜ〴ぜ〰ぴはぜ〴ぜ〰ごひづちぴぜ〴ぜ〰こにどのぜ〴ぜ〰ぁふぴはどねねふのづぜ〴ぜ〰いどびづちびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぁばばひはちっとづびぜ〴ぜ〰はてぜ〴ぜ〰ねどげぎぁぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰てはひぜ〴ぜ〰こにどのぜ〴ぜ〰ぁふぴはどねねふのづぜ〴ぜ〰いどびづちびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㈩‾㸊⡜㌷㙜㌷㝜〰ぃぬどのどっちぬぜ〴ぜ〰ごひどちぬびぜ〴ぜ〰さびどのでぜ〴ぜ〰ねどげぎぁぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰てはひぜ〴ぜ〰ごひづちぴどのでぜ〴ぜ〰こにどのぜ〴ぜ〰いどびづちびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㌩‾㸊⡜㌷㙜㌷㝜〰ごはばどっちぬぜ〴ぜ〰ぎちのはつづぬどぶづひべぜ〴ぜ〰はてぜ〴ぜ〰ねどげぎぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Children: Item: Title: ぉのぜ〴ぜ〰ざどぶはぜ〴ぜ〰ぁばばひはちっとづびぜ〴ぜ〰はてぜ〴ぜ〰ねどげぎぁぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰てはひぜ〴ぜ〰こにどのぜ〴ぜ〰ぁふぴはどねねふのづぜ〴ぜ〰いどびづちびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㈩‾㸊⡜㌷㙜㌷㝜〰ぃぬどのどっちぬぜ〴ぜ〰ごひどちぬびぜ〴ぜ〰さびどのでぜ〴ぜ〰ねどげぎぁぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰てはひぜ〴ぜ〰ごひづちぴどのでぜ〴ぜ〰こにどのぜ〴ぜ〰いどびづちびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㌩‾㸊⡜㌷㙜㌷㝜〰ごはばどっちぬぜ〴ぜ〰ぎちのはつづぬどぶづひべぜ〴ぜ〰はてぜ〴ぜ〰ねどげぎぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: ぃぬどのどっちぬぜ〴ぜ〰ごひどちぬびぜ〴ぜ〰さびどのでぜ〴ぜ〰ねどげぎぁぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰ごとづひちばべぜ〴ぜ〰てはひぜ〴ぜ〰ごひづちぴどのでぜ〴ぜ〰こにどのぜ〴ぜ〰いどびづちびづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㌩‾㸊⡜㌷㙜㌷㝜〰ごはばどっちぬぜ〴ぜ〰ぎちのはつづぬどぶづひべぜ〴ぜ〰はてぜ〴ぜ〰ねどげぎぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: ごはばどっちぬぜ〴ぜ〰ぎちのはつづぬどぶづひべぜ〴ぜ〰はてぜ〴ぜ〰ねどげぎぁぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: ぃはのっぬふびどはのび〬ぜ〴ぜ〰がどねどぴちぴどはのびぜ〴ぜ〰ちのつぜ〴ぜ〰うふぴふひづぜ〴ぜ〰ぐづひびばづっぴどぶづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: UXBNGN+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: UXBNGN+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VSHNAE+Rpcxr FontSubset: 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Subtype: Link Rect: 219, 95, 257, 105 Annotation: Subtype: Link Rect: 263, 95, 299, 105 Page: Sequence: 25 Annotations: Annotation: Subtype: Link Rect: 267, 714, 304, 725 Annotation: Subtype: Link Rect: 310, 714, 345, 725 Annotation: Subtype: Link Rect: 163, 676, 200, 686 Annotation: Subtype: Link Rect: 206, 676, 243, 686 Annotation: Subtype: Link Rect: 269, 637, 306, 648 Annotation: Subtype: Link Rect: 247, 599, 284, 609 Annotation: Subtype: Link Rect: 402, 559, 440, 570 Annotation: Subtype: Link Rect: 131, 534, 169, 544 Annotation: Subtype: Link Rect: 270, 508, 308, 519 Annotation: Subtype: Link Rect: 181, 483, 219, 493 Annotation: Subtype: Link Rect: 290, 457, 327, 467 Annotation: Subtype: Link Rect: 136, 418, 174, 428 Annotation: Subtype: Link Rect: 180, 418, 216, 428 Annotation: Subtype: Link Rect: 414, 378, 452, 389 Annotation: Subtype: Link Rect: 458, 378, 494, 389 Annotation: Subtype: Link Rect: 76, 307, 166, 338 Annotation: Subtype: Link Rect: 234, 301, 407, 312 Checksum: 7c9b9120 Type: CRC32 Checksum: 5c2e12120634fc90580bb454e62160d6 Type: MD5 Checksum: 75fe951de119bbb5058371e5ec67cecc50fd3ea0 Type: SHA-1