249449577f620df2625bd92e29eb8654  pmc_33328447.pdf
6e51f5eb72e5225c5eff486643ec576e365435de  pmc_33328447.pdf
8f1542031eabd450615bed9beafac0b75b8f90f12a9b2a0f523860bfa96e0492  pmc_33328447.pdf

Title:           The apple REFPOP—a reference population for genomics-assisted breeding in apple
Subject:         Horticulture Research, doi:10.1038/s41438-020-00408-8
Keywords:        
Author:          Michaela Jung
Creator:         Springer
Producer:        iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Thu Oct 29 04:18:40 2020 CET
ModDate:         Fri Oct 30 05:23:25 2020 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           16
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1413729 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
LLICPF+AdvOTa9103878                 Type 1C           WinAnsi          yes yes no      44  0
LLICLE+AdvOT07517017                 Type 1C           WinAnsi          yes yes no      73  0
LLICPG+AdvOTf0bf83d5.I               Type 1C           WinAnsi          yes yes no      45  0
LLICOE+AdvOT07517017+fb              Type 1C           Custom           yes yes yes     97  0
LLICPE+AdvOT07517017+20              Type 1C           Custom           yes yes yes     98  0
LLIDBI+AdvOTce3d9a73                 Type 1C           WinAnsi          yes yes no      48  0
LLIDBJ+AdvAGaramond-R                Type 1C           WinAnsi          yes yes no      49  0
LLICPH+AdvOTa9103878+fb              Type 1C           Custom           yes yes yes     50  0
LLICPI+AdvOTa9103878+20              Type 1C           WinAnsi          yes yes no      52  0
LLICDB+AdvOT46dcae81                 Type 1C           WinAnsi          yes yes no      74  0
LLICDC+AdvOT65f8a23b.I               Type 1C           WinAnsi          yes yes no     616  0
LLICEC+AdvMyriad_R                   Type 1C           WinAnsi          yes yes no     617  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  no     618  0
LLICLC+AdvOT3b30f6db.B               Type 1C           WinAnsi          yes yes no      51  0
LLICLD+AdvOT46dcae81+20              Type 1C           WinAnsi          yes yes no      75  0
LLIDCK+AdvTT67e40053                 Type 1C           WinAnsi          yes yes no      46  0
LLIDCL+AdvTTab7e17fd                 Type 1C           WinAnsi          yes yes no      47  0
LLJDLG+AdvOT0d9ab1db.I               Type 1C           WinAnsi          yes yes no      99  0
LLJPFB+AdvOTce3d9a73+fb              Type 1C           Custom           yes yes yes    109  0
LLJDMH+AdvOTa9103878+22              Type 1C           Custom           yes yes yes    110  0
LLLANH+AdvOT56309c18.I               Type 1C           WinAnsi          yes yes no     313  0
LLLANI+AdvOTf0bf83d5.I+03            Type 1C           Custom           yes yes yes    314  0
LLLAOK+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     315  0
LLLAOL+AdvOTfcc824aa.BI+03           Type 1C           Custom           yes yes yes    316  0
LLLAOI+AdvOTfcc824aa.BI              Type 1C           WinAnsi          yes yes no     317  0
LLLAOJ+AdvP4C4E74                    Type 1C           Custom           yes yes yes    318  0
LLLBAL+AdvP4C4E59                    Type 1C           WinAnsi          yes yes no     361  0
LLLBDL+AdvTT7b515deb                 Type 1C           WinAnsi          yes yes no     386  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-10-02 04:17:22 CEST
 RepresentationInformation: pmc_33328447.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-03-31 11:43:39 CEST
  Size: 1413729
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 708
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: The apple REFPOP—a reference population for’genomics-assisted breeding in apple
      Destination: title_link
      Children: 
       Item: 
        Title: Introduction
        Destination: A1
       Item: 
        Title: Results
        Destination: A2
        Children: 
         Item: 
          Title: Composition of the apple REFPOP
          Destination: B1
         Item: 
          Title: Marker imputation and validation of the imputation output
          Destination: B2
         Item: 
          Title: Linkage disequilibrium and population structure
          Destination: B3
         Item: 
          Title: Phenotypic analyses
          Destination: B4
         Item: 
          Title: Genome-wide association and prediction analyses
          Destination: B5
       Item: 
        Title: Discussion
        Destination: A3
        Children: 
         Item: 
          Title: Composition of the apple REFPOP
          Destination: B6
         Item: 
          Title: Expanding genomic information via imputation
          Destination: B7
         Item: 
          Title: Insights into apple population genomics
          Destination: B8
         Item: 
          Title: An efficient design for genomics-assisted breeding
          Destination: B9
         Item: 
          Title: Prospect of the apple REFPOP for multi-environment, multi-management and multi-trait testing
          Destination: B10
       Item: 
        Title: Conclusion
        Destination: A4
       Item: 
        Title: Materials and methods
        Destination: A5
        Children: 
         Item: 
          Title: Composition of apple REFPOP plant material
          Destination: B11
         Item: 
          Title: Multiplication of plant material and planting design
          Destination: B12
         Item: 
          Title: Molecular marker genotyping
          Destination: B13
         Item: 
          Title: Marker imputation
          Destination: B14
         Item: 
          Title: Genomic data analyses
          Destination: B15
          Children: 
           Item: 
            Title: Linkage disequilibrium
            Destination: C1
           Item: 
            Title: Population structure
            Destination: C2
         Item: 
          Title: Phenotype scoring
          Destination: B16
         Item: 
          Title: Phenotypic data analyses
          Destination: B17
          Children: 
           Item: 
            Title: Correction of spatial heterogeneity
            Destination: C3
           Item: 
            Title: Broad-sense heritability and phenotypic variation
            Destination: C4
           Item: 
            Title: Phenotypic least-square means
            Destination: C5
         Item: 
          Title: Genome-wide association and prediction analysis
          Destination: B18
          Children: 
           Item: 
            Title: Genome-wide association study
            Destination: C6
           Item: 
            Title: Genomic prediction
            Destination: C7
           Item: 
            Title: Comparison of GWAS and genomic prediction performance under various SNP densities
            Destination: C8
           Item: 
            Title: Analysis of prediction precision
            Destination: C9
       Item: 
        Title: Acknowledgements
        Destination: M1
       Item: 
        Title: Acknowledgements
        Destination: M1
   Info: 
    Title: The apple REFPOP a reference population for genomics-assisted breeding in apple
    Author: Michaela Jung
    Subject: Horticulture Research, doi:10.1038/s41438-020-00408-8
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Thu Oct 29 04:48:40 CET 2020
    ModDate: Fri Oct 30 05:23:25 CET 2020
   ID: 0x6b17e1561105f2e04fa7a2a1235c09de, 0xa8737cee350c7ec4ef0b4e6fd91dde01
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 492
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 814
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 742
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1500
      ImageHeight: 991
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1600
      ImageHeight: 1605
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: LLLBDL+AdvTT7b515deb
      FontSubset: true
      FirstChar: 174
      LastChar: 174
      FontDescriptor: 
       FontName: LLLBDL+AdvTT7b515deb
       Flags: Nonsymbolic
       FontBBox: -93, -187, 854, 843
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLICLE+AdvOT07517017
      FontSubset: true
      FirstChar: 35
      LastChar: 248
      FontDescriptor: 
       FontName: LLICLE+AdvOT07517017
       Flags: Nonsymbolic
       FontBBox: -41, -250, 812, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLICDB+AdvOT46dcae81
      FontSubset: true
      FirstChar: 40
      LastChar: 215
      FontDescriptor: 
       FontName: LLICDB+AdvOT46dcae81
       Flags: Nonsymbolic
       FontBBox: -41, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLICLD+AdvOT46dcae81+20
      FontSubset: true
      FirstChar: 145
      LastChar: 151
      FontDescriptor: 
       FontName: LLICLD+AdvOT46dcae81+20
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1125, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLICOE+AdvOT07517017+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: LLICOE+AdvOT07517017+fb
       Flags: Symbolic
       FontBBox: 0, 0, 677, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LLICPE+AdvOT07517017+20
      FontSubset: true
      FirstChar: 2
      LastChar: 150
      FontDescriptor: 
       FontName: LLICPE+AdvOT07517017+20
       Flags: Symbolic
       FontBBox: 0, -208, 1041, 864
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LLJDLG+AdvOT0d9ab1db.I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: LLJDLG+AdvOT0d9ab1db.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 864, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLICDC+AdvOT65f8a23b.I
      FontSubset: true
      FirstChar: 72
      LastChar: 117
      FontDescriptor: 
       FontName: LLICDC+AdvOT65f8a23b.I
       Flags: Nonsymbolic
       FontBBox: -104, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLICEC+AdvMyriad_R
      FontSubset: true
      FirstChar: 35
      LastChar: 95
      FontDescriptor: 
       FontName: LLICEC+AdvMyriad_R
       Flags: Nonsymbolic
       FontBBox: -41, -239, 1125, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLLBAL+AdvP4C4E59
      FontSubset: true
      FirstChar: 94
      LastChar: 94
      FontDescriptor: 
       FontName: LLLBAL+AdvP4C4E59
       Flags: Nonsymbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLICPF+AdvOTa9103878
      FontSubset: true
      FirstChar: 37
      LastChar: 237
      FontDescriptor: 
       FontName: LLICPF+AdvOTa9103878
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -239, 1020, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLICPG+AdvOTf0bf83d5.I
      FontSubset: true
      FirstChar: 44
      LastChar: 181
      FontDescriptor: 
       FontName: LLICPG+AdvOTf0bf83d5.I
       Flags: Serif, Nonsymbolic
       FontBBox: -187, -239, 1062, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLJPFB+AdvOTce3d9a73+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: LLJPFB+AdvOTce3d9a73+fb
       Flags: Symbolic
       FontBBox: 0, 0, 791, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LLIDCK+AdvTT67e40053
      FontSubset: true
      FirstChar: 174
      LastChar: 174
      FontDescriptor: 
       FontName: LLIDCK+AdvTT67e40053
       Flags: Nonsymbolic
       FontBBox: -72, -218, 927, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLJDMH+AdvOTa9103878+22
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: LLJDMH+AdvOTa9103878+22
       Flags: Symbolic
       FontBBox: -166, -166, 718, 864
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LLIDCL+AdvTTab7e17fd
      FontSubset: true
      FirstChar: 61
      LastChar: 61
      FontDescriptor: 
       FontName: LLIDCL+AdvTTab7e17fd
       Flags: Nonsymbolic
       FontBBox: -156, -250, 1072, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLIDBI+AdvOTce3d9a73
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: LLIDBI+AdvOTce3d9a73
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLIDBJ+AdvAGaramond-R
      FontSubset: true
      FirstChar: 35
      LastChar: 95
      FontDescriptor: 
       FontName: LLIDBJ+AdvAGaramond-R
       Flags: Nonsymbolic
       FontBBox: -177, -260, 1093, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLICPH+AdvOTa9103878+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: LLICPH+AdvOTa9103878+fb
       Flags: Symbolic
       FontBBox: 0, -10, 812, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LLICLC+AdvOT3b30f6db.B
      FontSubset: true
      FirstChar: 49
      LastChar: 121
      FontDescriptor: 
       FontName: LLICLC+AdvOT3b30f6db.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLICPI+AdvOTa9103878+20
      FontSubset: true
      FirstChar: 133
      LastChar: 150
      FontDescriptor: 
       FontName: LLICPI+AdvOTa9103878+20
       Flags: Nonsymbolic
       FontBBox: -166, -218, 968, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLLANH+AdvOT56309c18.I
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: LLLANH+AdvOT56309c18.I
       Flags: Nonsymbolic
       FontBBox: -93, -250, 906, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLLANI+AdvOTf0bf83d5.I+03
      FontSubset: true
      FirstChar: 1
      LastChar: 5
      FontDescriptor: 
       FontName: LLLANI+AdvOTf0bf83d5.I+03
       Flags: Symbolic
       FontBBox: -114, -239, 937, 822
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LLLAOK+AdvP4C4E51
      FontSubset: true
      FirstChar: 59
      LastChar: 59
      FontDescriptor: 
       FontName: LLLAOK+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLLAOL+AdvOTfcc824aa.BI+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: LLLAOL+AdvOTfcc824aa.BI+03
       Flags: Symbolic
       FontBBox: -114, -229, 968, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LLLAOI+AdvOTfcc824aa.BI
      FontSubset: true
      FirstChar: 71
      LastChar: 121
      FontDescriptor: 
       FontName: LLLAOI+AdvOTfcc824aa.BI
       Flags: Nonsymbolic
       FontBBox: -197, -239, 1093, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LLLAOJ+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 254
      FontDescriptor: 
       FontName: LLLAOJ+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41438-020-00408-8</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">The apple REFPOP—a reference population for genomics-assisted breeding in apple</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Michaela Jung</rdf:li>
               <rdf:li>Morgane Roth</rdf:li>
               <rdf:li>Maria José Aranzana</rdf:li>
               <rdf:li>Annemarie Auwerkerken</rdf:li>
               <rdf:li>Marco Bink</rdf:li>
               <rdf:li>Caroline Denancé</rdf:li>
               <rdf:li>Christian Dujak</rdf:li>
               <rdf:li>Charles-Eric Durel</rdf:li>
               <rdf:li>Carolina Font i Forcada</rdf:li>
               <rdf:li>Celia M. Cantin</rdf:li>
               <rdf:li>Walter Guerra</rdf:li>
               <rdf:li>Nicholas P. Howard</rdf:li>
               <rdf:li>Beat Keller</rdf:li>
               <rdf:li>Mariusz Lewandowski</rdf:li>
               <rdf:li>Matthew Ordidge</rdf:li>
               <rdf:li>Marijn Rymenants</rdf:li>
               <rdf:li>Nadia Sanin</rdf:li>
               <rdf:li>Bruno Studer</rdf:li>
               <rdf:li>Edward Zurawicz</rdf:li>
               <rdf:li>François Laurens</rdf:li>
               <rdf:li>Andrea Patocchi</rdf:li>
               <rdf:li>Hélène Muranty</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag></rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Horticulture Research, doi:10.1038/s41438-020-00408-8</rdf:li>
            </rdf:Alt>
         </dc:description>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:doi>10.1038/s41438-020-00408-8</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41438-020-00408-8</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Horticulture Research</prism:publicationName>
         <prism:copyright>© 2020, The Author(s)</prism:copyright>
         <prism:issn>2052-7276</prism:issn>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:doi>10.1038/s41438-020-00408-8</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1038/s41438-020-00408-8</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2020-10-30T05:23:25+01:00</xmp:ModifyDate>
         <xmp:CreateDate>2020-10-29T08:48:40+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2020-10-30T05:23:25+01:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:f0d2c4aa-3ef7-4a21-ab26-1c6edbddbb84</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:1a271a2d-da8a-43bb-8410-3e8365c4440e</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:43167430-416f-417f-928e-8a0eaefbf325</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2020-10-29T08:49:23+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/">
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Maria José Aranzana</author:name>
                  <author:orcid>http://orcid.org/0000-0002-0240-8021</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Nicholas P. Howard</author:name>
                  <author:orcid>http://orcid.org/0000-0001-7094-2229</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 455, 735, 538, 743
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 292, 603, 293, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 292, 603, 293, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 603, 303, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 293, 603, 302, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 301, 603, 302, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 137, 575, 138, 586
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 137, 575, 138, 586
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 147, 575, 148, 586
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 139, 575, 147, 586
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 146, 575, 147, 586
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 284, 266, 288, 275
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 242, 218, 245, 228
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 247, 218, 251, 228
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 376, 254, 380, 264
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 446, 182, 450, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 427, 158, 431, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 269, 59, 385, 66
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 162, 155, 234, 163
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 284, 648, 288, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 155, 624, 159, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 253, 601, 257, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 262, 601, 269, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 208, 529, 215, 539
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 92, 517, 96, 527
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 155, 505, 159, 515
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 78, 469, 85, 479
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 103, 445, 111, 455
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 218, 421, 225, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 223, 385, 227, 395
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 100, 110, 107, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 109, 110, 116, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 364, 529, 367, 539
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 530, 297, 535, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 53
      Annotation: 
       Subtype: Link
       Rect: 319, 230, 326, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 328, 230, 335, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 232, 357, 237, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 53
      Annotation: 
       Subtype: Link
       Rect: 176, 321, 181, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 53
      Annotation: 
       Subtype: Link
       Rect: 119, 249, 124, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 112, 202, 116, 211
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 254, 58, 258, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 460, 297, 465, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 366, 118, 371, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 291
      Annotation: 
       Subtype: Link
       Rect: 445, 98, 453, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 77, 357, 82, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 216, 226, 221, 235
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 200, 94, 205, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 353, 357, 358, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 400, 333, 405, 343
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 426, 297, 431, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 475, 261, 480, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 325, 142, 330, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 77, 70, 81, 80
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 403, 128, 407, 136
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 78, 106, 83, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 433, 166, 438, 176
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 257, 656, 262, 666
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 270, 608, 274, 618
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 123, 122, 130, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 129, 62, 137, 72
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 429, 684, 436, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 325, 541, 332, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 385, 505, 392, 515
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 325, 481, 332, 491
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 356, 457, 363, 467
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 415, 397, 422, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 338, 98, 345, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 347, 98, 354, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 76, 696, 80, 706
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 221, 660, 228, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 237, 505, 245, 515
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 127, 469, 130, 479
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 96, 397, 100, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 101, 397, 109, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 131, 349, 138, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 215, 182, 219, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 221, 182, 228, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 230, 182, 237, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 199, 146, 203, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 235, 86, 242, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 401, 684, 408, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 484, 648, 488, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 489, 648, 497, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 391, 612, 395, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 504, 589, 508, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 510, 589, 517, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 491, 505, 495, 515
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 462, 457, 469, 467
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 471, 457, 478, 467
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 346, 397, 350, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 355, 397, 362, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 364, 397, 372, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 445, 373, 453, 383
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 414, 302, 421, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 423, 302, 431, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 151, 589, 159, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 260, 110, 267, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 454, 696, 461, 706
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 434, 302, 442, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 443, 302, 451, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 445, 226, 455
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 85, 397, 92, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 147, 397, 154, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 244, 397, 247, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 76, 361, 83, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 176, 242, 183, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 432, 541, 436, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 343, 445, 346, 455
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 348, 445, 355, 455
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 357, 445, 364, 455
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 379, 433, 383, 443
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 477, 326, 485, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 104, 601, 111, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 153, 146, 157, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 159, 146, 166, 156
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 227, 86, 235, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 408, 684, 416, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 478, 648, 485, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 321, 577, 324, 586
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 326, 577, 333, 586
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 335, 577, 342, 586
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 531, 481, 538, 491
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 407, 321, 412, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 53
      Annotation: 
       Subtype: Link
       Rect: 370, 278, 377, 287
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 379, 278, 386, 287
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 512, 194, 519, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 416, 134, 423, 144
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 377, 118, 382, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 53
      Annotation: 
       Subtype: Link
       Rect: 416, 110, 423, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 489, 58, 494, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 53
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 207, 680, 211, 690
       Flags: Print
       AppearanceDictionary: true
       Destination: 53
      Annotation: 
       Subtype: Link
       Rect: 281, 493, 288, 503
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 108, 302, 115, 311
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 219, 266, 226, 275
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 240, 230, 247, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 266, 62, 269, 72
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 529, 660, 536, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 529, 624, 536, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 393, 242, 400, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 81, 660, 88, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 185, 589, 192, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 252, 361, 260, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 528, 660, 535, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 509, 536, 514, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 461, 441, 466, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 324, 158, 331, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 519, 86, 527, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
     Thumb: true
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 262, 660, 269, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 150, 469, 157, 479
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 428, 672, 435, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 514, 636, 521, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 511, 417, 516, 427
       Flags: Print
       AppearanceDictionary: true
       Destination: 339
      Annotation: 
       Subtype: Link
       Rect: 324, 405, 328, 415
       Flags: Print
       AppearanceDictionary: true
       Destination: 319
      Annotation: 
       Subtype: Link
       Rect: 459, 409, 466, 419
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 452, 157, 459, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
      Annotation: 
       Subtype: Link
       Rect: 393, 145, 401, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 392
     Thumb: true
    Page: 
     Label: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 197, 331, 255, 338
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 268, 331, 290, 338
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 322, 131, 329
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 58, 304, 117, 311
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 129, 304, 227, 311
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 233, 221, 279, 228
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 212, 141, 219
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 181, 119, 288, 126
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 558, 519, 565
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 260, 639, 290, 646
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 72, 630, 149, 637
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 270, 477, 290, 485
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 72, 468, 273, 476
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 72, 459, 97, 467
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 472, 522, 538, 529
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 320, 513, 394, 521
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 488adbe1
   Type: CRC32
  Checksum: 249449577f620df2625bd92e29eb8654
   Type: MD5
  Checksum: 6e51f5eb72e5225c5eff486643ec576e365435de
   Type: SHA-1
  Checksum: 8f1542031eabd450615bed9beafac0b75b8f90f12a9b2a0f523860bfa96e0492
   Type: SHA-256