f93eb4228f75a02793d681f790ddf247 pmc_33328887.pdf 726188be35a100496ff2a633ed61faa7f290494b pmc_33328887.pdf 271173522a68c52fd8563e25f23dd48d1a84ac9642740da7db87c419a97255d5 pmc_33328887.pdf Title: Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models Subject: Microglia are the main immune cells of the central nervous system (CNS), and they are devoted to the active surveillance of the CNS during homeostasis and disease. Keywords: IL-10 (interleukin-10), IL-6 (interleukin-6), phagocytosis, proliferation, neuroinflammation, microglial clusters, P2RY12, APOE Author: Beatriz Almolda Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Tue Nov 17 12:20:43 2020 CET ModDate: Tue Nov 17 14:40:48 2020 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 25 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 17885079 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 1039 0 EBWDLF+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 1042 0 MBDULF+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 1045 0 YBJLDK+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 1048 0 PGOXZI+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 1051 0 EOMBWZ+MinionPro-Regular Type 1 Custom yes yes no 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NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models Children: Item: Title: INTRODUCTION Item: Title: MATERIALS AND METHODS Children: Item: Title: Animals Item: Title: Perforant Pathway Transection and Experimental Groups Item: Title: Facial Nerve Axotomy and Experimental Groups Item: Title: 5' Bromodeoxyuridine Injections Item: Title: Tissue Processing for Histological Analysis Item: Title: Single Immunohistochemistry Item: Title: Double and Triple Immunohistochemistry Item: Title: Brightfield Microscopy Quantification Item: Title: Confocal Microscopy Quantification Item: Title: Tissue Processing for Protein Quantification Item: Title: Enzyme-Linked Adsorbent Immunoassay for sTREM2 Detection Item: Title: Isolation of Myelin and Fluorescent Labeling With pHrodoTM Green STP Ester Item: Title: Myelin Phagocytosis Assay and Flow Cytometry Item: Title: Statistical Analysis Item: Title: RESULTS Children: Item: Title: TREM2 Is Upregulated in the Denervated ML of the DG After PPT Item: Title: TREM2 Is Upregulated In the Lesioned FN After FNA Item: Title: Phenotypic and Functional Characterization of TREM2+ Microglial Cells After PPT and FNA Children: Item: Title: Expression of Proliferation Markers Item: Title: Expression of the Phagocytic Markers CD16/32 and CD68 Item: Title: Expression of the Phagocytic Ligands ApoE and Galectin-3 Item: Title: Expression of the Homeostatic Microglial Marker P2RY12 Item: Title: Microglial Phagocytosis of Myelin by TREM2+ Microglia After PPT and FNA Item: Title: Transgenic Overproduction of Either IL-6 or IL-10 Modifies TREM2 Expression, Especially After Anterograde Degeneration (PPT Mo搀攀氀㰼⽄⡳瑡牳散瑩潮汩湫⸲〩⽓⽇潔漾㸼㰯䄠ㄱ㠰‰⁒⽎數琠ㄱ㜶‰⁒⽐慲敮琠ㄱ㘰‰⁒⽔楴汥‱ㄸㄠ〠刾㸼㰯䄠ㄱ㘹‰⁒⽐慲敮琠ㄱ㘰‰⁒⽐牥瘠ㄱ㜰‰⁒⽔楴汥‱ㄷㄠ〠刾㸼㰯䄠ㄱ㘷‰⁒⽎數琠ㄱ㘰‰⁒⽐慲敮琠ㄱ〸‰⁒⽐牥瘠ㄱㄱ‰⁒⽔楴汥‱ㄶ㠠〠刾㸨Phenotypic and Functional Characterization of TREM2+ Microglial Cells After PPT and FNA Item: Title: DISCUSSION Children: Item: Title: TREM2 Is Increased in Activated Microglial Cells After Both PPT and FNA Item: Title: TREM2+ Cells Expressed Markers Related to Proliferation and Phagocytosis After FNA and PPT Item: Title: Pro-inflammatory Rather Than Anti-Inflammatory Local Microenvironments Influence Microglial TREM2 Expression Mainly After PPT 戀甀琀 䄀氀猀漀 䄀昀琀攀爀 䘀一䄩㰼⽄⡳瑡牳散瑩潮汩湫⸲㤩⽓⽇潔漾㸨TREM2+ Cells Expressed Markers Related to Proliferation and Phagocytosis After FNA and PPT Item: Title: CONCLUSIONS Item: Title: DATA AVAILABILITY STATEMENT Item: Title: ETHICS STATEMENT Item: Title: AUTHOR CONTRIBUTIONS Item: Title: FUNDING Item: Title: ACKNOWLEDGMENTS Item: Title: SUPPLEMENTARY MATERIAL Item: Title: REFERENCES Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: BVBUGA+MTGU FontSubset: true FirstChar: 98 LastChar: 109 FontDescriptor: FontName: BVBUGA+MTGU Flags: Symbolic FontBBox: 25, -213, 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FontBBox: -199, -358, 1684, 1002 FontFile: true EncodingDictionary: Differences: true XMP: application/pdf Beatriz Almolda Microglia are the main immune cells of the central nervous system (CNS), and they are devoted to the active surveillance of the CNS during homeostasis and disease. 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