c8bf15cddb054c3a0fcfc2f2add45175 pmc_33339845.pdf 69261851a215e3f44c54e62c88e6db3354b9281b pmc_33339845.pdf 27d33e072400030c7b4c23350073c75a7c597e903f7fffbb9f18bf0f53d1c982 pmc_33339845.pdf Title: Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker Subject: Scientific Reports, https://doi.org/10.1038/s41598-020-78999-4 Author: José Luis Izquierdo-Garcia Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sat Dec 12 15:27:30 2020 CET ModDate: Mon Dec 14 10:38:10 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2498001 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TLYVLW+Wingdings-Regular Type 1C WinAnsi yes yes yes 307 0 MinionPro-Regular Type 1C Custom yes no yes 49 0 TTHKFH+Corbel-Bold CID TrueType Identity-H yes yes yes 52 0 Corbel2 TrueType WinAnsi yes no yes 53 0 HGHVTF+Corbel CID TrueType Identity-H yes yes yes 54 0 MinionPro-Bold Type 1C Custom yes no yes 50 0 MinionPro-It Type 1C Custom yes no yes 51 0 PHAGBP+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 232 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-04 02:33:32 CEST RepresentationInformation: pmc_33339845.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-12-28 03:45:51 CET Size: 2498001 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 375 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker Children: Item: Title: Results Children: Item: Title: Study population. Item: Title: Characterisation of the TB metabolic fingerprint using HF-NMR. Item: Title: HF-NMR-based profile to discriminate TB. Item: Title: Characterisation of the TB metabolic profile using LF-NMR. Item: Title: TB discrimination from LF-NMR-based metabolic profile. Item: Title: Discussion Item: Title: Methods Children: Item: Title: Ethical statement. Item: Title: Study population. Item: Title: Collection and preparation of urine samples for NMR analysis. Item: Title: NMR spectral acquisition and processing. Item: Title: Data analysis. Children: Item: Title: Statistical analysis of the study population. Item: Title: Statistical analysis of metabolomic data. Item: Title: References Item: Title: Acknowledgements Info: Title: Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker Author: José Luis Izquierdo-Garcia Subject: Scientific Reports, https://doi.org/10.1038/s41598-020-78999-4 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sat Dec 12 15:57:30 CET 2020 ModDate: Mon Dec 14 10:38:10 CET 2020 ID: 0x3b05223b6b37259048d07128f2fc58a9, 0xbdb35f172f1b461320dee5140f386a91 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1772 ImageHeight: 920 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1772 ImageHeight: 1648 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: 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2020-12-14T10:38:10+01:00 application/pdf https://doi.org/10.1038/s41598-020-78999-4 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-020-78999-4 Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker José Luis Izquierdo-Garcia Patricia Comella-del-Barrio Ramón Campos-Olivas Raquel Villar-Hernández Cristina Prat-Aymerich Maria Luiza De Souza-Galvão Maria Angeles Jiménez-Fuentes Juan Ruiz-Manzano Zoran Stojanovic Adela González Mar Serra-Vidal Esther García-García Beatriz Muriel-Moreno Joan Pau Millet Israel Molina-Pinargote Xavier Casas Javier Santiago Fina Sabriá Carmen Martos Christian Herzmann Jesús Ruiz-Cabello José Domínguez 10.1038/s41598-020-78999-4 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-020-78999-4 10.1038/s41598-020-78999-4 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-020-78999-4 noindex springer.com springerlink.com VoR 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