48f7beb59977665a2634a4f4ee0151ea pmc_33379225.pdf b61ba656ab7c756ed4c1ac60d7a210c171af88a7 pmc_33379225.pdf dff697886a46fb5f293590194638a8ab53b593964aeb25684c1d383711a6d4ef pmc_33379225.pdf Title: Exploring Risk and Resilient Profiles for Functional Impairment and Baseline Predictors in a 2-Year Follow-Up First-Episode Psychosis Cohort Using Latent Class Growth Analysis Subject: Being able to predict functional outcomes after First-Episode Psychosis (FEP) is a major goal in psychiatry. Thus, we aimed to identify trajectories of psychosocial functioning in a FEP cohort followed-up for 2 years in order to find premorbid/baseline predictors for each trajectory. Additionally, we explored diagnosis distribution within the different trajectories. A total of 261 adults with FEP were included. Latent class growth analysis identified four distinct trajectories: Mild impairment-Improving trajectory (Mi-I) (38.31% of the sample), Moderate impairment-Stable trajectory (Mo-S) (18.39%), Severe impairment-Improving trajectory (Se-I) (12.26%), and Severe impairment-Stable trajectory (Se-S) (31.03%). Participants in the Mi-I trajectory were more likely to have higher parental socioeconomic status, less severe baseline depressive and negative symptoms, and better premorbid adjustment than individuals in the Se-S trajectory. Participants in the Se-I trajectory were more likely to have better baseline verbal learning and memory and better premorbid adjustment than those in the Se-S trajectory. Lower baseline positive symptoms predicted a Mo-S trajectory vs. Se-S trajectory. Diagnoses of Bipolar disorder and Other psychoses were more prevalent among individuals falling into Mi-I trajectory. Our findings suggest four distinct trajectories of psychosocial functioning after FEP. We also identified social, clinical, and cognitive factors associated with more resilient trajectories, thus providing insights for early interventions targeting psychosocial functioning. Keywords: first-episode psychosis; functional outcomes; risk factors; early intervention; neurocognition; latent class analysis; precision medicine Author: Estela Salagre, Iria Grande, Brisa Solé, Gisela Mezquida, Manuel J. Cuesta, Covadonga M. Díaz-Caneja, Silvia Amoretti, Antonio Lobo, Ana González-Pinto, Carmen Moreno, Laura Pina-Camacho, Iluminada Corripio, Immaculada Baeza, Daniel Bergé, Norma Verdolini, André F. Carvalho, Eduard Vieta, Miquel Bernardo and PEPs Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Dec 28 12:55:30 2020 CET ModDate: Mon Dec 28 13:00:32 2020 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1066775 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IYDCBB+VnURWPalladioL Type 1 Custom yes yes no 10 0 TUBMEC+URWPalladioL-Ital Type 1 Custom yes yes no 15 0 LAIJII+URWPalladioL-Bold Type 1 Custom yes yes no 20 0 MQNFNS+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 IOJCNK+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 36 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 39 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 61 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 65 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 69 0 ICRTVP+CMSY10 Type 1 Builtin yes yes no 84 0 TZMBWO+URWPalladioL-BoldItal Type 1 Custom yes yes no 97 0 FMPLPF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 111 0 FMPMCG+PalatinoLinotype TrueType WinAnsi yes yes no 114 0 FMPMDI+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 117 0 FNAEJI+DengXian CID TrueType Identity-H yes yes yes 120 0 JLZORU+EURM10 Type 1 Builtin yes yes no 136 0 FMPLPF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 150 0 FMPMCG+PalatinoLinotype TrueType WinAnsi yes yes no 153 0 FMPMDI+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 156 0 FNAOLK+Arial CID TrueType Identity-H yes yes yes 183 0 FMPLPF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 189 0 FMPMCF+PalatinoLinotype CID TrueType Identity-H yes yes yes 192 0 FMPMCG+PalatinoLinotype TrueType WinAnsi yes yes no 198 0 FMPMDI+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 201 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:17:12 CEST RepresentationInformation: pmc_33379225.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:43:40 CEST Size: 1066775 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 507 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Experimental Section Destination: section.2 Children: Item: Title: Participants Destination: subsection.2.1 Item: Title: Assessment Destination: subsection.2.2 Children: Item: Title: Baseline Sociodemographic Data Destination: subsubsection.2.2.1 Item: Title: Baseline Clinical and Functional Assessment Destination: subsubsection.2.2.2 Item: Title: 2-Month Follow-Up Neuropsychological Assessment Destination: subsubsection.2.2.3 Item: Title: Statistical Analysis Destination: subsection.2.3 Children: Item: Title: Identification of Functional Trajectories: Latent Class Growth Analysis Destination: subsubsection.2.3.1 Item: Title: Identification of Baseline Predictors of Functional Trajectory Membership Destination: subsubsection.2.3.2 Item: Title: Diagnosis Distribution within the Identified Functional Trajectories Destination: subsubsection.2.3.3 Item: Title: Results Destination: section.3 Children: Item: Title: Sample Characteristics and Attrition Analysis Destination: subsection.3.1 Item: Title: Latent Classes of Functional Trajectories Destination: subsection.3.2 Item: Title: Baseline Predictors of Trajectory Membership Destination: subsection.3.3 Item: Title: Exploring Diagnoses Distribution among Functional Trajectories throughout the Follow-Up Destination: subsection.3.4 Item: Title: Post-Hoc Mediation Analysis Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Limitations Destination: section.5 Item: Title: Conclusions Destination: section.6 Item: Title: Destination: section.A. Item: Title: References Destination: figure.caption.8 Info: Title: Exploring Risk and Resilient Profiles for Functional Impairment and Baseline Predictors in a 2-Year Follow-Up First-Episode Psychosis Cohort Using Latent Class Growth Analysis Author: Estela Salagre, Iria Grande, Brisa Solé, Gisela Mezquida, Manuel J. Cuesta, Covadonga M. Díaz-Caneja, Silvia Amoretti, Antonio Lobo, Ana González-Pinto, Carmen Moreno, Laura Pina-Camacho, Iluminada Corripio, Immaculada Baeza, Daniel Bergé, Norma Verdolini, André F. Carvalho, Eduard Vieta, Miquel Bernardo and PEPs Group Subject: Being able to predict functional outcomes after First-Episode Psychosis (FEP) is a major goal in psychiatry. Thus, we aimed to identify trajectories of psychosocial functioning in a FEP cohort followed-up for 2 years in order to find premorbid/baseline predictors for each trajectory. Additionally, we explored diagnosis distribution within the different trajectories. A total of 261 adults with FEP were included. Latent class growth analysis identified four distinct trajectories: Mild impairment-Improving trajectory (Mi-I) (38.31% of the sample), Moderate impairment-Stable trajectory (Mo-S) (18.39%), Severe impairment-Improving trajectory (Se-I) (12.26%), and Severe impairment-Stable trajectory (Se-S) (31.03%). Participants in the Mi-I trajectory were more likely to have higher parental socioeconomic status, less severe baseline depressive and negative symptoms, and better premorbid adjustment than individuals in the Se-S trajectory. Participants in the Se-I trajectory were more likely to have better baseline verbal learning and memory and better premorbid adjustment than those in the Se-S trajectory. Lower baseline positive symptoms predicted a Mo-S trajectory vs. Se-S trajectory. Diagnoses of Bipolar disorder and Other psychoses were more prevalent among individuals falling into Mi-I trajectory. Our findings suggest four distinct trajectories of psychosocial functioning after FEP. We also identified social, clinical, and cognitive factors associated with more resilient trajectories, thus providing insights for early interventions targeting psychosocial functioning. 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Subtype: Link Rect: 381, 146, 419, 157 Annotation: Subtype: Link Rect: 425, 146, 461, 157 Annotation: Subtype: Link Rect: 59, 112, 97, 122 Annotation: Subtype: Link Rect: 103, 112, 139, 122 Checksum: 92e0f836 Type: CRC32 Checksum: 48f7beb59977665a2634a4f4ee0151ea Type: MD5 Checksum: b61ba656ab7c756ed4c1ac60d7a210c171af88a7 Type: SHA-1 Checksum: dff697886a46fb5f293590194638a8ab53b593964aeb25684c1d383711a6d4ef Type: SHA-256