ae6ca20677516d06777efb895fcbb0e3 pmc_33391171.pdf a0bdebfb90a1d323490398273315f7d3b9f923c6 pmc_33391171.pdf 9f26f6e6d9b402197e0f8b7c3a9bd8fe0b412a5aff3d061b865b00a784556301 pmc_33391171.pdf Title: Intensive Teenage Activity Is Associated With Greater Muscle Hyperintensity on T1W Magnetic Resonance Imaging in Adults With Dysferlinopathy Subject: Practice of sports during childhood or adolescence correlates with an earlier onset and more rapidly progressing phenotype in dysferlinopathies. Keywords: dysferlinopathy, Magnetic Resonace Imaging (MRI), Miyoshi myopathy, LGMDR2, limb girdle muscle dystrophy, exercise Author: Jordi Diaz-Manera Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Wed Dec 16 09:44:26 2020 CET ModDate: Wed Dec 16 09:45:28 2020 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 1744361 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YTIPEM+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 36 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 49 0 AHVJPQ+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 51 0 BWOZZT+HelveticaNeueLTStd-MdIt Type 1C Custom yes yes no 56 0 TYOFQE+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 31 0 GBAUGV+RMTMI Type 1C WinAnsi yes yes no 64 0 BMYBIG+MinionPro-Regular Type 1C Custom yes yes no 66 0 WAMJTV+MinionPro-It Type 1C Custom yes yes no 68 0 PVRSOE+MinionPro-Bold Type 1C Custom yes yes no 82 0 QYKTVY+MTSY Type 1C Custom yes yes yes 97 0 UADLTO+MTSYB Type 1C Custom yes yes no 99 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:17:11 CEST RepresentationInformation: pmc_33391171.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:43:40 CEST Size: 1744361 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 219 FreeObjects: 14 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Intensive Teenage Activity Is Associated With Greater Muscle Hyperintensity on T1W Magnetic Resonance Imaging in Adults With Dysferlinopathy Destination: ariclecounter.1 Children: Item: Title: Introduction Destination: section*.2 Item: Title: Methods Destination: section*.3 Children: Item: Title: Study Subjects Destination: section*.4 Item: Title: Semiquantitative MRI Assessment Destination: section*.5 Item: Title: Exercise Scoring Destination: section*.6 Item: Title: Statistical Analysis Destination: section*.7 Item: Title: Results Destination: section*.8 Children: Item: Title: Demographics Destination: section*.9 Item: Title: Age Adjusted Mercuri Score Destination: section*.10 Item: Title: Symptom Duration and Age Adjusted Mercuri Score Destination: section*.11 Item: Title: Discussion Destination: section*.12 Item: Title: Data Availability Statement Destination: section*.13 Item: Title: Ethics Statement Destination: section*.14 Item: Title: Author Contributions Destination: section*.15 Item: Title: Funding Destination: section*.16 Item: Title: Acknowledgments Destination: section*.17 Item: Title: Supplementary Material Destination: section*.18 Item: Title: References Destination: section*.19 Info: Title: Intensive Teenage Activity Is Associated With Greater Muscle Hyperintensity on T1W Magnetic Resonance Imaging in Adults With Dysferlinopathy Author: Jordi Diaz-Manera Subject: Practice of sports during childhood or adolescence correlates with an earlier onset and more rapidly progressing phenotype in dysferlinopathies. Keywords: dysferlinopathy, Magnetic Resonace Imaging (MRI), Miyoshi myopathy, LGMDR2, limb girdle muscle dystrophy, exercise Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Wed Dec 16 10:14:26 CET 2020 ModDate: Wed Dec 16 10:15:28 CET 2020 ID: 0x51aebd8c79bd920b6842127acb9c0935, 0x269ad9ae8cac9948b49e17b4f42c8f28 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1251 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1251 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1251 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1251 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 697 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: GBAUGV+RMTMI FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: GBAUGV+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 682, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PIAOFJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PIAOFJ+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: QYKTVY+MTSY FontSubset: true FirstChar: 13 LastChar: 68 FontDescriptor: FontName: QYKTVY+MTSY Flags: Symbolic FontBBox: 0, -209, 944, 679 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BMYBIG+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: BMYBIG+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PVRSOE+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: PVRSOE+MinionPro-Bold Flags: Symbolic FontBBox: -7, -245, 860, 703 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: AHVJPQ+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 244 FontDescriptor: FontName: AHVJPQ+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 729 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: UADLTO+MTSYB FontSubset: true FirstChar: 68 LastChar: 68 FontDescriptor: FontName: UADLTO+MTSYB Flags: Symbolic, AllCap FontBBox: 0, 0, 724, 387 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: YTIPEM+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 151 FontDescriptor: FontName: YTIPEM+HelveticaNeueLTStd-Lt Flags: Serif, Symbolic FontBBox: -30, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: WAMJTV+MinionPro-It FontSubset: true FirstChar: 2 LastChar: 169 FontDescriptor: FontName: WAMJTV+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 1003, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BWOZZT+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 0 LastChar: 134 FontDescriptor: FontName: BWOZZT+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -133, -205, 995, 731 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: TYOFQE+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 40 LastChar: 124 FontDescriptor: FontName: TYOFQE+HelveticaNeueLTStd-Bd Flags: Nonsymbolic FontBBox: -19, -214, 848, 786 FontFile3: true Encoding: WinAnsiEncoding XMP: 2020-12-16T14:14:26+05:30 LaTeX with hyperref package + hypdvips 2020-12-16T14:15:28+05:30 2020-12-16T14:15:28+05:30 application/pdf Practice of sports during childhood or adolescence correlates with an earlier onset and more rapidly progressing phenotype in dysferlinopathies. Jordi Diaz-Manera Intensive Teenage Activity Is Associated With Greater Muscle Hyperintensity on T1W Magnetic Resonance Imaging in Adults With Dysferlinopathy dysferlinopathy Magnetic Resonace Imaging (MRI) Miyoshi myopathy LGMDR2 limb girdle muscle dystrophy exercise dysferlinopathy, Magnetic Resonace Imaging (MRI), Miyoshi myopathy, LGMDR2, limb girdle muscle dystrophy, exercise dvips + MiKTeX GPL Ghostscript 9.0 uuid:6bc988e3-43c2-4502-be7f-377533589293 uuid:26544096-15cc-478e-8de1-55362f5da277 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 719, 144, 755 Annotation: Subtype: Link Rect: 474, 736, 551, 744 Annotation: Subtype: Link Rect: 458, 728, 500, 736 Annotation: Subtype: Link Rect: 500, 729, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 451, 720, 551, 728 Annotation: Subtype: Link Rect: 521, 678, 551, 709 Annotation: Subtype: Link Rect: 43, 30, 111, 38 Annotation: Subtype: Link Rect: 114, 30, 174, 38 Annotation: Subtype: Link Rect: 414, 29, 551, 38 Annotation: Subtype: Link Rect: 87, 504, 160, 513 Annotation: Subtype: Link Rect: 53, 366, 160, 374 Annotation: Subtype: Link Rect: 74, 69, 160, 76 Annotation: Subtype: Link Rect: 176, 547, 551, 660 Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 250, 463, 256, 474 Destination: External Annotation: Subtype: Link Rect: 137, 417, 144, 428 Destination: External Annotation: Subtype: Link Rect: 147, 417, 153, 428 Destination: External Annotation: Subtype: Link Rect: 139, 371, 146, 382 Destination: External Annotation: Subtype: Link Rect: 96, 268, 102, 279 Destination: External Annotation: Subtype: Link Rect: 108, 268, 114, 279 Destination: External Annotation: Subtype: Link Rect: 94, 210, 100, 222 Destination: External Annotation: Subtype: Link Rect: 269, 84, 276, 96 Destination: External Annotation: Subtype: Link Rect: 279, 84, 285, 96 Destination: External Annotation: Subtype: Link Rect: 352, 495, 359, 506 Destination: External Annotation: Subtype: Link Rect: 366, 268, 378, 280 Destination: External Annotation: Subtype: Link Rect: 307, 152, 405, 162 Destination: External Annotation: Subtype: Link Rect: 534, 97, 546, 108 Destination: External Annotation: Subtype: Link Rect: 541, 85, 548, 97 Destination: External Annotation: Subtype: Link Rect: 43, 28, 111, 36 Annotation: Subtype: Link Rect: 114, 28, 174, 36 Annotation: Subtype: Link Rect: 414, 28, 551, 37 Page: Label: 3 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 279, 651, 285, 662 Destination: External Annotation: Subtype: Link Rect: 47, 617, 53, 628 Destination: External Annotation: Subtype: Link Rect: 307, 706, 405, 717 Destination: External Annotation: Subtype: Link Rect: 500, 674, 506, 685 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 414, 29, 551, 38 Page: Label: 4 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 483, 524, 513, 533 Destination: External Annotation: Subtype: Link Rect: 438, 490, 468, 499 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 414, 29, 551, 38 Page: Label: 5 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 218, 156, 253, 166 Destination: External Annotation: Subtype: Link Rect: 129, 64, 164, 75 Destination: External Annotation: Subtype: Link Rect: 307, 216, 341, 227 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 414, 29, 551, 38 Page: Label: 6 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 220, 227, 254, 237 Destination: External Annotation: Subtype: Link Rect: 254, 192, 289, 203 Destination: External Annotation: Subtype: Link Rect: 135, 181, 170, 191 Destination: External Annotation: Subtype: Link Rect: 468, 195, 475, 206 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 414, 29, 551, 38 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 142, 116, 148, 128 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 414, 29, 551, 38 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 47, 502, 53, 514 Destination: External Annotation: Subtype: Link Rect: 59, 502, 65, 514 Destination: External Annotation: Subtype: Link Rect: 138, 307, 149, 319 Destination: External Annotation: Subtype: Link Rect: 151, 307, 162, 319 Destination: External Annotation: Subtype: Link Rect: 137, 147, 148, 158 Destination: External Annotation: Subtype: Link Rect: 151, 147, 162, 158 Destination: External Annotation: Subtype: Link Rect: 43, 29, 111, 37 Annotation: Subtype: Link Rect: 114, 29, 174, 37 Annotation: Subtype: Link Rect: 414, 29, 551, 38 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 436, 649, 535, 660 Annotation: Subtype: Link Rect: 552, 525, 303, 550 Annotation: Subtype: Link Rect: 292, 417, 56, 438 Annotation: Subtype: Link Rect: 126, 352, 209, 361 Annotation: Subtype: Link Rect: 70, 324, 158, 333 Annotation: Subtype: Link Rect: 70, 287, 131, 295 Annotation: Subtype: Link Rect: 70, 248, 153, 257 Annotation: Subtype: Link Rect: 70, 221, 131, 229 Annotation: Subtype: Link Rect: 129, 182, 212, 191 Annotation: Subtype: Link Rect: 173, 155, 276, 162 Annotation: Subtype: Link Rect: 70, 126, 170, 134 Annotation: Subtype: Link Rect: 165, 97, 225, 106 Annotation: Subtype: Link Rect: 331, 467, 416, 475 Annotation: Subtype: Link Rect: 341, 409, 407, 418 Annotation: Subtype: Link Rect: 331, 371, 438, 380 Annotation: Subtype: Link Rect: 405, 145, 431, 152 Annotation: Subtype: Link Rect: 431, 145, 463, 152 Annotation: Subtype: Link Rect: 463, 145, 499, 153 Annotation: Subtype: Link Rect: 499, 145, 522, 152 Annotation: Subtype: Link Rect: 522, 144, 549, 153 Annotation: Subtype: Link Rect: 43, 28, 111, 36 Annotation: Subtype: Link Rect: 114, 28, 174, 36 Annotation: Subtype: Link Rect: 414, 28, 551, 37 Checksum: b55e3e51 Type: CRC32 Checksum: ae6ca20677516d06777efb895fcbb0e3 Type: MD5 Checksum: a0bdebfb90a1d323490398273315f7d3b9f923c6 Type: SHA-1 Checksum: 9f26f6e6d9b402197e0f8b7c3a9bd8fe0b412a5aff3d061b865b00a784556301 Type: SHA-256