2bd27bde1376de98541d2c3106adac3c pmc_33395752.pdf 141a826bdc2b1284958a5bb6ae05df72f56a9148 pmc_33395752.pdf 76262a4f75db5df6dc1e49118cd31d16508e8d735288564c5660b0b7f23fbd5f pmc_33395752.pdf Title: Biomarkers of response to ibrutinib plus nivolumab in relapsed diffuse large B-cell lymphoma, follicular lymphoma, or Richter•s transformation Subject: Translational Oncology, 14 (2021) 100977. doi:10.1016/j.tranon.2020.100977 Keywords: "Ibrutinib"; "Nivolumab"; "Non-hodgkin's lymphoma"; "Biomarkers"; "Phase I/II trial" Author: Brendan P. 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cannot be found Offset: 805978 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1112 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Biomarkers of response to ibrutinib plus nivolumab in relapsed diffuse large B-cell lymphoma, follicular lymphoma, or Richter’s transformation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Patients and study design Destination: 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Title: Patients and treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: DLBCL subtyping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Treatment responses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Clinical outcome analyses by biomarker Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Children: Item: Title: PD-L1 expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Exome analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Children: Item: Title: Responders versus nonresponders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: PFS >24 versus 24 months in DLBCL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Gene expression profiling analysis Destination: 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Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Supplementary materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Info: Title: Biomarkers of response to ibrutinib plus nivolumab in relapsed diffuse large B-cell lymphoma, follicular lymphoma, or Richter•s transformation Author: Brendan P. Hodkinson Subject: Translational Oncology, 14 (2021) 100977. doi:10.1016/j.tranon.2020.100977 Keywords: "Ibrutinib"; "Nivolumab"; "Non-hodgkin's lymphoma"; "Biomarkers"; "Phase I/II trial" Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sun Dec 06 08:20:54 CET 2020 ModDate: Sun Dec 06 08:21:33 CET 2020 ID: 0x46526b3ffe57cecc5cd0975aae31f102, 0x223ef049b6259385cbb38518548e92ba Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 249 ImageHeight: 273 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 118 ImageHeight: 118 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 221 ImageHeight: 297 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: KCOBJB+CharisSIL-Bold FontSubset: true FirstChar: 2 LastChar: 214 FontDescriptor: FontName: KCOBJB+CharisSIL-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -90, -231, 956, 918 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCOAEH+STIXMath-Regular FontSubset: true FirstChar: 2 LastChar: 61 FontDescriptor: FontName: KCOAEH+STIXMath-Regular Flags: Serif, Symbolic FontBBox: -970, -341, 1096, 1023 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCOEFA+STIXMathCalligraphy-Regular FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: KCOEFA+STIXMathCalligraphy-Regular Flags: Symbolic FontBBox: 63, -103, 629, 609 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCOGCG+Gulliver FontSubset: true FirstChar: 2 LastChar: 148 FontDescriptor: FontName: KCOGCG+Gulliver Flags: Serif, Symbolic FontBBox: -115, -211, 1042, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCNFNJ+dummy-space FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: KCNFNJ+dummy-space Flags: Nonsymbolic FontBBox: 0, 0, 0, 0 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KCNFNI+CharisSIL FontSubset: true FirstChar: 2 LastChar: 214 FontDescriptor: FontName: KCNFNI+CharisSIL Flags: Serif, Symbolic FontBBox: -79, -229, 922, 894 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCOFMH+STIXMath-Italic FontSubset: true FirstChar: 2 LastChar: 62 FontDescriptor: FontName: KCOFMH+STIXMath-Italic Flags: Symbolic, Italic FontBBox: 49, -24, 621, 534 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCOAGI+CharisSIL-Italic FontSubset: true FirstChar: 2 LastChar: 242 FontDescriptor: FontName: KCOAGI+CharisSIL-Italic Flags: Serif, Symbolic, Italic FontBBox: -130, -229, 903, 737 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCNNOF+UniversLTStd FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: KCNNOF+UniversLTStd Flags: Symbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCNPCO+ZapfDingbats FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: KCNPCO+ZapfDingbats Flags: Symbolic FontBBox: -1, -143, 981, 820 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCOGCH+Gulliver-Italic FontSubset: true FirstChar: 45 LastChar: 119 FontDescriptor: FontName: KCOGCH+Gulliver-Italic Flags: Serif, Symbolic, Italic FontBBox: -141, -211, 1053, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCPNFA+STIXMathScript-Regular FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: KCPNFA+STIXMathScript-Regular Flags: Symbolic FontBBox: 0, -324, 1229, 830 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 2020-12-06T12:20:54+05:30 Elsevier 2020-12-06T12:21:33+05:30 2020-12-06T12:21:33+05:30 Acrobat Distiller 10.0.0 (Windows) Ibrutinib,Nivolumab,Non-hodgkin's lymphoma,Biomarkers,Phase I/II trial application/pdf doi:10.1016/j.tranon.2020.100977 Elsevier Inc. Translational Oncology, 14 (2021) 100977. doi:10.1016/j.tranon.2020.100977 Ibrutinib Nivolumab Non-hodgkin's lymphoma Biomarkers Phase I/II trial Biomarkers of response to ibrutinib plus nivolumab in relapsed diffuse large B-cell lymphoma, follicular lymphoma, or Richter•s transformation Brendan P. Hodkinson Michael Schaffer Joshua D. Brody Wojciech Jurczak Cecilia Carpio Dina Ben-Yehuda Irit Avivi Ann Forslund Muhit Özcan John Alvarez Rob Ceulemans Nele Fourneau Anas Younes Sriram Balasubramanian uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c uuid:b7a317cd-0d88-46be-8e30-951f5ffb8f9e journal © 2020 The Authors. Published by Elsevier Inc. 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Annotation: Subtype: Link Rect: 352, 376, 374, 385 Annotation: Subtype: Link Rect: 376, 376, 392, 385 Annotation: Subtype: Link Rect: 320, 367, 579, 386 Annotation: Subtype: Link Rect: 321, 360, 344, 369 Annotation: Subtype: Link Rect: 320, 351, 579, 370 Annotation: Subtype: Link Rect: 321, 345, 343, 353 Annotation: Subtype: Link Rect: 344, 345, 372, 353 Annotation: Subtype: Link Rect: 373, 345, 399, 353 Annotation: Subtype: Link Rect: 401, 345, 424, 353 Annotation: Subtype: Link Rect: 320, 328, 579, 354 Annotation: Subtype: Link Rect: 321, 321, 344, 329 Annotation: Subtype: Link Rect: 346, 321, 377, 329 Annotation: Subtype: Link Rect: 378, 321, 413, 329 Annotation: Subtype: Link Rect: 415, 321, 456, 329 Annotation: Subtype: Link Rect: 458, 321, 489, 329 Annotation: Subtype: Link Rect: 491, 321, 518, 329 Annotation: Subtype: Link Rect: 520, 321, 536, 329 Annotation: Subtype: Link Rect: 320, 304, 579, 330 Annotation: Subtype: Link Rect: 321, 297, 366, 305 Annotation: Subtype: Link Rect: 367, 297, 416, 305 Annotation: Subtype: Link Rect: 418, 297, 456, 305 Annotation: Subtype: Link Rect: 457, 297, 497, 305 Annotation: Subtype: Link Rect: 498, 297, 528, 305 Annotation: Subtype: Link Rect: 529, 297, 557, 305 Annotation: Subtype: Link Rect: 321, 289, 338, 297 Annotation: Subtype: Link Rect: 320, 272, 579, 298 Annotation: Subtype: Link Rect: 321, 265, 365, 274 Annotation: Subtype: Link Rect: 368, 265, 402, 274 Annotation: Subtype: Link Rect: 405, 265, 431, 274 Annotation: Subtype: Link Rect: 433, 265, 474, 274 Annotation: Subtype: Link Rect: 476, 265, 512, 274 Annotation: Subtype: Link Rect: 514, 265, 557, 274 Annotation: Subtype: Link Rect: 321, 257, 338, 266 Annotation: Subtype: Link Rect: 320, 248, 579, 267 Annotation: Subtype: Link Rect: 321, 241, 352, 250 Annotation: Subtype: Link Rect: 353, 241, 396, 250 Annotation: Subtype: Link Rect: 398, 241, 418, 250 Annotation: Subtype: Link Rect: 419, 241, 447, 250 Annotation: Subtype: Link Rect: 449, 241, 486, 250 Annotation: Subtype: Link Rect: 487, 241, 523, 250 Annotation: Subtype: Link Rect: 525, 241, 541, 250 Annotation: Subtype: Link Rect: 320, 224, 579, 251 Annotation: Subtype: Link Rect: 321, 217, 363, 226 Annotation: Subtype: Link Rect: 365, 217, 398, 226 Annotation: Subtype: Link Rect: 400, 217, 423, 226 Annotation: Subtype: Link Rect: 425, 217, 455, 226 Annotation: Subtype: Link Rect: 458, 217, 487, 226 Annotation: Subtype: Link Rect: 490, 217, 520, 226 Annotation: Subtype: Link Rect: 523, 217, 539, 226 Annotation: Subtype: Link Rect: 320, 200, 579, 227 Annotation: Subtype: Link Rect: 321, 193, 356, 202 Annotation: Subtype: Link Rect: 358, 193, 396, 202 Annotation: Subtype: Link Rect: 397, 193, 435, 202 Annotation: Subtype: Link Rect: 436, 193, 476, 202 Annotation: Subtype: Link Rect: 478, 193, 513, 202 Annotation: Subtype: Link Rect: 320, 176, 579, 203 Annotation: Subtype: Link Rect: 321, 169, 359, 178 Annotation: Subtype: Link Rect: 361, 169, 394, 178 Annotation: Subtype: Link Rect: 395, 169, 422, 178 Annotation: Subtype: Link Rect: 424, 169, 446, 178 Annotation: Subtype: Link Rect: 447, 169, 481, 178 Annotation: Subtype: Link Rect: 482, 169, 513, 178 Annotation: Subtype: Link Rect: 514, 169, 530, 178 Annotation: Subtype: Link Rect: 320, 152, 579, 179 Annotation: Subtype: Link Rect: 321, 145, 364, 154 Annotation: Subtype: Link Rect: 366, 145, 409, 154 Annotation: Subtype: Link Rect: 410, 145, 449, 154 Annotation: Subtype: Link Rect: 451, 145, 488, 154 Annotation: Subtype: Link Rect: 490, 145, 527, 154 Annotation: Subtype: Link Rect: 529, 145, 557, 154 Annotation: Subtype: Link Rect: 321, 137, 338, 146 Annotation: Subtype: Link Rect: 320, 128, 579, 147 Annotation: Subtype: Link Rect: 321, 121, 342, 130 Annotation: Subtype: Link Rect: 344, 121, 387, 130 Annotation: Subtype: Link Rect: 389, 121, 414, 130 Annotation: Subtype: Link Rect: 416, 121, 446, 130 Annotation: Subtype: Link Rect: 448, 121, 481, 130 Annotation: Subtype: Link Rect: 483, 121, 517, 130 Annotation: Subtype: Link Rect: 519, 121, 536, 130 Annotation: Subtype: Link Rect: 320, 104, 579, 131 Annotation: Subtype: Link Rect: 321, 97, 338, 106 Annotation: Subtype: Link Rect: 339, 97, 369, 106 Annotation: Subtype: Link Rect: 371, 97, 411, 106 Annotation: Subtype: Link Rect: 412, 97, 450, 106 Annotation: Subtype: Link Rect: 451, 97, 480, 106 Annotation: Subtype: Link Rect: 481, 97, 507, 106 Annotation: Subtype: Link Rect: 508, 97, 524, 106 Annotation: Subtype: Link Rect: 320, 81, 579, 107 Annotation: Subtype: Link Rect: 321, 74, 357, 82 Annotation: Subtype: Link Rect: 359, 74, 381, 82 Annotation: Subtype: Link Rect: 382, 74, 414, 82 Annotation: Subtype: Link Rect: 416, 74, 449, 82 Annotation: Subtype: Link Rect: 450, 74, 477, 82 Annotation: Subtype: Link Rect: 478, 74, 515, 82 Annotation: Subtype: Link Rect: 517, 74, 533, 82 Annotation: Subtype: Link Rect: 320, 57, 579, 83 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 52, 727, 84, 736 Annotation: Subtype: Link Rect: 86, 727, 118, 736 Annotation: Subtype: Link Rect: 120, 727, 153, 736 Annotation: Subtype: Link Rect: 155, 727, 194, 736 Annotation: Subtype: Link Rect: 196, 727, 229, 736 Annotation: Subtype: Link Rect: 231, 727, 270, 736 Annotation: Subtype: Link Rect: 272, 727, 288, 736 Annotation: Subtype: Link Rect: 25, 710, 294, 737 Annotation: Subtype: Link Rect: 52, 703, 87, 712 Annotation: Subtype: Link Rect: 92, 703, 137, 712 Annotation: Subtype: Link Rect: 142, 703, 180, 712 Annotation: Subtype: Link Rect: 185, 703, 223, 712 Annotation: Subtype: Link Rect: 228, 703, 259, 712 Annotation: Subtype: Link Rect: 264, 703, 288, 712 Annotation: Subtype: Link Rect: 52, 695, 70, 704 Annotation: Subtype: Link Rect: 25, 678, 294, 705 Annotation: Subtype: Link Rect: 52, 671, 102, 680 Annotation: Subtype: Link Rect: 104, 671, 136, 680 Annotation: Subtype: Link Rect: 138, 671, 177, 680 Annotation: Subtype: Link Rect: 178, 671, 215, 680 Annotation: Subtype: Link Rect: 25, 662, 294, 681 Annotation: Subtype: Link Rect: 321, 727, 353, 736 Annotation: Subtype: Link Rect: 355, 727, 392, 736 Annotation: Subtype: Link Rect: 393, 727, 429, 736 Annotation: Subtype: Link Rect: 430, 727, 463, 736 Annotation: Subtype: Link Rect: 464, 727, 487, 736 Annotation: Subtype: Link Rect: 488, 727, 514, 736 Annotation: Subtype: Link Rect: 515, 727, 531, 736 Annotation: Subtype: Link Rect: 320, 702, 579, 737 Annotation: Subtype: Link Rect: 321, 695, 370, 704 Annotation: Subtype: Link Rect: 372, 695, 395, 704 Annotation: Subtype: Link Rect: 397, 695, 433, 704 Annotation: Subtype: Link Rect: 435, 695, 457, 704 Annotation: Subtype: Link Rect: 459, 695, 509, 704 Annotation: Subtype: Link Rect: 320, 678, 579, 705 Annotation: Subtype: Link Rect: 321, 671, 353, 680 Annotation: Subtype: Link Rect: 354, 671, 377, 680 Annotation: Subtype: Link Rect: 379, 671, 396, 680 Annotation: Subtype: Link Rect: 320, 662, 579, 681 Checksum: e13b627f Type: CRC32 Checksum: 2bd27bde1376de98541d2c3106adac3c Type: MD5 Checksum: 141a826bdc2b1284958a5bb6ae05df72f56a9148 Type: SHA-1