8e77545f22cd0265b1ce13939ef24f44 2020_Neurobiol_Disease_Modul_Caballero.pdf ce0cae677c922918ef3458498cf0c5cd9e7e8dd9 2020_Neurobiol_Disease_Modul_Caballero.pdf 06d87e81673e2b2c48dad41211b69f56afa5cce89286ebfb27029f703646adc6 2020_Neurobiol_Disease_Modul_Caballero.pdf Title: Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice Subject: Neurobiology of Disease, 137 (2020) 104793. doi:10.1016/j.nbd.2020.104793 Keywords: Neuregulin 1; ErbB receptors; Motoneuron; Motor function; Amyotrophic lateral sclerosis; Spinal cord; Neuromuscular junction; Author: Guillem Mòdol-Caballero Creator: Elsevier CreationDate: Thu Apr 16 11:40:17 2020 CEST ModDate: Thu Apr 16 11:40:17 2020 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2623399 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VLRCLY+CharisSIL CID Type 0C Identity-H yes yes yes 752 0 KBADCE+AdvOT596495f2 Type 1C WinAnsi yes yes no 727 0 KBADEF+AdvOT0de51fd2 Type 1C WinAnsi yes yes no 728 0 KBADFF+AdvOT8608a8d1+20 Type 1C Custom yes yes yes 733 0 KBADFG+AdvOT7fb33346.I Type 1C WinAnsi yes yes no 734 0 KBADFH+AdvOT596495f2+fb Type 1C Custom yes yes yes 741 0 KBADFI+AdvOT1efcda3b.B Type 1C WinAnsi yes yes no 747 0 OYFMRM+CharisSIL-Italic CID Type 0C Identity-H yes yes yes 351 0 KBADGJ+AdvOT596495f2+20 Type 1C Custom yes yes yes 346 0 KBADHJ+AdvOT596495f2+03 Type 1C Custom yes yes yes 341 0 KBADJK+AdvOT7fb33346.I+fb Type 1C Custom yes yes yes 359 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:47:12 CEST RepresentationInformation: 2020_Neurobiol_Disease_Modul_Caballero.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 11:43:44 CEST Size: 2623399 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul ID: PDF-HUL-128 InfoMessage: Outlines contain recursive references. MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 801 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Animals Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Virus production and administration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Electrophysiological tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Locomotion tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: RNA extraction and real time PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Western blot analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Measurement of muscle biomarkers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Histological analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Viral-delivery of NRG-I in skeletal muscles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: NRG1-I overexpression preserves neuromuscular function of the treated SOD1G93A mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: NRG1-I overexpression preserves spinal MNs and reduces neuroinflammation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: NRG1-I signaling through ErbB receptors produces motor functional improvement in the treated SOD1G93A mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: mk:H1_18 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Children: Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: mk:H1_18 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Info: Title: Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice Author: Guillem Mòdol-Caballero Subject: Neurobiology of Disease, 137 (2020) 104793. doi:10.1016/j.nbd.2020.104793 Keywords: Neuregulin 1; 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