1322c153c04b5e5869e75165f475e168  1_s2.0_S2352914820300265_main.pdf
9299c13bdbf3a7c70f4fa16b3da8d19fe07ab802  1_s2.0_S2352914820300265_main.pdf
d4438b7565d0c284f7c49b1dbcc19b3689923564542c097445257411a8c61722  1_s2.0_S2352914820300265_main.pdf

Title:          Mortality prediction enhancement in end-stage renal disease: A machine learning approach
Subject:        Informatics in Medicine Unlocked, 19 (2020) 100351. doi:10.1016/j.imu.2020.100351
Keywords:       Mortality prediction,End-stage renal disease,Machine learning,LSTM,Random forest
Author:         Edwar Macias
Creator:        Elsevier
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Tue Jun  9 10:10:54 2020 CEST
ModDate:        Tue Jun  9 14:00:33 2020 CEST
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          10
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      1672882 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
XJRZII+CharisSIL                     CID TrueType      Identity-H       yes yes yes    647  0
YJEXTS+STIX-Regular                  Type 1C           Custom           yes yes yes    652  0
VLUIDZ+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    657  0
ICQJGZ+CharisSIL-Bold                CID TrueType      Identity-H       yes yes yes    662  0
NNLAUQ+TeX_CM_Roman                  Type 1C           Builtin          yes yes yes    667  0
GBNAGF+Univers                       Type 1C           Builtin          yes yes yes    671  0
MPRAJN+CharisSIL                     CID TrueType      Identity-H       yes yes yes    638  0
AZMNXC+TeX_CM_Maths_Italic           Type 1C           Builtin          yes yes yes    263  0
CLBVQJ+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    256  0
AXMAMG+STIX-Italic                   Type 1C           Custom           yes yes yes    267  0
SXQVNQ+TeX_CM_Maths_Extension        Type 1C           Builtin          yes yes yes    272  0
DBVHPF+TeX_CM_Maths_Symbols          Type 1C           Builtin          yes yes yes    276  0
TFHXZX+ArialUnicodeMS                CID TrueType      Identity-H       yes yes yes     39  0
NWPTQT+STIX-Bold                     Type 1C           Custom           yes yes yes     44  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-04-19 02:32:35 CEST
 RepresentationInformation: 1_s2.0_S2352914820300265_main.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-04-17 01:40:43 CEST
  Size: 1672882
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 744
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Outlines: 
     Item: 
      Title: Mortality prediction enhancement in end-stage renal disease: A machine learning approach
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
      Children: 
       Item: 
        Title: 1 Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
       Item: 
        Title: 2 Materials and methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
        Children: 
         Item: 
          Title: 2.1 Data selection
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
          Children: 
           Item: 
            Title: 2.1.1 Diagnoses
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
           Item: 
            Title: 2.1.2 Laboratory
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
           Item: 
            Title: 2.1.3 HD variables
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
         Item: 
          Title: 2.2 Data pre-processing
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: 2.3 Learning models
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
          Children: 
           Item: 
            Title: 2.3.1 Feature selection-Random forest
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
           Item: 
            Title: 2.3.2 Predictive model-LSTM
            Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
       Item: 
        Title: 3 Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
        Children: 
         Item: 
          Title: 3.1 Feature selection-RF
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
         Item: 
          Title: 3.2 Predictive model-LSTM
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: 4 Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
       Item: 
        Title: 5 Conclusion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
       Item: 
        Title: Ethical statement
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
       Item: 
        Title: Author contribution
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
       Item: 
        Title: Declaration of competing interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
       Item: 
        Title: Acknowledgements
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
   Info: 
    Title: Mortality prediction enhancement in end-stage renal disease: A machine learning approach
    Author: Edwar Macias
    Subject: Informatics in Medicine Unlocked, 19 (2020) 100351. doi:10.1016/j.imu.2020.100351
    Keywords: Mortality prediction,End-stage renal disease,Machine learning,LSTM,Random forest
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Tue Jun 09 10:10:54 CEST 2020
    ModDate: Tue Jun 09 14:00:33 CEST 2020
   ID: 0x66047f12b37497e8a73edc15d55e3edd, 0x0fca6c144d2651a37a4701a29e66b776
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 236
      ImageHeight: 298
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 248
      ImageHeight: 271
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1458
      ImageHeight: 762
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1456
      ImageHeight: 684
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1599
      ImageHeight: 770
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1599
      ImageHeight: 773
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: VLUIDZ+CharisSIL-Italic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: ICQJGZ+CharisSIL-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: XJRZII+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: TFHXZX+ArialUnicodeMS
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: SXQVNQ+TeX_CM_Maths_Extension
      FontSubset: true
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: SXQVNQ+TeX_CM_Maths_Extension
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: DBVHPF+TeX_CM_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: DBVHPF+TeX_CM_Maths_Symbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: AZMNXC+TeX_CM_Maths_Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: AZMNXC+TeX_CM_Maths_Italic
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: NNLAUQ+TeX_CM_Roman
      FontSubset: true
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: NNLAUQ+TeX_CM_Roman
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: AXMAMG+STIX-Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 20
      FontDescriptor: 
       FontName: AXMAMG+STIX-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: YJEXTS+STIX-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 24
      FontDescriptor: 
       FontName: YJEXTS+STIX-Regular
       Flags: Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NWPTQT+STIX-Bold
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: NWPTQT+STIX-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -998, -552, 2000, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GBNAGF+Univers
      FontSubset: true
      FirstChar: 32
      LastChar: 251
      FontDescriptor: 
       FontName: GBNAGF+Univers
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: VLUIDZ+CharisSIL-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: VLUIDZ+CharisSIL-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -716, -533, 1627, 1318
       FontFile2: true
     Font: 
      BaseFont: ICQJGZ+CharisSIL-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ICQJGZ+CharisSIL-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -720, -533, 1759, 1320
       FontFile2: true
     Font: 
      BaseFont: XJRZII+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: XJRZII+CharisSIL
       Flags: Nonsymbolic
       FontBBox: -692, -533, 1623, 1319
       FontFile2: true
     Font: 
      BaseFont: TFHXZX+ArialUnicodeMS
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: TFHXZX+ArialUnicodeMS
       Flags: Nonsymbolic
       FontBBox: -1011, -279, 2260, 1074
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 5.1.2">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1016/j.imu.2020.100351</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier Ltd</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Informatics in Medicine Unlocked, 19 (2020) 100351. doi:10.1016/j.imu.2020.100351</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Mortality prediction</rdf:li>
               <rdf:li>End-stage renal disease</rdf:li>
               <rdf:li>Machine learning</rdf:li>
               <rdf:li>LSTM</rdf:li>
               <rdf:li>Random forest</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Mortality prediction enhancement in end-stage renal disease: A machine learning approach</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Edwar Macias</rdf:li>
               <rdf:li>Antoni Morell</rdf:li>
               <rdf:li>Javier Serrano</rdf:li>
               <rdf:li>Jose Lopez Vicario</rdf:li>
               <rdf:li>Jose Ibeas</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Informatics in Medicine Unlocked</prism:publicationName>
         <prism:copyright>© 2020 The Authors. Published by Elsevier Ltd.</prism:copyright>
         <prism:issn>2352-9148</prism:issn>
         <prism:volume>19</prism:volume>
         <prism:coverDisplayDate>1 January 2020</prism:coverDisplayDate>
         <prism:coverDate>2020-01-01</prism:coverDate>
         <prism:pageRange>100351</prism:pageRange>
         <prism:startingPage>100351</prism:startingPage>
         <prism:doi>10.1016/j.imu.2020.100351</prism:doi>
         <prism:url>https://doi.org/10.1016/j.imu.2020.100351</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.imu.2020.100351</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <d2UUdnMmPzgqLzdiGm9mMm8NNmgyNlwf_mPuGmPeKyMz_mMaMytaJo9ePodeNodaKmtaTma/>
         <pdfx:doi>10.1016/j.imu.2020.100351</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CreationDate--Text>9th June 2020</pdfx:CreationDate--Text>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2020-06-09T12:00:33</xmp:ModifyDate>
         <xmp:CreateDate>2020-06-09T08:10:54</xmp:CreateDate>
         <xmp:MetadataDate>2020-06-09T12:00:33</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>9th June 2020</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
         <pdf:Keywords>Mortality prediction,End-stage renal disease,Machine learning,LSTM,Random forest</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:b6ed5266-03cb-4855-90c0-636283357f42</xmpMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 105, 576, 111, 587
       Flags: Print
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 112, 579, 116, 584
       Flags: Print
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 112, 571, 190, 582
       Flags: Print
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 190, 571, 431, 582
       Flags: Print
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 431, 571, 435, 582
       Flags: Print
       Destination: 623
      Annotation: 
       Subtype: Link
       Rect: 231, 300, 236, 308
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 165, 269, 170, 277
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 172, 269, 177, 277
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 132, 237, 136, 245
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 210, 195, 214, 203
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 260, 195, 264, 203
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 77, 185, 81, 193
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 137, 185, 141, 193
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 496, 310, 513, 318
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 327, 279, 349, 287
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 389, 269, 411, 277
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 336, 258, 345, 266
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 338, 237, 347, 245
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 409, 237, 418, 245
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 447, 216, 456, 224
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 337, 195, 346, 203
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 309, 175, 318, 182
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 102, 114, 176, 121
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 216, 114, 289, 121
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 330, 114, 403, 121
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 446, 114, 512, 121
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 104, 105, 111
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 722, 369, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 269, 667, 402, 675
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 87, 179, 94
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 297, 749, 300, 757
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 213, 748, 381, 760
      Annotation: 
       Subtype: Link
       Rect: 499, 616, 528, 645
      Annotation: 
       Subtype: Link
       Rect: 39, 49, 131, 56
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 112, 321, 132, 329
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 507, 720, 533, 728
       Flags: Print
       Destination: 1
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 94, 465, 113, 473
       Flags: Print
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 506, 689, 515, 696
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 521, 525, 541, 533
       Flags: Print
       Destination: 16
      Annotation: 
       Subtype: Link
       Rect: 420, 483, 429, 491
       Flags: Print
       Destination: 187
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 87, 573, 107, 581
       Flags: Print
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 130, 241, 139, 249
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 435, 661, 444, 669
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 510, 620, 519, 627
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 306, 599, 327, 607
       Flags: Print
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 460, 557, 479, 565
       Flags: Print
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 438, 420, 457, 428
       Flags: Print
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 513, 248, 525, 256
       Flags: Print
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 530, 248, 557, 256
       Flags: Print
       Destination: 81
      Annotation: 
       Subtype: Link
       Rect: 431, 185, 442, 193
       Flags: Print
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 499, 185, 519, 193
       Flags: Print
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 381, 143, 403, 151
       Flags: Print
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 515, 81, 536, 89
       Flags: Print
       Destination: 89
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 267, 71, 288, 79
       Flags: Print
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 306, 113, 332, 121
       Flags: Print
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 318, 92, 342, 100
       Flags: Print
       Destination: 100
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 90, 143, 116, 151
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 491, 122, 517, 130
       Flags: Print
       Destination: 108
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 158, 87, 182, 95
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 348, 87, 374, 95
       Flags: Print
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 439, 87, 464, 95
       Flags: Print
       Destination: 100
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 37, 397, 58, 405
       Flags: Print
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 89, 334, 109, 342
       Flags: Print
       Destination: 89
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 322, 474, 555, 480
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 466, 538, 472
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 458, 551, 464
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 450, 515, 456
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 442, 554, 448
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 434, 543, 440
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 426, 453, 432
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 418, 555, 424
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 410, 547, 416
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 402, 555, 408
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 394, 421, 400
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 386, 555, 392
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 378, 529, 384
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 370, 555, 376
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 362, 555, 369
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 354, 532, 361
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 346, 555, 353
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 338, 376, 345
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 330, 525, 337
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 322, 537, 329
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 314, 552, 321
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 306, 549, 313
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 298, 551, 305
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 290, 546, 297
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 282, 543, 289
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 274, 555, 281
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 266, 491, 273
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 259, 552, 265
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 251, 531, 257
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 243, 555, 249
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 235, 555, 241
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 322, 227, 506, 233
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 219, 543, 225
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 211, 546, 217
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 203, 505, 209
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 195, 547, 201
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 187, 555, 193
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 179, 426, 185
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 171, 555, 177
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 163, 555, 169
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 155, 532, 161
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 147, 534, 153
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 139, 555, 145
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 131, 482, 137
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 123, 537, 129
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 115, 534, 121
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 107, 423, 113
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 99, 546, 105
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 91, 555, 98
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 83, 383, 90
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 75, 554, 82
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 67, 555, 74
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 59, 369, 66
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 52, 453, 59, 460
       Flags: Print
       Destination: 108
      Annotation: 
       Subtype: Link
       Rect: 67, 432, 74, 438
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 67, 358, 74, 365
       Flags: Print
       Destination: 187
      Annotation: 
       Subtype: Link
       Rect: 52, 285, 59, 292
       Flags: Print
       Destination: 187
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 732, 286, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 724, 286, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 716, 78, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 708, 245, 714
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 700, 286, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 692, 286, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 684, 114, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 676, 260, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 668, 286, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 660, 286, 666
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 652, 258, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 644, 279, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 636, 280, 643
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 628, 204, 635
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 620, 254, 627
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 612, 266, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 604, 286, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 596, 272, 603
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 588, 75, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 580, 286, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 572, 269, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 565, 267, 571
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 557, 163, 563
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 549, 263, 555
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 541, 274, 547
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 732, 555, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 724, 352, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 716, 531, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 708, 552, 714
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 700, 550, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 692, 505, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 684, 507, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 676, 549, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 668, 527, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 660, 450, 666
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 652, 553, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 644, 525, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 636, 517, 643
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 628, 536, 635
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 604, 544, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 596, 540, 603
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 588, 553, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 580, 555, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 572, 555, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 565, 543, 571
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 557, 555, 563
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 549, 377, 555
       Flags: Print
  Checksum: 50d1414d
   Type: CRC32
  Checksum: 1322c153c04b5e5869e75165f475e168
   Type: MD5
  Checksum: 9299c13bdbf3a7c70f4fa16b3da8d19fe07ab802
   Type: SHA-1