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Title:           Integrating nanoparticle quantification and statistical design of experiments for efficient HIV-1 virus-like particle production in High Five cells
Subject:         Appl Microbiol Biotechnol, doi:10.1007/s00253-019-10319-x
Keywords:        High Five cells,Virus-like particle,Response surface methodology,Multiple-criteria decision analysis,Nanoparticle
Author:          Eduard Puente-Massaguer
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     Item: 
      Title: Integrating...
      Destination: maintitle
      Children: 
       Item: 
        Title: Abstract
        Destination: Section11
       Item: 
        Title: Introduction
        Destination: Section12
       Item: 
        Title: Materials and methods
        Destination: Section13
        Children: 
         Item: 
          Title: Cell line and culture maintenance
          Destination: Section24
         Item: 
          Title: Baculovirus stock preparation and titration
          Destination: Section25
         Item: 
          Title: Cell growth and baculovirus infection conditions
          Destination: Section26
         Item: 
          Title: Flow cytometry
          Destination: Section27
         Item: 
          Title: Fluorescence confocal microscopy
          Destination: Section28
         Item: 
          Title: GageGFP quantification
          Destination: Section29
         Item: 
          Title: VLP quantification using nanoparticle tracking analysis
          Destination: Section210
         Item: 
          Title: Nanoparticle quantification using flow virometry
          Destination: Section211
         Item: 
          Title: Analytical ultracentrifugation
          Destination: Section212
         Item: 
          Title: Cryogenic transmission electron microscopy
          Destination: Section213
         Item: 
          Title: Multiple optimization of VLP production conditions
          Destination: Section214
         Item: 
          Title: Statistical analyses
          Destination: Section215
       Item: 
        Title: Results
        Destination: Section116
        Children: 
         Item: 
          Title: Definition of the experimental space boundaries
          Destination: Section217
         Item: 
          Title: Combining RSM and MCDA to define the optimal VLP production conditions
          Destination: Section218
         Item: 
          Title: Validating the quantity and quality global optima
          Destination: Section219
         Item: 
          Title: Comparison with other VLP production conditions
          Destination: Section220
       Item: 
        Title: Discussion
        Destination: Section121
       Item: 
        Title: References
        Destination: Section122
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    Keywords: High Five cells,Virus-like particle,Response surface methodology,Multiple-criteria decision analysis,Nanoparticle
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     Thumb: true
  Checksum: 53cc9e62
   Type: CRC32
  Checksum: 3bcef431abad0339b143e49781920bf6
   Type: MD5
  Checksum: bff427de4948afc2584a4ab50c7433af81c10a7f
   Type: SHA-1
  Checksum: 628474c422f1560e832fe0f75875704e8b0ef1353941488466fd52b408ec6c88
   Type: SHA-256