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Title:          Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab
Subject:        BMC Molecular and Cell Biology, 2019, doi:10.1186/s12860-019-0244-x
Keywords:       mAb,Protein structure,Folding,Disulfide bonds,Renaturalization,LC,HC,mAb assembly,Urea,Anti-HER2,Non-covalent,Slow dialysis,Glutathione,2-mercaptoethanol,Affinity chromatography,Trastuzumab,Immunoglobulin
Author:         Mercè Farràs
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        Title: Results
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      Title: Background
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        Title: Unfolding and folding a mAb without physical separation
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        Title: MAb denaturation and reduction
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        Title: MAb or chains refolding by slow dialysis
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        Title: Analytical methods
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          Title: SDS-PAGE gels
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          Title: SEC-HPLC
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          Title: ELISA assay
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      Title: Acknowledgements
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      Title: Authors’ contributions
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      Title: Availability of data and materials
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    Title: Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab
    Author: Mercè Farràs
    Subject: BMC Molecular and Cell Biology, 2019, doi:10.1186/s12860-019-0244-x
    Keywords: mAb,Protein structure,Folding,Disulfide bonds,Renaturalization,LC,HC,mAb assembly,Urea,Anti-HER2,Non-covalent,Slow dialysis,Glutathione,2-mercaptoethanol,Affinity chromatography,Trastuzumab,Immunoglobulin
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