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Title:           Clinical implications of intratumor heterogeneity: challenges and opportunities
Subject:         J Mol Med, doi:10.1007/s00109-020-01874-2
Keywords:        Intratumor heterogeneity,Liquid biopsy,Artificial intelligence,Antitumor therapeutics
Author:          Santiago Ramón y Cajal
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      Title: Clinical implications of intratumor heterogeneity: challenges and opportunities
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       Item: 
        Title: Abstract
        Destination: Section11
       Item: 
        Title: Background
        Destination: Section12
       Item: 
        Title: Phenotypic heterogeneity: the particular case of morphologic heterogeneity
        Destination: Section13
       Item: 
        Title: Molecular heterogeneity: a genomic substrate for both tumor biology and evolution
        Destination: Section14
        Children: 
         Item: 
          Title: Causes of molecular heterogeneity
          Destination: Section25
         Item: 
          Title: Understanding the role of genomic instability as an enabling characteristic of cancer
          Destination: Section26
       Item: 
        Title: Epigenetic heterogeneity
        Destination: Section17
        Children: 
         Item: 
          Title: Proteomic heterogeneity: going beyond the genome
          Destination: Section28
       Item: 
        Title: Biological interactions among distinct tumor clones and the microenvironment: the stroma may have a significant impact on phenotypic heterogeneity
        Destination: Section19
       Item: 
        Title: How to address tumor heterogeneity in a clinical setting
        Destination: Section110
       Item: 
        Title: How do we envision cancer research and treatment in the coming years?
        Destination: Section111
       Item: 
        Title: References
        Destination: Section112
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   Type: CRC32
  Checksum: 581f07ed55099700c037e06b1c2211f8
   Type: MD5
  Checksum: 0a555e89221947bc8e5147972e10e17a55c15ac3
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