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Title:           Control of glutamate release by complexes of adenosine and cannabinoid receptors
Subject:         BMC Biology, 2020, doi:10.1186/s12915-020-0739-0
Keywords:        Adenosine A2A receptor,Cannabinoid CB1 receptor,GPCR heteromers,Adenylyl cyclase,Glutamate transmission,Striatum
Author:          Attila Köfalvi
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       Item: 
        Title: Results
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       Item: 
        Title: Conclusions
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     Item: 
      Title: Background
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     Item: 
      Title: Results
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      Children: 
       Item: 
        Title: A2AR and CB1R in the A2AR-CB1R heteromer couple to their respective cognate Gs and Gi proteins in HEK-293T cells
        Destination: sectionSec3
       Item: 
        Title: The A2AR-CB1R heteromer has a different quaternary structure compared to the A2AR-D2R and the A1R-A2AR heterotetramers
        Destination: sectionSec4
       Item: 
        Title: The C-terminal domain of the partner receptor determines the homomeric interfaces in the A2AR-CB1R heterotetramer
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       Item: 
        Title: The A2AR-CB1R heterotetramer provides a frame for the canonical Gs-Gi antagonistic interaction at the AC level
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       Item: 
        Title: Presynaptic A2AR-CB1R heterotetramers mediate the cannabinoid-induced inhibition of striatal glutamate release
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     Item: 
      Title: Discussion
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     Item: 
      Title: Conclusions
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     Item: 
      Title: Methods
      Destination: sectionSec10
      Children: 
       Item: 
        Title: Expression vectors and fusion proteins
        Destination: sectionSec11
       Item: 
        Title: HIV TAT-fused TM peptides
        Destination: sectionSec12
       Item: 
        Title: Cell cultures and transient transfection
        Destination: sectionSec13
       Item: 
        Title: Bimolecular fluorescence complementation (BiFC)
        Destination: sectionSec14
       Item: 
        Title: Bioluminescence resonance energy transfer (BRET) with donor and acceptor complementation
        Destination: sectionSec15
       Item: 
        Title: Complemented donor-acceptor resonance energy transfer (CODA-RET)
        Destination: sectionSec16
       Item: 
        Title: cAMP accumulation
        Destination: sectionSec17
       Item: 
        Title: Computational model of the A2AR-CB1R heterotetramer
        Destination: sectionSec18
       Item: 
        Title: [14C]glutamate release assay from striatal glutamatergic terminals
        Destination: sectionSec19
     Item: 
      Title: Supplementary information
      Destination: sectionSec20
     Item: 
      Title: Acknowledgements
      Destination: section1
     Item: 
      Title: Authors’ contributions
      Destination: section2
     Item: 
      Title: Funding
      Destination: section3
     Item: 
      Title: Availability of data and materials
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     Item: 
      Title: Ethics approval
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     Item: 
      Title: Consent for publication
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     Item: 
      Title: Competing interests
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     Item: 
      Title: Author details
      Destination: section5
     Item: 
      Title: References
      Destination: sectionBib1
     Item: 
      Title: Publisher’s Note
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    Author: Attila Köfalvi
    Subject: BMC Biology, 2020, doi:10.1186/s12915-020-0739-0
    Keywords: Adenosine A2A receptor,Cannabinoid CB1 receptor,GPCR heteromers,Adenylyl cyclase,Glutamate transmission,Striatum
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