11c63a10a62421ef72e8bfd3e051cb4b pmc_32009910.pdf edf5696d7ef5967685efa9cde9170a9c09a87640 pmc_32009910.pdf 49c54af95df6a6577df4a1410bd64383ca9ddb8d6ff5c8d28eaba9c0fc2f7787 pmc_32009910.pdf Title: Novel Activity Detection Algorithm to Characterize Spontaneous Stepping During Multimodal Spinal Neuromodulation After Mid-Thoracic Spinal Cord Injury in Rats Subject: A mid-thoracic spinal cord injury (SCI) severely impairs activation of the lower limb sensorimotor spinal networks, leading to paralysis. Keywords: sub-threshold spinal cord stimulation, spinal cord injury, spontaneous cage activity, EMG, muscle coordination, strychnine, quipazine, evoked potentials Author: V. Reggie Edgerton and Parag Gad Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Thu Jan 2 10:05:22 2020 CET ModDate: Thu Jan 2 10:05:22 2020 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 7173808 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EQNUPA+MinionPro-Regular Type 1 Custom yes yes no 29 0 UAKFVQ+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 30 0 DEKRYD+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 31 0 YQLHNJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 36 0 JQRKCK+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 37 0 CIXIHH+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 38 0 CNJNZI+MTSYN Type 1 Builtin yes yes no 39 0 YCPNCQ+MinionPro-It Type 1 Custom yes yes no 130 0 ZGGDTM+MinionPro-Bold Type 1 Custom yes yes no 196 0 WSNAZU+MTGU Type 1 Builtin yes yes no 204 0 PAARCL+RBLMI Type 1 Builtin yes yes no 279 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:15:40 CEST RepresentationInformation: pmc_32009910.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:44:02 CEST Size: 7173808 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 808 FreeObjects: 10 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Novel Activity Detection Algorithm to Characterize Spontaneous Stepping During Multimodal Spinal Neuromodulation After Mid-Thoracic Spinal Cord Injury in Rats Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Animal Preparation and Care Item: Title: Head Connector and Intramuscular EMG Electrode Implantation Item: Title: Spinal Cord Transection and Electrode Implantation Procedures and Post-surgical Animal Care Item: Title: Training Procedures Item: Title: Stimulation and Testing Procedures Item: Title: Signal Processing Item: Title: Thresholding Item: Title: Activity Detection Item: Title: MEP Analysis Item: Title: Statistical Analyses Item: Title: Results Children: Item: Title: Task Recognition Validity Item: Title: Electropharmacological Treatments Modulate the Functional State of Spinal Circuitry Item: Title: Evoked Responses Correlate With Spontaneous Step-Like Activity Item: Title: Discussion Item: Title: Conclusion Item: Title: Data Availability Statement Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Supplementary Material Item: Title: References Info: Title: Novel Activity Detection Algorithm to Characterize Spontaneous Stepping During Multimodal Spinal Neuromodulation After Mid-Thoracic Spinal Cord Injury in Rats Author: V. Reggie Edgerton and Parag Gad Subject: A mid-thoracic spinal cord injury (SCI) severely impairs activation of the lower limb sensorimotor spinal networks, leading to paralysis. Keywords: sub-threshold spinal cord stimulation, spinal cord injury, spontaneous cage activity, EMG, muscle coordination, strychnine, quipazine, evoked potentials Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.15 CreationDate: Thu Jan 02 10:35:22 CET 2020 ModDate: Thu Jan 02 10:35:22 CET 2020 ID: 0x036f88797444622f85b28dc7bb3924a4, 0x036f88797444622f85b28dc7bb3924a4 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: YCPNCQ+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 169 FontDescriptor: FontName: YCPNCQ+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YQLHNJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: YQLHNJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -166, -218, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ZGGDTM+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: ZGGDTM+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JQRKCK+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 39 LastChar: 243 FontDescriptor: FontName: JQRKCK+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -165, -214, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CIXIHH+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: CIXIHH+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -165, -218, 1125, 947 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CNJNZI+MTSYN FontSubset: true FirstChar: 2 LastChar: 68 FontDescriptor: FontName: CNJNZI+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: PAARCL+RBLMI FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: PAARCL+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true Font: BaseFont: WSNAZU+MTGU FontSubset: true FirstChar: 109 LastChar: 115 FontDescriptor: FontName: WSNAZU+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: EQNUPA+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: EQNUPA+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: UAKFVQ+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 40 LastChar: 150 FontDescriptor: FontName: UAKFVQ+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -166, -218, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: DEKRYD+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: DEKRYD+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -166, -214, 1050, 967 FontFile: true EncodingDictionary: Differences: true XMP: sub-threshold spinal cord stimulation, spinal cord injury, spontaneous cage activity, EMG, muscle coordination, strychnine, quipazine, evoked potentials pdfTeX-1.40.15 1.5 application/pdf Novel Activity Detection Algorithm to Characterize Spontaneous Stepping During Multimodal Spinal Neuromodulation After Mid-Thoracic Spinal Cord Injury in Rats A mid-thoracic spinal cord injury (SCI) severely impairs activation of the lower limb sensorimotor spinal networks, leading to paralysis. V. 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