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Keywords: PVT1, lncRNA, siRNA, ceRNA, Myc, colorectal/gastric cancer Author: Águeda Martı́nez-Barriocanal Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Thu Jan 30 09:21:15 2020 CET ModDate: Thu Jan 30 10:08:36 2020 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 2958706 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HEQLIS+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes no 34 0 XTVSAB+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 39 0 DNHXFB+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 52 0 DIEPVB+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 54 0 VCBSWT+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 61 0 WIHLBA+MinionPro-Regular Type 1C Custom yes yes no 64 0 WLNQGP+MinionPro-Bold Type 1C Custom yes yes no 69 0 AICVTL+MinionPro-It Type 1C WinAnsi yes yes no 71 0 ISZPRW+RMTMI Type 1C Custom yes yes no 122 0 MYPIIP+MTSY Type 1C Custom yes yes yes 205 0 WBCJEU+MTGU Type 1C Custom yes yes no 272 0 MFULSX+HelveticaNeueLTStd-Md Type 1C WinAnsi yes yes no 323 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:14:39 CEST RepresentationInformation: pmc_32083000.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:44:12 CEST Size: 2958706 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 677 FreeObjects: 21 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: PVT1 Long Non-coding RNA in Gastrointestinal Cancer Destination: ariclecounter.1 Children: Item: Title: Introduction Destination: section*.2 Item: Title: PVT1 Expression in Normal and Tumor Tissue Destination: section*.3 Item: Title: PVT1 and MYC Destination: section*.4 Item: Title: Oncogenic PVT1 Functions in Colorectal and Gastric Cancer Destination: section*.5 Children: Item: Title: miRNA Production Destination: section*.6 Item: Title: ceRNA Destination: section*.7 Children: Item: Title: miR-152 Destination: section*.8 Item: Title: miR-186 Destination: section*.9 Item: Title: miR-455 Destination: section*.10 Item: Title: miR-128 Destination: section*.11 Item: Title: miR-214 Destination: section*.12 Item: Title: Protein Stabilization Destination: section*.13 Children: Item: Title: STAT3 Destination: section*.14 Item: Title: LIN28 Destination: section*.15 Item: Title: Epigenetic Regulation Destination: section*.16 Item: Title: PVT1 As A Prognostic Biomarker Destination: section*.17 Item: Title: PVT1 and Resistance to Therapeutic Agents Destination: section*.18 Item: Title: Conclusions and Future Perspectives Destination: section*.19 Item: Title: Author Contributions Destination: section*.20 Item: Title: Funding Destination: section*.21 Item: Title: References Destination: section*.22 Info: Title: PVT1 Long Non-coding RNA in Gastrointestinal Cancer Author: Águeda Martı́nez-Barriocanal Subject: Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. 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and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. Águeda Martı́nez-Barriocanal Diego Arango and Higinio Dopeso PVT1 Long Non-coding RNA in Gastrointestinal Cancer PVT1 lncRNA siRNA ceRNA Myc colorectal/gastric cancer PVT1, lncRNA, siRNA, ceRNA, Myc, colorectal/gastric cancer dvips + MiKTeX GPL Ghostscript 9.0 uuid:dc403f17-aee6-4973-a3d2-31c3f30a394a uuid:6a4bb6a8-ecb9-4d18-94a3-8d0320b181c2 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 719, 140, 755 Annotation: Subtype: Link Rect: 522, 736, 551, 744 Annotation: Subtype: Link Rect: 465, 728, 508, 736 Annotation: Subtype: Link Rect: 508, 728, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 457, 720, 551, 728 Annotation: Subtype: Link Rect: 521, 678, 551, 709 Annotation: Subtype: Link Rect: 43, 30, 109, 38 Annotation: Subtype: Link Rect: 112, 30, 172, 38 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Annotation: Subtype: Link Rect: 87, 405, 160, 414 Annotation: Subtype: Link Rect: 81, 267, 160, 275 Annotation: 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Annotation: Subtype: Link Rect: 153, 301, 169, 312 Destination: External Annotation: Subtype: Link Rect: 171, 301, 187, 312 Destination: External Annotation: Subtype: Link Rect: 194, 299, 229, 309 Destination: External Annotation: Subtype: Link Rect: 102, 278, 118, 290 Destination: External Annotation: Subtype: Link Rect: 120, 278, 136, 290 Destination: External Annotation: Subtype: Link Rect: 193, 193, 204, 204 Destination: External Annotation: Subtype: Link Rect: 210, 193, 222, 204 Destination: External Annotation: Subtype: Link Rect: 207, 156, 242, 166 Destination: External Annotation: Subtype: Link Rect: 227, 67, 238, 78 Destination: External Annotation: Subtype: Link Rect: 382, 370, 393, 381 Destination: External Annotation: Subtype: Link Rect: 397, 370, 413, 381 Destination: External Annotation: Subtype: Link Rect: 446, 345, 481, 355 Destination: External Annotation: Subtype: Link Rect: 530, 324, 546, 335 Destination: External Annotation: Subtype: Link Rect: 304, 313, 319, 324 Destination: External Annotation: Subtype: Link Rect: 416, 301, 427, 313 Destination: External Annotation: Subtype: Link Rect: 436, 299, 470, 309 Destination: External Annotation: Subtype: Link Rect: 397, 175, 412, 187 Destination: External Annotation: Subtype: Link Rect: 416, 175, 432, 187 Destination: External Annotation: Subtype: Link Rect: 403, 78, 418, 90 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 11 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 120, 697, 135, 708 Destination: External Annotation: Subtype: Link Rect: 141, 697, 157, 708 Destination: External Annotation: Subtype: Link Rect: 253, 651, 269, 662 Destination: External Annotation: Subtype: Link Rect: 272, 651, 287, 662 Destination: External Annotation: Subtype: Link Rect: 47, 637, 81, 648 Destination: External Annotation: Subtype: Link Rect: 205, 617, 221, 628 Destination: External Annotation: Subtype: Link Rect: 129, 536, 144, 548 Destination: External Annotation: Subtype: Link Rect: 147, 536, 162, 548 Destination: External Annotation: Subtype: Link Rect: 72, 358, 83, 369 Destination: External Annotation: Subtype: Link Rect: 90, 356, 125, 366 Destination: External Annotation: Subtype: Link Rect: 205, 324, 221, 335 Destination: External Annotation: Subtype: Link Rect: 223, 324, 239, 335 Destination: External Annotation: Subtype: Link Rect: 76, 261, 87, 273 Destination: External Annotation: Subtype: Link Rect: 105, 202, 139, 212 Destination: External Annotation: Subtype: Link Rect: 89, 67, 100, 78 Destination: External Annotation: Subtype: Link Rect: 498, 508, 513, 520 Destination: External Annotation: Subtype: Link Rect: 485, 474, 501, 485 Destination: External Annotation: Subtype: Link Rect: 505, 474, 520, 485 Destination: External Annotation: Subtype: Link Rect: 469, 439, 480, 451 Destination: External Annotation: Subtype: Link Rect: 469, 416, 480, 428 Destination: External Annotation: Subtype: Link Rect: 487, 414, 522, 425 Destination: External Annotation: Subtype: Link Rect: 396, 202, 430, 212 Destination: External Annotation: Subtype: Link Rect: 440, 204, 456, 216 Destination: External Annotation: Subtype: Link Rect: 391, 124, 402, 135 Destination: External Annotation: Subtype: Link Rect: 517, 113, 528, 124 Destination: External Annotation: Subtype: Link Rect: 465, 67, 476, 78 Destination: External Annotation: Subtype: Link Rect: 480, 67, 491, 78 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 47, 662, 58, 674 Destination: External Annotation: Subtype: Link Rect: 199, 628, 210, 640 Destination: External Annotation: Subtype: Link Rect: 215, 628, 231, 640 Destination: External Annotation: Subtype: Link Rect: 211, 605, 222, 617 Destination: External Annotation: Subtype: Link Rect: 225, 605, 236, 617 Destination: External Annotation: Subtype: Link Rect: 89, 594, 100, 605 Destination: External Annotation: Subtype: Link Rect: 234, 594, 245, 605 Destination: External Annotation: Subtype: Link Rect: 168, 559, 179, 571 Destination: External Annotation: Subtype: Link Rect: 126, 322, 137, 333 Destination: External Annotation: Subtype: Link Rect: 140, 322, 151, 333 Destination: External Annotation: Subtype: Link Rect: 107, 299, 123, 310 Destination: External Annotation: Subtype: Link Rect: 67, 253, 82, 264 Destination: External Annotation: Subtype: Link Rect: 85, 253, 101, 264 Destination: External Annotation: Subtype: Link Rect: 83, 173, 94, 184 Destination: External Annotation: Subtype: Link Rect: 99, 173, 115, 184 Destination: External Annotation: Subtype: Link Rect: 120, 173, 135, 184 Destination: External Annotation: Subtype: Link Rect: 212, 116, 227, 127 Destination: External Annotation: Subtype: Link Rect: 307, 708, 318, 720 Destination: External Annotation: Subtype: Link Rect: 322, 708, 338, 720 Destination: External Annotation: Subtype: Link Rect: 369, 685, 385, 697 Destination: External Annotation: Subtype: Link Rect: 403, 605, 414, 617 Destination: External Annotation: Subtype: Link Rect: 416, 605, 432, 617 Destination: External Annotation: Subtype: Link Rect: 434, 605, 450, 617 Destination: External Annotation: Subtype: Link Rect: 538, 559, 549, 571 Destination: External Annotation: Subtype: Link Rect: 304, 548, 319, 559 Destination: External Annotation: Subtype: Link Rect: 324, 548, 339, 559 Destination: External Annotation: Subtype: Link Rect: 423, 514, 439, 525 Destination: External Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 13 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 142, 531, 199, 541 Annotation: Subtype: Link Rect: 74, 495, 134, 502 Annotation: Subtype: Link Rect: 74, 456, 128, 465 Annotation: Subtype: Link Rect: 225, 438, 291, 446 Annotation: Subtype: Link Rect: 74, 408, 141, 418 Annotation: Subtype: Link Rect: 160, 390, 259, 399 Annotation: Subtype: Link Rect: 74, 363, 139, 370 Annotation: Subtype: Link Rect: 104, 333, 175, 342 Annotation: Subtype: Link Rect: 74, 304, 161, 313 Annotation: Subtype: Link Rect: 165, 277, 232, 285 Annotation: Subtype: Link Rect: 74, 248, 141, 257 Annotation: Subtype: Link Rect: 74, 211, 153, 219 Annotation: Subtype: Link Rect: 74, 173, 150, 181 Annotation: Subtype: Link Rect: 74, 135, 151, 143 Annotation: Subtype: Link Rect: 74, 96, 151, 105 Annotation: Subtype: Link Rect: 172, 79, 234, 86 Annotation: Subtype: Link Rect: 368, 550, 421, 559 Annotation: Subtype: Link Rect: 441, 533, 506, 540 Annotation: Subtype: Link Rect: 368, 512, 421, 521 Annotation: Subtype: Link Rect: 334, 484, 387, 493 Annotation: Subtype: Link Rect: 334, 456, 387, 465 Annotation: Subtype: Link Rect: 435, 437, 488, 446 Annotation: Subtype: Link Rect: 368, 410, 435, 418 Annotation: Subtype: Link Rect: 334, 382, 421, 389 Annotation: Subtype: Link Rect: 334, 352, 433, 361 Annotation: Subtype: Link Rect: 334, 314, 404, 323 Annotation: Subtype: Link Rect: 450, 285, 512, 295 Annotation: Subtype: Link Rect: 334, 247, 419, 256 Annotation: Subtype: Link Rect: 407, 238, 501, 247 Annotation: Subtype: Link Rect: 372, 221, 426, 228 Annotation: Subtype: Link Rect: 334, 192, 391, 200 Annotation: Subtype: Link Rect: 444, 172, 521, 181 Annotation: Subtype: Link Rect: 463, 153, 516, 162 Annotation: Subtype: Link Rect: 404, 134, 493, 143 Annotation: Subtype: Link Rect: 334, 105, 403, 114 Annotation: Subtype: Link Rect: 334, 77, 428, 86 Annotation: Subtype: Link Rect: 43, 28, 109, 37 Annotation: Subtype: Link Rect: 112, 28, 172, 36 Annotation: Subtype: Link Rect: 437, 28, 551, 37 Page: Label: 14 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 74, 688, 163, 697 Annotation: Subtype: Link Rect: 74, 661, 177, 668 Annotation: 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Annotation: Subtype: Link Rect: 222, 129, 291, 138 Annotation: Subtype: Link Rect: 61, 120, 85, 129 Annotation: Subtype: Link Rect: 74, 93, 139, 100 Annotation: Subtype: Link Rect: 334, 697, 417, 706 Annotation: Subtype: Link Rect: 368, 670, 453, 678 Annotation: Subtype: Link Rect: 334, 631, 417, 640 Annotation: Subtype: Link Rect: 444, 604, 505, 611 Annotation: Subtype: Link Rect: 552, 565, 320, 584 Annotation: Subtype: Link Rect: 379, 527, 471, 536 Annotation: Subtype: Link Rect: 552, 478, 320, 499 Annotation: Subtype: Link Rect: 334, 441, 399, 451 Annotation: Subtype: Link Rect: 334, 405, 409, 413 Annotation: Subtype: Link Rect: 334, 367, 419, 375 Annotation: Subtype: Link Rect: 410, 329, 487, 337 Annotation: Subtype: Link Rect: 404, 263, 489, 271 Annotation: Subtype: Link Rect: 372, 197, 443, 204 Annotation: Subtype: Link Rect: 334, 148, 390, 157 Annotation: Subtype: Link Rect: 334, 112, 436, 119 Annotation: Subtype: Link Rect: 334, 72, 424, 82 Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 15 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 169, 689, 253, 696 Annotation: Subtype: Link Rect: 153, 651, 238, 659 Annotation: Subtype: Link Rect: 133, 613, 230, 621 Annotation: Subtype: Link Rect: 74, 574, 157, 583 Annotation: Subtype: Link Rect: 129, 547, 186, 554 Annotation: Subtype: Link Rect: 191, 528, 257, 536 Annotation: Subtype: Link Rect: 74, 498, 161, 508 Annotation: Subtype: Link Rect: 169, 481, 272, 488 Annotation: Subtype: Link Rect: 74, 452, 159, 460 Annotation: Subtype: Link Rect: 74, 413, 166, 422 Annotation: Subtype: Link Rect: 74, 386, 126, 394 Annotation: Subtype: Link Rect: 74, 356, 163, 366 Annotation: Subtype: Link Rect: 169, 328, 236, 337 Annotation: Subtype: Link Rect: 148, 299, 227, 309 Annotation: Subtype: Link Rect: 195, 271, 274, 280 Annotation: Subtype: Link Rect: 97, 254, 150, 261 Annotation: Subtype: Link Rect: 186, 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Link Rect: 466, 281, 544, 290 Annotation: Subtype: Link Rect: 485, 263, 540, 271 Annotation: Subtype: Link Rect: 403, 235, 470, 242 Annotation: Subtype: Link Rect: 354, 205, 418, 214 Annotation: Subtype: Link Rect: 334, 176, 420, 185 Annotation: Subtype: Link Rect: 412, 150, 497, 157 Annotation: Subtype: Link Rect: 365, 121, 448, 129 Annotation: Subtype: Link Rect: 429, 82, 509, 91 Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 16 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 74, 689, 159, 696 Annotation: Subtype: Link Rect: 170, 650, 227, 659 Annotation: Subtype: Link Rect: 133, 621, 216, 630 Annotation: Subtype: Link Rect: 74, 594, 145, 602 Annotation: Subtype: Link Rect: 74, 564, 163, 574 Annotation: Subtype: Link Rect: 104, 536, 188, 545 Annotation: Subtype: Link Rect: 108, 498, 188, 508 Annotation: Subtype: Link Rect: 85, 460, 169, 469 Annotation: Subtype: 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Subtype: Link Rect: 400, 460, 480, 469 Annotation: Subtype: Link Rect: 368, 434, 431, 441 Annotation: Subtype: Link Rect: 475, 423, 551, 432 Annotation: Subtype: Link Rect: 321, 413, 358, 422 Annotation: Subtype: Link Rect: 426, 386, 511, 394 Annotation: Subtype: Link Rect: 334, 358, 386, 365 Annotation: Subtype: Link Rect: 334, 329, 419, 337 Annotation: Subtype: Link Rect: 334, 299, 412, 308 Annotation: Subtype: Link Rect: 469, 281, 540, 289 Annotation: Subtype: Link Rect: 372, 254, 447, 261 Annotation: Subtype: Link Rect: 393, 216, 459, 224 Annotation: Subtype: Link Rect: 350, 187, 425, 195 Annotation: Subtype: Link Rect: 422, 121, 448, 128 Annotation: Subtype: Link Rect: 448, 121, 480, 128 Annotation: Subtype: Link Rect: 479, 121, 515, 128 Annotation: Subtype: Link Rect: 514, 121, 537, 128 Annotation: Subtype: Link Rect: 552, 109, 303, 129 Annotation: Subtype: Link Rect: 43, 29, 109, 38 Annotation: Subtype: Link Rect: 112, 29, 172, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Checksum: 0def82e1 Type: CRC32 Checksum: 0166fad89e4446282ee7663a10485844 Type: MD5 Checksum: f5bb5d38d45a62f9d281a73798e2e688a1775d3c Type: SHA-1 Checksum: 46d755aef8a2f648b3a4d315dd579d94af0ec4002c4c755c026266b7ad4777a1 Type: SHA-256