36f4d41260706d630552b254508206b8 pmc_32098204.pdf 652ba719dc0e79f03f0daf429f9205fff4a3dbf5 pmc_32098204.pdf d3efb49a6bc08825c5c4dd33ea5d20fbc1b4480b2437130f4acfe3427632c2a5 pmc_32098204.pdf Producer: iText® 7.1.1 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Mon Mar 2 04:37:26 2020 CET ModDate: Mon Mar 2 04:37:26 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2816702 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AIQCCL+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 VVBZKI+Pxsy Type 1 Builtin yes yes no 15 0 PDHKLZ+VnURWPalladioL Type 1 Custom yes yes no 19 0 ELSFBG+URWPalladioL-Ital Type 1 Custom yes yes no 23 0 HMRNFL+URWPalladioL-Bold Type 1 Custom yes yes no 28 0 ZPATJZ+URWPalladioL-Roma Type 1 Custom yes yes no 32 0 SYXPPI+Rpxr Type 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yes no 284 0 BCDFEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 288 0 BCDGEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 292 0 TimesNewRomanPSMT TrueType WinAnsi no no no 296 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-18 06:57:08 CET RepresentationInformation: pmc_32098204.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-06 03:58:08 CEST Size: 2816702 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 499 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Cell Lines and Culture Conditions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Phase Contrast Microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Cell Transfection with siRNA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Children: Item: Title: Gene Expression Determination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Cell Growth Assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Sphere Formation Assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: RNA Extraction and Real-Time Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Protein Extraction and Western Blotting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Production of Polymeric Micelles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Physicochemical Characterization of the Polymeric Micelles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Children: Item: Title: Zeta Potential Measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Transmission Electron Microscopy (TEM) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Loading/Association Efficiency Determination Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Fourier-Transform Infrared Spectroscopy (FTIR) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Micelles Internalization: Flow Cytometry and Confocal Microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Flow Cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Confocal Microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Cell Cycle Assay by Flow Cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Tumor Cell Viability Assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Children: Item: Title: Viability Assay in Adherent Cell Cultures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Tumorsphere Viability Assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: SMC2 Silencing Causes Strong Reduction of Tumorsphere Formation in Cancer Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Physicochemical Characterization of Polymeric Micelles with Conjugated or Encapsulated SMC2 Antibodies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: In Vitro Efficacy of PM-SMC2 and PM-CON:SMC2 in Adherent Cultures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: PM-CON:SMC2 Micelles Show Faster Cellular Uptake than Control PM Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: G1/S Cell Cycle Arrest Induced by PM-CON:SMC2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Strong Anti-CSC Efficacy of PM-CON:SMC2 in Comparison with Free Ab-SMC2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: PM-CON:SMC2/5-FU and PM-CON:SMC2/PTX Combined Effect Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Conclusions 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