660d647f904d6d75aecb9d0cab2f2d21 pmc_32110891.pdf d5a44abcf85f95bf5ed2a90dcb85579979f979bb pmc_32110891.pdf db4d92c8570f921f3e8c0d3b48ab15aa1029ac9047e60dcaea57004e42b36c44 pmc_32110891.pdf Producer: iText® 7.1.1 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Fri Mar 20 13:10:10 2020 CET ModDate: Fri Mar 20 13:10:10 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1602694 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FKMORM+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 FRQEWY+VnURWPalladioL Type 1 Custom yes yes no 15 0 YUHVJB+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 PJHYAL+URWPalladioL-Bold Type 1 Custom yes yes no 24 0 PHWIMB+URWPalladioL-BoldItal Type 1 Custom yes yes no 28 0 BOGOBV+Rpxbi Type 1 Builtin yes yes no 32 0 LFBKTP+URWPalladioL-Roma Type 1 Custom yes yes no 36 0 OFLXAT+Rpxr Type 1 Builtin yes yes no 40 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 51 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 73 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 77 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 81 0 VVBZKI+Pxsy Type 1 Builtin yes yes no 88 0 YICMPF+Rpcxr Type 1 Builtin yes yes no 98 0 MPUDFL+PazoMath Type 1 Builtin yes yes no 105 0 QPZFHW+EURM10 Type 1 Builtin yes yes no 109 0 XGEDLN+Rpxb Type 1 Builtin yes yes no 122 0 LLQRUW+Pxbsy Type 1 Builtin yes yes no 132 0 MPDEBP+PalatinoLinotype CID TrueType Identity-H yes yes yes 152 0 MPDECP+PalatinoLinotype TrueType WinAnsi yes yes no 158 0 MPDEJP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 161 0 MPDELA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 164 0 MPDECP+PalatinoLinotype TrueType WinAnsi yes yes no 185 0 MPDEJP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 188 0 MPDELA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 191 0 MPDFHP+TimesNewRoman CID TrueType Identity-H yes yes yes 194 0 GBLQZB+Rpxi Type 1 Builtin yes yes no 204 0 MPDECP+PalatinoLinotype TrueType WinAnsi yes yes no 215 0 MPDEJP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 218 0 MPDELA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 221 0 MPDFHP+TimesNewRoman CID TrueType Identity-H yes yes yes 224 0 MPDECP+PalatinoLinotype TrueType WinAnsi yes yes no 241 0 MPDEJP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 244 0 MPDELA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 247 0 MPDFHP+TimesNewRoman CID TrueType Identity-H yes yes yes 250 0 MPDECP+PalatinoLinotype TrueType WinAnsi yes yes no 268 0 MPDEJP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 271 0 MPDELA+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 274 0 MPDFHP+TimesNewRoman CID TrueType Identity-H yes yes yes 277 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-18 06:56:21 CET RepresentationInformation: pmc_32110891.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-06 03:57:34 CEST Size: 1602694 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 528 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: MS Patients and Healthy Donors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Targeted DNA Resequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Selection of Candidate SNPs for Validation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: SNPs Genotyping Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Luciferase Reporter Assays Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Determination of Gene Expression Levels in PBMC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Flow Cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Standard Protocol Approvals, Registrations, and Patient Consents Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Children: Item: Title: Targeted Resequencing of MS Risk Genes in the Discovery Cohort Unmasks 32 SNPs Associated with MS Susceptibility Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Validation of Selected SNPs in an Independent Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Conditional Logistic Regression Analysis Reveals rs10892307 in the CXCR5 Locus as a New Independent Signal Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Tag-SNP Search of rs10892307 and Analysis within the Region Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Luciferase Reporter Assays Point to rs11602393 as the Casual Variant Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: rs10892307 Alleles Are Not Associated with Differences in CXCR5 mRNA Expression Levels in PBMC from MS Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: The Percentage of CXCR5 Positive Regulatory T Cells Is Increased in MS Patients Carrying the Minor Allele for rs10892307 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Info: Producer: iText® 7.1.1 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Fri Mar 20 13:10:10 CET 2020 ModDate: Fri Mar 20 13:10:10 CET 2020 ID: 0x0a852524b62f288d676f016d7804e409, 0x0a852524b62f288d676f016d7804e409 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: BOGOBV+Rpxbi FontSubset: true FirstChar: 43 LastChar: 43 FontDescriptor: FontName: BOGOBV+Rpxbi Flags: Symbolic FontBBox: -130, -281, 1004, 729 FontFile: true Font: BaseFont: YICMPF+Rpcxr FontSubset: true FirstChar: 151 LastChar: 174 FontDescriptor: FontName: YICMPF+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: LFBKTP+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 246 FontDescriptor: FontName: LFBKTP+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LLQRUW+Pxbsy FontSubset: true FirstChar: 0 LastChar: 121 FontDescriptor: FontName: LLQRUW+Pxbsy Flags: Symbolic FontBBox: 5, -978, 1382, 913 FontFile: true Font: BaseFont: OFLXAT+Rpxr FontSubset: true FirstChar: 11 LastChar: 62 FontDescriptor: FontName: OFLXAT+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: MPUDFL+PazoMath FontSubset: true FirstChar: 68 LastChar: 68 FontDescriptor: FontName: MPUDFL+PazoMath Flags: Symbolic FontBBox: -40, -283, 878, 946 FontFile: true Font: BaseFont: FKMORM+VnURWPalladioL-Bold FontSubset: true FirstChar: 160 LastChar: 226 FontDescriptor: FontName: FKMORM+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: GBLQZB+Rpxi FontSubset: true FirstChar: 11 LastChar: 11 FontDescriptor: FontName: GBLQZB+Rpxi Flags: Symbolic FontBBox: -162, -280, 856, 733 FontFile: true Font: BaseFont: QPZFHW+EURM10 FontSubset: true FirstChar: 12 LastChar: 22 FontDescriptor: FontName: QPZFHW+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: FRQEWY+VnURWPalladioL FontSubset: true FirstChar: 146 LastChar: 243 FontDescriptor: FontName: FRQEWY+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YUHVJB+URWPalladioL-Ital FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: YUHVJB+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PJHYAL+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 241 FontDescriptor: FontName: PJHYAL+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VVBZKI+Pxsy FontSubset: true FirstChar: 0 LastChar: 121 FontDescriptor: FontName: VVBZKI+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Font: BaseFont: XGEDLN+Rpxb FontSubset: true FirstChar: 14 LastChar: 47 FontDescriptor: FontName: XGEDLN+Rpxb Flags: Symbolic FontBBox: -57, -266, 932, 729 FontFile: true Font: BaseFont: PHWIMB+URWPalladioL-BoldItal FontSubset: true FirstChar: 49 LastChar: 117 FontDescriptor: FontName: PHWIMB+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 217, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 185, 614, 196, 628 Annotation: Subtype: Link Rect: 277, 614, 288, 628 Annotation: Subtype: Link Rect: 348, 601, 359, 614 Annotation: Subtype: Link Rect: 364, 588, 375, 601 Annotation: Subtype: Link Rect: 177, 38, 247, 50 Annotation: Subtype: Link Rect: 418, 38, 519, 50 Annotation: Subtype: Link Rect: 466, 86, 518, 105 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 212, 403, 219, 413 ActionDest: 290 Annotation: Subtype: Link Rect: 317, 390, 323, 399 ActionDest: 290 Annotation: Subtype: Link Rect: 215, 349, 222, 359 ActionDest: 290 Annotation: Subtype: Link Rect: 462, 322, 469, 331 ActionDest: 290 Annotation: Subtype: Link Rect: 229, 295, 236, 304 ActionDest: 293 Annotation: Subtype: Link Rect: 192, 228, 199, 237 ActionDest: 293 Annotation: Subtype: Link Rect: 423, 201, 430, 210 ActionDest: 290 Annotation: Subtype: Link Rect: 318, 106, 325, 115 ActionDest: 293 Annotation: Subtype: Link Rect: 123, 79, 130, 88 ActionDest: 293 Annotation: Subtype: Link Rect: 409, 79, 416, 88 ActionDest: 293 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 210, 743, 217, 752 ActionDest: 293 Annotation: Subtype: Link Rect: 113, 499, 120, 508 ActionDest: 290 Annotation: Subtype: Link Rect: 121, 499, 132, 508 ActionDest: 293 Annotation: Subtype: Link Rect: 133, 499, 145, 508 ActionDest: 293 Annotation: Subtype: Link Rect: 199, 431, 211, 440 ActionDest: 293 Annotation: Subtype: Link Rect: 300, 418, 312, 427 ActionDest: 293 Annotation: Subtype: Link Rect: 374, 377, 386, 386 ActionDest: 293 Annotation: Subtype: Link Rect: 229, 364, 241, 373 ActionDest: 293 Annotation: Subtype: Link Rect: 167, 350, 179, 359 ActionDest: 293 Annotation: Subtype: Link Rect: 438, 350, 450, 359 ActionDest: 293 Annotation: Subtype: Link Rect: 421, 323, 433, 332 ActionDest: 293 Annotation: Subtype: Link Rect: 88, 296, 100, 305 ActionDest: 293 Annotation: Subtype: Link Rect: 399, 296, 411, 305 ActionDest: 293 Annotation: Subtype: Link Rect: 202, 283, 214, 292 ActionDest: 293 Annotation: Subtype: Link Rect: 199, 269, 211, 278 ActionDest: 293 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 392, 524, 399, 533 ActionDest: 290 Annotation: Subtype: Link Rect: 186, 456, 193, 466 ActionDest: 290 Annotation: Subtype: Link Rect: 245, 171, 257, 180 ActionDest: 296 Annotation: Subtype: Link Rect: 271, 157, 282, 166 ActionDest: 296 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 251, 194, 263, 203 ActionDest: 296 Page: Sequence: 6 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 369, 740, 376, 752 ActionDest: 119 Annotation: Subtype: Link Rect: 128, 702, 135, 711 ActionDest: 290 Annotation: Subtype: Link Rect: 136, 702, 148, 711 ActionDest: 293 Annotation: Subtype: Link Rect: 182, 699, 189, 711 ActionDest: 119 Annotation: Subtype: Link Rect: 170, 567, 177, 576 ActionDest: 126 Annotation: Subtype: Link Rect: 313, 508, 320, 520 ActionDest: 129 Annotation: Subtype: Link Rect: 369, 429, 381, 439 ActionDest: 293 Annotation: Subtype: Link Rect: 282, 305, 289, 317 ActionDest: 136 Annotation: Subtype: Link Rect: 419, 281, 426, 290 ActionDest: 290 Annotation: Subtype: Link Rect: 463, 254, 470, 263 ActionDest: 290 Annotation: Subtype: Link Rect: 489, 197, 496, 209 ActionDest: 136 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 605, 442, 616, 450 ActionDest: 293 Annotation: Subtype: Link Rect: 600, 433, 610, 440 ActionDest: 293 Annotation: Subtype: Link Rect: 604, 424, 614, 431 ActionDest: 293 Annotation: Subtype: Link Rect: 604, 414, 614, 422 ActionDest: 293 Annotation: Subtype: Link Rect: 603, 358, 609, 365 ActionDest: 290 Annotation: Subtype: Link Rect: 599, 348, 605, 356 ActionDest: 290 Annotation: Subtype: Link Rect: 606, 335, 617, 343 ActionDest: 296 Annotation: Subtype: Link Rect: 606, 326, 617, 333 ActionDest: 296 Annotation: Subtype: Link Rect: 602, 316, 612, 324 ActionDest: 296 Annotation: Subtype: Link Rect: 606, 307, 617, 314 ActionDest: 296 Annotation: Subtype: Link Rect: 606, 297, 617, 305 ActionDest: 296 Annotation: Subtype: Link Rect: 606, 288, 617, 296 ActionDest: 296 Annotation: Subtype: Link Rect: 606, 279, 617, 286 ActionDest: 296 Annotation: Subtype: Link Rect: 603, 265, 609, 273 ActionDest: 290 Annotation: Subtype: Link Rect: 607, 252, 614, 259 ActionDest: 290 Annotation: Subtype: Link Rect: 195, 242, 205, 250 ActionDest: 293 Annotation: Subtype: Link Rect: 617, 242, 627, 250 ActionDest: 293 Annotation: Subtype: Link Rect: 605, 233, 612, 240 ActionDest: 290 Annotation: Subtype: Link Rect: 610, 224, 617, 231 ActionDest: 290 Annotation: Subtype: Link Rect: 604, 210, 610, 218 ActionDest: 290 Annotation: Subtype: Link Rect: 610, 201, 617, 208 ActionDest: 290 Annotation: Subtype: Link Rect: 608, 187, 619, 195 ActionDest: 293 Annotation: Subtype: Link Rect: 195, 178, 205, 185 ActionDest: 293 Annotation: Subtype: Link Rect: 617, 178, 627, 185 ActionDest: 293 Annotation: Subtype: Link Rect: 605, 168, 611, 176 ActionDest: 290 Annotation: Subtype: Link Rect: 603, 159, 609, 167 ActionDest: 290 Annotation: Subtype: Link Rect: 603, 146, 609, 153 ActionDest: 290 Annotation: Subtype: Link Rect: 601, 136, 607, 144 ActionDest: 290 Annotation: Subtype: Link Rect: 197, 127, 203, 134 ActionDest: 290 Annotation: Subtype: Link Rect: 618, 127, 625, 134 ActionDest: 290 Annotation: Subtype: Link Rect: 599, 117, 605, 125 ActionDest: 290 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 735, 264, 741, 271 ActionDest: 290 Annotation: Subtype: Link Rect: 357, 254, 363, 262 ActionDest: 290 Annotation: Subtype: Link Rect: 414, 245, 420, 252 ActionDest: 290 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 263, 211, 269, 219 ActionDest: 290 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 452, 283, 458, 291 ActionDest: 290 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 189, 639, 196, 651 ActionDest: 140 Annotation: Subtype: Link Rect: 301, 148, 402, 160 Annotation: Subtype: Link Rect: 318, 112, 325, 124 ActionDest: 140 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 331, 729, 343, 738 ActionDest: 296 Annotation: Subtype: Link Rect: 391, 726, 495, 738 Annotation: Subtype: Link Rect: 280, 589, 287, 601 ActionDest: 173 Annotation: Subtype: Link Rect: 169, 548, 175, 560 ActionDest: 173 Annotation: Subtype: Link Rect: 285, 548, 292, 560 ActionDest: 173 Annotation: Subtype: Link Rect: 443, 494, 450, 506 ActionDest: 173 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 245, 668, 252, 680 ActionDest: 201 Annotation: Subtype: Link Rect: 371, 272, 378, 284 ActionDest: 231 Annotation: Subtype: Link Rect: 256, 191, 262, 203 ActionDest: 258 Page: Sequence: 15 Page: Sequence: 16 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 224, 682, 236, 692 ActionDest: 293 Annotation: Subtype: Link Rect: 220, 655, 232, 665 ActionDest: 296 Annotation: Subtype: Link Rect: 330, 628, 337, 638 ActionDest: 290 Annotation: Subtype: Link Rect: 338, 628, 350, 638 ActionDest: 293 Annotation: Subtype: Link Rect: 307, 493, 319, 502 ActionDest: 296 Annotation: Subtype: Link Rect: 123, 453, 135, 462 ActionDest: 296 Annotation: Subtype: Link Rect: 442, 399, 453, 408 ActionDest: 296 Annotation: Subtype: Link Rect: 153, 372, 165, 381 ActionDest: 296 Annotation: Subtype: Link Rect: 398, 304, 409, 313 ActionDest: 296 Annotation: Subtype: Link Rect: 293, 291, 305, 300 ActionDest: 296 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 221, 729, 233, 738 ActionDest: 293 Annotation: Subtype: Link Rect: 395, 702, 407, 711 ActionDest: 296 Annotation: Subtype: Link Rect: 353, 661, 365, 671 ActionDest: 296 Annotation: Subtype: Link Rect: 398, 634, 410, 644 ActionDest: 296 Annotation: Subtype: Link Rect: 424, 580, 436, 590 ActionDest: 296 Annotation: Subtype: Link Rect: 245, 405, 257, 414 ActionDest: 296 Annotation: Subtype: Link Rect: 240, 364, 252, 373 ActionDest: 296 Annotation: Subtype: Link Rect: 368, 351, 380, 360 ActionDest: 296 Annotation: Subtype: Link Rect: 240, 310, 252, 319 ActionDest: 296 Annotation: Subtype: Link Rect: 175, 297, 187, 306 ActionDest: 296 Annotation: Subtype: Link Rect: 249, 283, 261, 292 ActionDest: 296 Annotation: Subtype: Link Rect: 194, 188, 206, 198 ActionDest: 296 Annotation: Subtype: Link Rect: 503, 135, 515, 144 ActionDest: 300 Annotation: Subtype: Link Rect: 108, 94, 120, 103 ActionDest: 300 Page: Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 130, 742, 142, 752 ActionDest: 296 Annotation: Subtype: Link Rect: 341, 583, 518, 594 Annotation: Subtype: Link Rect: 320, 181, 358, 192 Annotation: Subtype: Link Rect: 364, 181, 400, 192 Annotation: Subtype: Link Rect: 360, 156, 397, 166 Annotation: Subtype: Link Rect: 403, 156, 439, 166 Annotation: Subtype: Link Rect: 390, 129, 428, 140 Annotation: Subtype: Link Rect: 479, 90, 516, 101 Page: Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 300, 727, 337, 738 Annotation: Subtype: Link Rect: 343, 727, 379, 738 Annotation: Subtype: Link Rect: 177, 689, 214, 699 Annotation: Subtype: Link Rect: 220, 689, 256, 699 Annotation: Subtype: Link Rect: 271, 663, 309, 673 Annotation: Subtype: Link Rect: 193, 638, 230, 648 Annotation: Subtype: Link Rect: 100, 599, 137, 609 Annotation: Subtype: Link Rect: 279, 559, 317, 570 Annotation: Subtype: Link Rect: 350, 521, 387, 531 Annotation: Subtype: Link Rect: 219, 483, 257, 493 Annotation: Subtype: Link Rect: 213, 444, 250, 454 Annotation: Subtype: Link Rect: 257, 444, 293, 454 Annotation: Subtype: Link Rect: 145, 405, 183, 415 Annotation: Subtype: Link Rect: 189, 405, 225, 415 Annotation: Subtype: Link Rect: 100, 366, 137, 376 Annotation: Subtype: Link Rect: 143, 366, 179, 376 Annotation: Subtype: Link Rect: 100, 315, 137, 325 Annotation: Subtype: Link Rect: 381, 275, 419, 286 Annotation: Subtype: Link Rect: 425, 275, 461, 286 Annotation: Subtype: Link Rect: 402, 236, 439, 247 Annotation: Subtype: Link Rect: 446, 236, 482, 247 Annotation: Subtype: Link Rect: 478, 212, 516, 222 Annotation: Subtype: Link Rect: 100, 199, 136, 209 Annotation: Subtype: Link Rect: 100, 173, 137, 183 Annotation: Subtype: Link Rect: 232, 134, 269, 144 Annotation: Subtype: Link Rect: 276, 134, 312, 144 Annotation: Subtype: Link Rect: 198, 82, 235, 92 Annotation: Subtype: Link Rect: 241, 82, 277, 92 Page: Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 223, 728, 260, 738 Annotation: Subtype: Link Rect: 227, 701, 265, 712 Annotation: Subtype: Link Rect: 312, 676, 349, 686 Annotation: Subtype: Link Rect: 355, 676, 391, 686 Annotation: Subtype: Link Rect: 402, 637, 440, 648 Annotation: Subtype: Link Rect: 231, 599, 268, 609 Annotation: Subtype: Link Rect: 247, 560, 284, 570 Annotation: Subtype: Link Rect: 480, 521, 516, 531 Annotation: Subtype: Link Rect: 163, 496, 201, 506 Annotation: Subtype: Link Rect: 421, 456, 459, 467 Annotation: Subtype: Link Rect: 465, 456, 501, 467 Annotation: Subtype: Link Rect: 363, 430, 400, 441 Annotation: Subtype: Link Rect: 406, 430, 442, 441 Annotation: Subtype: Link Rect: 414, 391, 451, 402 Annotation: Subtype: Link Rect: 458, 391, 494, 402 Annotation: Subtype: Link Rect: 163, 354, 201, 364 Annotation: Subtype: Link Rect: 207, 354, 243, 364 Annotation: Subtype: Link Rect: 401, 327, 438, 338 Annotation: Subtype: Link Rect: 444, 327, 480, 338 Annotation: Subtype: Link Rect: 337, 288, 374, 299 Annotation: Subtype: Link Rect: 380, 288, 416, 299 Annotation: Subtype: Link Rect: 307, 263, 344, 273 Annotation: Subtype: Link Rect: 176, 224, 214, 234 Annotation: Subtype: Link Rect: 470, 211, 507, 222 Annotation: Subtype: Link Rect: 441, 198, 478, 209 Annotation: Subtype: Link Rect: 208, 160, 245, 170 Annotation: Subtype: Link Rect: 374, 133, 412, 144 Annotation: Subtype: Link Rect: 418, 133, 454, 144 Annotation: Subtype: Link Rect: 215, 95, 253, 105 Annotation: Subtype: Link Rect: 259, 95, 295, 105 Page: Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 136, 715, 174, 725 Annotation: Subtype: Link Rect: 180, 715, 216, 725 Annotation: Subtype: Link Rect: 246, 689, 283, 699 Annotation: Subtype: Link Rect: 289, 689, 325, 699 Annotation: Subtype: Link Rect: 76, 647, 166, 678 Annotation: Subtype: Link Rect: 234, 641, 407, 652 Checksum: 5d73aee4 Type: CRC32 Checksum: 660d647f904d6d75aecb9d0cab2f2d21 Type: MD5 Checksum: d5a44abcf85f95bf5ed2a90dcb85579979f979bb Type: SHA-1