30867ecbdcbd849b2e3bb51a43f4a406  pmc_32139811.pdf
acaca5e0c46fb52094c4f6692993a00d56563717  pmc_32139811.pdf
f92cb366700a0cedf27c8bd2718ce3aaf76aeb3d66503c86fcf611a940ac5be1  pmc_32139811.pdf

Title:          Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combination
Subject:        Scientific Reports, doi:10.1038/s41598-020-61169-x
Keywords:       
Author:         Daniel F. Jimamp#x000E9;nez-Garrido
Creator:        Springer
Producer:       iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:   Fri Feb 28 00:19:08 2020 CET
ModDate:        Fri Feb 28 11:51:29 2020 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          12
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      1241411 bytes
Optimized:      no
PDF version:    1.4

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
XBNPPD+Corbel-Bold                   CID TrueType      Identity-H       yes yes yes     59  0
MinionPro-It                         Type 1C           Custom           yes no  yes     60  0
EuclidSymbol-Bold                    Type 1C           Custom           yes no  yes    118  0
LPVMNC+Corbel-Bold2                  Type 1C           WinAnsi          yes yes yes     62  0
EuclidSymbol                         Type 1C           Custom           yes no  yes     63  0
MinionPro-Regular                    Type 1C           Custom           yes no  yes     61  0
NJSMOA+Corbel2                       Type 1C           WinAnsi          yes yes yes     64  0
HARCZJ+Corbel                        CID TrueType      Identity-H       yes yes yes     65  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes     66  0
NJSMOA+Corbel2                       Type 1C           WinAnsi          yes yes yes    328  0
GJNULL+Calibri                       Type 1C           WinAnsi          yes yes no      87  0
MinionPro-Bold                       Type 1C           WinAnsi          yes no  yes     88  0
STIXGeneral-Bold                     Type 1C           Custom           yes no  yes    186  0
NYLGAX+STIXGeneral-Regular           Type 1C           Custom           yes yes yes    187  0
FMKKSN+TimesNewRomanPSMT             Type 1C           WinAnsi          yes yes yes    296  0

Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2020-11-18 06:54:45 CET
 RepresentationInformation: pmc_32139811.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2020-07-06 03:56:45 CEST
  Size: 1241411
  Format: PDF
  Version: 1.4
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:Figure 1. Schematic diagram of the complete study.:63' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:
Table 1. Sociodemographic data of the sample. GAD⁜琀㴠䜀攀渀攀爀愀氀椀稀攀搀 䄀渀砀椀攀琀礀 䐀椀猀漀爀搀攀爀㬀 䴀䐠㴠䴀愀樀漀爀 搀攀瀀爀攀猀猀椀漀渀㬀 伀䌀䐠㴠伀戀猀攀猀猀椀瘀攀ⴀ䌀漀洀瀀甀氀猀椀瘀攀 䐀椀猀漀爀搀攀爀⻾￾＀㨀㘀㐩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㈲㜮ㄹ㔠㔵㘮㜶㌠㈳ㄮ㔱㔠㔴㐮㘲㉝⽈⽎⽁值㰯丠㜹‰⁒㸾㸾੥湤潢樊㜴‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_61169.indd:
Table 2. Means and confidence intervals obtained in sub-study 1. HAM-D⁜琀㴠䠀愀洀椀氀琀漀渀 䐀攀瀀爀攀猀猀椀漀渀 刀愀琀椀渀最 匀挀愀氀攀㬀 匀䌀䰀ⴀ㤀　ⴀ删㴠匀礀洀瀀琀漀洀 䌀栀攀挀欀ⴀ䰀椀猀琀ⴀ㤀　ⴀ刀攀瘀椀猀攀搀㬀 匀伀䴠㴠匀漀洀愀琀椀稀愀琀椀漀渀猀㬀 伀ⴀ䌠㴠伀戀猀攀猀猀椀瘀攀ⴀ䌀漀洀瀀甀氀猀椀瘀攀㬀 䤀ⴀ匠㴠䤀渀琀攀爀瀀攀爀猀漀渀愀氀 匀攀渀猀椀琀椀瘀椀琀㨀㘀㔩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㐴㠮ㄷ㔠㌶㘮㠸‴㔲⸴㤵″㔴⸶㈲崯䠯丯䅐㰼⽎‸〠〠刾㸾㸊敮摯扪਷㔠〠潢樊㰼⽆‴⽔祰支䅮湯琯䑥獴⣾＀匀瀀爀椀渀最攀爀一愀琀甀爀攀开匀挀椀刀攀瀀开㘀㄀㄀㘀㤀⸀椀渀搀搀㫾￾￾￾￾￾￾￾￾￾￾￾＀᛾＀￾￾＀吀愀戀氀攀 ㇾ￾＀⸠˾￾￾＀匀漀挀椀漀搀攀洀漀最爀愀瀀栀椀挀 搀愀琀愀 漀昀 琀栀攀 猀愀洀瀀氀攀⻾￾￾￾＀⃾￾￾＀䜀䄀䐠㴠䜀攀渀攀爀愀氀椀稀攀搀 䄀渀砀椀攀琀礀 䐀椀猀漀爀搀攀爀㬀 䴀䐠㴠䴀愀樀漀爀 搀攀瀀爀攀猀猀椀漀渀㬀 伀䌀䐠㴠伀戀猀攀猀猀椀瘀攀ⴀ䌀漀洀瀀甀氀猀椀瘀攀 䐀椀猀漀爀搀攀爀⻾￾＀㨀㘀㘩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔴㌮㔵㠠ㄹ㔮㤶㌠㔴㜮㠷㠠ㄸ㌮㠲㉝⽈⽎⽁值㰯丠㠱‰⁒㸾㸾੥湤潢樊㜶‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_61169.indd:
Table 3. Means and standard deviations from the sub-study 2. The middle column shows the differences observed between ayahuasca-naïve subjects and long-term ayahuasca users. The column on the right shows the differences found be:67' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:
Table 2. Means and confidence intervals obtained in sub-study 1. HAM-D⁜琀㴠䠀愀洀椀氀琀漀渀 䐀攀瀀爀攀猀猀椀漀渀 刀愀琀椀渀最 匀挀愀氀攀㬀 匀䌀䰀ⴀ㤀　ⴀ删㴠匀礀洀瀀琀漀洀 䌀栀攀挀欀ⴀ䰀椀猀琀ⴀ㤀　ⴀ刀攀瘀椀猀攀搀㬀 匀伀䴠㴠匀漀洀愀琀椀稀愀琀椀漀渀猀㬀 伀ⴀ䌠㴠伀戀猀攀猀猀椀瘀攀ⴀ䌀漀洀瀀甀氀猀椀瘀攀㬀 䤀ⴀ匠㴠䤀渀琀攀爀瀀攀爀猀漀渀愀氀 匀攀渀猀椀琀椀瘀椀琀㨀㘀㔩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㐴㠮ㄷ㔠㌶㘮㠸‴㔲⸴㤵″㔴⸶㈲崯䠯丯䅐㰼⽎‸〠〠刾㸾㸊敮摯扪਷㔠〠潢樊㰼⽆‴⽔祰支䅮湯琯䑥獴⣾＀匀瀀爀椀渀最攀爀一愀琀甀爀攀开匀挀椀刀攀瀀开㘀㄀㄀㘀㤀⸀椀渀搀搀㫾￾￾￾￾￾￾￾￾￾￾￾＀᛾＀￾￾＀吀愀戀氀攀 ㇾ￾＀⸠˾￾￾＀匀漀挀椀漀搀攀洀漀最爀愀瀀栀椀挀 搀愀琀愀 漀昀 琀栀攀 猀愀洀瀀氀攀⻾￾￾￾＀⃾￾￾＀䜀䄀䐠㴠䜀攀渀攀爀愀氀椀稀攀搀 䄀渀砀椀攀琀礀 䐀椀猀漀爀搀攀爀㬀 䴀䐠㴠䴀愀樀漀爀 搀攀瀀爀攀猀猀椀漀渀㬀 伀䌀䐠㴠伀戀猀攀猀猀椀瘀攀ⴀ䌀漀洀瀀甀氀猀椀瘀攀 䐀椀猀漀爀搀攀爀⻾￾＀㨀㘀㘩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔴㌮㔵㠠ㄹ㔮㤶㌠㔴㜮㠷㠠ㄸ㌮㠲㉝⽈⽎⽁值㰯丠㠱‰⁒㸾㸾੥湤潢樊㜶‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_61169.indd:
Table 3. Means and standard deviations from the sub-study 2. The middle column shows the differences observed between ayahuasca-naïve subjects and long-term ayahuasca users. The column on the right shows the differences found be:67' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:
Table 1. Sociodemographic data of the sample. GAD⁜琀㴠䜀攀渀攀爀愀氀椀稀攀搀 䄀渀砀椀攀琀礀 䐀椀猀漀爀搀攀爀㬀 䴀䐠㴠䴀愀樀漀爀 搀攀瀀爀攀猀猀椀漀渀㬀 伀䌀䐠㴠伀戀猀攀猀猀椀瘀攀ⴀ䌀漀洀瀀甀氀猀椀瘀攀 䐀椀猀漀爀搀攀爀⻾￾＀㨀㘀㘩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㔴㌮㔵㠠ㄹ㔮㤶㌠㔴㜮㠷㠠ㄸ㌮㠲㉝⽈⽎⽁值㰯丠㠱‰⁒㸾㸾੥湤潢樊㜶‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_61169.indd:
Table 3. Means and standard deviations from the sub-study 2. The middle column shows the differences observed between ayahuasca-naïve subjects and long-term ayahuasca users. The column on the right shows the differences found be:67' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:
Table 3. Means and standard deviations from the sub-study 2. The middle column shows the differences observed between ayahuasca-naïve subjects and long-term ayahuasca users. The column on the right shows the differences found be:67' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:
Table 3. Means and standard deviations from the sub-study 2. The middle column shows the differences observed between ayahuasca-naïve subjects and long-term ayahuasca users. The column on the right shows the differences found b:68' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:Figure 2. Confidence Intervals showing significant differences through different assessments in sub-study 1. HAM-D⁜琀㴠䠀愀洀椀氀琀漀渀 䐀攀瀀爀攀猀猀椀漀渀 刀愀琀椀渀最 匀挀愀氀攀㬀 匀䌀䰀ⴀ㤀　ⴀ删㴠匀礀洀瀀琀漀洀 䌀栀攀挀欀ⴀ䰀椀猀琀ⴀ㤀　ⴀ刀攀瘀椀猀攀搀㬀 匀䘀ⴀ㌀㘠㴠吀栀攀 䴀攀搀椀挀愀氀 伀甀琀挀漀洀攀猀 匀琀甀搀礀 ㌀㘀ⴀ椀琀攀洀 匀栀漀爀琀ⴀ䘀漀爀㨀㜀㜩⽂潲摥牛〠〠そ⽓畢瑹灥⽌楮欯䉓㰼⽗‰⽔祰支䉯牤敲⽓⽓㸾⽒散瑛㌶㐮㈴㐠㔳㐮㜶㌠㌶㠮㘸㈠㔲㈮㘲㉝⽈⽎⽁值㰯丠ㄵ㐠〠刾㸾㸊敮摯扪਱㌱‰扪਼㰯䘠㐯呹灥⽁湮潴⽄敳琨SpringerNature_SciRep_61169.indd:	14.	Osório, F. L. et al. Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Braz. J. Psych. 37, 13–20 (2015).
:78' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:
Table 3. Means and standard deviations from the sub-study 2. The middle column shows the differences observed between ayahuasca-naïve subjects and long-term ayahuasca users. The column on the right shows the differences found :81' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:	14.	Osório, F. L. et al. Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report. Braz. J. Psych. 37, 13–20 (2015).
:86' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:	16.	Palhano-Fontes, F. et al. Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychol. Med. 15, 1–9 (2018).
:87' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:	12.	Bouso, J. C. et al. Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of ayahuasca: A longitudinal study. Plos One. 7, e42421 (2012).
:105' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:	13.	Bouso, J. C. et al. Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans. Eur. Neuropsychopharmacol. 25, 483–92 (2015).
:106' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:	13.	Bouso, J. C. et al. Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans. Eur. Neuropsychopharmacol. 25, 483–92 (2015).
:107' cannot be found
   Offset: 693846
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'SpringerNature_SciRep_61169.indd:
Table 3. Means and standard deviations from the sub-study 2. The middle column shows the differences observed between ayahuasca-naïve subjects and long-term ayahuasca users. The column on the right shows the differences found:108' cannot be found
   Offset: 693846
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 499
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combinat ...
      Children: 
       Item: 
        Title: Results
       Item: 
        Title: Discussion
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Sub-study 1. 
          Children: 
           Item: 
            Title: Sample. 
         Item: 
          Title: Measures. 
         Item: 
          Title: Procedure. 
         Item: 
          Title: Statistical analysis. 
         Item: 
          Title: Sub-study 2. 
          Children: 
           Item: 
            Title: Sample. 
         Item: 
          Title: Measures. 
         Item: 
          Title: Procedure. 
         Item: 
          Title: Statistical analysis. 
         Item: 
          Title: Ethics. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Schematic diagram of the complete study.
       Item: 
        Title: Figure 2 Confidence Intervals showing significant differences through different assessments in sub-study 1.
       Item: 
        Title: Table 1 Sociodemographic data of the sample.
       Item: 
        Title: Table 2 Means and confidence intervals obtained in sub-study 1.
       Item: 
        Title: Table 3 Means and standard deviations from the sub-study 2.
   Info: 
    Title: Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combination
    Author: Daniel F. Jimamp#x000E9;nez-Garrido
    Subject: Scientific Reports, doi:10.1038/s41598-020-61169-x
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Fri Feb 28 00:49:08 CET 2020
    ModDate: Fri Feb 28 11:51:29 CET 2020
   ID: 0xe177e3dcdfc214bb18885128e04f5033, 0x61043319e54aa490ef022c15aff26a7b
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 113
      ImageHeight: 127
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1650
      ImageHeight: 1371
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: HARCZJ+Corbel
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: XBNPPD+Corbel-Bold
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: NJSMOA+Corbel2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: NJSMOA+Corbel2
       Flags: Nonsymbolic
       FontBBox: -553, -239, 1110, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: EuclidSymbol-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EuclidSymbol-Bold
       Flags: Symbolic
       FontBBox: -186, -308, 1101, 960
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GJNULL+Calibri
      FontSubset: true
      FirstChar: 32
      LastChar: 239
      FontDescriptor: 
       FontName: GJNULL+Calibri
       Flags: Nonsymbolic
       FontBBox: -503, -307, 1240, 964
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MinionPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: FMKKSN+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: FMKKSN+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: STIXGeneral-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIXGeneral-Bold
       Flags: Serif, Symbolic
       FontBBox: -1030, -455, 2000, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NYLGAX+STIXGeneral-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 31
      FontDescriptor: 
       FontName: NYLGAX+STIXGeneral-Regular
       Flags: Serif, Symbolic
       FontBBox: -995, -455, 2000, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LPVMNC+Corbel-Bold2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: LPVMNC+Corbel-Bold2
       Flags: Nonsymbolic
       FontBBox: -556, -239, 1155, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: EuclidSymbol
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EuclidSymbol
       Flags: Symbolic
       FontBBox: -166, -253, 1090, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: HARCZJ+Corbel
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: HARCZJ+Corbel
       Flags: Symbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
     Font: 
      BaseFont: XBNPPD+Corbel-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: XBNPPD+Corbel-Bold
       Flags: Symbolic
       FontBBox: -556, -239, 1155, 952
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41598-020-61169-x</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Scientific Reports, doi:10.1038/s41598-020-61169-x</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combination</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Daniel F. Jimamp#x000E9;nez-Garrido</rdf:li>
               <rdf:li>Maramp#x000ED;a Gamp#x000F3;mez-Sousa</rdf:li>
               <rdf:li>Genamp#x000ED;s Ona</rdf:li>
               <rdf:li>Rafael G. Santos</rdf:li>
               <rdf:li>Jaime E. C. Hallak</rdf:li>
               <rdf:li>Miguel amp#x000C1;ngel Alcamp#x000E1;zar-Camp#x000F3;rcoles</rdf:li>
               <rdf:li>Josamp#x000E9; Carlos Bouso</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:doi>10.1038/s41598-020-61169-x</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41598-020-61169-x</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Scientific Reports</prism:publicationName>
         <prism:copyright>© 2020, The Author(s)</prism:copyright>
         <prism:issn>2045-2322</prism:issn>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:doi>10.1038/s41598-020-61169-x</pdfx:doi>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2020-02-28T11:51:29+01:00</xmp:ModifyDate>
         <xmp:CreateDate>2020-02-28T04:49:08+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2020-02-28T11:51:29+01:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:f09fdb70-a416-4db3-b9d8-580bbfc2c713</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:a123c7c1-d0c5-4592-bfa0-6b1e5c3d4eab</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:72ed3b06-0263-4472-9317-80fd42f0cbcc</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2020-02-28T04:49:50+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 374, 496, 383, 484
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 473, 496, 482, 484
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 399, 292, 402, 280
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 303, 282, 306, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 248, 262, 251, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 274, 242, 276, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 332, 232, 335, 220
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 487, 222, 490, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 491, 222, 494, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 411, 202, 414, 190
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 415, 202, 418, 190
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 452, 192, 457, 180
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 459, 192, 465, 180
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 527, 182, 532, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 534, 182, 539, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 452, 162, 457, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 459, 162, 464, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 510, 142, 516, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 387, 122, 393, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 444, 53, 513, 43
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 457, 734, 460, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 383, 704, 389, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 188, 654, 193, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 195, 654, 200, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 321, 624, 326, 612
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 529, 604, 535, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 351, 574, 356, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 348, 564, 353, 552
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 308, 554, 314, 542
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 192, 534, 195, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 533, 474, 539, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 205, 464, 211, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 231, 444, 237, 432
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 267, 414, 273, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 456, 404, 462, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 302, 374, 308, 362
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 388, 324, 391, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 320, 314, 326, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 302, 304, 307, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 309, 304, 314, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 244, 214, 249, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 226, 146, 230, 133
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 226, 146, 230, 133
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 226, 146, 230, 133
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 226, 146, 230, 133
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 447, 66, 451, 53
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 403, 110, 408, 98
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 244, 60, 249, 48
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 251, 60, 256, 48
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 258, 60, 263, 48
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 300, 674, 303, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 304, 674, 310, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 394, 654, 397, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 482, 624, 488, 612
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 479, 484, 485, 472
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 479, 484, 485, 472
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 488, 484, 493, 472
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 522, 454, 528, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 438, 414, 442, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 174, 374, 179, 362
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 181, 374, 186, 362
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 188, 374, 193, 362
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 195, 374, 200, 362
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 280, 165, 285, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 289, 165, 294, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 389, 154, 394, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 268, 145, 274, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 454, 134, 460, 122
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 344, 124, 349, 112
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 493, 74, 499, 62
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 500, 74, 506, 62
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 498, 64, 504, 52
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 546, 54, 552, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 546, 83, 552, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 404, 73, 410, 61
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 532, 73, 537, 61
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 371, 335, 377, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 491, 325, 497, 313
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 499, 305, 505, 293
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 533, 285, 538, 273
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 540, 285, 545, 273
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 546, 285, 552, 273
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 442, 265, 448, 253
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 263, 185, 269, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 270, 175, 275, 163
       Flags: Print
       AppearanceDictionary: true
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 214, 125, 218, 113
       Flags: Print
       AppearanceDictionary: true
       Destination: null
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 475, 704, 481, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 482, 704, 488, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 489, 704, 495, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 419, 428, 424, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 543, 428, 549, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 370, 398, 376, 386
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 495, 398, 501, 386
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 402, 358, 407, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 544, 358, 549, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 383, 298, 389, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 543, 298, 549, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 387, 228, 393, 216
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 497, 228, 503, 216
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 397, 198, 402, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 543, 198, 549, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 457, 148, 462, 136
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 173, 138, 178, 126
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 414, 108, 420, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
      Annotation: 
       Subtype: Link
       Rect: 543, 108, 549, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 300
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 528, 626, 554, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 616, 238, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 528, 481, 554, 469
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 155, 471, 238, 459
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 167, 316, 412, 306
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 257, 388, 247
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 240, 445, 230
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 399, 624, 531, 614
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 349, 630, 441, 617
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 344, 520, 504, 508
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: d2ac3ad1
   Type: CRC32
  Checksum: 30867ecbdcbd849b2e3bb51a43f4a406
   Type: MD5
  Checksum: acaca5e0c46fb52094c4f6692993a00d56563717
   Type: SHA-1