f4f1bf2203d1f4b6adf848243275eafe pmc_32174954.pdf f9d0410c28d5684241a4574ed27cb003846b4f74 pmc_32174954.pdf 131db84d16ff831da96afbee5db69e94aca0e936423c9594fce1bafc91992899 pmc_32174954.pdf Title: Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar) Subject: Single-nucleotide polymorphisms (SNPs) are single genetic code variations considered one of the most common forms of nucleotide modifications. Keywords: single-nucleotide polymorphism, immune response, synonymous SNP, nonsynonymous SNP, homology modeling, 3D protein structure, molecular dynamics simulation, Salmo salar Author: Eva Vallejos-Vidal Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Wed Feb 26 08:02:31 2020 CET ModDate: Wed Feb 26 08:19:06 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 3618758 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DAFBIG+AdvOT34fe1490.B Type 1C WinAnsi yes yes no 947 0 DAFBIH+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 948 0 DAFBII+AdvOT01861455.I Type 1C WinAnsi yes yes no 949 0 DAFBIJ+AdvOT1deab444.I Type 1C WinAnsi yes yes no 950 0 DAFBIK+AdvOT6e5d2ec0 Type 1C WinAnsi yes yes no 951 0 DAFBIL+AdvOT6e5d2ec0+fb Type 1C Custom yes yes yes 952 0 DAFBIM+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 953 0 DAFBJN+AdvOT6e5d2ec0+20 Type 1C WinAnsi yes yes no 965 0 DAFBJO+AdvOT2f02755f.I Type 1C WinAnsi yes yes no 966 0 DAFBOP+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 508 0 DAFBON+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 504 0 DAFBOO+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 510 0 DAFBPP+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 521 0 DAFCAA+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 523 0 DAFCBB+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 525 0 DAFCBC+AdvOT34fe1490.B+fb Type 1C Custom yes yes yes 519 0 DAFCDC+AdvOT1deab444.I+fb Type 1C Custom yes yes yes 528 0 DAFHMO+AdvOT1deab444.I+20 Type 1C WinAnsi yes yes no 529 0 DAFHOP+AdvOT94be8fa4.B Type 1C WinAnsi yes yes no 533 0 DAFHPA+AdvOTd877c31c+21 Type 1C Custom yes yes yes 534 0 DAFNGN+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 539 0 DAFNGO+AdvOT1ef757c0+01 Type 1C Custom yes yes yes 535 0 DAFNIO+AdvOTd877c31c+03 Type 1C Custom yes yes yes 540 0 DAFNJO+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 541 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:45:07 CEST RepresentationInformation: pmc_32174954.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 11:44:19 CEST Size: 3618758 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'B31' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B103' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B111' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B111' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B63' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B78' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B78' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B33' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B79' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B91' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B91' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B80' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B64' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B93' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B89' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B19' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B88' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B18' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B19' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B88' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B88' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B75' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B75' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B101' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B23' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B48' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B48' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B62' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B62' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B41' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B50' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B40' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B40' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B42' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B41' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B42' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B42' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B73' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B15' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B15' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B61' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B104' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B85' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B85' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B81' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B83' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B60' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B110' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B110' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B111' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B111' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B30' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B17' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B31' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B103' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B65' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B77' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B77' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B28' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'B5' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B84' cannot be found Offset: 3590051 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B45' cannot be found Offset: 3590051 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1019 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Material and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Selection of Genes Modulated in Response to IPNV and Sequence Cluster Collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Data Mining for SNP Identification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Effect of SNPs on Gene Function Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Homology Modeling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: All-Atom Explicit Solvent MD Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: SNP Identification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: SNP Predicted Functionality Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Homology Modeling and All-Atom Explicit Solvent MD Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Info: Title: Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar) Author: Eva Vallejos-Vidal Subject: Single-nucleotide polymorphisms (SNPs) are single genetic code variations considered one of the most common forms of nucleotide modifications. 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Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar) Eva Vallejos-Vidal Sebastián Reyes-Cerpa Jaime Andrés Rivas-Pardo Kevin Maisey José M. Yáñez Hector Valenzuela Pablo A. Cea Victor Castro-Fernandez Lluis Tort Ana M. Sandino Mónica Imarai Felipe E. Reyes-López Single-nucleotide polymorphisms (SNPs) are single genetic code variations considered one of the most common forms of nucleotide modifications. single-nucleotide polymorphism immune response synonymous SNP nonsynonymous SNP homology modeling 3D protein structure molecular dynamics simulation Salmo salar uuid:7a343b6e-ae8f-4372-a34e-4e47cc297658 uuid:3393a6e4-3a3f-4ee2-aa83-8da02a02dc6d Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 608, 512, 629 Annotation: Subtype: Link Rect: 175, 585, 504, 606 Annotation: Subtype: Link Rect: 175, 562, 443, 583 Annotation: Subtype: Link Rect: 175, 539, 483, 560 Annotation: Subtype: Link Rect: 175, 516, 462, 537 Annotation: Subtype: Link Rect: 175, 493, 493, 514 Annotation: Subtype: Link Rect: 175, 470, 385, 491 Annotation: Subtype: Link Rect: 175, 447, 248, 456 Annotation: Subtype: Link Rect: 258, 447, 356, 456 Annotation: Subtype: Link Rect: 371, 447, 481, 456 Annotation: Subtype: Link Rect: 175, 436, 230, 445 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