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Title:           Milk yield, milk composition, and milk metabolomics of dairy goats intramammary-challenged with lipopolysaccharide under heat stress conditions
Subject:         Scientific Reports, doi:10.1038/s41598-020-61900-8
Keywords:        
Author:          Ahmed A. K. Salama
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     Item: 
      Title: Milk yield, milk composition, and milk metabolomics of dairy goats intramammary-challenged with lipopolysaccharide under he ...
      Children: 
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Animals, treatments and management conditions. 
         Item: 
          Title: Measurements, sampling, and analyses. 
         Item: 
          Title: Sample preparation and nuclear magnetic resonance spectroscopy procedures. 
         Item: 
          Title: Statistical analyses. 
          Children: 
           Item: 
            Title: Thermophysiological and lactational performance data. 
         Item: 
          Title: NMR data processing and analysis. 
       Item: 
        Title: Results and discussion
        Children: 
         Item: 
          Title: Effects of heat stress on physiological and productive performance. 
         Item: 
          Title: Responses to intramammary LPS challenge under thermo-neutral and heat stress conditions. 
         Item: 
          Title: Effect of heat stress on milk metabolome. 
         Item: 
          Title: Effect of intramammary LPS challenge on milk metabolome under thermal-neutral and heat stress conditions. 
       Item: 
        Title: Conclusions
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Hourly means and SEM for rectal temperature (a) and respiratory rate (b) following the intramammary injection of 10 μg E.
       Item: 
        Title: Figure 2 Hourly means and SEM for milk fat (a), protein (b), lactose (C), and SCC (d) following intramammary injection of endotoxin in dairy goats maintained under thermal neutral (TN n = 4) or heat stress (HS n = 4) conditions for 15 days.
       Item: 
        Title: Figure 3 Partial Least Squares-Discriminant Analysis (PLS-DA) scores plot of 1H NMR metabolomics spectra of milk produced from udder halves of goats maintained under thermo-neutral (TN n = 4) or heat stress (HS n = 4) conditions for 15 days.
       Item: 
        Title: Figure 4 Partial Least Squares-Discriminant Analysis (PLS-DA) scores plot of 1H NMR-milk metabolomics spectra in dairy goats maintained under thermal neutral (TN n = 4) or heat stress (HS n = 4) for 15 days.
       Item: 
        Title: Figure 5 Hourly means and SEM for milk metabolites detected by 1H NMR-based metabolomics.
       Item: 
        Title: Table 1 Rectal temperature and respiratory rate of dairy goats exposed to thermal neutral (TN n = 4) and heat stress (HS n = 4) conditions from day 1 to 11 (before the LPS treatment).
       Item: 
        Title: Table 2 Feed intake, water consumption and milk yield of dairy goats exposed to thermal neutral (TN n = 4) and heat stress (HS n = 4) conditions from day 1 to 11 (before the LPS treatment).
       Item: 
        Title: Table 3 Correlations between milk putative inflammation markers identified by NMR and milk components in dairy goats exposed to thermal neutral (TN n = 4) and heat stress (HS n = 4) conditions for 15 days.
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    Keywords: 
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PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
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