2174d9625954d617afe112921f4a8534 pmc_32197462.pdf bac39b4a7e944edc88ebdd67d75695905580ddbf pmc_32197462.pdf a28f16964ff4cdbe86003798b8986a88d0ac5287f325599aae5a129790d8df1f pmc_32197462.pdf Title: A Spanish Consensus on the Use of Safinamide for Parkinson’s Disease in Clinical Practice Subject: Safinamide is an approved drug for the treatment of motor fluctuations in Parkinson’s disease (PD). Scarce data are available on its use in clinical practice. A group of Spanish movement disorders specialists was convened to review the use of safinamide across different clinical scenarios that may guide neurologists in clinical practice. Eight specialists with recognized expertise in PD management elaborated the statements based on available evidence in the literature and on their clinical experience. The RAND/UCLA method was carried, with final conclusions accepted after a 2-round modified Delphi process. Higher level of agreement between panellists was reached for the following statements. Safinamide significantly improves mean daily OFF time without troublesome dyskinesias. Adjunctive treatment with safinamide is associated with motor improvements in patients with mid-to-late PD. The efficacy of safinamide on motor fluctuations is maintained at long-term, with no increase over time in dyskinesias severity. The clinical benefits of safinamide on pain and depression remain unclear. Safinamide presents a similar incidence of adverse events compared with placebo. The efficacy and safety of safinamide shown in the pivotal clinical trials are reproduced in clinical practice, with improvement of parkinsonian symptoms, decrease of daily OFF time, control of dyskinesias at the long term, and good tolerability and safety. Keywords: safinamide; efficacy; safety; fluctuations; dyskinesia; RAND/UCLA appropriateness method Author: Javier Pagonabarraga, José Matías Arbelo, Francisco Grandas, Maria-Rosario Luquin, Pablo Martínez Martín, Mari Cruz Rodríguez-Oroz, Francesc Valldeoriola and Jaime Kulisevsky Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Wed Mar 18 13:51:25 2020 CET ModDate: Wed Mar 18 13:51:25 2020 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 297388 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XIIWGG+URWPalladioL-Ital Type 1 Custom yes yes no 118 0 YRUEFB+URWPalladioL-Bold Type 1 Custom yes yes no 119 0 YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 120 0 LZLNDM+URWPalladioL-Roma Type 1 Custom yes yes no 121 0 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ごとづぜ〴ぜ〰げぁぎい〯さぃがぁぜ〴ぜ〰きづぴとはつぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰がどぴづひちぴふひづぜ〴ぜ〰こづちひっとぜ〴ぜ〰こぴひちぴづでべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰いづぬばとどぜ〴ぜ〰げはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: がどぴづひちぴふひづぜ〴ぜ〰こづちひっとぜ〴ぜ〰こぴひちぴづでべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰いづぬばとどぜ〴ぜ〰げはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いづぬばとどぜ〴ぜ〰げはふのつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぅててどっちっべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸱ Children: Item: Title: ぅててどっちっべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸱ Children: Item: Title: いづぜ〴ぜ〰ぎはぶはぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸲ Item: Title: きはぴはひぜ〴ぜ〰こべねばぴはねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸱⸳ Item: Title: ぎはの〭きはぴはひぜ〴ぜ〰こべねばぴはねびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰こちてづぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸲⸱ Item: Title: こちてづぴべぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸲⸱ Children: Item: Title: きはびぴぜ〴ぜ〰ぃはねねはのぜ〴ぜ〰ぁぅびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸲⸲ Item: Title: いべびにどのづびどちびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸲⸳ Item: Title: ぃはのてふびどはのちぬぜ〴ぜ〰こべのつひはねづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぐちぴどづのぴぜ〴ぜ〰ぐひはてどぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸳⸱ Item: Title: ぐちぴどづのぴぜ〴ぜ〰ぐひはてどぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獵扳散瑩潮⸳⸳⸱ Children: Item: Title: 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