2cfffdd759ac6458488aafe3817cebbf pmc_32199820.pdf 0be40974d3ae05bf3d40cbd908f9174cee52bb4b pmc_32199820.pdf 48ad4f44d83101e124b0809481afb6356970fe55995faba4dbd05d54012a7c11 pmc_32199820.pdf Title: The taming of PARP1 and its impact on NAD+ metabolism Subject: Molecular Metabolism, 38 (2020) 100950. doi:10.1016/j.molmet.2020.01.014 Author: Sarah Hurtado-Bagès Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Dec 31 23:45:16 9 LMT ModDate: Wed Jun 10 20:11:10 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1254726 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LDPNLL+AdvOTad521943 Type 1C WinAnsi yes yes no 1205 0 LDPNLM+AdvP4C4E74 Type 1C Custom yes yes yes 1210 0 LDPNLN+AdvP4C4E59 Type 1C Custom yes yes yes 1215 0 LDPNLO+AdvOT9d0303c0.B Type 1C WinAnsi yes yes no 1217 0 LDPNLP+AdvOT8e81dcaa Type 1C WinAnsi yes yes no 1220 0 LDPNMA+AdvPSSym Type 1C Custom yes yes no 1224 0 LDPNNB+AdvOT8e81dcaa+fb Type 1C Custom yes yes yes 1203 0 LDPNNC+AdvPS44A44B Type 1C WinAnsi yes yes no 1230 0 LDPNND+AdvPS3F4C13 Type 1C WinAnsi yes yes no 1232 0 LDPOCC+AdvOT8e81dcaa+20 Type 1C WinAnsi yes yes no 950 0 LEAHDL+AdvOT8e81dcaa+01 Type 1C Custom yes yes no 959 0 LEAHFM+AdvTT2876772e+20 Type 1C Custom yes yes yes 966 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-18 06:50:59 CET RepresentationInformation: pmc_32199820.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-06 03:54:29 CEST Size: 1254726 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Improperly formed date Offset: 1231931 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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referenced object 'bib30' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib34' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib35' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib36' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib37' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib6' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib40' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib41' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib42' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib43' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib45' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib45' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib45' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib46' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib45' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib47' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib48' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib49' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib50' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib51' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib53' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib54' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib55' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib56' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib57' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib58' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib59' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib60' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib59' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib59' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib55' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib55' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib70' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib71' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib72' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib71' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib72' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib73' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib74' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib75' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib42' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib76' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib77' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib78' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib73' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib78' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib79' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib80' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib81' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib45' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib82' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib83' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib77' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib74' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib84' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib74' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib76' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib76' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib77' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib85' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib86' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib87' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib88' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib89' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib90' cannot be found Offset: 1216045 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib91' cannot be found Offset: 1216045 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1284 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: The taming of PARP1 and its impact on NAD+ metabolism Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: 1. PARP1 is a key mediator of nuclear poly-ADP-ribose signaling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Children: Item: Title: 1.1. The family of PARP enzymes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 1.2. Activation of PARP1 by DNA damage Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 1.3. Regulation of PARP1 and its role in transcription Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2. NAD+ metabolism Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: 2.1. Regeneration of the NAD+ pool Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.2. Compartmentalization of NAD+ metabolism and synthesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 3. The impact of acute PARP1 activation on metabolism Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 4. Taming of the PARP1 stress response by the histone variant macroH2A1.1 in differentiated cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Children: Item: Title: 4.1. MacroH2A histone variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 4.2. MacroH2A1.1 macrodomain binds and inhibits ADP-ribosylated PARP1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 4.3. MacroH2A1.1 couples differentiated state and NAD+ metabolism Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 5. Conclusion and outlook Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Conflict of interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Info: Title: The taming of PARP1 and its impact on NAD+ metabolism Author: Sarah Hurtado-Bagès Subject: Molecular Metabolism, 38 (2020) 100950. doi:10.1016/j.molmet.2020.01.014 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) ID: 0x54cb5f580c41f0d2bcf48a2cd54aede9, 0x1b45ddc23b62ac4eb7f2d9f90dddadb9 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 103 ImageHeight: 102 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1659 ImageHeight: 1582 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1659 ImageHeight: 1774 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1659 ImageHeight: 1594 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: LDPNND+AdvPS3F4C13 FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: LDPNND+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LDPNLO+AdvOT9d0303c0.B FontSubset: true FirstChar: 45 LastChar: 122 FontDescriptor: FontName: LDPNLO+AdvOT9d0303c0.B Flags: Nonsymbolic FontBBox: -31, -218, 770, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LDPNNB+AdvOT8e81dcaa+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LDPNNB+AdvOT8e81dcaa+fb Flags: Symbolic FontBBox: 0, 0, 500, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDPNLP+AdvOT8e81dcaa FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: LDPNLP+AdvOT8e81dcaa Flags: Nonsymbolic FontBBox: -31, -208, 770, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LDPNLL+AdvOTad521943 FontSubset: true FirstChar: 40 LastChar: 232 FontDescriptor: FontName: LDPNLL+AdvOTad521943 Flags: Nonsymbolic FontBBox: -31, -229, 802, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LDPOCC+AdvOT8e81dcaa+20 FontSubset: true FirstChar: 146 LastChar: 148 FontDescriptor: FontName: LDPOCC+AdvOT8e81dcaa+20 Flags: Nonsymbolic FontBBox: -156, -145, 1000, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LEAHFM+AdvTT2876772e+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LEAHFM+AdvTT2876772e+20 Flags: Symbolic FontBBox: -218, -197, 1302, 781 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDPNMA+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LDPNMA+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: LDPNLM+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 254 FontDescriptor: FontName: LDPNLM+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDPNNC+AdvPS44A44B FontSubset: true FirstChar: 68 LastChar: 101 FontDescriptor: FontName: LDPNNC+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LDPNLN+AdvP4C4E59 FontSubset: true FirstChar: 2 LastChar: 42 FontDescriptor: FontName: LDPNLN+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LEAHDL+AdvOT8e81dcaa+01 FontSubset: true FirstChar: 20 LastChar: 20 FontDescriptor: FontName: LEAHDL+AdvOT8e81dcaa+01 Flags: Nonsymbolic FontBBox: -10, -166, 770, 885 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: application/pdf doi:10.1016/j.molmet.2020.01.014 The taming of PARP1 and its impact on NAD+ metabolism Sarah Hurtado-Bagès Gunnar Knobloch Andreas G. Ladurner Marcus Buschbeck PARP1 NAD+ Epigenetics MacroH2A Metabolism Homeostasis Molecular Metabolism, 38 (2020) 100950. doi:10.1016/j.molmet.2020.01.014 Elsevier GmbH journal Molecular Metabolism © 2020 The Authors. 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