0f6c67a145763d1aca12487cae93dd22 pmc_32244331.pdf a1c5e393d7ababa02eb1fb8cfc3ef1e4d08b21fd pmc_32244331.pdf 8c053878b32658ea99b54c1254bc6ddf2b6e47f9df089ee43ee95da9e5131d56 pmc_32244331.pdf Title: Clinical and Neurophysiological Correlates of Emotion and Food Craving Regulation in Patients with Anorexia Nervosa Subject: Background: Difficulties in emotion regulation and craving regulation have been linked to eating symptomatology in patients with anorexia nervosa (AN), contributing to the maintenance of their eating disorder. Methods: To investigate clinical and electrophysiological correlates of these processes, 20 patients with AN and 20 healthy controls (HC) completed a computerized task during EEG recording, where they were instructed to down-regulate negative emotions or food craving. Participants also completed self-report measures of emotional regulation and food addiction. The P300 and Late Positive Potential (LPP) ERPs were analysed. Results: LPP amplitudes were significantly smaller during down-regulation of food craving among both groups. Independent of task condition, individuals with AN showed smaller P300 amplitudes compared to HC. Among HC, the self-reported use of re-appraisal strategies positively correlated with LPP amplitudes during emotional regulation task, while suppressive strategies negatively correlated with LPP amplitudes. The AN group, in comparison to the HC group, exhibited greater food addiction, greater use of maladaptive strategies, and emotional dysregulation. Conclusions: Despite the enhanced self-reported psychopathology among AN, both groups indicated neurophysiological evidence of food craving regulation as evidenced by blunted LPP amplitudes in the relevant task condition. Further research is required to delineate the mechanisms associated with reduced overall P300 amplitudes among individuals with AN. Keywords: food craving; food addiction; emotion regulation; eating disorders; anorexia nervosa; event related potentials; EEG; neurophysiology; psychopathology Author: Nuria Mallorquí-Bagué, María Lozano-Madrid, Giulia Testa, Cristina Vintró-Alcaraz, Isabel Sánchez, Nadine Riesco, José César Perales, Juan Francisco Navas, Ignacio Martínez-Zalacaín, Alberto Megías, Roser Granero, Misericordia Veciana De Las Heras, Rayane Chami, Susana Jiménez-Murcia, José Antonio Fernández-Formoso, Janet Treasure and Fernando Fernández-Aranda Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Tue Mar 31 11:34:26 2020 CEST ModDate: Tue Mar 31 11:34:26 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 897280 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- 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ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-06 03:52:33 CEST Size: 897280 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぐちひぴどっどばちのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぐひはっづつふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぃぬどのどっちぬぜ〴ぜ〰ぁびびづびびねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぅぬづっぴひはばとべびどはぬはでどっちぬぜ〴ぜ〰ぁびびづびびねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぬづっぴひはばとべびどはぬはでどっちぬぜ〴ぜ〰げづっはひつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぐちひぴどっどばちのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰ぐひはっづつふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぃぬどのどっちぬぜ〴ぜ〰ぁびびづびびねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぅぬづっぴひはばとべびどはぬはでどっちぬぜ〴ぜ〰ぁびびづびびねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぬづっぴひはばとべびどはぬはでどっちぬぜ〴ぜ〰げづっはひつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぐひはっづつふひづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰ぃぬどのどっちぬぜ〴ぜ〰ぁびびづびびねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぅぬづっぴひはばとべびどはぬはでどっちぬぜ〴ぜ〰ぁびびづびびねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぬづっぴひはばとべびどはぬはでどっちぬぜ〴ぜ〰げづっはひつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぃぬどのどっちぬぜ〴ぜ〰ぁびびづびびねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰ぅぬづっぴひはばとべびどはぬはでどっちぬぜ〴ぜ〰ぁびびづびびねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぬづっぴひはばとべびどはぬはでどっちぬぜ〴ぜ〰げづっはひつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぅぬづっぴひはばとべびどはぬはでどっちぬぜ〴ぜ〰ぁびびづびびねづのぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㔩‾㸊⡜㌷㙜㌷㝜〰ぅぬづっぴひはばとべびどはぬはでどっちぬぜ〴ぜ〰げづっはひつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: ぅぬづっぴひはばとべびどはぬはでどっちぬぜ〴ぜ〰げづっはひつどのでぜ〴ぜ〰ちのつぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㘩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぃはねばちひどびはのぜ〴ぜ〰はてぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぐひはてどぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぅげぐぜ〴ぜ〰げづびふぬぴび〺ぜ〴ぜ〰ぅねはぴどはのぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰ごちびにぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぅげぐぜ〴ぜ〰げづびふぬぴび〺ぜ〴ぜ〰うははつぜ〴ぜ〰ぃひちぶどのでぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰ごちびにぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃはひひづぬちぴどはのびぜ〴ぜ〰ぢづぴぷづづのぜ〴ぜ〰ぅげぐびぜ〴ぜ〰ちのつぜ〴ぜ〰こづぬて〭ひづばはひぴづつぜ〴ぜ〰ぅねはぴどはのちぬぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰こぴひちぴづでどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: ぃはねばちひどびはのぜ〴ぜ〰はてぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぐひはてどぬづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰ぅげぐぜ〴ぜ〰げづびふぬぴび〺ぜ〴ぜ〰ぅねはぴどはのぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰ごちびにぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぅげぐぜ〴ぜ〰げづびふぬぴび〺ぜ〴ぜ〰うははつぜ〴ぜ〰ぃひちぶどのでぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰ごちびにぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃはひひづぬちぴどはのびぜ〴ぜ〰ぢづぴぷづづのぜ〴ぜ〰ぅげぐびぜ〴ぜ〰ちのつぜ〴ぜ〰こづぬて〭ひづばはひぴづつぜ〴ぜ〰ぅねはぴどはのちぬぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰こぴひちぴづでどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぅげぐぜ〴ぜ〰げづびふぬぴび〺ぜ〴ぜ〰ぅねはぴどはのぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰ごちびにぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㌩‾㸊⡜㌷㙜㌷㝜〰ぅげぐぜ〴ぜ〰げづびふぬぴび〺ぜ〴ぜ〰うははつぜ〴ぜ〰ぃひちぶどのでぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰ごちびにぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃはひひづぬちぴどはのびぜ〴ぜ〰ぢづぴぷづづのぜ〴ぜ〰ぅげぐびぜ〴ぜ〰ちのつぜ〴ぜ〰こづぬて〭ひづばはひぴづつぜ〴ぜ〰ぅねはぴどはのちぬぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰こぴひちぴづでどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぅげぐぜ〴ぜ〰げづびふぬぴび〺ぜ〴ぜ〰うははつぜ〴ぜ〰ぃひちぶどのでぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰ごちびにぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㐩‾㸊⡜㌷㙜㌷㝜〰ぃはひひづぬちぴどはのびぜ〴ぜ〰ぢづぴぷづづのぜ〴ぜ〰ぅげぐびぜ〴ぜ〰ちのつぜ〴ぜ〰こづぬて〭ひづばはひぴづつぜ〴ぜ〰ぅねはぴどはのちぬぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰こぴひちぴづでどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: ぃはひひづぬちぴどはのびぜ〴ぜ〰ぢづぴぷづづのぜ〴ぜ〰ぅげぐびぜ〴ぜ〰ちのつぜ〴ぜ〰こづぬて〭ひづばはひぴづつぜ〴ぜ〰ぅねはぴどはのちぬぜ〴ぜ〰げづでふぬちぴどはのぜ〴ぜ〰こぴひちぴづでどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: 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