24ef19595603277c1c2f4bf18dbf5585 pmc_32260326.pdf 770218f69c0f5d86a7c70b8f0043984747842c77 pmc_32260326.pdf 3a4f486cfa643cd5e332735296d2dc456ec6e6c24e6b314839a0d6d03060a3b4 pmc_32260326.pdf Title: Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc Subject: First designed and published in 1998 as a laboratory tool to study Myc perturbation, Omomyc has come a long way in the past 22 years. This dominant negative has contributed to our understanding of Myc biology when expressed, first, in normal and cancer cells, and later in genetically-engineered mice, and has shown remarkable anti-cancer properties in a wide range of tumor types. The recently described therapeutic effect of purified Omomyc mini-protein—following the surprising discovery of its cell-penetrating capacity—constitutes a paradigm shift. Now, much more than a proof of concept, the most characterized Myc inhibitor to date is advancing in its drug development pipeline, pushing Myc inhibition into the clinic. Keywords: omomyc; Myc; cancer; Myc inhibition; mouse models; peptides; anticancer drugs; new therapeutics Author: Daniel Massó-Vallés and Laura Soucek Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Sat Apr 4 09:54:00 2020 CEST ModDate: Sat Apr 4 09:54:00 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1394770 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ODCMRI+URWPalladioL-Ital Type 1 Custom yes yes no 128 0 MJXXHI+URWPalladioL-Bold Type 1 Custom yes yes no 129 0 HJOMHV+VnURWPalladioL-Bold Type 1 Custom yes yes no 130 0 CGZDDW+URWPalladioL-Roma Type 1 Custom yes yes no 131 0 XHDYZV+VnURWPalladioL Type 1 Custom yes yes no 132 0 MHAHCD+Rpxr Type 1 Builtin yes yes no 133 0 PFKOHU+TimesNewRomanPS-BoldItalicMT Type 1C 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BCDIEE+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 420 0 YNURIB+Rpxmi Type 1 Builtin yes yes no 468 0 OYKGSM+Rpxb Type 1 Builtin yes yes no 550 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 728 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 03:44:33 CEST RepresentationInformation: pmc_32260326.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 11:44:27 CEST Size: 1394770 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 9 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮㄩ‾㸊⡜㌷㙜㌷㝜〰きべっぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㈩‾㸊⡜㌷㙜㌷㝜〰きべっぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㌩‾㸊⡜㌷㙜㌷㝜〰きべっぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰ごとづひちばづふぴどっぜ〴ぜ〰ごちひでづぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Children: Item: Title: きべっぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㈩‾㸊⡜㌷㙜㌷㝜〰きべっぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㌩‾㸊⡜㌷㙜㌷㝜〰きべっぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰ごとづひちばづふぴどっぜ〴ぜ〰ごちひでづぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きべっぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮ㄮ㌩‾㸊⡜㌷㙜㌷㝜〰きべっぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰ごとづひちばづふぴどっぜ〴ぜ〰ごちひでづぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きべっぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰ごとづひちばづふぴどっぜ〴ぜ〰ごちひでづぴぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: くねはねべっぜ〴ぜ〰いづびどでのぜ〴ぜ〰ちのつぜ〴ぜ〰ぃとちひちっぴづひどぺちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰きべっぜ〴ぜ〰いはねどのちのぴぜ〴ぜ〰ぎづでちぴどぶづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〳ㅜ〰びぜ〴ぜ〰げはぬづぜ〴ぜ〰どのぜ〴ぜ〰きべっ〭どのつふっづつぜ〴ぜ〰ごひちのびちっぴどぶちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ごひちのびひづばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰ちのつぜ〴ぜ〰ぅばどでづのづぴどっぜ〴ぜ〰きちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰ちのつぜ〴ぜ〰こぴづねのづびびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: くねはねべっぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰きべっぜ〴ぜ〰いはねどのちのぴぜ〴ぜ〰ぎづでちぴどぶづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〳ㅜ〰びぜ〴ぜ〰げはぬづぜ〴ぜ〰どのぜ〴ぜ〰きべっ〭どのつふっづつぜ〴ぜ〰ごひちのびちっぴどぶちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ごひちのびひづばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰ちのつぜ〴ぜ〰ぅばどでづのづぴどっぜ〴ぜ〰きちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰ちのつぜ〴ぜ〰こぴづねのづびびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: くねはねべっぜ〳ㅜ〰びぜ〴ぜ〰げはぬづぜ〴ぜ〰どのぜ〴ぜ〰きべっ〭どのつふっづつぜ〴ぜ〰ごひちのびちっぴどぶちぴどはのぜ〴ぜ〰ちのつぜ〴ぜ〰ごひちのびひづばひづびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰ちのつぜ〴ぜ〰ぅばどでづのづぴどっぜ〴ぜ〰きちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰ちのつぜ〴ぜ〰こぴづねのづびびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: くねはねべっぜ〴ぜ〰ちのつぜ〴ぜ〰ぅばどでづのづぴどっぜ〴ぜ〰きちひにづひびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰ちのつぜ〴ぜ〰こぴづねのづびびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: くねはねべっぜ〴ぜ〰ちのつぜ〴ぜ〰こぴづねのづびびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: くねはねべっぜ〴ぜ〰ちびぜ〴ぜ〰ちぜ〴ぜ〰ぐひははてぜ〴ぜ〰はてぜ〴ぜ〰ぃはのっづばぴぜ〴ぜ〰ぴとちぴぜ〴ぜ〰きべっぜ〴ぜ〰ぉのとどぢどぴどはのぜ〴ぜ〰どびぜ〴ぜ〰ちぜ〴ぜ〰ざどちぢぬづぜ〴ぜ〰ごとづひちばづふぴどっぜ〴ぜ〰くばぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮ㄩ‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぴひはぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰ちのつぜ〴ぜ〰こどつづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぶはぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Children: Item: Title: くねはねべっぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぴひはぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㌮㈩‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰ちのつぜ〴ぜ〰こどつづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぶはぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: くねはねべっぜ〴ぜ〰ぅててどっちっべぜ〴ぜ〰ちのつぜ〴ぜ〰こどつづぜ〴ぜ〰ぅててづっぴびぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぶはぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: うひはねぜ〴ぜ〰ぐひははてぜ〴ぜ〰はてぜ〴ぜ〰ぃはのっづばぴぜ〴ぜ〰ぴはぜ〴ぜ〰ぐとちひねちっはぬはでどっちぬぜ〴ぜ〰ぁばばひはちっとぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰げづっはねぢどのちのぴぜ〴ぜ〰くねはねべっぜ〴ぜ〰どびぜ〴ぜ〰ちぜ〴ぜ〰ぃづぬぬ〭ばづのづぴひちぴどのでぜ〴ぜ〰ぐづばぴどつづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰くねはねべっぜ〴ぜ〰きどのど〭ぐひはぴづどのぜ〴ぜ〰あづとちぶづびぜ〴ぜ〰ちびぜ〴ぜ〰どぴびぜ〴ぜ〰ごひちのびでづのどっちぬぬべ〭づへばひづびびづつぜ〴ぜ〰ぃはふのぴづひばちひぴぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちのちびちぬぜ〴ぜ〰はひぜ〴ぜ〰ぉのぴひちぶづのはふびぜ〴ぜ〰ぁつねどのどびぴひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰くねはねべっぜ〴ぜ〰どびぜ〴ぜ〰こちてづぜ〴ぜ〰ちのつぜ〴ぜ〰ぅててどっちっどはふびぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぶはぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Children: Item: Title: げづっはねぢどのちのぴぜ〴ぜ〰くねはねべっぜ〴ぜ〰どびぜ〴ぜ〰ちぜ〴ぜ〰ぃづぬぬ〭ばづのづぴひちぴどのでぜ〴ぜ〰ぐづばぴどつづぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ごとづぜ〴ぜ〰くねはねべっぜ〴ぜ〰きどのど〭ぐひはぴづどのぜ〴ぜ〰あづとちぶづびぜ〴ぜ〰ちびぜ〴ぜ〰どぴびぜ〴ぜ〰ごひちのびでづのどっちぬぬべ〭づへばひづびびづつぜ〴ぜ〰ぃはふのぴづひばちひぴぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちのちびちぬぜ〴ぜ〰はひぜ〴ぜ〰ぉのぴひちぶづのはふびぜ〴ぜ〰ぁつねどのどびぴひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰くねはねべっぜ〴ぜ〰どびぜ〴ぜ〰こちてづぜ〴ぜ〰ちのつぜ〴ぜ〰ぅててどっちっどはふびぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぶはぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ごとづぜ〴ぜ〰くねはねべっぜ〴ぜ〰きどのど〭ぐひはぴづどのぜ〴ぜ〰あづとちぶづびぜ〴ぜ〰ちびぜ〴ぜ〰どぴびぜ〴ぜ〰ごひちのびでづのどっちぬぬべ〭づへばひづびびづつぜ〴ぜ〰ぃはふのぴづひばちひぴぜ〴ぜ〰どのぜ〴ぜ〰ぃちのっづひぜ〴ぜ〰ぃづぬぬびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰ぉのぴひちのちびちぬぜ〴ぜ〰はひぜ〴ぜ〰ぉのぴひちぶづのはふびぜ〴ぜ〰ぁつねどのどびぴひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰くねはねべっぜ〴ぜ〰どびぜ〴ぜ〰こちてづぜ〴ぜ〰ちのつぜ〴ぜ〰ぅててどっちっどはふびぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぶはぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぉのぴひちのちびちぬぜ〴ぜ〰はひぜ〴ぜ〰ぉのぴひちぶづのはふびぜ〴ぜ〰ぁつねどのどびぴひちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰くねはねべっぜ〴ぜ〰どびぜ〴ぜ〰こちてづぜ〴ぜ〰ちのつぜ〴ぜ〰ぅててどっちっどはふびぜ〴ぜ〰ぉのぜ〴ぜ〰ざどぶはぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: くのではどのでぜ〴ぜ〰げづびづちひっとぜ〴ぜ〰ちのつぜ〴ぜ〰うふぴふひづぜ〴ぜ〰いどひづっぴどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮ㄩ‾㸊⡜㌷㙜㌷㝜〰くねはねべっぜ〴ぜ〰うふびどはのぜ〴ぜ〰ぷどぴとぜ〴ぜ〴ぜ〳㑜〰ぐとべぬはねづひびぜ〳㕜〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㈩‾㸊⡜㌷㙜㌷㝜〰ぉのっぬふびどはのぜ〴ぜ〰あはつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㌩‾㸊⡜㌷㙜㌷㝜〰ざちひどちのぴびぜ〴ぜ〰はてぜ〴ぜ〰くねはねべっぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぢえがえがずぜ〴ぜ〰きどのど〭ぐひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Children: Item: Title: くねはねべっぜ〴ぜ〰うふびどはのぜ〴ぜ〰ぷどぴとぜ〴ぜ〴ぜ〳㑜〰ぐとべぬはねづひびぜ〳㕜〰ぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㈩‾㸊⡜㌷㙜㌷㝜〰ぉのっぬふびどはのぜ〴ぜ〰あはつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㌩‾㸊⡜㌷㙜㌷㝜〰ざちひどちのぴびぜ〴ぜ〰はてぜ〴ぜ〰くねはねべっぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぢえがえがずぜ〴ぜ〰きどのど〭ぐひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: ぉのっぬふびどはのぜ〴ぜ〰あはつどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㌩‾㸊⡜㌷㙜㌷㝜〰ざちひどちのぴびぜ〴ぜ〰はてぜ〴ぜ〰くねはねべっぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぢえがえがずぜ〴ぜ〰きどのど〭ぐひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: ざちひどちのぴびぜ〴ぜ〰はてぜ〴ぜ〰くねはねべっぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㔮㐩‾㸊⡜㌷㙜㌷㝜〰くぴとづひぜ〴ぜ〰ぢえがえがずぜ〴ぜ〰きどのど〭ぐひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: くぴとづひぜ〴ぜ〰ぢえがえがずぜ〴ぜ〰きどのど〭ぐひはぴづどのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸶ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: 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