1896b42db29c7aec59f7135caab8ffd2  pmc_32295630.pdf
dec9141c4f62eea1cb8475ac0760230ef1bcd318  pmc_32295630.pdf
795135de66904cec22a1204da16469840236f093467700311b072c1f9639dade  pmc_32295630.pdf

Title:           An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination
Subject:         Journal of Hematology & Oncology, 2020, doi:10.1186/s13045-020-00863-9
Keywords:        Acute myeloid leukemia,CXCR4,Targeted nanoparticle,Auristatin nanoconjugate,Leukemic stem cells,Disseminated AML mouse model
Author:          Victor Pallarès
Creator:         Arbortext Advanced Print Publisher 9.1.440/W Unicode
Producer:        Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Mon Apr 13 07:52:12 2020 CEST
ModDate:         Wed Apr 15 16:33:33 2020 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           19
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       22308007 bytes
Optimized:       no
PDF version:     1.3


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
LEHMIJ+PjlbdwAdvTT7329fd89.I         Type 1C           WinAnsi          yes yes no      20  0
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     26  0
LEHCMO+WgthmmAdvTTaf7f9f4f.B         Type 1C           WinAnsi          yes yes no      23  0
LEHLHK+JmqsyfAdvTTe45e47d2           Type 1C           WinAnsi          yes yes no      24  0
LEHLHL+YvhhwcAdvTTb5929f4c           Type 1C           WinAnsi          yes yes no      25  0
LEHLHM+WnfsrqAdvTTb5929f4c+20        Type 1C           WinAnsi          yes yes no      94  0
LEHLHN+BqmwcbAdvTT99c4c969           Type 1C           WinAnsi          yes yes no      27  0
LEHLIO+VjxplhAdvTT1b53b5fb.I         Type 1C           WinAnsi          yes yes no      95  0
LEHMMK+WjsxvjAdvTT86d47313+20        Type 1C           WinAnsi          yes yes no      19  0
LEHMNL+YlwbwxAdvTT8861b38f.I         Type 1C           WinAnsi          yes yes no      21  0
LEHMMJ+VpjkssAdvTT86d47313           Type 1C           WinAnsi          yes yes no      22  0
LEHMPL+RdgtjsAdvTT86d47313+03        Type 1C           Custom           yes yes yes    325  0
LEIGGD+WfxgtyAdvTT86d47313+21        Type 1C           WinAnsi          yes yes no     377  0
LEIGHE+CvtpdrAdvTTb5929f4c+22        Type 1C           Custom           yes yes no     378  0
LEIGGC+PkkbpfAdvTT86d47313+22        Type 1C           Custom           yes yes no     379  0
LELCKG+PjkbjtAdvTT83913201.I         Type 1C           WinAnsi          yes yes no      84  0
LEPFEO+TlmmxfAdvTT43ccf47d+20        Type 1C           WinAnsi          yes yes no      92  0
LEPFDN+TfmvnfAdvTT43ccf47d           Type 1C           WinAnsi          yes yes no      93  0
LFACGP+KkbljqAdvTT99c4c969+20        Type 1C           WinAnsi          yes yes no     354  0
LFACEA+YvcqpdAdvTTb5929f4c+03        Type 1C           Custom           yes yes yes    355  0
LFACLP+BflgyfAdvTTaf7f9f4f.B+20      Type 1C           WinAnsi          yes yes no     421  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-10-02 04:12:05 CEST
 RepresentationInformation: pmc_32295630.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-03-31 11:44:31 CEST
  Size: 22308007
  Format: PDF
  Version: 1.3
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 555
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Abstract
      Destination: sectionAbs1
      Children: 
       Item: 
        Title: Background
        Destination: sectionASec1
       Item: 
        Title: Methods
        Destination: sectionASec2
       Item: 
        Title: Results
        Destination: sectionASec3
       Item: 
        Title: Conclusions
        Destination: sectionASec4
     Item: 
      Title: Background
      Destination: sectionSec1
     Item: 
      Title: Methods
      Destination: sectionSec2
      Children: 
       Item: 
        Title: Drugs, nanoparticle, and nanoconjugate
        Destination: sectionSec3
       Item: 
        Title: Cell lines
        Destination: sectionSec4
       Item: 
        Title: Quantitation of CXCR4 membrane levels in AML cell lines
        Destination: sectionSec5
       Item: 
        Title: Antineoplastic effect and internalization analyses of T22-GFP-H6-Auristatin in CXCR4+ AML cells in’vitro
        Destination: sectionSec6
       Item: 
        Title: Evaluation of the antineoplastic effect of T22-GFP-H6-Auristatin in a disseminated CXCR4+ AML mouse model
        Destination: sectionSec7
       Item: 
        Title: Detection of AML cells in circulating blood
        Destination: sectionSec8
       Item: 
        Title: Immunohistochemical staining of leukemic cells in AML affected organs
        Destination: sectionSec9
       Item: 
        Title: Toxicity analyses in tissues and blood
        Destination: sectionSec10
       Item: 
        Title: Statistical analysis
        Destination: sectionSec11
     Item: 
      Title: Results
      Destination: sectionSec12
      Children: 
       Item: 
        Title: T22-GFP-H6-Auristatin nanoconjugate synthesis and characterization
        Destination: sectionSec13
       Item: 
        Title: CXCR4-dependent NC internalization and killing of CXCR4 + AML cells in’vitro
        Destination: sectionSec14
       Item: 
        Title: Generation of a CXCR4+ AML model with bone marrow and extramedullar involvement
        Destination: sectionSec15
       Item: 
        Title: Nanoconjugate reduction of leukemia dissemination in the bone marrow and extramedullar sites
        Destination: sectionSec16
       Item: 
        Title: Nanoconjugate reduction of AML cell burden in the bone marrow, circulating blood, liver, and spleen
        Destination: sectionSec17
       Item: 
        Title: NC anticancer effect measured as organ affectation by CD45 cells and associated toxicity
        Destination: sectionSec18
     Item: 
      Title: Discussion
      Destination: sectionSec19
     Item: 
      Title: Conclusions
      Destination: sectionSec20
     Item: 
      Title: Supplementary information
      Destination: sectionSec21
     Item: 
      Title: Abbreviations
      Destination: sectionabr1
     Item: 
      Title: Acknowledgements
      Destination: section1
     Item: 
      Title: Authors’ contributions
      Destination: section2
     Item: 
      Title: Funding
      Destination: section3
     Item: 
      Title: Availability of data and materials
      Destination: section4
     Item: 
      Title: Ethics approval and consent to participate
      Destination: sectionFPar1
     Item: 
      Title: Consent for publication
      Destination: sectionFPar2
     Item: 
      Title: Competing interests
      Destination: sectionFPar3
     Item: 
      Title: Author details
      Destination: section5
     Item: 
      Title: References
      Destination: sectionBib1
     Item: 
      Title: Publisher’s Note
      Destination: ArtNote2
   Info: 
    Title: An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination
    Author: Victor Pallarès
    Subject: Journal of Hematology & Oncology, 2020, doi:10.1186/s13045-020-00863-9
    Keywords: Acute myeloid leukemia,CXCR4,Targeted nanoparticle,Auristatin nanoconjugate,Leukemic stem cells,Disseminated AML mouse model
    Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode
    Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Mon Apr 13 07:52:12 CEST 2020
    ModDate: Wed Apr 15 16:33:33 CEST 2020
   ID: 0x09a3ef05b13e226ae9e2765295496bac, 0x736c776a7d5a7dbc6742a5d19c5827b7
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 176
      ImageHeight: 182
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 688
      ImageHeight: 126
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 54
      ImageHeight: 103
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1714
      ImageHeight: 2420
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1949
      ImageHeight: 2292
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1935
      ImageHeight: 2485
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1949
      ImageHeight: 2148
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1949
      ImageHeight: 1612
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1949
      ImageHeight: 2311
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1849
      ImageHeight: 2485
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1420
      ImageHeight: 2425
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: LFACGP+KkbljqAdvTT99c4c969+20
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: LFACGP+KkbljqAdvTT99c4c969+20
       Flags: Nonsymbolic
       FontBBox: -447, -197, 1583, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LFACEA+YvcqpdAdvTTb5929f4c+03
      FontSubset: true
      FirstChar: 1
      LastChar: 5
      FontDescriptor: 
       FontName: LFACEA+YvcqpdAdvTTb5929f4c+03
       Flags: Symbolic
       FontBBox: -531, -260, 802, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LEHMPL+RdgtjsAdvTT86d47313+03
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: LEHMPL+RdgtjsAdvTT86d47313+03
       Flags: Symbolic
       FontBBox: -364, -250, 906, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LFACLP+BflgyfAdvTTaf7f9f4f.B+20
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: LFACLP+BflgyfAdvTTaf7f9f4f.B+20
       Flags: Nonsymbolic
       FontBBox: -468, -197, 1656, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEHMMK+WjsxvjAdvTT86d47313+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: LEHMMK+WjsxvjAdvTT86d47313+20
       Flags: Nonsymbolic
       FontBBox: -354, -218, 1291, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEHMIJ+PjlbdwAdvTT7329fd89.I
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: LEHMIJ+PjlbdwAdvTT7329fd89.I
       Flags: Nonsymbolic
       FontBBox: -218, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LELCKG+PjkbjtAdvTT83913201.I
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: LELCKG+PjkbjtAdvTT83913201.I
       Flags: Nonsymbolic
       FontBBox: -93, -250, 906, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEHMNL+YlwbwxAdvTT8861b38f.I
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: LEHMNL+YlwbwxAdvTT8861b38f.I
       Flags: Serif, Nonsymbolic
       FontBBox: -187, -239, 1062, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEHMMJ+VpjkssAdvTT86d47313
      FontSubset: true
      FirstChar: 32
      LastChar: 215
      FontDescriptor: 
       FontName: LEHMMJ+VpjkssAdvTT86d47313
       Flags: Serif, Nonsymbolic
       FontBBox: -218, -239, 1020, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEHCMO+WgthmmAdvTTaf7f9f4f.B
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: LEHCMO+WgthmmAdvTTaf7f9f4f.B
       Flags: Nonsymbolic
       FontBBox: -218, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEHLHK+JmqsyfAdvTTe45e47d2
      FontSubset: true
      FirstChar: 32
      LastChar: 232
      FontDescriptor: 
       FontName: LEHLHK+JmqsyfAdvTTe45e47d2
       Flags: Nonsymbolic
       FontBBox: -218, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEHLHL+YvhhwcAdvTTb5929f4c
      FontSubset: true
      FirstChar: 32
      LastChar: 252
      FontDescriptor: 
       FontName: LEHLHL+YvhhwcAdvTTb5929f4c
       Flags: Nonsymbolic
       FontBBox: -41, -250, 812, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEIGGD+WfxgtyAdvTT86d47313+21
      FontSubset: true
      FirstChar: 32
      LastChar: 153
      FontDescriptor: 
       FontName: LEIGGD+WfxgtyAdvTT86d47313+21
       Flags: Nonsymbolic
       FontBBox: -20, -208, 1208, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LEIGHE+CvtpdrAdvTTb5929f4c+22
      FontSubset: true
      FirstChar: 21
      LastChar: 22
      FontDescriptor: 
       FontName: LEIGHE+CvtpdrAdvTTb5929f4c+22
       Flags: Nonsymbolic
       FontBBox: -10, -218, 1083, 812
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: LEHLHN+BqmwcbAdvTT99c4c969
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: LEHLHN+BqmwcbAdvTT99c4c969
       Flags: Nonsymbolic
       FontBBox: -41, -250, 854, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEIGGC+PkkbpfAdvTT86d47313+22
      FontSubset: true
      FirstChar: 21
      LastChar: 22
      FontDescriptor: 
       FontName: LEIGGC+PkkbpfAdvTT86d47313+22
       Flags: Nonsymbolic
       FontBBox: -166, -250, 1031, 864
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: LEPFEO+TlmmxfAdvTT43ccf47d+20
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: LEPFEO+TlmmxfAdvTT43ccf47d+20
       Flags: Nonsymbolic
       FontBBox: -343, -218, 947, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEPFDN+TfmvnfAdvTT43ccf47d
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: LEPFDN+TfmvnfAdvTT43ccf47d
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 1010, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEHLHM+WnfsrqAdvTTb5929f4c+20
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: LEHLHM+WnfsrqAdvTTb5929f4c+20
       Flags: Nonsymbolic
       FontBBox: -447, -208, 1375, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LEHLIO+VjxplhAdvTT1b53b5fb.I
      FontSubset: true
      FirstChar: 32
      LastChar: 118
      FontDescriptor: 
       FontName: LEHLIO+VjxplhAdvTT1b53b5fb.I
       Flags: Nonsymbolic
       FontBBox: -114, -250, 864, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.139439, 2010/09/27-13:37:26        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords>Acute myeloid leukemia,CXCR4,Targeted nanoparticle,Auristatin nanoconjugate,Leukemic stem cells,Disseminated AML mouse model</pdf:Keywords>
         <pdf:Producer>Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1186/s13045-020-00863-9</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Journal of Hematology &amp; Oncology</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Journal of Hematology &amp; Oncology, 2020, doi:10.1186/s13045-020-00863-9</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Acute myeloid leukemia</rdf:li>
               <rdf:li>CXCR4</rdf:li>
               <rdf:li>Targeted nanoparticle</rdf:li>
               <rdf:li>Auristatin nanoconjugate</rdf:li>
               <rdf:li>Leukemic stem cells</rdf:li>
               <rdf:li>Disseminated AML mouse model</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Victor Pallarès</rdf:li>
               <rdf:li>Ugutz Unzueta</rdf:li>
               <rdf:li>Aïda Falgàs</rdf:li>
               <rdf:li>Laura Sánchez-García</rdf:li>
               <rdf:li>Naroa Serna</rdf:li>
               <rdf:li>Alberto Gallardo</rdf:li>
               <rdf:li>Gordon A. Morris</rdf:li>
               <rdf:li>Lorena Alba-Castellón</rdf:li>
               <rdf:li>Patricia Álamo</rdf:li>
               <rdf:li>Jorge Sierra</rdf:li>
               <rdf:li>Antonio Villaverde</rdf:li>
               <rdf:li>Esther Vázquez</rdf:li>
               <rdf:li>Isolda Casanova</rdf:li>
               <rdf:li>Ramon Mangues</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:ModifyDate>2020-04-15T16:33:33+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2020-04-15T16:33:33+02:00</xmp:MetadataDate>
         <xmp:CreateDate>2020-04-13T13:52:12+08:00</xmp:CreateDate>
         <xmp:CreatorTool>Arbortext Advanced Print Publisher 9.1.440/W Unicode</xmp:CreatorTool>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:25c2a412-df04-4cf1-88d3-4fbe51ab3ab1</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:b5a4dea0-a32e-4ace-b67b-d5b02e2e64a2</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:25c2a412-df04-4cf1-88d3-4fbe51ab3ab1</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2020-04-13T15:46:52+08:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>editorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag EditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Editor information: contains the name of each editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>seriesEditorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag SeriesEditorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Series editor information: contains the name of each series editor and his/her ORCID identifier.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>EditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/editorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>editor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of editor information: name and ORCID of an editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>SeriesEditorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>seriesEditor</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of series editor information: name and ORCID of a series editor.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of a series editor.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of a series editor.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/X ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 496, 635, 538, 677
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 400, 73, 518, 80
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 338, 65, 477, 72
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 114, 201, 185, 208
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 188, 201, 256, 208
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 192, 125, 199
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 269, 520, 274, 530
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 280, 520, 285, 530
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 259, 472, 264, 482
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 148, 448, 153, 458
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 166, 436, 171, 446
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 172, 424, 177, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 184, 424, 189, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 90, 412, 95, 422
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 101, 412, 106, 422
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 112, 412, 122, 422
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 274, 376, 284, 386
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 56, 364, 66, 374
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 271, 352, 276, 362
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 283, 352, 288, 362
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 56, 340, 66, 350
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 134, 292, 144, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 59, 220, 69, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 145, 184, 150, 194
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 157, 184, 167, 194
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 216, 172, 226, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 233, 172, 244, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 114, 136, 124, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 132, 136, 142, 146
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 113, 124, 123, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 129, 124, 139, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 158, 100, 163, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 169, 100, 179, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 332, 522, 342, 532
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 407, 285, 417, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 166, 489, 176, 498
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 459, 465, 469, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
     Thumb: true
    Page: 
     Sequence: 4
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 239, 357, 249, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 325, 489, 330, 498
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
     Thumb: true
    Page: 
     Sequence: 6
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 453, 69, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 523, 237, 528, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 414, 141, 419, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 355, 93, 360, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 318
     Thumb: true
    Page: 
     Sequence: 8
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 275, 573, 280, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 148, 441, 153, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 242, 393, 247, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 233, 345, 238, 354
       Flags: Print
       AppearanceDictionary: true
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 189, 249, 194, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 111, 177, 116, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 167, 105, 172, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 510, 549, 515, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 490, 525, 495, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 467, 441, 472, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 304, 393, 309, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 434, 357, 439, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 408, 297, 413, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 304, 225, 309, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 466, 213, 471, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
      Annotation: 
       Subtype: Link
       Rect: 427, 189, 432, 198
       Flags: Print
       AppearanceDictionary: true
       Destination: 321
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 124, 81, 129, 90
       Flags: Print
       AppearanceDictionary: true
       Destination: 328
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 79, 597, 84, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: 328
      Annotation: 
       Subtype: Link
       Rect: 444, 633, 449, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 411, 585, 416, 594
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 108, 669, 113, 678
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 279, 633, 284, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 332
      Annotation: 
       Subtype: Link
       Rect: 176, 369, 181, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 347
      Annotation: 
       Subtype: Link
       Rect: 511, 621, 516, 630
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 526, 585, 531, 594
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 467, 501, 472, 510
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 452, 417, 457, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
     Thumb: true
    Page: 
     Sequence: 13
     Thumb: true
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 180, 441, 185, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 241, 381, 246, 390
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 142, 297, 147, 306
       Flags: Print
       AppearanceDictionary: true
       Destination: 314
      Annotation: 
       Subtype: Link
       Rect: 224, 225, 229, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 343, 225, 353, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 359, 225, 369, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 328, 201, 333, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 343, 177, 353, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 359, 177, 369, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 438, 141, 448, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
     Thumb: true
    Page: 
     Sequence: 15
     Thumb: true
    Page: 
     Sequence: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 283, 549, 288, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 56, 537, 61, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 67, 537, 77, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 125, 453, 130, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 136, 453, 146, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 82, 273, 92, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 98, 273, 108, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 165, 249, 170, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 176, 249, 186, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 266, 213, 276, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 118, 129, 128, 138
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 413, 477, 423, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 428, 477, 438, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 308, 345, 313, 354
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 522, 261, 533, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 378, 213, 388, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 395, 213, 405, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 308, 201, 318, 210
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 502, 153, 507, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 513, 153, 518, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 526, 153, 536, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 304, 141, 314, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 321, 141, 331, 150
       Flags: Print
       AppearanceDictionary: true
       Destination: 7
      Annotation: 
       Subtype: Link
       Rect: 159, 608, 187, 616
       Flags: Print
       AppearanceDictionary: true
       Destination: 14
     Thumb: true
    Page: 
     Sequence: 17
     Thumb: true
    Page: 
     Sequence: 18
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 230, 575, 284, 583
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 566, 133, 574
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 404, 657, 538, 665
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 648, 352, 656
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 354, 630, 525, 638
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 621, 335, 629
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 147, 530, 155
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 138, 353, 146
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 19
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 71, 202, 202, 209
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 367, 594, 487, 602
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: f6b4ff7c
   Type: CRC32
  Checksum: 1896b42db29c7aec59f7135caab8ffd2
   Type: MD5
  Checksum: dec9141c4f62eea1cb8475ac0760230ef1bcd318
   Type: SHA-1
  Checksum: 795135de66904cec22a1204da16469840236f093467700311b072c1f9639dade
   Type: SHA-256