ce5726ccbede1c5a8efbb9569ffa247d pmc_32340309.pdf 0680f3962efba83c5910250de605efaaf743b65d pmc_32340309.pdf c7fd7ecbb366993f750b513b156e48322f8f76addb2075537bab4ec409cb1094 pmc_32340309.pdf Title: Association between the 2018 WCRF/AICR and the Low-Risk Lifestyle Scores with Colorectal Cancer Risk in the Predimed Study Subject: Limited longitudinal studies have been conducted to evaluate colorectal cancer (CRC) incidence based on the updated 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations or other global lifestyle indices, and none in aged populations at high cardiovascular risk. We aimed to assess the association between CRC incidence and adherence to two emerging lifestyles indices (2018 WCRF/AICR score and another low-risk lifestyle (LRL) score comprising smoking status, alcohol consumption, physical activity, diet, and body mass index) in the Spanish PREvencion con DIeta MEDiterranea (PREDIMED) cohort. We studied 7216 elderly men and women at high cardiovascular risk. The 2018 WCRF/AICR and LRL scores were calculated. Multivariable Cox proportional regression models were fitted to estimate the HRs (hazard ratios) and 95% confidence intervals (CIs) for incident CRC events. During a median interquartile range (IQR) follow-up of 6.0 (4.4–7.3) years, 97 CRC events were considered. A significant linear association was observed between each 1-point increment in the WCRF/AICR score (score range from 0 to 7) and CRC risk (HR (95% CI) = 0.79 (0.63–0.99)). Similarly, each 1-point increment in the LRL score (score range from 0 to 5) was associated with a 22% reduction in CRC risk (0.78 (0.64–0.96)). Adhering to emergent lifestyle scores might substantially reduce CRC incidence in elderly individuals. Further longitudinal studies, which take different lifestyle indexes into account, are warranted in the future. Keywords: WCRF/AICR score; low-risk lifestyle index; colorectal cancer; PREDIMED; lifestyle patterns Author: Laura Barrubés, Nancy Babio, Pablo Hernández-Alonso, Estefania Toledo, Judith B. Ramírez Sabio, Ramón Estruch, Emilio Ros, Montserrat Fitó, Angel M Alonso-Gómez, Miquel Fiol, Jose Lapetra, Lluís Serra-Majem, Xavier Pintó, Miguel Ruiz-Canela, Dolores Corella, Olga Castañer, Manuel Macías-González and Jordi Salas-Salvadó Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu Apr 23 12:33:30 2020 CEST ModDate: Thu Apr 23 12:33:30 2020 CEST Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 695337 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ADBDXI+URWPalladioL-Ital Type 1 Custom yes yes no 95 0 FDBIOP+URWPalladioL-Bold Type 1 Custom yes yes no 96 0 OKOJSI+Rpxb Type 1 Builtin yes yes no 97 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 98 0 TZHQKH+URWPalladioL-Roma Type 1 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