e703e1302e8e741f742d86d39e7c777c pmc_32344939.pdf 10801d6433f19648e2150c231dead06c9f58d079 pmc_32344939.pdf 231d08729f7401975e4f64334880c8f30d71b1c9addc85a93ba21bb1a4c8d2dd pmc_32344939.pdf Title: Effect of Subcutaneous Insulin on Spirometric Maneuvers in Patients with Type 1 Diabetes: A Case-Control Study Subject: In order to compare spirometric maneuvers in adults according to the presence of type 1 diabetes, a case-control study including 75 patients with type 1 diabetes and 75 controls matched by sex, age, and body mass index were designed. In addition, 75 patients with type 1 diabetes were added to examine the potential the impact of subcutaneous insulin therapy on pulmonary function. Lung function measurements were assessed according to the global initiative for chronic obstructive lung disease guidelines. Basal insulin included long-acting insulin analogues and the delivered background insulin in patients with pump therapy. Bolus insulin included rapid-acting insulin analogues and the delivered insulin to cover postprandial hyperglycemias. Patients with type 1 diabetes showed lower spirometric values in comparison to the control group, together with a higher prevalence of forced expiratory volume in the first second (FEV1) <80% (10.7% vs. 2.7%, p = 0.044) and restrictive ventilatory pattern (10.7% vs. 0%, p = 0.006) The dose of basal insulin (U/kg/day) showed a negative correlation with forced vital capacity (FVC) (r = -0.205, p = 0.012) and FEV1 (r = -0.182, p = 0.026). The optimal cut-off value for identifying patients with a restrictive spirometric pattern was 0.5 U/kg/day of basal insulin. Additionally, basal insulin (U/kg/day) independently predicted the presence of both a restrictive spirometric pattern (OR = 77.1 (3.2 to 1816.6), p = 0.007) and an abnormal FEV1 (OR = 29.9 (1.5 to 562.8), p = 0.023). In patients with type 1 diabetes, higher basal insulin dosage seems to be related with an impairment of pulmonary function. Keywords: basal insulin; bolus insulin; lung function; spirometry; type 1 diabetes Author: Enric Sánchez, Chadia Mizab, Ariadna Sauret, Ferran Barbé, Raquel Martí, Carolina López-Cano, Marta Hernández, Liliana Gutiérrez-Carrasquilla, Paola Carmona, Jessica González, Mireia Dalmases, Cristina Hernández, Rafael Simó and Albert Lecube Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Sat Apr 25 15:26:17 2020 CEST ModDate: Sat Apr 25 15:26:17 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 999113 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- RGODHM+URWPalladioL-Ital Type 1 Custom yes yes no 64 0 FSDXII+URWPalladioL-Bold Type 1 Custom yes yes no 65 0 PQOKRE+Rpxb Type 1 Builtin yes yes no 66 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 67 0 QTLELQ+Pxbsy Type 1 Builtin yes yes no 68 0 ZHKNRQ+URWPalladioL-Roma Type 1 Custom yes yes no 69 0 PODKHO+VnURWPalladioL Type 1 Custom yes yes no 70 0 OFLXAT+Rpxr Type 1 Builtin yes yes no 71 0 YAUXRL+Pxsy Type 1 Builtin yes yes no 72 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 77 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 78 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 97 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 98 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 99 0 QDCWHF+EURM10 Type 1 Builtin yes yes no 133 0 YNURIB+Rpxmi Type 1 Builtin yes yes no 134 0 LYGTIE+URWPalladioL-BoldItal Type 1 Custom yes yes no 158 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 171 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 198 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 199 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 200 0 ABCDEE+Palatino Linotype,BoldItalic TrueType WinAnsi yes yes no 201 0 ABCDEE+Palatino Linotype,Bold CID TrueType Identity-H yes yes yes 202 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 203 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 232 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 233 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 234 0 ABCDEE+Palatino Linotype,BoldItalic TrueType WinAnsi yes yes no 235 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 236 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-18 06:42:50 CET RepresentationInformation: pmc_32344939.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-06 03:47:21 CEST Size: 999113 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰こぴちぴづねづのぴぜ〴ぜ〰はのぜ〴ぜ〰ぅぴとどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰いづびどでのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつべぜ〴ぜ〰ちのつぜ〴ぜ〰いづびっひどばぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつべぜ〴ぜ〰ぐはばふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰がふのでぜ〴ぜ〰うふのっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: こぴちぴづねづのぴぜ〴ぜ〰はのぜ〴ぜ〰ぅぴとどっびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰いづびどでのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつべぜ〴ぜ〰ちのつぜ〴ぜ〰いづびっひどばぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつべぜ〴ぜ〰ぐはばふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰がふのでぜ〴ぜ〰うふのっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いづびどでのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつべぜ〴ぜ〰ちのつぜ〴ぜ〰いづびっひどばぴどはのぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰こぴふつべぜ〴ぜ〰ぐはばふぬちぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰がふのでぜ〴ぜ〰うふのっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きづちびふひづねづのぴぜ〴ぜ〰はてぜ〴ぜ〰がふのでぜ〴ぜ〰うふのっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: RGODHM+URWPalladioL-Ital FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: RGODHM+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: FSDXII+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 150 FontDescriptor: FontName: FSDXII+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PQOKRE+Rpxb FontSubset: true FirstChar: 11 LastChar: 61 FontDescriptor: FontName: PQOKRE+Rpxb Flags: Symbolic FontBBox: -57, -266, 932, 729 FontFile: true Font: BaseFont: JYPLJJ+VnURWPalladioL-Bold FontSubset: true FirstChar: 161 LastChar: 226 FontDescriptor: FontName: JYPLJJ+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QTLELQ+Pxbsy FontSubset: true FirstChar: 121 LastChar: 121 FontDescriptor: FontName: QTLELQ+Pxbsy Flags: Symbolic FontBBox: 5, -978, 1382, 913 FontFile: true Font: BaseFont: ZHKNRQ+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: ZHKNRQ+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QDCWHF+EURM10 FontSubset: true FirstChar: 11 LastChar: 12 FontDescriptor: FontName: QDCWHF+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: PODKHO+VnURWPalladioL FontSubset: true FirstChar: 128 LastChar: 226 FontDescriptor: FontName: PODKHO+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: YNURIB+Rpxmi FontSubset: true FirstChar: 12 LastChar: 12 FontDescriptor: FontName: YNURIB+Rpxmi Flags: Symbolic FontBBox: -70, -289, 949, 802 FontFile: true Font: BaseFont: OFLXAT+Rpxr FontSubset: true FirstChar: 11 LastChar: 62 FontDescriptor: FontName: OFLXAT+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: YAUXRL+Pxsy FontSubset: true FirstChar: 0 LastChar: 121 FontDescriptor: FontName: YAUXRL+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Font: BaseFont: VSHNAE+Rpcxr FontSubset: true FirstChar: 169 LastChar: 169 FontDescriptor: FontName: VSHNAE+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: LYGTIE+URWPalladioL-BoldItal FontSubset: true FirstChar: 110 LastChar: 114 FontDescriptor: FontName: LYGTIE+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 217, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 152, 640, 163, 654 Annotation: Subtype: Link Rect: 178, 626, 189, 640 Annotation: Subtype: Link Rect: 368, 613, 379, 626 Annotation: Subtype: Link Rect: 458, 613, 469, 626 Annotation: Subtype: Link Rect: 159, 602, 170, 613 Annotation: Subtype: Link Rect: 466, 339, 518, 358 Annotation: Subtype: Link Rect: 181, 38, 251, 50 Annotation: Subtype: Link Rect: 418, 38, 519, 50 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 339, 659, 346, 668 ActionDest: 336 Annotation: Subtype: Link Rect: 429, 632, 436, 641 ActionDest: 336 Annotation: Subtype: Link Rect: 508, 604, 515, 614 ActionDest: 336 Annotation: Subtype: Link Rect: 299, 578, 306, 587 ActionDest: 336 Annotation: Subtype: Link Rect: 307, 577, 313, 587 ActionDest: 336 Annotation: Subtype: Link Rect: 384, 537, 391, 546 ActionDest: 336 Annotation: Subtype: Link Rect: 392, 537, 399, 546 ActionDest: 336 Annotation: Subtype: Link Rect: 185, 523, 192, 533 ActionDest: 336 Annotation: Subtype: Link Rect: 130, 510, 137, 519 ActionDest: 336 Annotation: Subtype: Link Rect: 430, 483, 437, 492 ActionDest: 336 Annotation: Subtype: Link Rect: 437, 483, 444, 492 ActionDest: 336 Annotation: Subtype: Link Rect: 445, 483, 452, 492 ActionDest: 336 Annotation: Subtype: Link Rect: 260, 442, 267, 452 ActionDest: 336 Annotation: Subtype: Link Rect: 267, 442, 279, 452 ActionDest: 336 Annotation: Subtype: Link Rect: 438, 402, 450, 411 ActionDest: 336 Annotation: Subtype: Link Rect: 387, 361, 399, 370 ActionDest: 336 Annotation: Subtype: Link Rect: 402, 361, 414, 370 ActionDest: 364 Annotation: Subtype: Link Rect: 172, 117, 184, 127 ActionDest: 364 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 246, 742, 258, 752 ActionDest: 364 Annotation: Subtype: Link Rect: 333, 388, 340, 400 ActionDest: 154 Annotation: Subtype: Link Rect: 410, 351, 422, 360 ActionDest: 364 Annotation: Subtype: Link Rect: 451, 337, 463, 346 ActionDest: 364 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 438, 713, 445, 725 ActionDest: 167 Annotation: Subtype: Link Rect: 322, 384, 334, 393 ActionDest: 364 Annotation: Subtype: Link Rect: 103, 330, 115, 339 ActionDest: 364 Annotation: Subtype: Link Rect: 361, 276, 373, 285 ActionDest: 364 Annotation: Subtype: Link Rect: 283, 235, 295, 244 ActionDest: 364 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 447, 562, 454, 574 ActionDest: 182 Annotation: Subtype: Link Rect: 273, 153, 281, 165 ActionDest: 191 Annotation: Subtype: Link Rect: 304, 139, 311, 151 ActionDest: 191 Annotation: Subtype: Link Rect: 508, 99, 515, 111 ActionDest: 191 Page: Sequence: 6 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 318, 672, 325, 684 ActionDest: 259 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 126, 702, 138, 711 ActionDest: 364 Annotation: Subtype: Link Rect: 217, 634, 229, 644 ActionDest: 364 Annotation: Subtype: Link Rect: 127, 594, 139, 603 ActionDest: 364 Annotation: Subtype: Link Rect: 299, 567, 311, 576 ActionDest: 364 Annotation: Subtype: Link Rect: 368, 540, 374, 549 ActionDest: 336 Annotation: Subtype: Link Rect: 220, 486, 232, 495 ActionDest: 364 Annotation: Subtype: Link Rect: 151, 445, 163, 454 ActionDest: 364 Annotation: Subtype: Link Rect: 503, 432, 515, 441 ActionDest: 364 Annotation: Subtype: Link Rect: 183, 391, 195, 400 ActionDest: 364 Annotation: Subtype: Link Rect: 305, 310, 317, 319 ActionDest: 364 Annotation: Subtype: Link Rect: 459, 283, 466, 292 ActionDest: 336 Annotation: Subtype: Link Rect: 467, 283, 479, 292 ActionDest: 364 Annotation: Subtype: Link Rect: 232, 256, 244, 265 ActionDest: 336 Annotation: Subtype: Link Rect: 247, 256, 259, 265 ActionDest: 364 Annotation: Subtype: Link Rect: 148, 202, 160, 211 ActionDest: 336 Annotation: Subtype: Link Rect: 163, 202, 174, 211 ActionDest: 364 Annotation: Subtype: Link Rect: 388, 188, 400, 198 ActionDest: 336 Annotation: Subtype: Link Rect: 400, 189, 412, 198 ActionDest: 364 Annotation: Subtype: Link Rect: 178, 148, 190, 157 ActionDest: 364 Annotation: Subtype: Link Rect: 456, 80, 468, 90 ActionDest: 364 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 168, 661, 180, 671 ActionDest: 336 Annotation: Subtype: Link Rect: 262, 567, 274, 576 ActionDest: 364 Annotation: Subtype: Link Rect: 274, 567, 286, 576 ActionDest: 364 Annotation: Subtype: Link Rect: 244, 526, 256, 535 ActionDest: 364 Annotation: Subtype: Link Rect: 144, 499, 156, 508 ActionDest: 364 Annotation: Subtype: Link Rect: 346, 445, 358, 454 ActionDest: 364 Annotation: Subtype: Link Rect: 124, 378, 136, 387 ActionDest: 372 Annotation: Subtype: Link Rect: 310, 351, 322, 360 ActionDest: 336 Annotation: Subtype: Link Rect: 363, 297, 375, 306 ActionDest: 372 Annotation: Subtype: Link Rect: 337, 81, 518, 92 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 100, 506, 137, 516 Annotation: Subtype: Link Rect: 143, 506, 179, 516 Annotation: Subtype: Link Rect: 141, 480, 178, 490 Annotation: Subtype: Link Rect: 185, 480, 221, 490 Annotation: Subtype: Link Rect: 150, 454, 186, 464 Annotation: Subtype: Link Rect: 469, 428, 506, 439 Annotation: Subtype: Link Rect: 368, 389, 405, 400 Annotation: Subtype: Link Rect: 100, 351, 137, 361 Annotation: Subtype: Link Rect: 384, 324, 421, 335 Annotation: Subtype: Link Rect: 100, 274, 137, 284 Annotation: Subtype: Link Rect: 327, 208, 364, 219 Annotation: Subtype: Link Rect: 376, 169, 413, 180 Annotation: Subtype: Link Rect: 419, 169, 456, 180 Annotation: Subtype: Link Rect: 478, 144, 516, 154 Annotation: Subtype: Link Rect: 100, 132, 136, 142 Annotation: Subtype: Link Rect: 383, 93, 420, 103 Annotation: Subtype: Link Rect: 426, 93, 462, 103 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 256, 715, 294, 725 Annotation: Subtype: Link Rect: 355, 675, 392, 686 Annotation: Subtype: Link Rect: 150, 638, 187, 648 Annotation: Subtype: Link Rect: 355, 598, 392, 609 Annotation: Subtype: Link Rect: 479, 585, 516, 596 Annotation: Subtype: Link Rect: 150, 547, 187, 557 Annotation: Subtype: Link Rect: 401, 508, 439, 519 Annotation: Subtype: Link Rect: 154, 457, 191, 467 Annotation: Subtype: Link Rect: 198, 457, 234, 467 Annotation: Subtype: Link Rect: 265, 430, 303, 441 Annotation: Subtype: Link Rect: 309, 430, 345, 441 Annotation: Subtype: Link Rect: 332, 404, 369, 415 Annotation: Subtype: Link Rect: 154, 366, 190, 376 Annotation: Subtype: Link Rect: 285, 340, 323, 351 Annotation: Subtype: Link Rect: 329, 340, 365, 351 Annotation: Subtype: Link Rect: 145, 289, 182, 299 Annotation: Subtype: Link Rect: 359, 249, 396, 260 Annotation: Subtype: Link Rect: 367, 211, 404, 222 Annotation: Subtype: Link Rect: 447, 185, 485, 196 Annotation: Subtype: Link Rect: 159, 121, 196, 131 Annotation: Subtype: Link Rect: 202, 121, 238, 131 Annotation: Subtype: Link Rect: 426, 94, 464, 105 Annotation: Subtype: Link Rect: 470, 94, 506, 105 Annotation: Subtype: Link Rect: 389, 69, 427, 80 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 150, 715, 187, 725 Annotation: Subtype: Link Rect: 191, 676, 228, 686 Annotation: Subtype: Link Rect: 76, 634, 166, 665 Annotation: Subtype: Link Rect: 234, 629, 407, 639 Checksum: addbec0a Type: CRC32 Checksum: e703e1302e8e741f742d86d39e7c777c Type: MD5 Checksum: 10801d6433f19648e2150c231dead06c9f58d079 Type: SHA-1