538043b73aaf70b1033821e510fee989  pmc_32368692.pdf
f57cbe1423f8962931c0f94683281bd418c9f212  pmc_32368692.pdf
29fa087ef49c6aa4eb1f0d66f0183ccc90d830c5b2aa7c02ac6d39fd322ca5d2  pmc_32368692.pdf

Title:           Design of the β3-Adrenergic Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure Trial
Subject:         JACC: Basic to Translational Science, 5 (2020) 317-327. doi:10.1016/j.jacbts.2020.01.009
Author:          Ines Garcia-Lunar MD
Creator:         Elsevier
Producer:        Acrobat Distiller 8.1.0 (Windows)
CreationDate:    18th April 2020
ModDate:         Sat Apr 18 07:53:20 2020 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           11
Encrypted:       no
Page size:       576 x 773.972 pts
Page rot:        0
File size:       1298213 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
OOOJLA+AdvOT61751f86                 Type 1C           WinAnsi          yes yes no    1079  0
OOOJMB+AdvPSSym                      Type 1C           WinAnsi          yes yes no    1081  0
OOOINK+AdvOT5b669f61                 Type 1C           WinAnsi          yes yes no    1046  0
OOOINL+AdvOTa2a4c9ce                 Type 1C           WinAnsi          yes yes no    1048  0
OOOINM+AdvPS3F4C13                   Type 1C           WinAnsi          yes yes no    1050  0
OOOINN+AdvOTe81213fa                 Type 1C           WinAnsi          yes yes no    1052  0
OOOJJJ+AdvOT2986fa51                 Type 1C           WinAnsi          yes yes no    1066  0
OOOJKK+AdvOT2986fa51+20              Type 1C           WinAnsi          yes yes no    1056  0
OOOJKL+AdvOT8f503d4a                 Type 1C           WinAnsi          yes yes no    1058  0
OOOJKM+AdvP4C4E74                    Type 1C           Custom           yes yes yes   1063  0
OOOJKN+AdvOTc3f2c111.B               Type 1C           WinAnsi          yes yes no    1067  0
OOOJKO+AdvOTc3f2c111.B+fb            Type 1C           Custom           yes yes yes   1072  0
OOOJKP+AdvPS4BD310                   Type 1C           WinAnsi          yes yes no    1074  0
OOOJNB+AdvOT2986fa51+fb              Type 1C           Custom           yes yes yes    711  0
OOOJNC+AdvOT78d326c7                 Type 1C           WinAnsi          yes yes no     706  0
OOOJND+AdvOTe81213fa+20              Type 1C           WinAnsi          yes yes no     716  0
OOOJOE+AdvOTe81213fa+fb              Type 1C           Custom           yes yes yes    712  0
OOOJPG+AdvOT1a97e067.I               Type 1C           WinAnsi          yes yes no     713  0
OOOJPH+AdvOTd9ad3ae4.I               Type 1C           WinAnsi          yes yes no     725  0
OOOJPI+AdvOT61751f86+20              Type 1C           WinAnsi          yes yes no     728  0
OOOKAI+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     732  0
OOOKBJ+AdvOTe60b6cd3.B               Type 1C           WinAnsi          yes yes no     742  0
OOOKBK+AdvOT8817665d                 Type 1C           WinAnsi          yes yes no     740  0
OOOKCK+AdvPS480274                   Type 1C           WinAnsi          yes yes no     743  0
OOOLAG+AdvPS44A44B                   Type 1C           WinAnsi          yes yes no     751  0
OOONGJ+AdvOTf2345705                 Type 1C           WinAnsi          yes yes no     764  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-10-02 04:10:37 CEST
 RepresentationInformation: pmc_32368692.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-03-31 11:46:25 CEST
  Size: 1298213
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid indirect destination - referenced object 'aff11' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff2' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff4' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff13' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff9' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff5' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff10' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff15' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff7' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff8' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff12' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff3' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff14' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff6' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff7' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff12' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff2' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff4' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff15' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff10' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff6' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff13' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff3' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff8' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff11' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff9' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff5' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff14' cannot be found
   ID: PDF-HUL-122
   Offset: 1261281
  ErrorMessage: Improperly formed date
   ID: PDF-HUL-133
   Offset: 1279140
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 1141
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Design of the β3-Adrenergic Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure Trial
      Destination: titlink1
      Children: 
       Item: 
        Title: Methods
        Destination: flink1
        Children: 
         Item: 
          Title: Study hypothesis
          Destination: slink1
         Item: 
          Title: Study endpoints
          Destination: slink2
          Children: 
           Item: 
            Title: Efficacy measures
            Destination: thirlink1
         Item: 
          Title: Study population and inclusion/exclusion criteria
          Destination: slink3
         Item: 
          Title: Study design
          Destination: slink4
         Item: 
          Title: Sample size
          Destination: slink5
          Children: 
           Item: 
            Title: Manufacturing of study medication
            Destination: thirlink2
         Item: 
          Title: Statistical methods
          Destination: slink6
          Children: 
           Item: 
            Title: Randomization procedure
            Destination: thirlink3
           Item: 
            Title: Statistical analysis
            Destination: thirlink4
         Item: 
          Title: Description of the study procedures and examinations
          Destination: slink7
          Children: 
           Item: 
            Title: Right heart catheterization
            Destination: thirlink5
           Item: 
            Title: 6-min walking test
            Destination: thirlink6
           Item: 
            Title: Quality of life questionnaire
            Destination: thirlink7
           Item: 
            Title: Physical examination
            Destination: thirlink8
           Item: 
            Title: Blood samples
            Destination: thirlink9
           Item: 
            Title: ECG
            Destination: thirlink10
           Item: 
            Title: Echocardiography
            Destination: thirlink11
           Item: 
            Title: CMR
            Destination: thirlink12
           Item: 
            Title: CMR analysis
            Destination: thirlink13
           Item: 
            Title: CCT
            Destination: thirlink14
         Item: 
          Title: Duration of the study
          Destination: slink8
       Item: 
        Title: Discussion
        Destination: flink2
        Children: 
         Item: 
          Title: Study limitations
          Destination: slink9
       Item: 
        Title: Conclusions
        Destination: flink3
       Item: 
        Title: References
        Destination: blink1
   Info: 
    Title: Design of the β3-Adrenergic Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure Trial
    Author: Ines Garcia-Lunar MD
    Subject: JACC: Basic to Translational Science, 5 (2020) 317-327. doi:10.1016/j.jacbts.2020.01.009
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
   ID: 0x302bb090526dbe662cabf145bc8c3e9c, 0xacb05678449d634699c63ff87ed4f780
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1046
      ImageHeight: 697
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1595
      ImageHeight: 527
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1968
      ImageHeight: 1036
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: OOOJNC+AdvOT78d326c7
      FontSubset: true
      FirstChar: 80
      LastChar: 80
      FontDescriptor: 
       FontName: OOOJNC+AdvOT78d326c7
       Flags: Nonsymbolic
       FontBBox: -41, -260, 979, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJNB+AdvOT2986fa51+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OOOJNB+AdvOT2986fa51+fb
       Flags: Symbolic
       FontBBox: 19, 0, 916, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OOOJOE+AdvOTe81213fa+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OOOJOE+AdvOTe81213fa+fb
       Flags: Symbolic
       FontBBox: 19, 0, 947, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OOOJPG+AdvOT1a97e067.I
      FontSubset: true
      FirstChar: 58
      LastChar: 116
      FontDescriptor: 
       FontName: OOOJPG+AdvOT1a97e067.I
       Flags: Serif, Nonsymbolic
       FontBBox: -156, -239, 1062, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJND+AdvOTe81213fa+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: OOOJND+AdvOTe81213fa+20
       Flags: Nonsymbolic
       FontBBox: -187, -125, 1250, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJPH+AdvOTd9ad3ae4.I
      FontSubset: true
      FirstChar: 97
      LastChar: 116
      FontDescriptor: 
       FontName: OOOJPH+AdvOTd9ad3ae4.I
       Flags: Nonsymbolic
       FontBBox: -135, -239, 927, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOINK+AdvOT5b669f61
      FontSubset: true
      FirstChar: 46
      LastChar: 90
      FontDescriptor: 
       FontName: OOOINK+AdvOT5b669f61
       Flags: Nonsymbolic
       FontBBox: -41, -197, 1083, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOINL+AdvOTa2a4c9ce
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: OOOINL+AdvOTa2a4c9ce
       Flags: Nonsymbolic
       FontBBox: -20, -197, 1072, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJPI+AdvOT61751f86+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: OOOJPI+AdvOT61751f86+20
       Flags: Nonsymbolic
       FontBBox: -187, -197, 1031, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOINM+AdvPS3F4C13
      FontSubset: true
      FirstChar: 98
      LastChar: 98
      FontDescriptor: 
       FontName: OOOINM+AdvPS3F4C13
       Flags: Nonsymbolic
       FontBBox: 0, -291, 875, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOINN+AdvOTe81213fa
      FontSubset: true
      FirstChar: 37
      LastChar: 243
      FontDescriptor: 
       FontName: OOOINN+AdvOTe81213fa
       Flags: Serif, Nonsymbolic
       FontBBox: -31, -239, 989, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOKAI+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: OOOKAI+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJKK+AdvOT2986fa51+20
      FontSubset: true
      FirstChar: 134
      LastChar: 150
      FontDescriptor: 
       FontName: OOOJKK+AdvOT2986fa51+20
       Flags: Nonsymbolic
       FontBBox: -145, -114, 1270, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJKL+AdvOT8f503d4a
      FontSubset: true
      FirstChar: 45
      LastChar: 114
      FontDescriptor: 
       FontName: OOOJKL+AdvOT8f503d4a
       Flags: Nonsymbolic
       FontBBox: -52, -197, 1093, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOKBK+AdvOT8817665d
      FontSubset: true
      FirstChar: 35
      LastChar: 36
      FontDescriptor: 
       FontName: OOOKBK+AdvOT8817665d
       Flags: Nonsymbolic
       FontBBox: -20, -208, 1000, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOKBJ+AdvOTe60b6cd3.B
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: OOOKBJ+AdvOTe60b6cd3.B
       Flags: Nonsymbolic
       FontBBox: -52, -250, 947, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJKM+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 254
      FontDescriptor: 
       FontName: OOOJKM+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OOOKCK+AdvPS480274
      FontSubset: true
      FirstChar: 86
      LastChar: 86
      FontDescriptor: 
       FontName: OOOKCK+AdvPS480274
       Flags: Nonsymbolic
       FontBBox: 0, -208, 1354, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJJJ+AdvOT2986fa51
      FontSubset: true
      FirstChar: 37
      LastChar: 169
      FontDescriptor: 
       FontName: OOOJJJ+AdvOT2986fa51
       Flags: Nonsymbolic
       FontBBox: -52, -239, 885, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJKN+AdvOTc3f2c111.B
      FontSubset: true
      FirstChar: 40
      LastChar: 223
      FontDescriptor: 
       FontName: OOOJKN+AdvOTc3f2c111.B
       Flags: Nonsymbolic
       FontBBox: -52, -250, 927, 1000
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOLAG+AdvPS44A44B
      FontSubset: true
      FirstChar: 100
      LastChar: 100
      FontDescriptor: 
       FontName: OOOLAG+AdvPS44A44B
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1000, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJKO+AdvOTc3f2c111.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OOOJKO+AdvOTc3f2c111.B+fb
       Flags: Symbolic
       FontBBox: 19, 0, 937, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OOOJKP+AdvPS4BD310
      FontSubset: true
      FirstChar: 98
      LastChar: 98
      FontDescriptor: 
       FontName: OOOJKP+AdvPS4BD310
       Flags: Nonsymbolic
       FontBBox: 0, -208, 989, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJLA+AdvOT61751f86
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: OOOJLA+AdvOT61751f86
       Flags: Nonsymbolic
       FontBBox: -10, -197, 916, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOOJMB+AdvPSSym
      FontSubset: true
      FirstChar: 170
      LastChar: 170
      FontDescriptor: 
       FontName: OOOJMB+AdvPSSym
       Flags: Nonsymbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OOONGJ+AdvOTf2345705
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: OOONGJ+AdvOTf2345705
       Flags: Nonsymbolic
       FontBBox: -62, -239, 895, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.jacbts.2020.01.009</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Design of the &amp;beta;3-Adrenergic Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart&amp;nbsp;Failure&amp;nbsp;Trial</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Ines Garcia-Lunar MD</rdf:li>
               <rdf:li>Isabel Blanco PhD</rdf:li>
               <rdf:li>Leticia Fernández-Friera PhD</rdf:li>
               <rdf:li>Susanna Prat-Gonzàlez PhD</rdf:li>
               <rdf:li>Paloma Jordà MD</rdf:li>
               <rdf:li>Javier Sánchez PhD</rdf:li>
               <rdf:li>Daniel Pereda PhD</rdf:li>
               <rdf:li>Sandra Pujadas MD</rdf:li>
               <rdf:li>Mercedes Rivas PhD</rdf:li>
               <rdf:li>Eduard Solé-Gonzalez MD</rdf:li>
               <rdf:li>Jorge Vázquez MD</rdf:li>
               <rdf:li>Zorba Blázquez MD</rdf:li>
               <rdf:li>Juan García-Picart MD</rdf:li>
               <rdf:li>Pedro Caravaca MD</rdf:li>
               <rdf:li>Noemí Escalera BPT</rdf:li>
               <rdf:li>Pablo Garcia-Pavia PhD</rdf:li>
               <rdf:li>Juan Delgado PhD</rdf:li>
               <rdf:li>Javier Segovia-Cubero PhD</rdf:li>
               <rdf:li>Valentín Fuster PhD</rdf:li>
               <rdf:li>Eulalia Roig PhD</rdf:li>
               <rdf:li>Joan Albert Barberá PhD</rdf:li>
               <rdf:li>Borja Ibanez PhD</rdf:li>
               <rdf:li>Ana García-Álvarez PhD</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>adrenoreceptors</rdf:li>
               <rdf:li>imaging</rdf:li>
               <rdf:li>pulmonary hypertension</rdf:li>
               <rdf:li>treatment</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">JACC: Basic to Translational Science, 5 (2020) 317-327. doi:10.1016/j.jacbts.2020.01.009</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>JACC: Basic to Translational Science</prism:publicationName>
         <prism:copyright>© 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.</prism:copyright>
         <prism:issn>2452-302X</prism:issn>
         <prism:volume>5</prism:volume>
         <prism:number>4</prism:number>
         <prism:coverDisplayDate>April 2020</prism:coverDisplayDate>
         <prism:pageRange>317-327</prism:pageRange>
         <prism:startingPage>317</prism:startingPage>
         <prism:endingPage>327</prism:endingPage>
         <prism:doi>10.1016/j.jacbts.2020.01.009</prism:doi>
         <prism:url>https://doi.org/10.1016/j.jacbts.2020.01.009</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.jacbts.2020.01.009</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>6.5</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.jacbts.2020.01.009</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CreationDate--Text>18th April 2020</pdfx:CreationDate--Text>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:ModifyDate>2020-04-18T11:23:20+05:30</xap:ModifyDate>
         <xap:MetadataDate>2020-04-18T11:23:20+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>18th April 2020</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:2f9a610e-9b8a-4a17-a2ce-adf387e8d32a</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:738c9348-a2e8-4fe5-afda-2d51db53798f</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 317
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 198, 512, 201, 519
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 203, 512, 206, 519
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 208, 512, 211, 519
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 284, 512, 287, 519
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 289, 512, 292, 519
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 407, 512, 410, 519
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 412, 512, 415, 519
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 417, 512, 419, 519
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 527, 512, 530, 519
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 183, 500, 186, 508
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 264, 500, 267, 508
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 269, 500, 273, 508
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 348, 500, 351, 508
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 353, 500, 356, 508
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 435, 500, 436, 508
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 518, 500, 520, 508
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 214, 488, 216, 496
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 291, 488, 294, 496
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 296, 488, 299, 496
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 378, 488, 380, 496
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 469, 488, 471, 496
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 190, 476, 191, 484
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 273, 476, 276, 484
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 277, 476, 281, 484
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 373, 476, 376, 484
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 378, 476, 381, 484
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 383, 476, 388, 484
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 462, 476, 466, 484
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 467, 476, 469, 484
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 216, 464, 220, 472
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 221, 464, 225, 472
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 306, 464, 309, 472
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 311, 464, 314, 472
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 383, 464, 384, 472
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 481, 464, 485, 472
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 486, 464, 490, 472
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 181, 452, 184, 460
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 185, 452, 189, 460
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 190, 452, 194, 460
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 286, 452, 289, 460
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 291, 452, 294, 460
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 296, 452, 299, 460
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 407, 20, 537, 27
      Annotation: 
       Subtype: Link
       Rect: 513, 597, 537, 621
      Annotation: 
       Subtype: Link
       Rect: 202, 703, 364, 708
    Page: 
     Label: 318
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 450, 557, 498, 564
      Annotation: 
       Subtype: Link
       Rect: 178, 521, 355, 529
      Annotation: 
       Subtype: Link
       Rect: 192, 460, 196, 467
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 198, 460, 203, 467
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 242, 436, 254, 443
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 171, 352, 176, 360
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 178, 352, 182, 360
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 144, 328, 149, 336
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 193, 268, 197, 276
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 200, 268, 205, 276
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 354, 472, 362, 479
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 501, 472, 508, 479
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 510, 472, 518, 479
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 390, 412, 397, 419
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 400, 412, 408, 419
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 442, 388, 462, 396
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 446, 328, 454, 336
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 457, 328, 465, 336
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 238, 52, 308, 58
    Page: 
     Label: 319
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 142, 646, 151, 654
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 154, 646, 162, 654
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 198, 587, 207, 594
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 44, 503, 53, 511
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 157, 455, 179, 463
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 221, 455, 242, 463
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 44, 360, 54, 367
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 96, 348, 116, 355
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 44, 240, 53, 248
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 436, 246, 463, 254
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 345, 76, 376, 83
       Destination: 51
    Page: 
     Label: 320
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 200, 144, 228, 152
       Destination: 51
      Annotation: 
       Subtype: Link
       Rect: 233, 144, 263, 152
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 506, 228, 534, 236
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 159, 500, 162, 506
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 488, 457, 491, 464
       Destination: 42
    Page: 
     Label: 321
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 51, 446, 78, 454
       Destination: 51
      Annotation: 
       Subtype: Link
       Rect: 126, 348, 135, 355
       Destination: 318
    Page: 
     Label: 322
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 332, 143, 335, 150
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 343, 117, 346, 123
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 334, 82, 337, 89
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 132, 47, 152, 52
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 164, 47, 167, 52
       Destination: 51
    Page: 
     Label: 323
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 169, 85, 179, 92
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 379, 360, 388, 367
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 390, 360, 399, 367
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 429, 85, 452, 92
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 262, 37, 299, 44
       Destination: 59
    Page: 
     Label: 324
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 186, 276, 196, 284
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 350, 539, 416, 547
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 459, 419, 468, 427
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 370, 348, 438, 355
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 446, 348, 456, 355
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 384, 120, 452, 128
       Destination: 59
    Page: 
     Label: 325
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 44, 622, 49, 630
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 52, 622, 61, 630
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 196, 563, 205, 570
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 146, 527, 150, 535
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 125, 515, 134, 523
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 106, 408, 115, 416
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 141, 396, 148, 404
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 150, 396, 158, 404
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 235, 325, 242, 332
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 76, 241, 96, 249
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 235, 181, 242, 189
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 44, 133, 53, 141
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 55, 133, 64, 141
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 306, 587, 311, 594
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 262, 527, 272, 535
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 433, 336, 442, 343
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 407, 324, 411, 331
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 414, 324, 419, 331
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 422, 324, 426, 331
       Destination: 114
      Annotation: 
       Subtype: Link
       Rect: 429, 324, 450, 331
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 416, 97, 425, 104
       Destination: 318
    Page: 
     Label: 326
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 611, 232, 618
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 235, 611, 244, 618
       Destination: 318
      Annotation: 
       Subtype: Link
       Rect: 229, 457, 295, 465
      Annotation: 
       Subtype: Link
       Rect: 109, 445, 184, 453
      Annotation: 
       Subtype: Link
       Rect: 278, 398, 315, 405
      Annotation: 
       Subtype: Link
       Rect: 109, 386, 136, 393
      Annotation: 
       Subtype: Link
       Rect: 115, 338, 243, 344
      Annotation: 
       Subtype: Link
       Rect: 109, 329, 243, 335
      Annotation: 
       Subtype: Link
       Rect: 109, 320, 243, 326
      Annotation: 
       Subtype: Link
       Rect: 109, 311, 243, 317
      Annotation: 
       Subtype: Link
       Rect: 109, 302, 197, 308
      Annotation: 
       Subtype: Link
       Rect: 116, 290, 243, 296
      Annotation: 
       Subtype: Link
       Rect: 109, 281, 243, 287
      Annotation: 
       Subtype: Link
       Rect: 109, 272, 243, 278
      Annotation: 
       Subtype: Link
       Rect: 109, 263, 243, 269
      Annotation: 
       Subtype: Link
       Rect: 109, 254, 138, 260
      Annotation: 
       Subtype: Link
       Rect: 116, 241, 243, 247
      Annotation: 
       Subtype: Link
       Rect: 109, 232, 243, 238
      Annotation: 
       Subtype: Link
       Rect: 109, 223, 130, 229
      Annotation: 
       Subtype: Link
       Rect: 117, 210, 243, 216
      Annotation: 
       Subtype: Link
       Rect: 109, 201, 243, 207
      Annotation: 
       Subtype: Link
       Rect: 109, 192, 243, 198
      Annotation: 
       Subtype: Link
       Rect: 109, 184, 127, 190
      Annotation: 
       Subtype: Link
       Rect: 116, 171, 243, 177
      Annotation: 
       Subtype: Link
       Rect: 109, 162, 243, 168
      Annotation: 
       Subtype: Link
       Rect: 109, 153, 243, 159
      Annotation: 
       Subtype: Link
       Rect: 109, 144, 219, 150
      Annotation: 
       Subtype: Link
       Rect: 117, 131, 243, 137
      Annotation: 
       Subtype: Link
       Rect: 109, 122, 243, 128
      Annotation: 
       Subtype: Link
       Rect: 109, 113, 243, 119
      Annotation: 
       Subtype: Link
       Rect: 109, 104, 220, 110
      Annotation: 
       Subtype: Link
       Rect: 116, 92, 243, 98
      Annotation: 
       Subtype: Link
       Rect: 109, 83, 243, 89
      Annotation: 
       Subtype: Link
       Rect: 109, 74, 243, 80
      Annotation: 
       Subtype: Link
       Rect: 109, 65, 194, 71
      Annotation: 
       Subtype: Link
       Rect: 117, 52, 243, 58
      Annotation: 
       Subtype: Link
       Rect: 109, 43, 243, 49
      Annotation: 
       Subtype: Link
       Rect: 255, 338, 388, 344
      Annotation: 
       Subtype: Link
       Rect: 255, 329, 388, 335
      Annotation: 
       Subtype: Link
       Rect: 255, 320, 388, 326
      Annotation: 
       Subtype: Link
       Rect: 255, 311, 388, 317
      Annotation: 
       Subtype: Link
       Rect: 255, 302, 388, 308
      Annotation: 
       Subtype: Link
       Rect: 255, 293, 388, 299
      Annotation: 
       Subtype: Link
       Rect: 255, 284, 388, 290
      Annotation: 
       Subtype: Link
       Rect: 255, 275, 388, 281
      Annotation: 
       Subtype: Link
       Rect: 255, 266, 273, 272
      Annotation: 
       Subtype: Link
       Rect: 262, 252, 388, 258
      Annotation: 
       Subtype: Link
       Rect: 255, 243, 388, 249
      Annotation: 
       Subtype: Link
       Rect: 255, 234, 326, 240
      Annotation: 
       Subtype: Link
       Rect: 330, 234, 334, 240
      Annotation: 
       Subtype: Link
       Rect: 265, 220, 388, 226
      Annotation: 
       Subtype: Link
       Rect: 255, 211, 388, 217
      Annotation: 
       Subtype: Link
       Rect: 255, 202, 388, 208
      Annotation: 
       Subtype: Link
       Rect: 255, 193, 388, 199
      Annotation: 
       Subtype: Link
       Rect: 255, 184, 352, 190
      Annotation: 
       Subtype: Link
       Rect: 263, 170, 388, 176
      Annotation: 
       Subtype: Link
       Rect: 255, 161, 388, 167
      Annotation: 
       Subtype: Link
       Rect: 255, 152, 388, 158
      Annotation: 
       Subtype: Link
       Rect: 255, 143, 388, 149
      Annotation: 
       Subtype: Link
       Rect: 255, 134, 388, 140
      Annotation: 
       Subtype: Link
       Rect: 255, 125, 270, 131
      Annotation: 
       Subtype: Link
       Rect: 264, 111, 388, 117
      Annotation: 
       Subtype: Link
       Rect: 255, 102, 388, 108
      Annotation: 
       Subtype: Link
       Rect: 255, 93, 375, 99
      Annotation: 
       Subtype: Link
       Rect: 264, 80, 388, 86
      Annotation: 
       Subtype: Link
       Rect: 255, 71, 388, 77
      Annotation: 
       Subtype: Link
       Rect: 255, 62, 388, 68
      Annotation: 
       Subtype: Link
       Rect: 255, 53, 388, 59
      Annotation: 
       Subtype: Link
       Rect: 255, 44, 277, 50
      Annotation: 
       Subtype: Link
       Rect: 410, 338, 534, 344
      Annotation: 
       Subtype: Link
       Rect: 400, 329, 534, 335
      Annotation: 
       Subtype: Link
       Rect: 400, 320, 534, 326
      Annotation: 
       Subtype: Link
       Rect: 400, 311, 534, 317
      Annotation: 
       Subtype: Link
       Rect: 400, 302, 475, 308
      Annotation: 
       Subtype: Link
       Rect: 410, 290, 534, 296
      Annotation: 
       Subtype: Link
       Rect: 400, 281, 534, 287
      Annotation: 
       Subtype: Link
       Rect: 400, 272, 534, 278
      Annotation: 
       Subtype: Link
       Rect: 400, 263, 534, 269
      Annotation: 
       Subtype: Link
       Rect: 400, 254, 481, 260
      Annotation: 
       Subtype: Link
       Rect: 410, 242, 534, 248
      Annotation: 
       Subtype: Link
       Rect: 400, 233, 534, 239
      Annotation: 
       Subtype: Link
       Rect: 400, 224, 534, 230
      Annotation: 
       Subtype: Link
       Rect: 400, 215, 534, 221
      Annotation: 
       Subtype: Link
       Rect: 400, 206, 534, 212
      Annotation: 
       Subtype: Link
       Rect: 400, 197, 446, 203
      Annotation: 
       Subtype: Link
       Rect: 410, 184, 534, 190
      Annotation: 
       Subtype: Link
       Rect: 400, 176, 534, 181
      Annotation: 
       Subtype: Link
       Rect: 400, 167, 534, 173
      Annotation: 
       Subtype: Link
       Rect: 400, 158, 534, 164
      Annotation: 
       Subtype: Link
       Rect: 400, 149, 534, 155
      Annotation: 
       Subtype: Link
       Rect: 400, 140, 431, 146
      Annotation: 
       Subtype: Link
       Rect: 410, 127, 534, 133
      Annotation: 
       Subtype: Link
       Rect: 400, 118, 534, 124
      Annotation: 
       Subtype: Link
       Rect: 400, 109, 534, 115
      Annotation: 
       Subtype: Link
       Rect: 400, 100, 534, 106
      Annotation: 
       Subtype: Link
       Rect: 400, 91, 534, 97
      Annotation: 
       Subtype: Link
       Rect: 400, 82, 534, 88
      Annotation: 
       Subtype: Link
       Rect: 400, 73, 422, 79
      Annotation: 
       Subtype: Link
       Rect: 410, 61, 534, 67
      Annotation: 
       Subtype: Link
       Rect: 400, 52, 534, 58
      Annotation: 
       Subtype: Link
       Rect: 400, 43, 534, 49
    Page: 
     Label: 327
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 41, 672, 175, 678
      Annotation: 
       Subtype: Link
       Rect: 41, 663, 175, 669
      Annotation: 
       Subtype: Link
       Rect: 41, 654, 85, 660
      Annotation: 
       Subtype: Link
       Rect: 52, 642, 175, 648
      Annotation: 
       Subtype: Link
       Rect: 41, 633, 175, 639
      Annotation: 
       Subtype: Link
       Rect: 41, 624, 175, 630
      Annotation: 
       Subtype: Link
       Rect: 41, 615, 175, 621
      Annotation: 
       Subtype: Link
       Rect: 41, 606, 121, 612
      Annotation: 
       Subtype: Link
       Rect: 51, 593, 175, 599
      Annotation: 
       Subtype: Link
       Rect: 41, 584, 175, 590
      Annotation: 
       Subtype: Link
       Rect: 41, 575, 175, 581
      Annotation: 
       Subtype: Link
       Rect: 41, 566, 175, 572
      Annotation: 
       Subtype: Link
       Rect: 41, 557, 175, 563
      Annotation: 
       Subtype: Link
       Rect: 41, 548, 106, 554
      Annotation: 
       Subtype: Link
       Rect: 51, 536, 175, 542
      Annotation: 
       Subtype: Link
       Rect: 41, 527, 175, 533
      Annotation: 
       Subtype: Link
       Rect: 41, 518, 165, 524
      Annotation: 
       Subtype: Link
       Rect: 51, 505, 175, 511
      Annotation: 
       Subtype: Link
       Rect: 41, 496, 175, 502
      Annotation: 
       Subtype: Link
       Rect: 41, 487, 160, 493
      Annotation: 
       Subtype: Link
       Rect: 52, 475, 175, 481
      Annotation: 
       Subtype: Link
       Rect: 41, 466, 175, 472
      Annotation: 
       Subtype: Link
       Rect: 41, 457, 175, 463
      Annotation: 
       Subtype: Link
       Rect: 41, 448, 175, 454
      Annotation: 
       Subtype: Link
       Rect: 41, 439, 175, 445
      Annotation: 
       Subtype: Link
       Rect: 41, 430, 64, 436
      Annotation: 
       Subtype: Link
       Rect: 51, 418, 175, 424
      Annotation: 
       Subtype: Link
       Rect: 41, 409, 175, 415
      Annotation: 
       Subtype: Link
       Rect: 41, 400, 175, 406
      Annotation: 
       Subtype: Link
       Rect: 41, 391, 175, 397
      Annotation: 
       Subtype: Link
       Rect: 41, 382, 175, 388
      Annotation: 
       Subtype: Link
       Rect: 41, 373, 99, 379
      Annotation: 
       Subtype: Link
       Rect: 52, 360, 175, 366
      Annotation: 
       Subtype: Link
       Rect: 41, 351, 175, 357
      Annotation: 
       Subtype: Link
       Rect: 41, 342, 175, 348
      Annotation: 
       Subtype: Link
       Rect: 41, 333, 81, 339
      Annotation: 
       Subtype: Link
       Rect: 51, 321, 175, 327
      Annotation: 
       Subtype: Link
       Rect: 41, 312, 159, 318
      Annotation: 
       Subtype: Link
       Rect: 164, 312, 170, 318
      Annotation: 
       Subtype: Link
       Rect: 41, 303, 175, 309
      Annotation: 
       Subtype: Link
       Rect: 41, 294, 149, 300
      Annotation: 
       Subtype: Link
       Rect: 52, 281, 175, 287
      Annotation: 
       Subtype: Link
       Rect: 41, 272, 175, 278
      Annotation: 
       Subtype: Link
       Rect: 41, 263, 175, 269
      Annotation: 
       Subtype: Link
       Rect: 41, 255, 136, 260
      Annotation: 
       Subtype: Link
       Rect: 52, 242, 175, 248
      Annotation: 
       Subtype: Link
       Rect: 41, 233, 175, 239
      Annotation: 
       Subtype: Link
       Rect: 41, 224, 175, 230
      Annotation: 
       Subtype: Link
       Rect: 41, 215, 175, 221
      Annotation: 
       Subtype: Link
       Rect: 41, 206, 160, 212
      Annotation: 
       Subtype: Link
       Rect: 52, 194, 175, 200
      Annotation: 
       Subtype: Link
       Rect: 41, 185, 175, 191
      Annotation: 
       Subtype: Link
       Rect: 41, 176, 175, 182
      Annotation: 
       Subtype: Link
       Rect: 41, 167, 175, 173
      Annotation: 
       Subtype: Link
       Rect: 41, 158, 175, 164
      Annotation: 
       Subtype: Link
       Rect: 41, 149, 58, 155
      Annotation: 
       Subtype: Link
       Rect: 51, 136, 175, 142
      Annotation: 
       Subtype: Link
       Rect: 41, 127, 175, 133
      Annotation: 
       Subtype: Link
       Rect: 41, 118, 175, 124
      Annotation: 
       Subtype: Link
       Rect: 41, 109, 175, 115
      Annotation: 
       Subtype: Link
       Rect: 41, 100, 173, 106
      Annotation: 
       Subtype: Link
       Rect: 51, 88, 175, 94
      Annotation: 
       Subtype: Link
       Rect: 41, 79, 175, 85
      Annotation: 
       Subtype: Link
       Rect: 41, 70, 175, 76
      Annotation: 
       Subtype: Link
       Rect: 41, 61, 135, 67
      Annotation: 
       Subtype: Link
       Rect: 197, 672, 320, 678
      Annotation: 
       Subtype: Link
       Rect: 187, 663, 320, 669
      Annotation: 
       Subtype: Link
       Rect: 187, 654, 320, 660
      Annotation: 
       Subtype: Link
       Rect: 187, 645, 232, 651
      Annotation: 
       Subtype: Link
       Rect: 197, 633, 320, 639
      Annotation: 
       Subtype: Link
       Rect: 187, 624, 320, 630
      Annotation: 
       Subtype: Link
       Rect: 187, 615, 320, 621
      Annotation: 
       Subtype: Link
       Rect: 187, 606, 320, 612
      Annotation: 
       Subtype: Link
       Rect: 187, 597, 320, 603
      Annotation: 
       Subtype: Link
       Rect: 187, 588, 211, 594
      Annotation: 
       Subtype: Link
       Rect: 197, 576, 320, 582
      Annotation: 
       Subtype: Link
       Rect: 187, 567, 320, 573
      Annotation: 
       Subtype: Link
       Rect: 187, 558, 320, 564
      Annotation: 
       Subtype: Link
       Rect: 187, 549, 320, 555
      Annotation: 
       Subtype: Link
       Rect: 187, 540, 320, 546
      Annotation: 
       Subtype: Link
       Rect: 187, 531, 320, 537
      Annotation: 
       Subtype: Link
       Rect: 187, 522, 229, 528
      Annotation: 
       Subtype: Link
       Rect: 197, 509, 320, 515
      Annotation: 
       Subtype: Link
       Rect: 187, 500, 320, 506
      Annotation: 
       Subtype: Link
       Rect: 187, 492, 320, 497
      Annotation: 
       Subtype: Link
       Rect: 187, 483, 320, 489
      Annotation: 
       Subtype: Link
       Rect: 187, 474, 319, 480
      Annotation: 
       Subtype: Link
       Rect: 197, 461, 320, 467
      Annotation: 
       Subtype: Link
       Rect: 187, 452, 320, 458
      Annotation: 
       Subtype: Link
       Rect: 187, 443, 320, 449
      Annotation: 
       Subtype: Link
       Rect: 187, 434, 278, 440
      Annotation: 
       Subtype: Link
       Rect: 197, 422, 320, 428
      Annotation: 
       Subtype: Link
       Rect: 187, 413, 320, 419
      Annotation: 
       Subtype: Link
       Rect: 187, 404, 320, 410
      Annotation: 
       Subtype: Link
       Rect: 187, 395, 313, 401
      Annotation: 
       Subtype: Link
       Rect: 197, 383, 320, 389
      Annotation: 
       Subtype: Link
       Rect: 187, 374, 320, 380
      Annotation: 
       Subtype: Link
       Rect: 187, 365, 320, 371
      Annotation: 
       Subtype: Link
       Rect: 187, 356, 288, 362
      Annotation: 
       Subtype: Link
       Rect: 198, 343, 320, 349
      Annotation: 
       Subtype: Link
       Rect: 187, 334, 320, 340
      Annotation: 
       Subtype: Link
       Rect: 187, 326, 320, 331
      Annotation: 
       Subtype: Link
       Rect: 187, 317, 320, 323
      Annotation: 
       Subtype: Link
       Rect: 187, 308, 234, 314
      Annotation: 
       Subtype: Link
       Rect: 197, 295, 320, 301
      Annotation: 
       Subtype: Link
       Rect: 187, 286, 320, 292
      Annotation: 
       Subtype: Link
       Rect: 187, 277, 320, 283
      Annotation: 
       Subtype: Link
       Rect: 187, 268, 320, 274
      Annotation: 
       Subtype: Link
       Rect: 187, 259, 320, 265
      Annotation: 
       Subtype: Link
       Rect: 187, 250, 315, 256
      Annotation: 
       Subtype: Link
       Rect: 197, 238, 320, 244
      Annotation: 
       Subtype: Link
       Rect: 187, 229, 320, 235
      Annotation: 
       Subtype: Link
       Rect: 187, 220, 320, 226
      Annotation: 
       Subtype: Link
       Rect: 187, 211, 320, 217
      Annotation: 
       Subtype: Link
       Rect: 187, 202, 320, 208
      Annotation: 
       Subtype: Link
       Rect: 187, 193, 320, 199
      Annotation: 
       Subtype: Link
       Rect: 187, 184, 320, 190
      Annotation: 
       Subtype: Link
       Rect: 187, 175, 305, 181
      Annotation: 
       Subtype: Link
       Rect: 309, 175, 313, 181
      Annotation: 
       Subtype: Link
       Rect: 197, 163, 320, 169
      Annotation: 
       Subtype: Link
       Rect: 187, 154, 320, 160
      Annotation: 
       Subtype: Link
       Rect: 187, 145, 320, 151
      Annotation: 
       Subtype: Link
       Rect: 187, 136, 320, 142
      Annotation: 
       Subtype: Link
       Rect: 187, 127, 320, 133
      Annotation: 
       Subtype: Link
       Rect: 187, 118, 320, 124
      Annotation: 
       Subtype: Link
       Rect: 187, 109, 229, 115
      Annotation: 
       Subtype: Link
       Rect: 198, 97, 320, 103
      Annotation: 
       Subtype: Link
       Rect: 187, 88, 320, 94
      Annotation: 
       Subtype: Link
       Rect: 187, 79, 320, 85
      Annotation: 
       Subtype: Link
       Rect: 187, 70, 320, 76
      Annotation: 
       Subtype: Link
       Rect: 187, 61, 320, 67
      Annotation: 
       Subtype: Link
       Rect: 332, 672, 466, 678
      Annotation: 
       Subtype: Link
       Rect: 332, 663, 400, 669
      Annotation: 
       Subtype: Link
       Rect: 343, 650, 466, 656
      Annotation: 
       Subtype: Link
       Rect: 332, 641, 466, 647
      Annotation: 
       Subtype: Link
       Rect: 332, 632, 466, 638
      Annotation: 
       Subtype: Link
       Rect: 332, 623, 466, 629
      Annotation: 
       Subtype: Link
       Rect: 332, 614, 466, 620
      Annotation: 
       Subtype: Link
       Rect: 332, 605, 466, 611
      Annotation: 
       Subtype: Link
       Rect: 332, 596, 360, 602
      Annotation: 
       Subtype: Link
       Rect: 343, 583, 466, 589
      Annotation: 
       Subtype: Link
       Rect: 332, 574, 466, 580
      Annotation: 
       Subtype: Link
       Rect: 332, 565, 466, 571
      Annotation: 
       Subtype: Link
       Rect: 332, 556, 466, 562
      Annotation: 
       Subtype: Link
       Rect: 332, 547, 466, 553
      Annotation: 
       Subtype: Link
       Rect: 332, 538, 353, 544
      Annotation: 
       Subtype: Link
       Rect: 343, 524, 466, 530
      Annotation: 
       Subtype: Link
       Rect: 332, 515, 466, 521
      Annotation: 
       Subtype: Link
       Rect: 332, 506, 466, 512
      Annotation: 
       Subtype: Link
       Rect: 332, 497, 392, 503
      Annotation: 
       Subtype: Link
       Rect: 343, 484, 466, 490
      Annotation: 
       Subtype: Link
       Rect: 332, 475, 466, 481
      Annotation: 
       Subtype: Link
       Rect: 332, 466, 466, 472
      Annotation: 
       Subtype: Link
       Rect: 332, 457, 466, 463
      Annotation: 
       Subtype: Link
       Rect: 332, 448, 354, 454
      Annotation: 
       Subtype: Link
       Rect: 343, 436, 466, 442
      Annotation: 
       Subtype: Link
       Rect: 332, 427, 466, 433
      Annotation: 
       Subtype: Link
       Rect: 332, 418, 466, 424
      Annotation: 
       Subtype: Link
       Rect: 332, 409, 368, 415
      Annotation: 
       Subtype: Link
       Rect: 343, 396, 466, 402
      Annotation: 
       Subtype: Link
       Rect: 332, 387, 466, 393
      Annotation: 
       Subtype: Link
       Rect: 332, 378, 466, 384
      Annotation: 
       Subtype: Link
       Rect: 332, 369, 403, 375
      Annotation: 
       Subtype: Link
       Rect: 342, 355, 466, 361
      Annotation: 
       Subtype: Link
       Rect: 332, 346, 466, 352
      Annotation: 
       Subtype: Link
       Rect: 332, 338, 466, 343
      Annotation: 
       Subtype: Link
       Rect: 332, 329, 466, 334
      Annotation: 
       Subtype: Link
       Rect: 332, 320, 371, 326
      Annotation: 
       Subtype: Link
       Rect: 342, 306, 466, 312
      Annotation: 
       Subtype: Link
       Rect: 332, 297, 466, 303
      Annotation: 
       Subtype: Link
       Rect: 332, 288, 466, 294
      Annotation: 
       Subtype: Link
       Rect: 332, 279, 457, 285
      Annotation: 
       Subtype: Link
       Rect: 342, 267, 466, 273
      Annotation: 
       Subtype: Link
       Rect: 332, 258, 466, 264
      Annotation: 
       Subtype: Link
       Rect: 332, 249, 466, 255
      Annotation: 
       Subtype: Link
       Rect: 332, 240, 466, 246
      Annotation: 
       Subtype: Link
       Rect: 332, 231, 466, 237
      Annotation: 
       Subtype: Link
       Rect: 332, 222, 360, 228
      Annotation: 
       Subtype: Link
       Rect: 343, 209, 466, 215
      Annotation: 
       Subtype: Link
       Rect: 332, 200, 466, 206
      Annotation: 
       Subtype: Link
       Rect: 332, 191, 466, 197
      Annotation: 
       Subtype: Link
       Rect: 332, 182, 431, 188
      Annotation: 
       Subtype: Link
       Rect: 342, 170, 466, 175
      Annotation: 
       Subtype: Link
       Rect: 332, 161, 466, 167
      Annotation: 
       Subtype: Link
       Rect: 332, 152, 466, 158
      Annotation: 
       Subtype: Link
       Rect: 332, 143, 424, 149
      Annotation: 
       Subtype: Link
       Rect: 343, 130, 466, 136
      Annotation: 
       Subtype: Link
       Rect: 332, 121, 466, 127
      Annotation: 
       Subtype: Link
       Rect: 332, 112, 466, 118
      Annotation: 
       Subtype: Link
       Rect: 332, 103, 400, 109
  Checksum: 2d157efd
   Type: CRC32
  Checksum: 538043b73aaf70b1033821e510fee989
   Type: MD5
  Checksum: f57cbe1423f8962931c0f94683281bd418c9f212
   Type: SHA-1
  Checksum: 29fa087ef49c6aa4eb1f0d66f0183ccc90d830c5b2aa7c02ac6d39fd322ca5d2
   Type: SHA-256