69bebf72602a1340ff2b4cd0950d379d pmc_32392815.pdf 8b5fa969ee474f5938cae7dc5513fb6a8e2b9fec pmc_32392815.pdf 7bd8662699f58e38ef3099eebe6b74f6ceb41f0aca865f76ff74507d863aa2c2 pmc_32392815.pdf Title: Clinical Outcomes of a Zika Virus Mother–Child Pair Cohort in Spain Subject: Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4–6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4–39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations. Keywords: zika virus; microcephaly; congenital infection; adverse outcome; arboviruses Author: Antoni Soriano-Arandes, Marie Antoinette Frick, Milagros García López-Hortelano, Elena Sulleiro, Carlota Rodó, María Paz Sánchez-Seco, Marta Cabrera-Lafuente, Anna Suy, María De la Calle, Mar Santos, Eugenia Antolin, María del Carmen Viñuela, María Espiau, Ainara Salazar, Borja Guarch-Ibáñez, Ana Vázquez, Juan Navarro-Morón, José-Tomás Ramos-Amador, Andrea Martin-Nalda, Eva Dueñas, Daniel Blázquez-Gamero, Resurrección Reques-Cosme, Iciar Olabarrieta, Luis Prieto, Fernando De Ory, Claire Thorne, Thomas Byrne, Anthony E. Ades, Elisa Ruiz-Burga, Carlo Giaquinto, María José Mellado-Peña, Alfredo García-Alix, Elena Carreras and Pere Soler-Palacín Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.18 CreationDate: Thu May 7 13:27:57 2020 CEST ModDate: Thu May 7 13:27:57 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 452451 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NOVNFJ+URWPalladioL-Ital Type 1 Custom yes yes no 80 0 JDOYEO+URWPalladioL-Bold Type 1 Custom yes yes no 81 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 82 0 KPPJAQ+URWPalladioL-Roma Type 1 Custom yes yes no 83 0 YZFCZI+VnURWPalladioL Type 1 Custom yes yes no 84 0 OFLXAT+Rpxr Type 1 Builtin yes yes no 85 0 UXHOAG+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 91 0 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Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: ぉのぴひはつふっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸲ Item: Title: げづびふぬぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぅばどつづねどはぬはでどっちぬぜ〴ぜ〰ちのつぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぃとちひちっぴづひどびぴどっびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐちひぴどっどばちのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰がちぢはひちぴはひべぜ〴ぜ〰ぃはのてどひねちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きちぴづひのちぬぜ〴ぜ〰ぉのてづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰さぬぴひちびはふのつぜ〴ぜ〰ちのつぜ〴ぜ〰きげぉぜ〴ぜ〰げづびふぬぴびぜ〴ぜ〰つふひどのでぜ〴ぜ〰ぐひづでのちのっどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰きちぴづひのちぬ〬ぜ〴ぜ〰うづぴちぬ〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぎづはのちぴちぬぜ〴ぜ〰くふぴっはねづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Children: Item: Title: ぅばどつづねどはぬはでどっちぬぜ〴ぜ〰ちのつぜ〴ぜ〰ぃぬどのどっちぬぜ〴ぜ〰ぃとちひちっぴづひどびぴどっびぜ〴ぜ〰はてぜ〴ぜ〰ぴとづぜ〴ぜ〰ぐちひぴどっどばちのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㈩‾㸊⡜㌷㙜㌷㝜〰がちぢはひちぴはひべぜ〴ぜ〰ぃはのてどひねちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きちぴづひのちぬぜ〴ぜ〰ぉのてづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰さぬぴひちびはふのつぜ〴ぜ〰ちのつぜ〴ぜ〰きげぉぜ〴ぜ〰げづびふぬぴびぜ〴ぜ〰つふひどのでぜ〴ぜ〰ぐひづでのちのっどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰きちぴづひのちぬ〬ぜ〴ぜ〰うづぴちぬ〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぎづはのちぴちぬぜ〴ぜ〰くふぴっはねづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: がちぢはひちぴはひべぜ〴ぜ〰ぃはのてどひねちぴどはのぜ〴ぜ〰はてぜ〴ぜ〰きちぴづひのちぬぜ〴ぜ〰ぉのてづっぴどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㌩‾㸊⡜㌷㙜㌷㝜〰さぬぴひちびはふのつぜ〴ぜ〰ちのつぜ〴ぜ〰きげぉぜ〴ぜ〰げづびふぬぴびぜ〴ぜ〰つふひどのでぜ〴ぜ〰ぐひづでのちのっどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰きちぴづひのちぬ〬ぜ〴ぜ〰うづぴちぬ〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぎづはのちぴちぬぜ〴ぜ〰くふぴっはねづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: さぬぴひちびはふのつぜ〴ぜ〰ちのつぜ〴ぜ〰きげぉぜ〴ぜ〰げづびふぬぴびぜ〴ぜ〰つふひどのでぜ〴ぜ〰ぐひづでのちのっどづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㈮㐩‾㸊⡜㌷㙜㌷㝜〰きちぴづひのちぬ〬ぜ〴ぜ〰うづぴちぬ〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぎづはのちぴちぬぜ〴ぜ〰くふぴっはねづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: きちぴづひのちぬ〬ぜ〴ぜ〰うづぴちぬ〬ぜ〴ぜ〰ちのつぜ〴ぜ〰ぎづはのちぴちぬぜ〴ぜ〰くふぴっはねづびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸳ Item: Title: いどびっふびびどはのぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸴ Item: Title: きちぴづひどちぬびぜ〴ぜ〰ちのつぜ〴ぜ〰きづぴとはつびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮ㄩ‾㸊⡜㌷㙜㌷㝜〰ぅのひはぬねづのぴぜ〴ぜ〰ぃひどぴづひどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃはとはひぴぜ〴ぜ〰うはぬぬはぷ〭さばぜ〴ぜ〰ちのつぜ〴ぜ〰ぅのつばはどのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Children: Item: Title: ぅのひはぬねづのぴぜ〴ぜ〰ぃひどぴづひどちぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㈩‾㸊⡜㌷㙜㌷㝜〰ぃはとはひぴぜ〴ぜ〰うはぬぬはぷ〭さばぜ〴ぜ〰ちのつぜ〴ぜ〰ぅのつばはどのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはとはひぴぜ〴ぜ〰うはぬぬはぷ〭さばぜ〴ぜ〰ちのつぜ〴ぜ〰ぅのつばはどのぴびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳畢獥捴楯渮㐮㌩‾㸊⡜㌷㙜㌷㝜〰こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: こぴちぴどびぴどっちぬぜ〴ぜ〰ぁのちぬべびどびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: ぃはのっぬふびどはのびぜ〴〩਼㰠⽓ 䝯呯 䐠⡳散瑩潮⸵ Item: Title: げづてづひづのっづび Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: NOVNFJ+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: NOVNFJ+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JDOYEO+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 241 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