7f877de6491f06282f5e3e0bee508050 pmc_32422573.pdf 977575b1a7c3b1b1e178f0707eb46cb773a812da pmc_32422573.pdf c66241f9c86b83003819cca968992583426600f9ca40f62a39b9f6432139dbf4 pmc_32422573.pdf Title: Comprehensive Characterization of the Mutational Landscape in Localized Anal Squamous Cell Carcinoma Subject: Translational Oncology, 13 (2020) 100778. doi:10.1016/j.tranon.2020.100778 Author: Lucía Trilla-Fuertes Creator: Elsevier CreationDate: Thu Apr 30 11:16:56 2020 CEST ModDate: Thu Apr 30 11:16:56 2020 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1474211 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DEDNCD+AdvTTe692faf0 Type 1C WinAnsi yes yes no 445 0 DEDNCE+AdvTT8608a8d1+20 Type 1C Custom yes yes yes 448 0 DEDNCF+AdvTT47f7fe79.I Type 1C WinAnsi yes yes no 450 0 DEDNCG+AdvTTdd3b7348.I Type 1C WinAnsi yes yes no 452 0 DEDNCH+AdvTT47f7fe79.I+fb Type 1C Custom yes yes yes 455 0 DEDNCI+AdvTTe692faf0+fb Type 1C Custom yes yes yes 458 0 DEDNDJ+AdvTTc9617e0c.B Type 1C WinAnsi yes yes no 460 0 DEDNDK+AdvTT8608a8d1 Type 1C WinAnsi yes yes no 462 0 DEDNFK+AdvTTc8c83e50 Type 1C WinAnsi yes yes no 464 0 DEDNGL+AdvTTe692faf0+20 Type 1C WinAnsi yes yes no 160 0 DEDNGM+AdvTTe692faf0+22 Type 1C Custom yes yes no 163 0 DEEEJB+AdvTTe692faf0+01 Type 1C Custom yes yes yes 164 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2020-11-18 06:39:18 CET RepresentationInformation: pmc_32422573.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2020-07-06 03:43:53 CEST Size: 1474211 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'em0005' cannot be found Offset: 1465361 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Comprehensive Characterization of the Mutational Landscape in Localized Anal Squamous Cell Carcinoma Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: DNA Isolation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Library Preparation, Exome Capture, and Illumina Sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Bioinformatics Exome Sequencing Data Processing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Prioritization of High-Impact Genetic Variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Filtering of the Most Frequent Genetic Variants in Our Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Visual Validation of the High-Impact Genetic Variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Pathway Annotation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Genes Associated with Prognosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Statistical Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Children: Item: Title: Patient Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Exome Sequencing Experiments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Relevant Genes and Their Associated Genetic Variants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Ontology Analysis of the High-Impact Genetic Variants Identified Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Characterization of the Most Frequently Mutated Genes in Our Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Genetic Variants Associated with Prognosis in ASCC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Declarations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Children: Item: Title: Ethics Approval and Consent to Participate Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Availability of Supporting Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Declaration of Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Authors' Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 245 ImageHeight: 269 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1541 ImageHeight: 1065 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1778 ImageHeight: 950 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2132 ImageHeight: 614 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2014 ImageHeight: 1506 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 942 ImageHeight: 479 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: DEDNFK+AdvTTc8c83e50 FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: DEDNFK+AdvTTc8c83e50 Flags: Nonsymbolic FontBBox: -10, -250, 968, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEDNCE+AdvTT8608a8d1+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DEDNCE+AdvTT8608a8d1+20 Flags: Symbolic FontBBox: -968, -333, 2000, 1020 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEDNGL+AdvTTe692faf0+20 FontSubset: true FirstChar: 147 LastChar: 150 FontDescriptor: FontName: DEDNGL+AdvTTe692faf0+20 Flags: Nonsymbolic FontBBox: -468, -302, 1093, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEDNCF+AdvTT47f7fe79.I FontSubset: true FirstChar: 39 LastChar: 243 FontDescriptor: FontName: DEDNCF+AdvTT47f7fe79.I Flags: Serif, Nonsymbolic FontBBox: -156, -250, 1000, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEDNGM+AdvTTe692faf0+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: DEDNGM+AdvTTe692faf0+22 Flags: Nonsymbolic FontBBox: 0, -250, 927, 875 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DEDNCG+AdvTTdd3b7348.I FontSubset: true FirstChar: 38 LastChar: 38 FontDescriptor: FontName: DEDNCG+AdvTTdd3b7348.I Flags: Nonsymbolic FontBBox: -166, -208, 906, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEEEJB+AdvTTe692faf0+01 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DEEEJB+AdvTTe692faf0+01 Flags: Symbolic FontBBox: -93, -260, 1229, 1197 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEDNCH+AdvTT47f7fe79.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DEDNCH+AdvTT47f7fe79.I+fb Flags: Symbolic FontBBox: -125, -218, 906, 875 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEDNCI+AdvTTe692faf0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DEDNCI+AdvTTe692faf0+fb Flags: Symbolic FontBBox: 19, 0, 916, 875 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DEDNDJ+AdvTTc9617e0c.B FontSubset: true FirstChar: 39 LastChar: 117 FontDescriptor: FontName: DEDNDJ+AdvTTc9617e0c.B Flags: Nonsymbolic FontBBox: -83, -250, 947, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEDNCD+AdvTTe692faf0 FontSubset: true FirstChar: 37 LastChar: 250 FontDescriptor: FontName: DEDNCD+AdvTTe692faf0 Flags: Serif, Nonsymbolic FontBBox: -72, -250, 916, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DEDNDK+AdvTT8608a8d1 FontSubset: true FirstChar: 38 LastChar: 62 FontDescriptor: FontName: DEDNDK+AdvTT8608a8d1 Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.tranon.2020.100778 Comprehensive Characterization of the Mutational Landscape in Localized Anal Squamous Cell Carcinoma Lucía Trilla-Fuertes Ismael Ghanem Joan Maurel Laura G-Pastrián Marta Mendiola Cristina Peña Rocío López-Vacas Guillermo Prado-Vázquez Elena López-Camacho Andrea Zapater-Moros Victoria Heredia Miriam Cuatrecasas Pilar García-Alfonso Jaume Capdevila Carles Conill Rocío García-Carbonero Karen E. Heath Ricardo Ramos-Ruiz Carlos Llorens Ángel Campos-Barros Angelo Gámez-Pozo Jaime Feliu Juan Ángel Fresno Vara Translational Oncology, 13 (2020) 100778. doi:10.1016/j.tranon.2020.100778 The Authors journal Translational Oncology (c) 2020 The Authors All rights reserved 1936-5233 13 7 July 2020 100778 100778 10.1016/j.tranon.2020.100778 https://doi.org/10.1016/j.tranon.2020.100778 2010-04-23 true 10.1016/j.tranon.2020.100778 elsevier.com sciencedirect.com VoR 6.5 10.1016/j.tranon.2020.100778 noindex 2010-04-23 true elsevier.com sciencedirect.com Elsevier 2020-04-30T09:16:56Z 2020-04-30T09:16:56Z 2020-04-30T09:16:56Z True uuid:38eb2fc8-ee05-4d60-af24-1544e46c3b05 uuid:989d68f6-fbae-4eca-b0e2-9889132bf4d6 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 501, 602, 529, 630 Annotation: Subtype: Link Rect: 127, 577, 131, 588 Destination: 331 Annotation: Subtype: Link Rect: 209, 577, 213, 588 Destination: 331 Annotation: Subtype: Link Rect: 278, 577, 281, 588 Destination: 331 Annotation: Subtype: Link Rect: 365, 577, 369, 588 Destination: 331 Annotation: Subtype: Link Rect: 371, 577, 375, 588 Destination: 331 Annotation: Subtype: Link Rect: 455, 577, 459, 588 Destination: 331 Annotation: Subtype: Link Rect: 461, 577, 464, 588 Destination: 331 Annotation: Subtype: Link Rect: 531, 577, 536, 588 Destination: 331 Annotation: Subtype: Link Rect: 124, 564, 128, 575 Destination: 331 Annotation: Subtype: Link Rect: 252, 564, 256, 575 Destination: 331 Annotation: Subtype: Link Rect: 363, 564, 367, 575 Destination: 331 Annotation: Subtype: Link Rect: 477, 564, 481, 575 Destination: 331 Annotation: Subtype: Link Rect: 114, 551, 117, 562 Destination: 331 Annotation: Subtype: Link Rect: 119, 551, 123, 562 Destination: 331 Annotation: Subtype: Link Rect: 220, 551, 223, 562 Destination: 331 Annotation: Subtype: Link Rect: 321, 551, 324, 562 Destination: 331 Annotation: Subtype: Link Rect: 409, 551, 413, 562 Destination: 331 Annotation: Subtype: Link Rect: 479, 551, 481, 562 Destination: 331 Annotation: Subtype: Link Rect: 148, 539, 155, 549 Destination: 331 Annotation: Subtype: Link Rect: 231, 539, 235, 549 Destination: 331 Annotation: Subtype: Link Rect: 335, 539, 339, 549 Destination: 331 Annotation: Subtype: Link Rect: 411, 539, 416, 549 Destination: 331 Annotation: Subtype: Link Rect: 521, 539, 525, 549 Destination: 331 Annotation: Subtype: Link Rect: 130, 526, 134, 536 Destination: 331 Annotation: Subtype: Link Rect: 194, 526, 199, 536 Destination: 331 Annotation: Subtype: Link Rect: 201, 526, 203, 536 Destination: 331 Annotation: Subtype: Link Rect: 205, 526, 209, 536 Destination: 331 Annotation: Subtype: Link Rect: 212, 527, 217, 538 Destination: 331 Annotation: Subtype: Link Rect: 333, 526, 336, 536 Destination: 331 Annotation: Subtype: Link Rect: 338, 526, 342, 536 Destination: 331 Annotation: Subtype: Link Rect: 344, 527, 350, 538 Destination: 331 Annotation: Subtype: Link Rect: 188, 130, 193, 138 Destination: 21 Annotation: Subtype: Link Rect: 309, 151, 313, 159 Destination: 21 Annotation: Subtype: Link Rect: 316, 151, 320, 159 Destination: 21 Annotation: Subtype: Link Rect: 361, 130, 365, 138 Destination: 21 Annotation: Subtype: Link Rect: 367, 130, 372, 138 Destination: 21 Annotation: Subtype: Link Rect: 232, 749, 362, 756 Annotation: Subtype: Link Rect: 94, 96, 161, 102 Destination: null Annotation: Subtype: Link Rect: 192, 96, 288, 102 Annotation: Subtype: Link Rect: 37, 67, 189, 74 Annotation: Subtype: Link Rect: 535, 57, 557, 64 Annotation: Subtype: Link Rect: 37, 48, 176, 55 Annotation: Subtype: Link Rect: 320, 721, 366, 729 Annotation: Subtype: Link Rect: 267, 665, 417, 673 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 113, 658, 117, 665 Destination: 21 Annotation: Subtype: Link Rect: 242, 658, 247, 665 Destination: 21 Annotation: Subtype: Link Rect: 209, 637, 213, 645 Destination: 21 Annotation: Subtype: Link Rect: 114, 563, 132, 571 Destination: 21 Annotation: Subtype: Link Rect: 533, 710, 557, 718 Annotation: Subtype: Link Rect: 306, 699, 492, 707 Annotation: Subtype: Link Rect: 483, 689, 492, 697 Destination: 21 Annotation: Subtype: Link Rect: 440, 678, 449, 686 Destination: 21 Annotation: Subtype: Link Rect: 420, 668, 430, 676 Destination: 21 Annotation: Subtype: Link Rect: 354, 647, 363, 655 Destination: 21 Annotation: Subtype: Link Rect: 415, 647, 424, 655 Destination: 24 Annotation: Subtype: Link Rect: 508, 647, 557, 655 Annotation: Subtype: Link Rect: 306, 637, 360, 645 Annotation: Subtype: Link Rect: 444, 626, 453, 634 Destination: 24 Annotation: Subtype: Link Rect: 309, 605, 318, 613 Destination: 24 Annotation: Subtype: Link Rect: 408, 595, 530, 603 Annotation: Subtype: Link Rect: 421, 487, 430, 495 Destination: 24 Annotation: Subtype: Link Rect: 445, 420, 454, 428 Destination: 24 Annotation: Subtype: Link Rect: 309, 410, 387, 418 Annotation: Subtype: Link Rect: 417, 256, 514, 264 Annotation: Subtype: Link Rect: 340, 246, 349, 254 Destination: 24 Annotation: Subtype: Link Rect: 386, 159, 395, 167 Destination: 24 Annotation: Subtype: Link Rect: 387, 117, 415, 125 Destination: 4 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 308, 417, 334, 425 Destination: 4 Annotation: Subtype: Link Rect: 308, 176, 334, 184 Destination: 4 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 110, 511, 138, 519 Destination: 8 Annotation: Subtype: Link Rect: 267, 375, 289, 383 Destination: 8 Annotation: Subtype: Link Rect: 37, 365, 41, 373 Destination: 8 Annotation: Subtype: Link Rect: 403, 365, 433, 373 Destination: 13 Annotation: Subtype: Link Rect: 413, 354, 438, 362 Destination: 17 Annotation: Subtype: Link Rect: 512, 344, 540, 352 Destination: 17 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 204, 93, 213, 101 Destination: 24 Annotation: Subtype: Link Rect: 135, 61, 144, 69 Destination: 21 Annotation: Subtype: Link Rect: 146, 61, 155, 69 Destination: 21 Annotation: Subtype: Link Rect: 502, 291, 519, 299 Destination: 21 Annotation: Subtype: Link Rect: 373, 270, 382, 278 Destination: 21 Annotation: Subtype: Link Rect: 401, 250, 410, 258 Destination: 21 Annotation: Subtype: Link Rect: 458, 208, 466, 216 Destination: 21 Annotation: Subtype: Link Rect: 339, 166, 343, 174 Destination: 21 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 195, 407, 204, 415 Destination: 24 Annotation: Subtype: Link Rect: 274, 376, 283, 384 Destination: 24 Annotation: Subtype: Link Rect: 262, 365, 266, 373 Destination: 21 Annotation: Subtype: Link Rect: 106, 303, 115, 311 Destination: 24 Annotation: Subtype: Link Rect: 174, 282, 183, 290 Destination: 24 Annotation: Subtype: Link Rect: 433, 344, 438, 352 Destination: 21 Annotation: Subtype: Link Rect: 331, 313, 340, 321 Destination: 24 Annotation: Subtype: Link Rect: 342, 313, 351, 321 Destination: 24 Annotation: Subtype: Link Rect: 452, 292, 461, 300 Destination: 24 Annotation: Subtype: Link Rect: 463, 292, 472, 300 Destination: 24 Annotation: Subtype: Link Rect: 379, 271, 401, 279 Destination: 24 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 248, 563, 289, 571 Annotation: Subtype: Link Rect: 37, 553, 159, 561 Annotation: Subtype: Link Rect: 224, 427, 289, 435 Annotation: Subtype: Link Rect: 37, 417, 91, 425 Annotation: Subtype: Link Rect: 322, 482, 350, 488 Annotation: Subtype: Link Rect: 322, 474, 557, 480 Annotation: Subtype: Link Rect: 322, 466, 557, 472 Annotation: Subtype: Link Rect: 322, 458, 418, 464 Annotation: Subtype: Link Rect: 484, 434, 557, 440 Annotation: Subtype: Link Rect: 322, 426, 369, 432 Annotation: Subtype: Link Rect: 396, 426, 424, 432 Annotation: Subtype: Link Rect: 322, 378, 350, 384 Annotation: Subtype: Link Rect: 506, 354, 557, 360 Annotation: Subtype: Link Rect: 322, 346, 368, 352 Annotation: Subtype: Link Rect: 395, 346, 422, 352 Annotation: Subtype: Link Rect: 374, 314, 402, 321 Annotation: Subtype: Link Rect: 403, 266, 431, 273 Annotation: Subtype: Link Rect: 528, 242, 557, 249 Annotation: Subtype: Link Rect: 322, 234, 368, 241 Annotation: Subtype: Link Rect: 395, 234, 422, 241 Annotation: Subtype: Link Rect: 322, 195, 350, 201 Annotation: Subtype: Link Rect: 403, 163, 431, 169 Annotation: Subtype: Link Rect: 475, 131, 503, 137 Annotation: Subtype: Link Rect: 443, 115, 546, 121 Annotation: Subtype: Link Rect: 322, 107, 557, 113 Annotation: Subtype: Link Rect: 322, 99, 426, 105 Annotation: Subtype: Link Rect: 322, 91, 557, 97 Annotation: Subtype: Link Rect: 322, 83, 557, 89 Annotation: Subtype: Link Rect: 322, 75, 485, 81 Annotation: Subtype: Link Rect: 443, 59, 557, 65 Annotation: Subtype: Link Rect: 322, 51, 341, 58 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 53, 734, 289, 740 Annotation: Subtype: Link Rect: 53, 726, 262, 732 Annotation: Subtype: Link Rect: 212, 702, 289, 708 Annotation: Subtype: Link Rect: 53, 694, 86, 700 Annotation: Subtype: Link Rect: 152, 670, 246, 676 Annotation: Subtype: Link Rect: 188, 622, 216, 628 Annotation: Subtype: Link Rect: 53, 590, 165, 597 Annotation: Subtype: Link Rect: 193, 590, 220, 597 Annotation: Subtype: Link Rect: 170, 566, 198, 573 Annotation: Subtype: Link Rect: 207, 510, 237, 517 Annotation: Subtype: Link Rect: 389, 726, 417, 732 Annotation: Subtype: Link Rect: 375, 702, 489, 708 Annotation: Subtype: Link Rect: 515, 702, 543, 708 Annotation: Subtype: Link Rect: 370, 686, 488, 692 Annotation: Subtype: Link Rect: 516, 686, 544, 692 Annotation: Subtype: Link Rect: 381, 654, 409, 660 Annotation: Subtype: Link Rect: 322, 622, 350, 628 Annotation: Subtype: Link Rect: 346, 590, 374, 597 Annotation: Subtype: Link Rect: 346, 558, 374, 565 Annotation: Subtype: Link Rect: 503, 542, 557, 549 Annotation: Subtype: Link Rect: 322, 534, 371, 541 Annotation: Subtype: Link Rect: 399, 534, 427, 541 Annotation: Subtype: Link Rect: 488, 518, 557, 525 Annotation: Subtype: Link Rect: 322, 510, 366, 517 Annotation: Subtype: Link Rect: 394, 510, 422, 517 Annotation: Subtype: Link Rect: 322, 487, 434, 493 Annotation: Subtype: Link Rect: 513, 487, 540, 493 Checksum: dcec1b70 Type: CRC32 Checksum: 7f877de6491f06282f5e3e0bee508050 Type: MD5 Checksum: 977575b1a7c3b1b1e178f0707eb46cb773a812da Type: SHA-1