2bdef36e2de0af514b4661881daf71e4 pmc_32434524.pdf f4f2eb6485e60c01eee1e4b508cf91da4a6998a9 pmc_32434524.pdf 224a6e45301fbc64ef51758cce2bf6c3ba2351526469c2eeb045aacfd85991a9 pmc_32434524.pdf Title: Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis Subject: Journal of Neuroinflammation, 2020, doi:10.1186/s12974-020-01840-2 Keywords: Multiple sclerosis,B cells,Human cytomegalovirus,Interferon-beta Author: Ana Zabalza Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue May 19 01:28:37 2020 CEST ModDate: Wed May 20 11:03:12 2020 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 2173212 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IBNLMJ+KcmfykAdvTTb5929f4c+22 Type 1C Custom yes yes no 89 0 MyriadPro-Regular Type 1C Custom yes no yes 19 0 IBNLMK+SfslhbAdvTT86d47313 Type 1C WinAnsi yes yes no 14 0 IBNMLF+HxdqckAdvTT7329fd89.I Type 1C WinAnsi yes yes no 15 0 IBNCIM+PvsdryAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 16 0 IBNLGG+TvkjjbAdvTTe45e47d2 Type 1C WinAnsi yes yes no 17 0 IBNLGH+YgldkcAdvTTb5929f4c Type 1C WinAnsi yes yes no 90 0 IBNLLG+LsjntwAdvTT99c4c969 Type 1C WinAnsi yes yes no 21 0 IBNLLH+TvbjynAdvTTb5929f4c+03 Type 1C Custom yes yes yes 127 0 IBNLMI+JtphvtAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 128 0 IBNMPG+MplthkAdvTT86d47313+22 Type 1C Custom yes yes no 13 0 IBNNAI+JjjjwkAdvTT86d47313+20 Type 1C WinAnsi yes yes no 18 0 IBNNAJ+NqktlcAdvTT99c4c969+03 Type 1C Custom yes yes yes 20 0 IBNMPH+BkwgxvAdvTT8861b38f.I Type 1C WinAnsi yes yes no 22 0 IBNNAH+HbnbmdAdvTT86d47313+03 Type 1C Custom yes yes yes 23 0 IBOJEB+YhdgdkAdvTTe45e47d2+03 Type 1C Custom yes yes yes 124 0 IBOJDA+PrqwccAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 125 0 IBOJDB+TwrnknAdvTT7329fd89.I+03 Type 1C Custom yes yes yes 126 0 IBPIPC+MhwbvvAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 120 0 IBPJFB+YkljcjAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 153 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:09:39 CEST RepresentationInformation: pmc_32434524.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:46:34 CEST Size: 2173212 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 369 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: sectionAbs1 Children: Item: Title: Background Destination: sectionASec1 Item: Title: Methods Destination: sectionASec2 Item: Title: Results Destination: sectionASec3 Item: Title: Conclusions Destination: sectionASec4 Item: Title: Introduction Destination: sectionSec1 Item: Title: Methods Destination: sectionSec2 Children: Item: Title: Samples Destination: sectionSec3 Item: Title: Herpesvirus serostatus Destination: sectionSec4 Item: Title: B cell immunophenotype Destination: sectionSec5 Item: Title: Functional analysis of B cells Destination: sectionSec6 Item: Title: Statistical analysis Destination: sectionSec7 Item: Title: Results Destination: sectionSec8 Children: Item: Title: Demographic description Destination: sectionSec9 Item: Title: Distribution of B cell subsets in untreated MS according to clinical forms and HCMV serology Destination: sectionSec10 Item: Title: Impact of HCMV on the B cell compartment in IFNβ-treated MS patients Destination: sectionSec11 Item: Title: Functional implications of HCMV on the cytokine profile of B cells in MS Destination: sectionSec12 Item: Title: Discussion Destination: sectionSec13 Item: Title: Conclusions Destination: sectionSec14 Item: Title: Supplementary information Destination: sectionSec15 Item: Title: Abbreviations Destination: sectionabr1 Item: Title: Acknowledgements Destination: section1 Item: Title: Authors’ contributions Destination: section2 Item: Title: Funding Destination: section3 Item: Title: Availability of data and materials Destination: section4 Item: Title: Ethics approval and consent to participate Destination: sectionFPar1 Item: Title: Consent for publication Destination: sectionFPar2 Item: Title: Competing interests Destination: sectionFPar3 Item: Title: Author details Destination: section5 Item: Title: References Destination: sectionBib1 Item: Title: Publisher’s Note Destination: ArtNote2 Info: Title: Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis Author: Ana Zabalza Subject: Journal of Neuroinflammation, 2020, doi:10.1186/s12974-020-01840-2 Keywords: Multiple sclerosis,B cells,Human cytomegalovirus,Interferon-beta Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue May 19 01:28:37 CEST 2020 ModDate: Wed May 20 11:03:12 CEST 2020 ID: 0x96a68ffd8d6206228ea984e41498df9a, 0x4dbbf2ca8468545b633a893236a22a80 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 176 ImageHeight: 182 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 54 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1949 ImageHeight: 1585 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1949 ImageHeight: 1044 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1420 ImageHeight: 1650 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1420 ImageHeight: 1978 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: IBNLMI+JtphvtAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 250 FontDescriptor: FontName: IBNLMI+JtphvtAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBNMPG+MplthkAdvTT86d47313+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: IBNMPG+MplthkAdvTT86d47313+22 Flags: Nonsymbolic FontBBox: -166, -250, 1031, 864 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBNLMK+SfslhbAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 177 FontDescriptor: FontName: IBNLMK+SfslhbAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBNMLF+HxdqckAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: IBNMLF+HxdqckAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBNCIM+PvsdryAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: IBNCIM+PvsdryAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBNLGG+TvkjjbAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 177 FontDescriptor: FontName: IBNLGG+TvkjjbAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBNNAI+JjjjwkAdvTT86d47313+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: IBNNAI+JjjjwkAdvTT86d47313+20 Flags: Nonsymbolic FontBBox: -354, -218, 1291, 812 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IBNNAJ+NqktlcAdvTT99c4c969+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: IBNNAJ+NqktlcAdvTT99c4c969+03 Flags: Symbolic FontBBox: -531, -250, 791, 958 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IBNLLG+LsjntwAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: IBNLLG+LsjntwAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBNMPH+BkwgxvAdvTT8861b38f.I FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: IBNMPH+BkwgxvAdvTT8861b38f.I Flags: Nonsymbolic FontBBox: -187, -239, 1062, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBNNAH+HbnbmdAdvTT86d47313+03 FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: IBNNAH+HbnbmdAdvTT86d47313+03 Flags: Symbolic FontBBox: -364, -250, 906, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IBPIPC+MhwbvvAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: IBPIPC+MhwbvvAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBNLMJ+KcmfykAdvTTb5929f4c+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: IBNLMJ+KcmfykAdvTTb5929f4c+22 Flags: Nonsymbolic FontBBox: -10, -218, 1083, 812 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: IBPJFB+YkljcjAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: IBPJFB+YkljcjAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBNLGH+YgldkcAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 246 FontDescriptor: FontName: IBNLGH+YgldkcAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBOJEB+YhdgdkAdvTTe45e47d2+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: IBOJEB+YhdgdkAdvTTe45e47d2+03 Flags: Symbolic FontBBox: -531, -250, 791, 947 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IBOJDA+PrqwccAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: IBOJDA+PrqwccAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IBOJDB+TwrnknAdvTT7329fd89.I+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: IBOJDB+TwrnknAdvTT7329fd89.I+03 Flags: Symbolic FontBBox: -531, -250, 947, 958 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IBNLLH+TvbjynAdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: IBNLLH+TvbjynAdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: Multiple sclerosis,B cells,Human cytomegalovirus,Interferon-beta Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) application/pdf 10.1186/s12974-020-01840-2 Journal of Neuroinflammation Journal of Neuroinflammation, 2020, doi:10.1186/s12974-020-01840-2 Multiple sclerosis B cells Human cytomegalovirus Interferon-beta Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis Ana Zabalza Andrea Vera Elisenda Alari-Pahissa Elvira Munteis Antía Moreira Jose Yélamos Mireia Llop Miguel López-Botet Jose E. Martínez-Rodríguez 2020-05-20T11:03:12+02:00 2020-05-20T11:03:12+02:00 2020-05-19T07:28:37+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode uuid:0073f2fc-74e1-4ed4-b8ae-abb165a252af uuid:8ab32584-6de8-400f-ac39-ae3cd84eeb18 default 1 converted uuid:0073f2fc-74e1-4ed4-b8ae-abb165a252af converted to PDF/A-2b pdfToolbox 2020-05-19T11:28:14+08:00 2 B Jose E. Martínez-Rodríguez http://orcid.org/0000-0001-6765-5587 Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 496, 635, 538, 677 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 292, 559, 301, 568 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 187, 217, 192, 227 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 200, 217, 204, 227 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 227, 205, 232, 215 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 339, 253, 344, 263 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 482, 229, 487, 239 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 494, 229, 499, 239 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 392, 193, 397, 203 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 510, 181, 515, 191 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 392, 157, 397, 167 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 509, 145, 519, 155 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 400, 73, 518, 80 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 65, 477, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 165, 206, 172 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 208, 525, 217, 534 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 140, 393, 145, 402 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 528, 513, 533, 522 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 403, 369, 408, 378 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 485, 321, 490, 330 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 490, 285, 494, 294 Flags: Print AppearanceDictionary: true Destination: 100 Annotation: Subtype: Link Rect: 524, 153, 529, 162 Flags: Print AppearanceDictionary: true Destination: 104 Annotation: Subtype: Link Rect: 333, 117, 343, 126 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 510, 105, 515, 114 Flags: Print AppearanceDictionary: true Destination: 104 Annotation: Subtype: Link Rect: 452, 57, 457, 66 Flags: Print AppearanceDictionary: true Destination: 104 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 145, 177, 150, 186 Flags: Print AppearanceDictionary: true Destination: 104 Annotation: Subtype: Link Rect: 182, 93, 187, 102 Flags: Print AppearanceDictionary: true Destination: 109 Annotation: Subtype: Link Rect: 391, 213, 396, 222 Flags: Print AppearanceDictionary: true Destination: 109 Annotation: Subtype: Link Rect: 430, 81, 435, 90 Flags: Print AppearanceDictionary: true Destination: 109 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 386, 429, 391, 438 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 398, 429, 403, 438 Flags: Print AppearanceDictionary: true Destination: 52 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 93, 225, 103, 234 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 109, 225, 118, 234 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 125, 201, 130, 210 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 135, 201, 140, 210 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 146, 201, 156, 210 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 162, 201, 172, 210 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 222, 177, 227, 186 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 99, 141, 103, 150 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 109, 141, 119, 150 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 223, 141, 228, 150 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 247, 93, 252, 102 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 259, 93, 269, 102 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 383, 153, 388, 162 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 396, 153, 401, 162 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 395, 105, 405, 114 Flags: Print AppearanceDictionary: true Destination: 6 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 210, 57, 220, 66 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 331, 129, 340, 138 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 399, 105, 409, 114 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 437, 57, 447, 66 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 454, 57, 463, 66 Flags: Print AppearanceDictionary: true Destination: 6 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 185, 681, 195, 690 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 233, 573, 238, 582 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 80, 440, 90, 449 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 95, 440, 105, 449 Flags: Print AppearanceDictionary: true Destination: 6 Annotation: Subtype: Link Rect: 230, 406, 284, 414 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 397, 133, 405 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 8 Thumb: true Checksum: 47c4671e Type: CRC32 Checksum: 2bdef36e2de0af514b4661881daf71e4 Type: MD5 Checksum: f4f2eb6485e60c01eee1e4b508cf91da4a6998a9 Type: SHA-1 Checksum: 224a6e45301fbc64ef51758cce2bf6c3ba2351526469c2eeb045aacfd85991a9 Type: SHA-256