a93fabb88240f04b8f5f6ec0498cf2e7 pmc_32457586.pdf 40337bf5905802b8191f2084dee723c1df070f53 pmc_32457586.pdf 7988e3a157902439fb91f444bf8d3372db7b4a1d5f91c629d1c80d7c3f33870d pmc_32457586.pdf Title: The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice Subject: Dysfunction and dysregulation at the genetic, neural, and behavioral levels point at the fine-tuning of broadly spread networks as critical for a wide array of behaviors and mental processes through the life span. Keywords: RDoC, PI3K/Akt, signaling pathway, anxiety, cognition, animal model, aging, fine tuning Author: Lydia Giménez-Llort Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Wed May 6 11:37:50 2020 CEST ModDate: Thu May 7 07:10:46 2020 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 3709006 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UTMKBO+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 511 0 GKBDWO+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 512 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 513 0 PKHJOY+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 514 0 VOEJQQ+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 515 0 SICQXQ+MinionPro-It Type 1 Custom yes yes no 315 0 NMRFOH+MinionPro-Regular Type 1 Custom yes yes no 312 0 DWSDUV+MTSYN Type 1 Builtin yes yes no 309 0 JBOOAN+MinionPro-Bold Type 1 Custom yes yes no 323 0 REPYQT+HelveticaNeueLTStd-Md Type 1 Custom yes yes no 320 0 WUCGOR+MTSY Type 1 Builtin yes yes no 322 0 YKLLPG+RMTMI Type 1 Builtin yes yes no 335 0 CMERJW+MTGU Type 1 Builtin yes yes no 336 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:09:19 CEST RepresentationInformation: pmc_32457586.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:46:36 CEST Size: 3709006 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 669 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice Children: Item: Title: INTRODUCTION Item: Title: MATERIALS AND METHODS Children: Item: Title: Analysis of the PDK1 K465E Mutation Item: Title: Generation of PDK1K465E/K465E Mice and Genotyping Analysis Item: Title: Animals Item: Title: Behavioral Assessments Children: Item: Title: Day 0: Reflexes and Sensorimotor Tasks Item: Title: Day 1: Corner Test and Open Field Test Item: Title: Day 2: T-Maze Item: Title: Day 3: Marble-Burying Test Item: Title: Statistics Item: Title: RESULTS Children: Item: Title: Somatic Growth/Body Weight Item: Title: Reflexes and Sensorimotor Tasks Item: Title: Corner Test Item: Title: Open Field Test Item: Title: Spontaneous Alternation in the T-Maze Item: Title: Marble Burying Test Item: Title: Body Weight and Behavioral Correlations Item: Title: DISCUSSION Item: Title: DATA AVAILABILITY STATEMENT Item: Title: ETHICS STATEMENT Item: Title: AUTHOR CONTRIBUTIONS Item: Title: FUNDING Item: Title: ACKNOWLEDGMENTS Item: Title: SUPPLEMENTARY MATERIAL Item: Title: REFERENCES Info: Title: The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice Author: Lydia Giménez-Llort Subject: Dysfunction and dysregulation at the genetic, neural, and behavioral levels point at the fine-tuning of broadly spread networks as critical for a wide array of behaviors and mental processes through the life span. 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