94f796f5ddcaa3d01adf84d5d0ef6283  pmc_32484557.pdf
7832e44df4bb256dc0b3ab2b01769f1a8965a31b  pmc_32484557.pdf
f1801d216736a94b8391c8d0bee79dfff96743230ee44d0d6b8b1d4edfd4dbec  pmc_32484557.pdf

Title:          
Subject:        
Keywords:       
Author:         
Creator:        XMLPublish v.3.0 Copyright 1991-2017 Aptara Inc.
Producer:       Acrobat Distiller 20.0 (Windows); modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version)
CreationDate:   Sun Jun 21 09:42:06 2020 CEST
ModDate:        Sun Jun 21 09:44:29 2020 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          6
Encrypted:      no
Page size:      612.284 x 790.866 pts
Page rot:       0
File size:      1678473 bytes
Optimized:      no
PDF version:    1.4

name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MDBAJM+TimesNewRomanMTStd            Type 1C           Custom           yes yes yes     68  0
MDBAJN+TimesNewRomanMTStd-BoldIt     Type 1C           Custom           yes yes yes     69  0
MDBAJO+TimesNewRomanMTStd-Italic     Type 1C           Custom           yes yes yes     70  0
MDBAJP+Helvetica-Bold                Type 1C           Custom           yes yes no      71  0
MDBBNJ+Helvetica                     Type 1C           WinAnsi          yes yes no      72  0
MDBCAI+MathematicalPi-One            Type 1C           Custom           yes yes no      73  0
MDBCBJ+MTSY                          Type 1C           Custom           yes yes no      74  0
MDBCBK+RMTMI                         Type 1C           Custom           yes yes yes     75  0
MDBCDK+TimesNewRomanMTStd-Bold       Type 1C           Custom           yes yes yes    134  0

Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2020-11-18 06:35:03 CET
 RepresentationInformation: pmc_32484557.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2020-07-06 03:41:06 CEST
  Size: 1678473
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: ISO PDF/A-1, Level B
  PDFMetadata: 
   Objects: 279
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseThumbs
   Info: 
    Title: 
    Author: 
    Subject: 
    Keywords: 
    Creator: XMLPublish v.3.0 Copyright 1991-2017 Aptara Inc.
    Producer: Acrobat Distiller 20.0 (Windows); modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version)
    CreationDate: Sun Jun 21 10:12:06 CEST 2020
    ModDate: Sun Jun 21 05:44:29 CEST 2020
   ID: 0x41924440e8ab227e35baa55b0a7cc3a5, 0x5aa2b1f9a4330a7ca735e965ed7de530
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1800
      ImageHeight: 1027
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1969
      ImageHeight: 982
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2348
      ImageHeight: 1770
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MDBAJM+TimesNewRomanMTStd
      FontSubset: true
      FirstChar: 2
      LastChar: 248
      FontDescriptor: 
       FontName: MDBAJM+TimesNewRomanMTStd
       Flags: Serif, Symbolic
       FontBBox: -94, -241, 1006, 916
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MDBAJN+TimesNewRomanMTStd-BoldIt
      FontSubset: true
      FirstChar: 52
      LastChar: 133
      FontDescriptor: 
       FontName: MDBAJN+TimesNewRomanMTStd-BoldIt
       Flags: Serif, Symbolic, Italic, ForceBold
       FontBBox: -266, -259, 1076, 942
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MDBAJO+TimesNewRomanMTStd-Italic
      FontSubset: true
      FirstChar: 2
      LastChar: 121
      FontDescriptor: 
       FontName: MDBAJO+TimesNewRomanMTStd-Italic
       Flags: Serif, Symbolic, Italic
       FontBBox: -271, -246, 1100, 904
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MDBCDK+TimesNewRomanMTStd-Bold
      FontSubset: true
      FirstChar: 45
      LastChar: 119
      FontDescriptor: 
       FontName: MDBCDK+TimesNewRomanMTStd-Bold
       Flags: Serif, Symbolic, ForceBold
       FontBBox: -191, -241, 1065, 957
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MDBAJP+Helvetica-Bold
      FontSubset: true
      FirstChar: 25
      LastChar: 180
      FontDescriptor: 
       FontName: MDBAJP+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: MDBBNJ+Helvetica
      FontSubset: true
      FirstChar: 40
      LastChar: 180
      FontDescriptor: 
       FontName: MDBBNJ+Helvetica
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MDBCAI+MathematicalPi-One
      FontSubset: true
      FirstChar: 2
      LastChar: 4
      FontDescriptor: 
       FontName: MDBCAI+MathematicalPi-One
       Flags: Symbolic
       FontBBox: -30, -210, 1000, 779
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: MDBCBJ+MTSY
      FontSubset: true
      FirstChar: 2
      LastChar: 2
      FontDescriptor: 
       FontName: MDBCBJ+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: MDBCBK+RMTMI
      FontSubset: true
      FirstChar: 47
      LastChar: 62
      FontDescriptor: 
       FontName: MDBCBK+RMTMI
       Flags: Symbolic, Italic
       FontBBox: 0, -213, 987, 680
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.1.0-jc003">
  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
    <rdf:Description rdf:about=""
        xmlns:dc="http://purl.org/dc/elements/1.1/"
        xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/"
        xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
        xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
        xmlns:xmp="http://ns.adobe.com/xap/1.0/"
      dc:format="xml"
      dc:identifier="doi:10.1093/nar/gkaa440"
      prism:aggregationType="journal"
      prism:publicationName="Nucleic Acids Research"
      prism:issn="1362-4962"
      prism:doi="10.1093/nar/gkaa440"
      prism:url="http://dx.doi.org/10.1093/nar/gkaa440"
      jav:journal_article_version="VoR"
      pdf:Producer="Acrobat Distiller 20.0 (Windows); modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version)"
      xmp:ModifyDate="2020-06-21T03:44:29-04:00"
      xmp:MetadataDate="2020-06-21T03:44:29-04:00">
      <dc:title>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">HomolWat: a web server tool to incorporate ‘homologous’ water molecules into GPCR structures</rdf:li>
        </rdf:Alt>
      </dc:title>
      <dc:creator>
        <rdf:Seq>
          <rdf:li>Eduardo Mayol</rdf:li>
          <rdf:li>Adrián García-Recio</rdf:li>
          <rdf:li>Johanna K S Tiemann</rdf:li>
          <rdf:li>Peter W Hildebrand</rdf:li>
          <rdf:li>Ramon Guixà-González</rdf:li>
          <rdf:li>Mireia Olivella</rdf:li>
          <rdf:li>Arnau Cordomí</rdf:li>
        </rdf:Seq>
      </dc:creator>
      <dc:description>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">Nucleic Acids Research</rdf:li>
        </rdf:Alt>
      </dc:description>
      <dc:publisher>
        <rdf:Bag>
          <rdf:li>Oxford University Press</rdf:li>
        </rdf:Bag>
      </dc:publisher>
    </rdf:Description>
  </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 54
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 128, 652, 137, 667
      Annotation: 
       Subtype: Link
       Rect: 264, 652, 273, 667
      Annotation: 
       Subtype: Link
       Rect: 416, 652, 426, 667
      Annotation: 
       Subtype: Link
       Rect: 122, 636, 132, 651
      Annotation: 
       Subtype: Link
       Rect: 292, 636, 302, 651
      Annotation: 
       Subtype: Link
       Rect: 401, 636, 411, 651
      Annotation: 
       Subtype: Link
       Rect: 536, 636, 546, 651
      Annotation: 
       Subtype: Link
       Rect: 40, 224, 290, 251
      Annotation: 
       Subtype: Link
       Rect: 230, 131, 247, 143
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 439, 449, 446, 462
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 447, 449, 454, 462
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 422, 405, 429, 418
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 468, 383, 475, 396
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 517, 350, 524, 363
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 311, 295, 323, 308
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 401, 219, 554, 231
      Annotation: 
       Subtype: Link
       Rect: 508, 153, 520, 166
       Destination: 99
    Page: 
     Label: 55
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 288, 689, 300, 701
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 132, 678, 144, 691
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 109, 656, 121, 669
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 121, 656, 133, 669
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 230, 645, 242, 658
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 150, 590, 270, 603
      Annotation: 
       Subtype: Link
       Rect: 129, 390, 141, 403
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 168, 357, 180, 370
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 57, 303, 69, 315
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 188, 281, 200, 293
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 131, 204, 297, 217
      Annotation: 
       Subtype: Link
       Rect: 173, 97, 185, 110
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 154, 53, 165, 66
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 321, 667, 328, 679
       Destination: 97
      Annotation: 
       Subtype: Link
       Rect: 356, 601, 368, 614
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 469, 470, 481, 482
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 396, 459, 403, 471
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 404, 459, 416, 471
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 458, 426, 470, 438
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 324, 404, 336, 416
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 382, 294, 394, 307
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 354, 207, 365, 219
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 555, 196, 567, 208
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 481, 64, 493, 77
       Destination: 99
    Page: 
     Label: 56
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 57, 318, 64, 330
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 125, 241, 132, 254
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 113, 230, 120, 243
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 121, 230, 128, 243
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 180, 208, 187, 221
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 188, 208, 195, 221
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 232, 208, 239, 221
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 510, 405, 522, 418
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 536, 394, 547, 407
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 509, 340, 521, 352
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 308, 329, 315, 341
       Destination: 98
      Annotation: 
       Subtype: Link
       Rect: 527, 208, 539, 221
       Destination: 99
    Page: 
     Label: 57
     Sequence: 4
    Page: 
     Label: 58
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 207, 689, 284, 701
      Annotation: 
       Subtype: Link
       Rect: 109, 656, 121, 669
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 253, 601, 265, 614
       Destination: 99
      Annotation: 
       Subtype: Link
       Rect: 78, 590, 90, 603
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 157, 590, 169, 603
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 40, 516, 291, 542
      Annotation: 
       Subtype: Link
       Rect: 121, 495, 287, 508
      Annotation: 
       Subtype: Link
       Rect: 41, 455, 131, 467
    Page: 
     Label: 59
     Sequence: 6
  Checksum: d6cb7907
   Type: CRC32
  Checksum: 94f796f5ddcaa3d01adf84d5d0ef6283
   Type: MD5
  Checksum: 7832e44df4bb256dc0b3ab2b01769f1a8965a31b
   Type: SHA-1