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Methods Destination: section.2 Children: Item: Title: Chemistry Destination: subsection.2.1 Item: Title: Instrumentation Destination: subsection.2.2 Item: Title: Synthesis of Lapatinib Derivative Destination: subsection.2.3 Item: Title: General Procedure for Hybrids 18 23 Preparation Destination: subsection.2.4 Children: Item: Title: Hybrid 18 Destination: subsubsection.2.4.1 Item: Title: Hybrid 19 Destination: subsubsection.2.4.2 Item: Title: Hybrid 20 Destination: subsubsection.2.4.3 Item: Title: Hybrid 21 Destination: subsubsection.2.4.4 Item: Title: Hybrid 22 Destination: subsubsection.2.4.5 Item: Title: Bioisoster 23 Destination: subsubsection.2.4.6 Item: Title: Biology Destination: subsection.2.5 Children: Item: Title: Tumor Cells Destination: subsubsection.2.5.1 Item: Title: Glia Primary Cell Culture Destination: subsubsection.2.5.2 Item: Title: Study Approval Destination: subsection.2.6 Item: Title: Cytotoxicity Assays Destination: subsection.2.7 Item: Title: Kinase Enzymatic Assays Destination: subsection.2.8 Item: Title: Flow Cytometry Analysis Destination: subsection.2.9 Item: Title: Statistical Analysis Destination: subsection.2.10 Item: Title: Fluorescence Microscopy Analysis Destination: subsection.2.11 Item: Title: In Vitro BNCT Experiments Destination: subsection.2.12 Children: Item: Title: Determination of Intracellular Boron by Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). Destination: subsubsection.2.12.1 Item: Title: Neutron-Irradiation Procedures Destination: subsubsection.2.12.2 Item: Title: Irradiation of Hybrid 19-, 22- or BPA-Treated HT-29 Cells Assays Destination: subsubsection.2.12.3 Item: Title: Cell Surviving Assay Destination: subsubsection.2.12.4 Item: Title: Results and Discussion Destination: section.3 Children: Item: Title: Design and Synthesis of Hybrids Carboranyl-Decorated Lapatinib-Scaffold Destination: subsection.3.1 Item: Title: Biological Studies Destination: subsection.3.2 Children: Item: Title: In Vitro Cytotoxicity Studies Destination: subsubsection.3.2.1 Item: Title: In Vitro Inhibition of EGRF by Hybrid 19 Destination: subsubsection.3.2.2 Item: Title: Effect of Hybrid 19 on Simulated Tumor Environment Destination: subsubsection.3.2.3 Item: Title: In Vitro BNCT Studies Destination: subsection.3.3 Children: Item: Title: Boron Cellular Accumulation Destination: subsubsection.3.3.1 Item: Title: Neutron Irradiation Treatments 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