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Title:           Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice
Subject:         Molecular Neurodegeneration, 2020, doi:10.1186/s13024-020-00382-8
Keywords:        APOE4,Astrocytes,Calcium signaling,Sex,Lysosome,Purinergic receptors,Lipidome
Author:          Raquel Larramona-Arcas
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       Item: 
        Title: Methods
        Destination: sectionASec2
       Item: 
        Title: Results
        Destination: sectionASec3
       Item: 
        Title: Conclusions
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     Item: 
      Title: Background
      Destination: sectionSec1
     Item: 
      Title: Materials and methods
      Destination: sectionSec2
      Children: 
       Item: 
        Title: Animal model
        Destination: sectionSec3
       Item: 
        Title: Cell culture
        Destination: sectionSec4
       Item: 
        Title: Ca2+ imaging in astrocytes ex’vivo in brain slices
        Destination: sectionSec5
       Item: 
        Title: Ca2+imaging in astrocytes in’vitro in immortalized astrocytes
        Destination: sectionSec6
       Item: 
        Title: Plasmid transfection and siRNA silencing
        Destination: sectionSec7
       Item: 
        Title: Lysosomal pH measurement
        Destination: sectionSec8
       Item: 
        Title: Immunocytochemistry
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       Item: 
        Title: Cholesterol staining
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       Item: 
        Title: Lysosomal isolation
        Destination: sectionSec11
       Item: 
        Title: Lipidomics
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       Item: 
        Title: Western blot
        Destination: sectionSec13
       Item: 
        Title: Measurement of mRNA expression
        Destination: sectionSec14
       Item: 
        Title: Statistical analysis
        Destination: sectionSec15
     Item: 
      Title: Results
      Destination: sectionSec16
      Children: 
       Item: 
        Title: APOE4 expression alters astrocytic excitability
        Destination: sectionSec17
       Item: 
        Title: Immortalized APOE4 astrocytes show increased Ca2+ mobilization from acidic stores
        Destination: sectionSec18
       Item: 
        Title: Dysregulation of V-ATPase activity contributes to the alteration of Ca2+ responses in APOE4 astrocytes
        Destination: sectionSec19
       Item: 
        Title: APOE3 expression in APOE4 astrocytes reduces cytosolic Ca2+ responses
        Destination: sectionSec20
       Item: 
        Title: ATP-induced Ca2+ responses are modulated by extracellular lipids in APOE3 but not APOE4 astrocytes
        Destination: sectionSec21
       Item: 
        Title: The absence of lipids potentiates Ca2+ release from the ER and extracellular Ca2+ entry in APOE3 but not APOE4 astrocytes
        Destination: sectionSec22
       Item: 
        Title: Lipidomics reveals distinct lipid composition in lysosomal and whole-cell membranes from APOE3 and APOE4 astrocytes
        Destination: sectionSec23
     Item: 
      Title: Discussion
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     Item: 
      Title: Conclusions
      Destination: sectionSec25
     Item: 
      Title: Abbreviations
      Destination: sectionabr1
     Item: 
      Title: Acknowledgements
      Destination: section1
     Item: 
      Title: Authors’ contributions
      Destination: section2
     Item: 
      Title: Funding
      Destination: section3
     Item: 
      Title: Availability of data and materials
      Destination: section4
     Item: 
      Title: Ethics approval
      Destination: sectionFPar1
     Item: 
      Title: Consent for publication
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     Item: 
      Title: Competing interests
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     Item: 
      Title: Author details
      Destination: section5
     Item: 
      Title: References
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     Item: 
      Title: Publisher’s Note
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    Title: Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice
    Author: Raquel Larramona-Arcas
    Subject: Molecular Neurodegeneration, 2020, doi:10.1186/s13024-020-00382-8
    Keywords: APOE4,Astrocytes,Calcium signaling,Sex,Lysosome,Purinergic receptors,Lipidome
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                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
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                           <pdfaType:description>Specifies the types of editor information: name and ORCID of an editor.</pdfaType:description>
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                                    <pdfaField:description>Gives the name of an editor.</pdfaField:description>
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                                    <pdfaField:valueType>URI</pdfaField:valueType>
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