ae94d82037a29b43035970f43441755a  pmc_32555447.pdf
99a94f6e7b41b588ea1abd16d79506713939e2c9  pmc_32555447.pdf
a7d3f36cbd313fa03e02719fbb295ded14ec51e0f91dcda78bb620956cdc2382  pmc_32555447.pdf

Title:           Identification of eQTLs associated with lipid metabolism in Longissimus dorsi muscle of pigs with different genetic backgrounds
Subject:         Scientific Reports, doi:10.1038/s41598-020-67015-4
Keywords:        
Author:          Lourdes Criado-Mesas
Creator:         Springer
Producer:        iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Wed Jun 10 11:21:16 2020 CEST
ModDate:         Thu Jun 11 16:44:45 2020 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       595.276 x 782.362 pts
Page rot:        0
File size:       2309935 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
TFZNWB+Corbel-Bold                   CID TrueType      Identity-H       yes yes yes     54  0
OTNLZL+ArialUnicodeMS                CID TrueType      Identity-H       yes yes yes    465  0
PZHBNJ+Corbel-BoldItalic             CID TrueType      Identity-H       yes yes yes    466  0
GXXYMS+Corbel-BoldItalic2            Type 1C           WinAnsi          yes yes yes    467  0
EuclidSymbol                         Type 1C           Custom           yes no  yes     59  0
EuclidSymbol-Bold                    Type 1C           Custom           yes no  yes    468  0
PJWTQY+Corbel-Bold2                  Type 1C           WinAnsi          yes yes yes     57  0
MinionPro-Regular                    Type 1C           Custom           yes no  yes     56  0
ABLGLL+Corbel2                       Type 1C           WinAnsi          yes yes yes     60  0
ZDEHCP+Corbel                        CID TrueType      Identity-H       yes yes yes     62  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes     63  0
ABLGLL+Corbel2                       Type 1C           WinAnsi          yes yes yes    523  0
MinionPro-It                         Type 1C           Custom           yes no  yes     55  0
MinionPro-Bold                       Type 1C           WinAnsi          yes no  yes     58  0
PFWZIJ+STIXGeneral-Regular           Type 1C           Custom           yes yes yes     61  0
PFWZIJ+TimesNewRomanPSMT             Type 1C           WinAnsi          yes yes yes    339  0
EuclidSymbol-Italic                  Type 1C           Custom           yes no  yes    340  0
STIXGeneral-Italic                   Type 1C           Custom           yes no  yes    341  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-10-02 04:07:33 CEST
 RepresentationInformation: pmc_32555447.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2023-03-31 11:46:46 CEST
  Size: 2309935
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 585
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Identification of eQTLs associated with lipid metabolism in Longissimus dorsi muscle of pigs with different genetic backgro ...
      Children: 
       Item: 
        Title: Results and discussion
        Children: 
         Item: 
          Title: Sex and genetic background effect on gene expression. 
         Item: 
          Title: Gene expression correlations. 
         Item: 
          Title: Genome-wide association studies for gene expression and eQTL identification. 
          Children: 
           Item: 
            Title: Cis-eQTLs. 
           Item: 
            Title: Trans-eQTLs. 
         Item: 
          Title: eGWAS analysis for each backcross independently. 
          Children: 
           Item: 
            Title: Cis-eQTLs. 
           Item: 
            Title: Hotspots identified in trans-eQTLs regions. 
       Item: 
        Title: Conclusions
       Item: 
        Title: Material and Methods
        Children: 
         Item: 
          Title: Animal material. 
         Item: 
          Title: Genotyping. 
         Item: 
          Title: Gene expression. 
         Item: 
          Title: Genome-wide association analysis for gene expression. 
         Item: 
          Title: Gene annotation. 
         Item: 
          Title: Co-expression and functional analysis. 
       Item: 
        Title: Acknowledgements
       Item: 
        Title: Figure 1 Comparison between females (F) and males (M) of mRNA expression levels of 45 lipid-related genes in animals from the 3BCs.
       Item: 
        Title: Figure 2 Comparison between the three experimental backcrosses in the mRNA expression levels of 45 lipid-related genes.
       Item: 
        Title: Figure 3 Gene co-expression network in 3BCs using the PCIT algorithm.
       Item: 
        Title: Figure 4 PhenoGram plot representing associated gene expression regions along pig chromosomes in the 3BCs study and in each backcross individually.
       Item: 
        Title: Figure 5 GWAS plot of muscle IGF2 gene expression in the 3BCs study.
       Item: 
        Title: Figure 6 Plot of mRNA expression values (NQ) of IGF2 in muscle tissue according to the IGF2:g.
       Item: 
        Title: Figure 7 GWAS plot of muscle ACSM5 gene expression in the 3BCs study.
       Item: 
        Title: Figure 8 (A) GeneMANIA analysis between SSC2 hotspot genes.
       Item: 
        Title: Figure 9 Co-expression network for genes associated with the BC1_DU trans-eQTL hotspot on SSC1 using the PCIT algorithm.
       Item: 
        Title: Table 1 Significant eQTLs for the 45-muscle gene expression study in 3BCs animals.
   Info: 
    Title: Identification of eQTLs associated with lipid metabolism in Longissimus dorsi muscle of pigs with different genetic backgrounds
    Author: Lourdes Criado-Mesas
    Subject: Scientific Reports, doi:10.1038/s41598-020-67015-4
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Wed Jun 10 11:51:16 CEST 2020
    ModDate: Thu Jun 11 16:44:45 CEST 2020
   ID: 0x2220c3d212f3d0ba23916aadcc8e0fc5, 0x21524d16dc5228884c154fa7b256ed43
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 730
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 832
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1650
      ImageHeight: 992
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1650
      ImageHeight: 2009
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 850
      ImageHeight: 731
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1250
      ImageHeight: 434
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1250
      ImageHeight: 421
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1000
      ImageHeight: 739
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1650
      ImageHeight: 744
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: OTNLZL+ArialUnicodeMS
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: PZHBNJ+Corbel-BoldItalic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: TFZNWB+Corbel-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: ZDEHCP+Corbel
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: GXXYMS+Corbel-BoldItalic2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: GXXYMS+Corbel-BoldItalic2
       Flags: Nonsymbolic, Italic
       FontBBox: -494, -239, 1194, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: PFWZIJ+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: PFWZIJ+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: EuclidSymbol-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EuclidSymbol-Bold
       Flags: Symbolic
       FontBBox: -186, -308, 1101, 960
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EuclidSymbol-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EuclidSymbol-Italic
       Flags: Symbolic, Italic
       FontBBox: -166, -276, 1162, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: STIXGeneral-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIXGeneral-Italic
       Flags: Serif, Symbolic, Italic
       FontBBox: -995, -455, 1485, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -201, -360, 1684, 1002
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -290, -360, 1684, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PJWTQY+Corbel-Bold2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: PJWTQY+Corbel-Bold2
       Flags: Nonsymbolic
       FontBBox: -556, -239, 1155, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MinionPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MinionPro-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -319, -360, 1684, 1024
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: EuclidSymbol
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EuclidSymbol
       Flags: Symbolic
       FontBBox: -166, -253, 1090, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ABLGLL+Corbel2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: ABLGLL+Corbel2
       Flags: Nonsymbolic
       FontBBox: -553, -239, 1110, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: PFWZIJ+STIXGeneral-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 31
      FontDescriptor: 
       FontName: PFWZIJ+STIXGeneral-Regular
       Flags: Serif, Symbolic
       FontBBox: -995, -455, 2000, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: OTNLZL+ArialUnicodeMS
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: OTNLZL+ArialUnicodeMS
       Flags: Symbolic
       FontBBox: -1011, -330, 2260, 1078
       FontFile2: true
     Font: 
      BaseFont: PZHBNJ+Corbel-BoldItalic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: PZHBNJ+Corbel-BoldItalic
       Flags: Symbolic, Italic
       FontBBox: -494, -239, 1194, 952
       FontFile2: true
     Font: 
      BaseFont: ZDEHCP+Corbel
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ZDEHCP+Corbel
       Flags: Symbolic
       FontBBox: -553, -239, 1110, 952
       FontFile2: true
     Font: 
      BaseFont: TFZNWB+Corbel-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: TFZNWB+Corbel-Bold
       Flags: Symbolic
       FontBBox: -556, -239, 1155, 952
       FontFile2: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.2-c001 63.143651, 2012/04/05-09:01:49        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41598-020-67015-4</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Scientific Reports, doi:10.1038/s41598-020-67015-4</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Identification of eQTLs associated with lipid metabolism in Longissimus dorsi muscle of pigs with different genetic backgrounds</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Lourdes Criado-Mesas</rdf:li>
               <rdf:li>Maria Ballester</rdf:li>
               <rdf:li>Daniel Crespo-Piazuelo</rdf:li>
               <rdf:li>Anna Castellamp#x000F3;</rdf:li>
               <rdf:li>Ana I. Fernamp#x000E1;ndez</rdf:li>
               <rdf:li>Josep M. Folch</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
         <prism:doi>10.1038/s41598-020-67015-4</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41598-020-67015-4</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Scientific Reports</prism:publicationName>
         <prism:copyright>© 2020, The Author(s)</prism:copyright>
         <prism:issn>2045-2322</prism:issn>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:doi>10.1038/s41598-020-67015-4</pdfx:doi>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2020-06-11T16:44:45+02:00</xmp:ModifyDate>
         <xmp:CreateDate>2020-06-10T14:51:16+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2020-06-11T16:44:45+02:00</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords></pdf:Keywords>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
      <rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:f332db2e-55b0-4343-be5d-776808e07f95</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:ac7f3622-8f0e-402f-bd55-8cfdfc9f8196</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:4e5f0afc-f6cd-4427-a221-0f54553db06c</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2020-06-10T14:52:38+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/">
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
      </rdf:Description>
      <rdf:Description rdf:about="" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#">
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 250, 509, 259, 495
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 341, 509, 350, 495
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 458, 509, 467, 495
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 461, 270, 464, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 379, 240, 382, 228
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 251, 190, 254, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 451, 180, 454, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 501, 170, 503, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 505, 170, 508, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 511, 170, 513, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 208, 140, 211, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 478, 120, 481, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 484, 120, 489, 108
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 264, 54, 377, 42
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 481, 655, 556, 637
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 325, 473, 331, 461
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 383, 443, 388, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 368, 423, 373, 411
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 456, 413, 461, 401
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 463, 413, 468, 401
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 392, 363, 398, 351
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 506, 304, 511, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 514, 304, 520, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 465, 254, 469, 242
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 349, 184, 355, 172
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 316, 164, 321, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 323, 164, 328, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 537, 144, 542, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 321, 114, 327, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 204, 84, 209, 72
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 287, 74, 293, 62
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 462, 64, 467, 52
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 363, 54, 369, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 467, 472, 473, 460
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 529, 462, 535, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 208, 422, 214, 410
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 517, 422, 523, 410
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 319, 392, 325, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 330, 352, 334, 340
       Flags: Print
       AppearanceDictionary: true
       Destination: 65
      Annotation: 
       Subtype: Link
       Rect: 494, 242, 500, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 501, 242, 507, 230
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 334, 170, 340, 158
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 203, 160, 208, 148
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 286, 130, 292, 118
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 510, 60, 516, 48
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 256, 198, 262, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 354, 106, 359, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 545, 106, 549, 94
       Flags: Print
       AppearanceDictionary: true
       Destination: 118
      Annotation: 
       Subtype: Link
       Rect: 202, 66, 206, 54
       Flags: Print
       AppearanceDictionary: true
       Destination: 137
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 322, 178, 327, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 529, 178, 535, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 291, 148, 297, 136
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 298, 148, 303, 136
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 330, 128, 334, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 137
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 345, 243, 350, 231
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 349, 213, 355, 201
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 339, 183, 344, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 362, 153, 366, 141
       Flags: Print
       AppearanceDictionary: true
       Destination: 159
      Annotation: 
       Subtype: Link
       Rect: 344, 73, 349, 61
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 502, 546, 507, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 517, 516, 522, 504
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 445, 476, 451, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 296, 456, 302, 444
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 406, 446, 412, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 470, 416, 476, 404
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 499, 406, 505, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 531, 366, 535, 354
       Flags: Print
       AppearanceDictionary: true
       Destination: 100
      Annotation: 
       Subtype: Link
       Rect: 463, 356, 469, 344
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 327, 326, 332, 314
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 400, 226, 405, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 170, 196, 175, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 118
      Annotation: 
       Subtype: Link
       Rect: 412, 105, 417, 93
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 546, 694, 552, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 411, 584, 417, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 290, 414, 295, 402
       Flags: Print
       AppearanceDictionary: true
       Destination: 118
      Annotation: 
       Subtype: Link
       Rect: 439, 304, 444, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 388, 294, 394, 282
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 278, 274, 282, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 137
      Annotation: 
       Subtype: Link
       Rect: 244, 264, 254, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 235
      Annotation: 
       Subtype: Link
       Rect: 520, 264, 530, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 235
      Annotation: 
       Subtype: Link
       Rect: 313, 204, 318, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 321, 204, 327, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 348, 194, 353, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 354, 194, 360, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 363, 194, 369, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 377, 124, 383, 112
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 385, 124, 390, 112
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 279, 104, 285, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 354, 54, 360, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 428, 262, 434, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 518, 192, 524, 180
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 539, 182, 545, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 546, 182, 552, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 310, 152, 314, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 235
      Annotation: 
       Subtype: Link
       Rect: 420, 142, 426, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 183, 724, 188, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 409, 724, 414, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 348, 674, 353, 662
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 460, 654, 466, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 182, 604, 188, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 181, 594, 187, 582
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 264, 584, 270, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 169, 574, 175, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 312, 394, 318, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 443, 324, 449, 312
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 184, 274, 189, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 347, 264, 353, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 188, 254, 194, 242
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 449, 244, 455, 232
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 456, 244, 462, 232
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 487, 134, 492, 122
       Flags: Print
       AppearanceDictionary: true
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 313, 114, 319, 102
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 522, 104, 528, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 549, 84, 554, 72
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 312, 64, 318, 52
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 390, 54, 396, 42
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 502, 724, 507, 712
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 280, 714, 286, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 287, 714, 293, 702
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 364, 686, 369, 674
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 437, 686, 443, 674
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 481, 588, 487, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 488, 588, 494, 576
       Flags: Print
       AppearanceDictionary: true
       Destination: 353
      Annotation: 
       Subtype: Link
       Rect: 220, 568, 226, 556
       Flags: Print
       AppearanceDictionary: true
       Destination: 360
      Annotation: 
       Subtype: Link
       Rect: 505, 538, 511, 526
       Flags: Print
       AppearanceDictionary: true
       Destination: 360
      Annotation: 
       Subtype: Link
       Rect: 416, 528, 421, 516
       Flags: Print
       AppearanceDictionary: true
       Destination: 360
      Annotation: 
       Subtype: Link
       Rect: 439, 518, 445, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 360
      Annotation: 
       Subtype: Link
       Rect: 483, 518, 489, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 360
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 223, 25, 370, 16
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 361, 413, 520, 401
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 349, 384, 441, 372
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 344, 275, 504, 263
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 652a3a90
   Type: CRC32
  Checksum: ae94d82037a29b43035970f43441755a
   Type: MD5
  Checksum: 99a94f6e7b41b588ea1abd16d79506713939e2c9
   Type: SHA-1
  Checksum: a7d3f36cbd313fa03e02719fbb295ded14ec51e0f91dcda78bb620956cdc2382
   Type: SHA-256