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2023-05-18) Date: 2024-10-02 04:06:36 CEST RepresentationInformation: 227832.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:46:50 CEST Size: 1619378 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 248 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Clinical and biomarker changes of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study Children: Item: Title: Introduction Item: Title: Methods Children: Item: Title: Study design and participants Item: Title: Procedures Item: Title: 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doi:10.1016/S0140-6736(20)30689-9 Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study Juan Fortea PhD Eduard Vilaplana PhD Maria Carmona-Iragui PhD Bessy Benejam BSc Laura Videla MSc Isabel Barroeta PhD Susana Fernández MD Miren Altuna MD Jordi Pegueroles MSc Víctor Montal MSc Silvia Valldeneu Sandra Giménez PhD Sofía González-Ortiz PhD Laia Muñoz BSc Teresa Estellés MD Ignacio Illán-Gala PhD Olivia Belbin PhD Valle Camacho PhD Liam Reese Wilson PhD Tiina Annus PhD Ricardo S Osorio MD Prof Sebastián Videla PhD Prof Sylvain Lehmann MD Anthony J Holland MD Daniel Alcolea PhD Jordi Clarimón PhD Shahid H Zaman PhD Rafael Blesa PhD Alberto Lleó PhD The Lancet, 395 (2020) 1988-1997. doi:10.1016/S0140-6736(20)30689-9 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license journal The Lancet Copyright © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. 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