981af0c2d86100532cb3d863abc138e6 pmc_32605631.pdf dddb065196f6082c4378a9e4f9c1e26cb35726fe pmc_32605631.pdf 6806d49992969c17cf3910d6c036beb93344b4f7d747f497978f4bb19532b7e5 pmc_32605631.pdf Title: High content drug screening for Fanconi anemia therapeutics Subject: Orphanet Journal of Rare Diseases, 2020, doi:10.1186/s13023-020-01437-1 Keywords: Fanconi anemia,High content screening,Drug repositioning,Cell-based assay Author: Helena Montanuy Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sun Jun 28 12:39:39 2020 CEST ModDate: Tue Jun 30 13:50:02 2020 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1616211 bytes Optimized: no PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 23 0 OFCGLD+KylgwjAdvTT86d47313 Type 1C WinAnsi yes yes no 18 0 OFCHIP+QcxbbpAdvTT7329fd89.I Type 1C WinAnsi yes yes no 20 0 OFCEPI+YmmgmgAdvTTaf7f9f4f.B Type 1C WinAnsi yes yes no 21 0 OFCGJP+FcsqtlAdvTTe45e47d2 Type 1C WinAnsi yes yes no 22 0 OFCGKA+DtcgdpAdvTTb5929f4c Type 1C WinAnsi yes yes no 56 0 OFCGKB+ShhsymAdvTTb5929f4c+20 Type 1C WinAnsi yes yes no 57 0 OFCGLB+FpsjtkAdvTT99c4c969 Type 1C WinAnsi yes yes no 24 0 OFCGLC+CtlyqxAdvTT1b53b5fb.I Type 1C WinAnsi yes yes no 58 0 OFCHMA+FltrgxAdvTT86d47313+03 Type 1C Custom yes yes yes 17 0 OFCHMB+MtsfkwAdvTT86d47313+20 Type 1C Custom yes yes yes 19 0 OFCLPI+HgmvxxAdvTTb5929f4c+22 Type 1C Custom yes yes no 214 0 OFCNEB+PbwdykAdvTTb5929f4c+03 Type 1C Custom yes yes yes 230 0 OFDBKJ+CxlbccAdvTT99c4c969+20 Type 1C WinAnsi yes yes no 348 0 OFDBJH+RbyqdjAdvTT86d47313+21 Type 1C WinAnsi yes yes no 341 0 OFDBJI+KhknftAdvTT8861b38f.I+03 Type 1C Custom yes yes yes 344 0 OFDBNJ+PhpbskAdvTTaf7f9f4f.B+20 Type 1C WinAnsi yes yes no 361 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-02 04:06:23 CEST RepresentationInformation: pmc_32605631.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:46:52 CEST Size: 1616211 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 408 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: sectionAbs1 Children: Item: Title: Background Destination: sectionASec1 Item: Title: Results Destination: sectionASec2 Item: Title: Conclusions Destination: sectionASec3 Item: Title: Background Destination: sectionSec1 Item: Title: Results Destination: sectionSec2 Children: Item: Title: FA-cell based system to monitor FANCD2 foci formation Destination: sectionSec3 Item: Title: High content screening Destination: sectionSec4 Item: Title: Hit validation Destination: sectionSec5 Item: Title: Discussion Destination: sectionSec6 Item: Title: Conclusions Destination: sectionSec7 Item: Title: Methods Destination: sectionSec8 Children: Item: Title: Reagents Destination: sectionSec9 Item: Title: Cell lines Destination: sectionSec10 Item: Title: Survival assay Destination: sectionSec11 Item: Title: Western blot Destination: sectionSec12 Item: Title: FANCD2 foci Destination: sectionSec13 Item: Title: High content screening Destination: sectionSec14 Item: Title: Micronucleus analysis by cell cytometry Destination: sectionSec15 Item: Title: Supplementary information Destination: sectionSec16 Item: Title: Acknowledgments Destination: section1 Item: Title: Authors’ contributions Destination: section2 Item: Title: Funding Destination: section3 Item: Title: Availability of data and materials Destination: section4 Item: Title: Ethics approval and consent to participate Destination: sectionFPar1 Item: Title: Consent for publication Destination: sectionFPar2 Item: Title: Competing interests Destination: sectionFPar3 Item: Title: Author details Destination: section5 Item: Title: References Destination: sectionBib1 Item: Title: Publisher’s Note Destination: ArtNote2 Info: Title: High content drug screening for Fanconi anemia therapeutics Author: Helena Montanuy Subject: Orphanet Journal of Rare Diseases, 2020, doi:10.1186/s13023-020-01437-1 Keywords: Fanconi anemia,High content screening,Drug repositioning,Cell-based assay Creator: Arbortext Advanced Print Publisher 9.1.440/W Unicode Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sun Jun 28 12:39:39 CEST 2020 ModDate: Tue Jun 30 13:50:02 CEST 2020 ID: 0x9ecea6db04b5748c158783c2d8eecc65, 0x77d1a6f381e2c5d26ff119477809ad4e Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 176 ImageHeight: 182 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 688 ImageHeight: 126 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 54 ImageHeight: 103 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1370 ImageHeight: 1879 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 594 ImageHeight: 264 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1322 ImageHeight: 1387 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: OFCNEB+PbwdykAdvTTb5929f4c+03 FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: OFCNEB+PbwdykAdvTTb5929f4c+03 Flags: Symbolic FontBBox: -531, -260, 802, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OFDBNJ+PhpbskAdvTTaf7f9f4f.B+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: OFDBNJ+PhpbskAdvTTaf7f9f4f.B+20 Flags: Nonsymbolic FontBBox: -468, -197, 1656, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFCHMA+FltrgxAdvTT86d47313+03 FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: OFCHMA+FltrgxAdvTT86d47313+03 Flags: Symbolic FontBBox: -364, -250, 906, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OFCGLD+KylgwjAdvTT86d47313 FontSubset: true FirstChar: 32 LastChar: 215 FontDescriptor: FontName: OFCGLD+KylgwjAdvTT86d47313 Flags: Serif, Nonsymbolic FontBBox: -218, -239, 1020, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFCHMB+MtsfkwAdvTT86d47313+20 FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: OFCHMB+MtsfkwAdvTT86d47313+20 Flags: Symbolic FontBBox: -354, -218, 1291, 812 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OFCHIP+QcxbbpAdvTT7329fd89.I FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: OFCHIP+QcxbbpAdvTT7329fd89.I Flags: Nonsymbolic FontBBox: -218, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFCEPI+YmmgmgAdvTTaf7f9f4f.B FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: OFCEPI+YmmgmgAdvTTaf7f9f4f.B Flags: Nonsymbolic FontBBox: -218, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFDBJH+RbyqdjAdvTT86d47313+21 FontSubset: true FirstChar: 32 LastChar: 153 FontDescriptor: FontName: OFDBJH+RbyqdjAdvTT86d47313+21 Flags: Nonsymbolic FontBBox: -20, -208, 1208, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFCGJP+FcsqtlAdvTTe45e47d2 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: OFCGJP+FcsqtlAdvTTe45e47d2 Flags: Nonsymbolic FontBBox: -218, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFCLPI+HgmvxxAdvTTb5929f4c+22 FontSubset: true FirstChar: 21 LastChar: 22 FontDescriptor: FontName: OFCLPI+HgmvxxAdvTTb5929f4c+22 Flags: Nonsymbolic FontBBox: -10, -218, 1083, 812 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: MyriadPro-Regular FirstChar: 1 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: OFCGKA+DtcgdpAdvTTb5929f4c FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: OFCGKA+DtcgdpAdvTTb5929f4c Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFCGLB+FpsjtkAdvTT99c4c969 FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: OFCGLB+FpsjtkAdvTT99c4c969 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFDBJI+KhknftAdvTT8861b38f.I+03 FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: OFDBJI+KhknftAdvTT8861b38f.I+03 Flags: Symbolic FontBBox: -291, -239, 937, 885 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: OFCGKB+ShhsymAdvTTb5929f4c+20 FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: OFCGKB+ShhsymAdvTTb5929f4c+20 Flags: Nonsymbolic FontBBox: -447, -208, 1375, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFCGLC+CtlyqxAdvTT1b53b5fb.I FontSubset: true FirstChar: 32 LastChar: 78 FontDescriptor: FontName: OFCGLC+CtlyqxAdvTT1b53b5fb.I Flags: Nonsymbolic FontBBox: -114, -250, 864, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OFDBKJ+CxlbccAdvTT99c4c969+20 FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: OFDBKJ+CxlbccAdvTT99c4c969+20 Flags: Nonsymbolic FontBBox: -447, -197, 1583, 864 FontFile3: true Encoding: WinAnsiEncoding XMP: Fanconi anemia,High content screening,Drug repositioning,Cell-based assay Acrobat Distiller 10.0.0 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) application/pdf 10.1186/s13023-020-01437-1 Orphanet Journal of Rare Diseases Orphanet Journal of Rare Diseases, 2020, doi:10.1186/s13023-020-01437-1 Fanconi anemia High content screening Drug repositioning Cell-based assay High content drug screening for Fanconi anemia therapeutics Helena Montanuy Cristina Camps-Fajol Jordi Carreras-Puigvert Maria Häggblad Bo Lundgren Miriam Aza-Carmona Thomas Helleday Jordi Minguillón Jordi Surrallés 2020-06-30T13:50:02+02:00 2020-06-30T13:50:02+02:00 2020-06-28T18:39:39+08:00 Arbortext Advanced Print Publisher 9.1.440/W Unicode uuid:c7192a44-4d9e-434d-b789-0f45ad245345 uuid:755aab09-7a33-4800-b590-1d0e8f763fe1 default 1 converted uuid:c7192a44-4d9e-434d-b789-0f45ad245345 converted to PDF/A-2b pdfToolbox 2020-06-28T20:19:25+08:00 2 B Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. editorInfo Bag EditorInformation external Editor information: contains the name of each editor and his/her ORCID identifier. seriesEditorInfo Bag SeriesEditorInformation external Series editor information: contains the name of each series editor and his/her ORCID identifier. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. EditorInformation http://springernature.com/ns/xmpExtensions/2.0/editorInfo/ editor Specifies the types of editor information: name and ORCID of an editor. name Text Gives the name of an editor. orcid URI Gives the ORCID of an editor. SeriesEditorInformation http://springernature.com/ns/xmpExtensions/2.0/seriesEditorInfo/ seriesEditor Specifies the types of series editor information: name and ORCID of a series editor. name Text Gives the name of a series editor. orcid URI Gives the ORCID of a series editor. http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://ns.adobe.com/pdfx/1.3/ pdfx PDF/X ID Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 496, 635, 538, 677 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 210, 328, 220 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 517, 150, 522, 160 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 528, 150, 533, 160 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 400, 73, 518, 80 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 338, 65, 477, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 114, 192, 180, 199 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 184, 192, 258, 199 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 279, 657, 284, 666 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 56, 645, 61, 654 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 124, 609, 129, 618 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 134, 609, 139, 618 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 59, 441, 64, 450 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 149, 189, 154, 198 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 154, 81, 159, 90 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 435, 609, 439, 618 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 469, 609, 474, 618 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 492, 561, 497, 570 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 484, 513, 489, 522 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 307, 453, 317, 462 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 325, 429, 330, 438 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 414, 429, 419, 438 Flags: Print AppearanceDictionary: true Destination: 204 Annotation: Subtype: Link Rect: 346, 393, 350, 402 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 526, 345, 531, 354 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 304, 309, 309, 318 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 475, 273, 480, 282 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 470, 225, 475, 234 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 389, 93, 394, 102 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 464, 93, 469, 102 Flags: Print AppearanceDictionary: true Destination: 226 Thumb: true Page: Sequence: 3 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 113, 177, 118, 186 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 217, 117, 227, 126 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 232, 117, 242, 126 Flags: Print AppearanceDictionary: true Destination: 207 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 89, 585, 99, 594 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 451, 693, 456, 702 Flags: Print AppearanceDictionary: true Destination: 263 Annotation: Subtype: Link Rect: 485, 669, 490, 678 Flags: Print AppearanceDictionary: true Destination: 263 Annotation: Subtype: Link Rect: 523, 573, 533, 582 Flags: Print AppearanceDictionary: true Destination: 207 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 92, 669, 101, 678 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 108, 669, 117, 678 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 185, 657, 190, 666 Flags: Print AppearanceDictionary: true Destination: 204 Annotation: Subtype: Link Rect: 201, 657, 211, 666 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 74, 621, 79, 630 Flags: Print AppearanceDictionary: true Destination: 263 Annotation: Subtype: Link Rect: 222, 549, 227, 558 Flags: Print AppearanceDictionary: true Destination: 263 Annotation: Subtype: Link Rect: 161, 489, 171, 498 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 177, 489, 187, 498 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 202, 357, 211, 366 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 59, 297, 69, 306 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 124, 249, 212, 258 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 224, 249, 229, 258 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 149, 237, 154, 246 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 405, 561, 414, 570 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 433, 537, 438, 546 Flags: Print AppearanceDictionary: true Destination: 263 Annotation: Subtype: Link Rect: 408, 393, 418, 402 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 424, 393, 434, 402 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 339, 333, 349, 342 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 485, 141, 495, 150 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 501, 141, 511, 150 Flags: Print AppearanceDictionary: true Destination: 207 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 128, 681, 137, 690 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 256, 189, 265, 198 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 59, 153, 69, 162 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 202, 81, 207, 90 Flags: Print AppearanceDictionary: true Destination: 204 Annotation: Subtype: Link Rect: 504, 609, 514, 618 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 339, 335, 349, 344 Flags: Print AppearanceDictionary: true Destination: 207 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 204, 645, 209, 654 Flags: Print AppearanceDictionary: true Destination: 204 Annotation: Subtype: Link Rect: 56, 537, 61, 546 Flags: Print AppearanceDictionary: true Destination: 226 Annotation: Subtype: Link Rect: 257, 261, 267, 270 Flags: Print AppearanceDictionary: true Destination: 207 Annotation: Subtype: Link Rect: 462, 669, 466, 678 Flags: Print AppearanceDictionary: true Destination: 204 Annotation: Subtype: Link Rect: 478, 635, 532, 643 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 626, 381, 634 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 119, 439, 251, 446 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 186, 194, 287, 201 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 390, 603, 494, 611 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 380, 486, 514, 494 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 4cac5adf Type: CRC32 Checksum: 981af0c2d86100532cb3d863abc138e6 Type: MD5 Checksum: dddb065196f6082c4378a9e4f9c1e26cb35726fe Type: SHA-1 Checksum: 6806d49992969c17cf3910d6c036beb93344b4f7d747f497978f4bb19532b7e5 Type: SHA-256