8d80d72c70c15c41d2dcb8d3ed58f39e pmc_32635360.pdf d63333c0d352ba57bf04f02b1ed2d7599fb9f12a pmc_32635360.pdf 80dd74a912bc62a416043e3e0e26bbac8e3d755b81101e75306d7451d4e371d2 pmc_32635360.pdf Producer: iText® 7.1.1 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Tue Jul 7 12:57:36 2020 CEST ModDate: Tue Jul 7 12:57:36 2020 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1137421 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LAATZK+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 COYECM+Pxsy Type 1 Builtin yes yes no 15 0 KORLVE+VnURWPalladioL Type 1 Custom yes yes no 19 0 FUUMET+URWPalladioL-Ital Type 1 Custom yes yes no 23 0 HGKJGS+URWPalladioL-Bold Type 1 Custom yes yes no 28 0 HROBSF+URWPalladioL-Roma Type 1 Custom yes yes no 32 0 OFLXAT+Rpxr Type 1 Builtin yes yes no 36 0 CUAJJQ+Pxbsy Type 1 Builtin yes yes no 40 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 49 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 71 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 75 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 79 0 ADDPAC+PalatinoLinotype CID TrueType Identity-H yes yes yes 92 0 ADECDK+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 98 0 ADDPBD+PalatinoLinotype TrueType WinAnsi yes yes no 101 0 ADDPIC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 104 0 ADDPJE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 107 0 ADEAMA+CalibriLight CID TrueType Identity-H yes yes yes 110 0 VUPETJ+Rpxb Type 1 Builtin yes yes no 120 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 124 0 ADDPBD+PalatinoLinotype TrueType WinAnsi yes yes no 134 0 ADDPIC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 137 0 ADDPJE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 140 0 ADEAMA+CalibriLight CID TrueType Identity-H yes yes yes 143 0 ADDPBD+PalatinoLinotype TrueType WinAnsi yes yes no 156 0 ADDPIC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 159 0 ADDPJE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 162 0 ADEAMA+CalibriLight CID TrueType Identity-H yes yes yes 165 0 VSHNAE+Rpcxr Type 1 Builtin yes yes no 195 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-21 02:45:14 CEST RepresentationInformation: pmc_32635360.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-31 11:46:56 CEST Size: 1137421 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 350 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Clinical-Pathological Features of Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Taxonomic Classification and Association with Gene Mutations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Association of Clusters with Response to NAC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Relevance to Clinical Implementation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Children: Item: Title: Study Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Immunohistochemical Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: RNA Expression Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Mutational Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Statistical Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Info: Producer: iText® 7.1.1 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Tue Jul 07 12:57:36 CEST 2020 ModDate: Tue Jul 07 12:57:36 CEST 2020 ID: 0x859a7e2718dcd6d664f6739e26abab37, 0x859a7e2718dcd6d664f6739e26abab37 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: HROBSF+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: HROBSF+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: KORLVE+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 226 FontDescriptor: FontName: KORLVE+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VSHNAE+Rpcxr FontSubset: true FirstChar: 169 LastChar: 169 FontDescriptor: FontName: VSHNAE+Rpcxr Flags: Symbolic FontBBox: -212, -286, 1344, 973 FontFile: true Font: BaseFont: OFLXAT+Rpxr FontSubset: true FirstChar: 11 LastChar: 62 FontDescriptor: FontName: OFLXAT+Rpxr Flags: Symbolic FontBBox: -40, -283, 904, 728 FontFile: true Font: BaseFont: FUUMET+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: FUUMET+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CUAJJQ+Pxbsy FontSubset: true FirstChar: 121 LastChar: 122 FontDescriptor: FontName: CUAJJQ+Pxbsy Flags: Symbolic FontBBox: 5, -978, 1382, 913 FontFile: true Font: BaseFont: VUPETJ+Rpxb FontSubset: true FirstChar: 61 LastChar: 61 FontDescriptor: FontName: VUPETJ+Rpxb Flags: Symbolic FontBBox: -57, -266, 932, 729 FontFile: true Font: BaseFont: LAATZK+VnURWPalladioL-Bold FontSubset: true FirstChar: 177 LastChar: 243 FontDescriptor: FontName: LAATZK+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: HGKJGS+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: HGKJGS+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: WBVKDJ+URWPalladioL-BoldItal FontSubset: true FirstChar: 112 LastChar: 112 FontDescriptor: FontName: WBVKDJ+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: COYECM+Pxsy FontSubset: true FirstChar: 0 LastChar: 122 FontDescriptor: FontName: COYECM+Pxsy Flags: Symbolic FontBBox: -21, -994, 1292, 912 FontFile: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 75, 757, 193, 793 Annotation: Subtype: Link Rect: 474, 757, 519, 793 Annotation: Subtype: Link Rect: 406, 640, 417, 654 Annotation: Subtype: Link Rect: 231, 626, 242, 640 Annotation: Subtype: Link Rect: 162, 602, 173, 613 Annotation: Subtype: Link Rect: 308, 602, 319, 613 Annotation: Subtype: Link Rect: 168, 38, 256, 50 Annotation: Subtype: Link Rect: 404, 38, 519, 50 Annotation: Subtype: Link Rect: 466, 303, 518, 322 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 441, 606, 448, 615 ActionDest: 185 Annotation: Subtype: Link Rect: 355, 579, 362, 588 ActionDest: 185 Annotation: Subtype: Link Rect: 362, 579, 369, 588 ActionDest: 185 Annotation: Subtype: Link Rect: 252, 552, 259, 561 ActionDest: 185 Annotation: Subtype: Link Rect: 316, 525, 323, 534 ActionDest: 185 Annotation: Subtype: Link Rect: 324, 525, 331, 534 ActionDest: 185 Annotation: Subtype: Link Rect: 467, 498, 474, 507 ActionDest: 185 Annotation: Subtype: Link Rect: 474, 498, 481, 507 ActionDest: 185 Annotation: Subtype: Link Rect: 104, 457, 111, 467 ActionDest: 189 Annotation: Subtype: Link Rect: 494, 430, 501, 440 ActionDest: 189 Annotation: Subtype: Link Rect: 504, 430, 516, 440 ActionDest: 189 Annotation: Subtype: Link Rect: 170, 403, 182, 413 ActionDest: 189 Annotation: Subtype: Link Rect: 406, 403, 418, 413 ActionDest: 189 Annotation: Subtype: Link Rect: 469, 403, 476, 413 ActionDest: 189 Annotation: Subtype: Link Rect: 479, 403, 491, 413 ActionDest: 189 Annotation: Subtype: Link Rect: 491, 403, 503, 413 ActionDest: 189 Annotation: Subtype: Link Rect: 504, 403, 516, 413 ActionDest: 189 Annotation: Subtype: Link Rect: 370, 295, 382, 304 ActionDest: 189 Annotation: Subtype: Link Rect: 125, 255, 137, 264 ActionDest: 189 Annotation: Subtype: Link Rect: 138, 255, 150, 264 ActionDest: 189 Annotation: Subtype: Link Rect: 150, 255, 162, 264 ActionDest: 189 Annotation: Subtype: Link Rect: 211, 241, 223, 250 ActionDest: 189 Annotation: Subtype: Link Rect: 224, 241, 236, 250 ActionDest: 189 Annotation: Subtype: Link Rect: 236, 241, 248, 250 ActionDest: 189 Annotation: Subtype: Link Rect: 106, 214, 118, 223 ActionDest: 189 Annotation: Subtype: Link Rect: 118, 214, 130, 223 ActionDest: 189 Annotation: Subtype: Link Rect: 412, 160, 424, 169 ActionDest: 189 Annotation: Subtype: Link Rect: 336, 133, 348, 142 ActionDest: 189 Annotation: Subtype: Link Rect: 491, 106, 503, 115 ActionDest: 189 Annotation: Subtype: Link Rect: 503, 106, 515, 115 ActionDest: 189 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 511, 521, 518, 533 ActionDest: 117 Annotation: Subtype: Link Rect: 345, 344, 352, 356 ActionDest: 86 Page: Sequence: 4 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 501, 591, 508, 603 ActionDest: 128 Annotation: Subtype: Link Rect: 207, 537, 214, 549 ActionDest: 128 Annotation: Subtype: Link Rect: 145, 205, 157, 215 ActionDest: 189 Annotation: Subtype: Link Rect: 305, 178, 317, 188 ActionDest: 189 Annotation: Subtype: Link Rect: 317, 178, 329, 188 ActionDest: 189 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 293, 518, 300, 529 ActionDest: 150 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 333, 666, 340, 678 ActionDest: 86 Annotation: Subtype: Link Rect: 462, 655, 474, 665 ActionDest: 192 Annotation: Subtype: Link Rect: 182, 396, 189, 406 ActionDest: 189 Annotation: Subtype: Link Rect: 111, 248, 123, 257 ActionDest: 189 Annotation: Subtype: Link Rect: 477, 126, 489, 136 ActionDest: 189 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 185, 729, 197, 738 ActionDest: 189 Annotation: Subtype: Link Rect: 198, 729, 209, 738 ActionDest: 189 Annotation: Subtype: Link Rect: 491, 729, 503, 738 ActionDest: 192 Annotation: Subtype: Link Rect: 503, 729, 515, 738 ActionDest: 192 Annotation: Subtype: Link Rect: 503, 675, 515, 684 ActionDest: 189 Annotation: Subtype: Link Rect: 247, 567, 259, 576 ActionDest: 189 Annotation: Subtype: Link Rect: 267, 445, 279, 454 ActionDest: 192 Annotation: Subtype: Link Rect: 127, 418, 139, 427 ActionDest: 192 Annotation: Subtype: Link Rect: 139, 418, 151, 427 ActionDest: 192 Annotation: Subtype: Link Rect: 157, 405, 169, 414 ActionDest: 192 Annotation: Subtype: Link Rect: 345, 391, 357, 400 ActionDest: 192 Annotation: Subtype: Link Rect: 345, 324, 357, 333 ActionDest: 192 Annotation: Subtype: Link Rect: 433, 310, 445, 319 ActionDest: 192 Annotation: Subtype: Link Rect: 214, 267, 334, 279 Annotation: Subtype: Link Rect: 367, 215, 374, 225 ActionDest: 189 Annotation: Subtype: Link Rect: 374, 215, 386, 225 ActionDest: 192 Annotation: Subtype: Link Rect: 368, 188, 375, 198 ActionDest: 189 Annotation: Subtype: Link Rect: 376, 189, 388, 198 ActionDest: 189 Annotation: Subtype: Link Rect: 388, 188, 400, 198 ActionDest: 192 Annotation: Subtype: Link Rect: 447, 107, 459, 117 ActionDest: 192 Annotation: Subtype: Link Rect: 460, 107, 472, 117 ActionDest: 192 Page: Sequence: 9 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 134, 702, 146, 711 ActionDest: 189 Annotation: Subtype: Link Rect: 225, 565, 237, 574 ActionDest: 192 Annotation: Subtype: Link Rect: 124, 538, 136, 547 ActionDest: 192 Annotation: Subtype: Link Rect: 237, 359, 414, 371 Annotation: Subtype: Link Rect: 333, 208, 518, 219 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 246, 374, 283, 384 Annotation: Subtype: Link Rect: 136, 322, 174, 332 Annotation: Subtype: Link Rect: 145, 271, 182, 281 Annotation: Subtype: Link Rect: 189, 271, 225, 281 Annotation: Subtype: Link Rect: 366, 231, 403, 242 Annotation: Subtype: Link Rect: 410, 231, 446, 242 Annotation: Subtype: Link Rect: 477, 192, 515, 203 Annotation: Subtype: Link Rect: 332, 154, 370, 165 Annotation: Subtype: Link Rect: 215, 116, 253, 126 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 100, 702, 137, 712 Annotation: Subtype: Link Rect: 307, 663, 344, 673 Annotation: Subtype: Link Rect: 251, 638, 288, 648 Annotation: Subtype: Link Rect: 323, 599, 361, 609 Annotation: Subtype: Link Rect: 367, 599, 403, 609 Annotation: Subtype: Link Rect: 100, 560, 137, 570 Annotation: Subtype: Link Rect: 143, 560, 179, 570 Annotation: Subtype: Link Rect: 180, 521, 217, 531 Annotation: Subtype: Link Rect: 223, 521, 259, 531 Annotation: Subtype: Link Rect: 352, 482, 390, 493 Annotation: Subtype: Link Rect: 409, 443, 447, 454 Annotation: Subtype: Link Rect: 100, 405, 137, 415 Annotation: Subtype: Link Rect: 100, 354, 137, 364 Annotation: Subtype: Link Rect: 100, 302, 137, 312 Annotation: Subtype: Link Rect: 474, 211, 512, 222 Annotation: Subtype: Link Rect: 100, 160, 137, 170 Annotation: Subtype: Link Rect: 143, 160, 179, 170 Annotation: Subtype: Link Rect: 326, 120, 364, 131 Annotation: Subtype: Link Rect: 370, 120, 406, 131 Annotation: Subtype: Link Rect: 340, 82, 378, 92 Annotation: Subtype: Link Rect: 384, 82, 420, 92 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 437, 727, 474, 738 Annotation: Subtype: Link Rect: 480, 727, 516, 738 Annotation: Subtype: Link Rect: 402, 701, 439, 712 Annotation: Subtype: Link Rect: 315, 663, 352, 673 Annotation: Subtype: Link Rect: 163, 625, 201, 635 Annotation: Subtype: Link Rect: 386, 585, 423, 596 Annotation: Subtype: Link Rect: 429, 585, 465, 596 Annotation: Subtype: Link Rect: 448, 547, 485, 557 Annotation: Subtype: Link Rect: 388, 508, 425, 519 Annotation: Subtype: Link Rect: 479, 469, 516, 480 Annotation: Subtype: Link Rect: 100, 457, 136, 467 Annotation: Subtype: Link Rect: 276, 418, 314, 428 Annotation: Subtype: Link Rect: 320, 418, 356, 428 Annotation: Subtype: Link Rect: 100, 366, 137, 376 Annotation: Subtype: Link Rect: 143, 366, 179, 376 Annotation: Subtype: Link Rect: 480, 340, 516, 351 Annotation: Subtype: Link Rect: 76, 298, 166, 329 Annotation: Subtype: Link Rect: 234, 292, 407, 303 Checksum: c07ff2c6 Type: CRC32 Checksum: 8d80d72c70c15c41d2dcb8d3ed58f39e Type: MD5 Checksum: d63333c0d352ba57bf04f02b1ed2d7599fb9f12a Type: SHA-1