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ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-03-31 11:46:56 CEST Size: 4508882 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 615 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Results Destination: section.2 Children: Item: Title: Identification of Novel Compounds That Compromise CSC Viability Destination: subsection.2.1 Item: Title: Compound 1 Impairs the Self-Renewal and Tumor Initiating Capacity of PDAC Cells by Depleting the CSC Compartment Destination: subsection.2.2 Item: Title: Characterization and Development of Chemical Probes to Study the Mechanism of Action of Series 1 Compounds Destination: subsection.2.3 Item: Title: Compound 2 Induces Lysosomal Membrane Permeabilization Destination: subsection.2.4 Item: Title: Broad Spectrum of LMP-Inducing Agents Target CSCs Destination: subsection.2.5 Item: Title: LMP Inhibits Pancreatic CSC-Mediated Tumorigenesis and Disease Recurrence In Vivo Destination: subsection.2.6 Item: Title: Discussion Destination: section.3 Item: Title: Materials and Methods Destination: section.4 Children: Item: Title: CNIO-640 Chemical Library Destination: subsection.4.1 Item: Title: Murine Embryonic Stem Cells Destination: subsection.4.2 Item: Title: Primary Human Pancreatic Cancer Cells Destination: subsection.4.3 Item: Title: Sphere Formation Assay Destination: subsection.4.4 Item: Title: Drug Screening and Cell Viability Assays Destination: subsection.4.5 Item: Title: Flow Cytometry Destination: subsection.4.6 Item: Title: In Vivo Assays Destination: subsection.4.7 Item: Title: Pharmacokinetic Studies (PK) Destination: subsection.4.8 Item: Title: KinomeScan Destination: subsection.4.9 Item: Title: Synthesis of Affinity Chemical Probes Destination: subsection.4.10 Item: Title: Kinase Assays Destination: subsection.4.11 Item: Title: Immunofluorescence with Click Chemistry Probes Destination: subsection.4.12 Item: Title: Acridine Orange Lysosomal Integrity Assay Destination: subsection.4.13 Item: Title: Measurement of Cytosolic Cathepsin Activity Destination: subsection.4.14 Item: Title: RNA Sequencing Destination: subsection.4.15 Item: Title: Statistical Analyses Destination: subsection.4.16 Item: Title: Data Availability Destination: subsection.4.17 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Producer: iText® 7.1.1 ©2000-2018 iText Group NV (AGPL-version) CreationDate: Wed Jul 08 12:44:36 CEST 2020 ModDate: Wed Jul 08 12:44:36 CEST 2020 ID: 0x59259ae6ae4be4e2d1f20715e8f3e250, 0x59259ae6ae4be4e2d1f20715e8f3e250 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: XYUBAL+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: XYUBAL+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, 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